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Research Article

Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection

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Pages 80-84 | Received 27 Aug 2018, Accepted 20 Oct 2018, Published online: 03 Feb 2019

References

  • Sgaramella N, Coates PJ, Strindlund K, et al. Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1. Br J Cancer. 2015;113:321–326.
  • Lee SY, Cho NH, Choi EC, et al. Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. Int J Oral Maxillofac Surg. 2010;39:678–683.
  • Elango KJ, Suresh A, Erode EM, et al. Role of human papilloma virus in oral tongue squamous cell carcinoma. Asian Pac J Cancer Prev. 2011;12:889–896.
  • Jeon JH, Kim MG, Park JY, et al. Analysis of the outcome of young age tongue squamous cell carcinoma. Maxillofac Plast Reconstr Surg. 2017;39:41.
  • Morbini P, Benazzo M. Human papillomavirus and head and neck carcinomas: focus on evidence in the babel of published data. Acta Otorhinolaryngol Ital. 2016;36:249–258.
  • Tachibana T, Orita Y, Marunaka H, et al. Neck metastasis in patients with T1-2 supraglottic cancer. Auris Nasus Larynx. 2018;45:540–545.
  • Dahlgren L, Dahlstrand HM, Lindquist D, et al. Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients. Int J Cancer. 2004;112:1015–1019.
  • Zheng Y, Xia P, Zheng HC, et al. The screening of viral risk factors in tongue and pharyngolaryngeal squamous carcinoma. Anticancer Res. 2010;30:1233–1238.
  • Orita Y, Gion Y, Tachibana T, et al. Laryngeal squamous cell papilloma is highly associated with human papillomavirus. Jpn J Clin Oncol. 2018;48:350–355.
  • Weinberger PM, Yu Z, Haffty BG, et al. Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin Cancer Res. 2004;10:5684–5691.
  • Ramshankar V, Soundara VT, Shyamsundar V, et al. Risk stratification of early stage oral tongue cancers based on HPV status and p16 immunoexpression. Asian Pac J Cancer Prev. 2014;15:8351–8359.
  • Zafereo ME, Xu L, Dahlstrom KR, et al. Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncol. 2016;56:47–53.
  • Minami K, Kogashiwa Y, Ebihara Y, et al. Human papillomavirus and p16 protein expression as prognostic biomarkers in mobile tongue cancer. Acta Otolaryngol. 2017;137:1121–1126.
  • Saghravanian N, Zamanzadeh M, Meshkat Z, et al. Evaluation of the prevalence rate and the prognostic effect of human papilloma virus infection in a group of patients with oral cavity squamous cell carcinoma. Iran J Cancer Prev. 2016;9:e3998.
  • Klingenberg B, Hafkamp HC, Haesevoets A, et al. p16 INK4A overexpression is frequently detected in tumour-free tonsil tissue without association with HPV. Histopathology. 2010;56:957–967.
  • Wilms T, Khan G, Coates PJ, et al. No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue. PLoS One. 2017;12:e0184201.

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