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BIOANALYTICAL

Determination of Mycophenolic Acid (MPA) and Its Acyl and Phenol Glucuronide Metabolits Simultaneously in Human Plasma by a Simplified HPLC Method

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Pages 2465-2475 | Received 21 Apr 2007, Accepted 01 Jun 2007, Published online: 29 Oct 2007

References

  • Beal , J. L. , Jones , C. E. , Taylor , P. J. and Tett , S. E. 1998 . Evaluation of an immunoassay (EMIT) for mycophenolic acid in plasma from renal transplant recipients compared with a high‐performance liquid chromatography assay . Ther. Drug Monit. , 20 : 685 – 690 .
  • Brandhorst , G. , Streit , F. , Goetze , S. , Oellerich , M. and Armstrong , V. W. 2006 . Quantification by liquid chromatography tandem mass spectrometry of mycophenolic acid and its phenol and acyl glucuronide metabolites . Clin. Chem. , 52 : 1962 – 1964 .
  • Bullingham , R. , Monroe , S. , Nicholls , A. and Hale , M. 1996 . Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single‐dose oral and intravenous administration . J. Clin Pharmacol. , 36 : 315 – 324 .
  • Bullingham , R. , Nicholls , A. and Hale , M. 1996 . Pharmacokinetics of mycophenolate mofetil (RS61443): a short review . Transplant. Proc. , 28 : 925 – 929 .
  • Bullingham , R. , Nicholls , A. J. and Kamm , B. R. 1998 . Clinical pharmacokinetics of mycophenolate mofetil . Clin. Pharmacokinet. , 34 : 429 – 455 .
  • Holt , D. W. 2002 . Monitoring mycophenolic acid . Ann. Clin. Biochem. , 39 : 173 – 183 .
  • Johnson , H. J. , Swan , S. K. , Heim‐Duthoy , K. L. , Nicholls , A. J. , Tsina , I. and Tarnowski , T. 1998 . The pharmacokinetics of a single oral dose of mycophenolate mofetil in patients with varying degrees of renal function . Clin. Pharmacol Ther. , 63 : 512 – 518 .
  • Jones , C. E. , Taylor , P. J. and Johnson , A. G. 1998 . High‐performance liquid chromatography determination of mycophenolic acid and its glucuronide metabolite in human plasma . J. Chromatogr B Biomed Sci Appl. , 708 : 229 – 234 .
  • Khoschsorur , G. and Erwa , W. 2004 . Liquid chromatographic method for simultaneous determination of mycophenolic acid and its phenol‐ and acylglucuronide metabolites in plasma . J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , 799 : 355 – 360 .
  • Patel , C. G. and Akhlaghi , F. 2006 . High‐performance liquid chromatography method for the determination of mycophenolic acid and its acyl and phenol glucuronide metabolites in human plasma . Ther. Drug Monit. , 28 : 116 – 122 .
  • Schutz , E. , Shipkova , M. , Armstrong , V. W. , Niedmann , P. D. , Weber , L. , Tonshoff , B. , Pethig , K. , Wahlers , T. , Braun , F. , Ringe , B. and Oellerich , M. 1998 . Therapeutic drug monitoring of mycophenolic acid: comparison of HPLC and immunoassay reveals new MPA metabolites . Transplant. Proc. , 30 : 1185 – 1187 .
  • Schutz , E. , Shipkova , M. , Armstrong , V. W. , Wieland , E. and Oellerich , M. 1999 . Identification of a pharmacologically active metabolite of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil . Clin. Chem. , 45 : 419 – 422 .
  • Shaw , L. M. , Nicholls , M. , Hale , Armstrong , V. W. , Oellerich , M. , Yatscoff , R. , Morris , R. E. , Holt , D. W. , Venkataramanan , R. , Haley , J. , Halloran , P. , Ettenger , R. , Keown , P. and Morris , R. G. 1998 . Therapeutic monitoring of mycophenolic acid: a consensus panel report . Clin. Biochem. , 5 : 317 – 322 .
  • Shaw , L. M. , Pawinski , T. , Korecka , M. and Nawrocki , A. 2002 . Monitoring of mycophenolic acid in clinical transplantation . Ther. Drug Monit. , 24 : 68 – 73 .
  • Shipkova , M. , Schutz , E. , Armstrong , V. W. , Niedmann , P. D. , Oellerich , M. and Wieland , E. 2000 . Determination of the acyl glucuronide metabolite of mycophenolic acid in human plasma by HPLC and Emit . Clin. Chem. , 46 : 365 – 372 .
  • Wieland , E. , Shipkova , M. , Schellhaas , U. , Schutz , E. , Niedmann , P. D. , Armstrong , V. W. and Oellerich , M. 2000 . Induction of cytokine release by the acyl glucuronide of mycophenolic acid: a link to side effects? . Clin. Biochem. , 33 : 107 – 113 .
  • Yu , Z. C. , Cai , W. M. , Xu , D. and Wang , X. H. 2005 . HPLC determination of mycophenolate mofetil and its active metabolite mycophenolic acid in human plasma . Chin. J. Pharm. Anal. , 25 : 381 – 384 .

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