HPLC Analysis of HI‐6 Dichloride and Dimethanesulfonate—Antidotes against Nerve Agents and Organophosphorus Pesticides

References

• Bajgar , J. , Fusek , J. , Kuca , K. , Bartosova , L. and Jun , D. 2007 . Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction . Mini‐Rev. Med. Chem. , 7 : 461 – 466 .
   PubMed Web of Science ®Google Scholar
• Benschop , H. P. , Konings , K. A.G. , Kossen , S. P. and Ligtenstein , D. A. 1981 . Determination of some pyridinium aldoxime compounds by means of ion‐pair reversed‐phase high‐performance liquid chromatography: application in biological material . J. Chromatogr. , 225 : 107 – 114 .
   PubMed Web of Science ®Google Scholar
• Hagedorn , I. 1973 . US Patent, Bis‐quaternary pyridinium salts . 3 : 773, 775
   Google Scholar
• Jun , D. , Bajgar , J. and Kuca , K. 2006 . In vitro comparison of eight acetylcholinesterase reactivators to reactivate VX inhibited ACHE . Toxicol. Lett. , 164 : S120 – S120 .
   Web of Science ®Google Scholar
• Jun , D. , Stodulka , P. , Kuca , K. , Koleckar , V. , Dolezal , B. , Simon , P. and Veverka , M. 2007 . TLC analysis of intermediates arising during the preparation of oxime HI‐6 dimethanesulfonate . J. Chromatogr. Sci. , In Press
   Web of Science ®Google Scholar
• Krummer , S. , Thiermann , H. , Worek , F. and Eyer , P. 2002 . Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI‐6 dichloride and HI‐6 dimethanesulfonate . Arch. Toxicol. , 76 : 589 – 595 .
   PubMed Web of Science ®Google Scholar
• Kuca , K. , Bartosova , L. , Kassa , J. , Cabal , J. , Bajgar , J. , Kunesova , G. and Jun , D. 2005 . Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent‐inhibited acetylcholinesterase in vitro and in vivo . Chem. Biol. Interact. , 157–158 : 367 – 368 .
   PubMed Web of Science ®Google Scholar
• Kuca , K. , Jun , D. and Musilek , K. 2006 . Structural requirements of acetylcholinesterase reactivators . Mini‐Rev. Med. Chem. , 6 : 269 – 277 .
   PubMed Web of Science ®Google Scholar
• Laufer , R. , Bathori , M. , Csermely , T. , Petroianu , G. , Kuca , K. , Toth , N. and Kalasz , H. 2007 . The TLC determination of hydrophilicity parameter of some pyridinium aldoximes . J. Liq. Chromatogr. , 30 : 2337 – 2344 .
   Web of Science ®Google Scholar
• Lorke , D. E. , Hasan , M. Y. , Nurulain , S. M. , Sheen , R. , Kuca , K. and Petroianu , G. A. 2007 . Entry of two new asymmetric bispyridinium oximes (K‐27 and K‐48) into the brain: comparison with obidoxime . J. Appl. Toxicol. , 27 : 482 – 490 .
   PubMed Web of Science ®Google Scholar
• Lundy , P. M. , Hill , I. , Lecavalier , P. , Hamilton , M. G. , Vair , C. , Davidson , C. , Weatherby , K. L. and Berger , B. J. 2005 . The pharmacokinetics and pharmacodynamics of two HI‐6 salts in swine and efficacy in the treatment of GF and soman poisoning . Toxicology , 208 : 399 – 409 .
   PubMed Web of Science ®Google Scholar
• Lundy , P. M. , Raveh , L. and Amitai , G. 2006 . Development of the bisquaternary oxime HI‐6 toward clinical use in the treatment of organophosphate nerve agent poisoning . Toxicol. Rev. , 25 : 231 – 243 .
   PubMedGoogle Scholar
• Sakurada , K. , Matsubara , K. , Shimizu , K. , Shiono , H. , Seto , Y. , Tsuge , K. , Yoshino , M. , Sakai , I. , Mukoyama , H. and Takatori , T. 2003 . Pralidoxime iodide (2‐Pam) penetrates across the blood‐brain barrier . Neurochem. Res. , 28 : 1401 – 1407 .
   PubMed Web of Science ®Google Scholar
• Shih , M. L. , Smith , J. R. and Salem , G. W. 1990 . High‐performance liquid chromatographic analysis of imidazolium and pyridinium oximes in plasma and urine . J. Chromatogr. , 527 : 371 – 379 .
   PubMed Web of Science ®Google Scholar
• Thiermann , H. , Seidl , S. and Eyer , P. 1996 . HI‐6 dimethanesulfonate has better dissolution properties than HI‐6 dichloride for application in dry/wet autoinjectors . Int. J. Pharm. , 137 : 167 – 176 .
   Google Scholar