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Research Article

Topical Budesonide Treatment Reduces Endothelial Expression of Intercellular Adhesion Molecules (Vascular Cell Adhesion Molecule-1 and P-selectin) and Eosinophil Infiltration in Nasal Polyps

Pages 362-368 | Published online: 08 Jul 2009

References

  • Larsen PL, Tos M. Origin and structure of nasal polyps. In: Mygind N, Lildholt T, eds. Nasal polypo-sis—an inflammatory disease and its treatment. Copen-hagen: Munksgaard, 1997: 17–30.
  • Hellquist HB. Nasal polyps update. Histopathology. Allergy and Asthma Proc 1996; 17: 237–42.
  • Kakoi H, Hiraide F. A histological study of formation and growth of nasal olyps. Acta Otolaryngol (Stockh) 1987; 103: 137–44.
  • Settipane GA. Epidemiology of nasal polyps. Allergy and Asthma Proc 1996; 17: 231–6.
  • Larsen PL, Tingsgaard PK, Harcourt J, Sofsrud G, Tos M. Nasal polyps and their relation to polyps/hy-pertrophic polypoid mucosa in the paranasal sinuses: a macro-, endo-, and microscopic study of autopsy mate-rials. Am J Rhinol 1998; 12: 45–51.
  • Springer TA. Traffic signals for lymphocyte recircula-tion and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301–14.
  • Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994; 8: 504–12.
  • Kitayama J, Fuhlbrigge RC, Puri KB, Springer TA. P-Selectin, L-selectin and oc4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothe-lial cells under physiological flow conditions. J Im-munol 1997; 159: 3929–39.
  • Tingsgaard PK, Larsen PL, Bock T, Lange Vejlsgaard G, Tos M. Expression of intercellular adhesion molecule-1 on the vascular endothelium in nasal polyps before, during and after topical glucocorticoid treatment. Acta Otolaryngol (Stockh) 1998; 118: 404–8.
  • Jahnsen FL, Haraldsen G, Aanesen JP, Haye R, Brashler JR. Eosinophil infiltration is related to in-creased expression of vascular cell adhesion molecule-1 in nasal polyps. Am J Respir Cell Mol Biol 1995; 12: 624–32.
  • Beck LA, Stellato C, Dawson Beall L, et al. Detection of the chemochine RANTES and endothelial adhesion molecules in nasal polyps. J. Allergy Clin Immunol 1996; 98: 766–80.
  • Fokkens WJ, Holm AF, Rijntjes E, Mulder PGH, Vroom TM. Characterization and quantification of cellular infiltrates in nasal mucosa of patients with grass pollen allergy, non-allergic patients with nasal polyps and controls. Int Arch Allergy Appl Immunol 1990; 93: 66–72.
  • Kanai N, Denburg J, Jordana M, Dolovich J. Nasal polyp inflammation. Effect of topical nasal steroid. Am Respir Crit Care Med 1994; 150: 1094–100.
  • Wardlaw AJ, Walsh GM, Symon FA. Adhesion inter-actions involved in eosinophil migration through vas-cular endothelium. Ann N Y Acad Sci 1996; 796: 124–37.
  • Sriramarao P, von Adrian UH, Butcher EC, Bourdon MA, Broide DH. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J Immunol 1994; 153: 4238–46.
  • Henriques GMO, Miotla JM, Corderio RSB, Wolitzky BA, Woolley ST, Hellewell PG. Selectins mediate eosinophil recruitment in vivo. A comparison with their role in neutrophil influx. Blood 1994; 87: 5297–304.
  • Hamilos DL, Leung DYM, Wood R, et al. Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with en-dothelial VCAM-1 upregulation and expression of TNF-a. Am J Respir Cell Mol Biol 1996; 15: 443–50.
  • Symon FA, Walsh GM, Watson SR, Wardlaw AJ. Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent. J Exp Med 1994; 180: 371–6.
  • Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann GA. Mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89: 9991–5.
  • Kaiser J, Bickl CA, Bochner BS, Schleimer RP. The effects of the potent glucocorticoid budesonide on ad-hesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules. J Pharmacol Exp Ther 1992; 267: 245–9.
  • Tessier PA, Cattaruzzi P, McColl SR. Inhibition of lymphocyte adhesion to cytochine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression. Arthritis Rheum 1996; 39: 226–34.
  • Perretti M, Wheller SK, Harris JG, Flower RJ. Mod-ulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-lfl and dexamethasone. Biochem Biophys Res Com 1996; 223: 112–7.
  • Auphan NDJA, Rosette C, Helmberg A, Karin M. Immunosupression by glucocorticoids: Inhibition of NF-KB activity through induction of IKB synthesis. Science 1995; 270: 286–90.
  • Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of IKBoc in me-diation of immunosuppression by glucocorticoids. Sci-ence 1995; 270: 283–6.
  • Manning AM, Bell FPRCL, Chosay JG, et al. NF-KB is activated during acute inflammation in vivo in asso-ciation with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. J Inflammation 1995; 45: 283–96.

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