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Pharmaceutical Analysis

Chromatographic Tandem Mass Spectrometric Detection of Physostigmine and its Major Metabolites in Rat Urine

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Pages 3256-3266 | Received 20 Aug 2007, Accepted 10 Sep 2007, Published online: 04 Feb 2008

References

  • Appolonova , S. A.A. , Shpak , A. V. and Semenov , V. A. 2004 . Liquid chromatography—electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine . J. Chromatogr. B , 800 : 281 – 289 .
  • Argyll‐Robertson , D. 1863 . On the Calabar bean as a new agent in ophthalmic medicine . Edinb. Med. J. , 8 : 815 – 820 .
  • Chan , S. A. , Chen , M. J. , Liu , T. Y. , Fuh , M. R. , Deng , J. F. , Wu , M. L. and Hsieh , S. J. 2003 . Determination of aristolochic acids in medicinal plant and herbal product by liquid chromatography‐electrospray‐ion trap mass spectrometry . Talanta , 60 : 679 – 685 .
  • Chung , E. W. , Ho , E. N.M. , Leung , D. K.K. , Tang , F. P.W. , Yin , K. C.H. and Wan , T. S.M. 2004 . Detection of anti‐ulcer drugs and their metabolites in horse urine by liquid chromatography—mass spectrometry . Chromatographia , 59 : S29 – S38 .
  • Davis , K. L. and Mohs , R. C. 1982 . Enhancement of memory processes in Alzheimer's disease with multiple‐dose intravenous physostigmine . Am. J. Psychiatry , 139 : 1421 – 1424 .
  • Dong , Q. G. , Gu , J. K. , Zhong , D. F. , Fawcett , J. P. and Chu , D. F. 2002 . Isolation and identification of the glucuronide of 4‐(3H‐1,2‐dihydro‐1‐pyrrolizinone‐2‐methylamino) benzoic acid from rabbit urine . J. Chromatogr. B , 772 : 369 – 372 .
  • Furey , M. L. , Pietrini , P. , Haxby , J. V. , Alexander , G. E. , Lee , H. C. VanMeter , J. 1997 . Cholinergic stimulation alter performance and task‐specific regional cerebral blood flow during working memory . Proc. Natl. Acad. Sci. USA , 94 : 6512 – 6516 .
  • Gangl , E. , Utkin , H. , Gerber , N. and Vouros , P. 2002 . The structural elucidation of metabolites of ritonavir and inidinavir by liquid chromatography mass spectrometry . J. Chromatogr. A , 974 : 91 – 101 .
  • Giacobini , E. , Somani , S. , McIlhany , M. , Downen , M. and Hallak , M. 1987 . Pharmacokinetics and pharmacodynamics of physostigmine after intravenous administration in beagle dog . Neuropharmacology , 26 : 831 – 836 .
  • Kerns , E. H. , Rourich , R. A. , Volk , K. J. and Lee , M. S. 1997 . Buspirone metabolite structure profile using a standard liquid chromatographic‐mass spectrometric protocol . J. Chromatogr. B , 698 : 133 – 145 .
  • Lam , W. and Ramanathan , R. 2002 . In electrospray ionization source hydrogen/deuterium exchange LC‐MS and LC‐MS/MS for characterization of metabolites . J. Am. Soc. Mass Spectrom. , 13 : 345 – 353 .
  • Maelicke , A. , Schrattenholz , A. , Samochocki , M. , Radina , M. and Albuquerque , E. X. 2000 . Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease . Behav. Brain Res. , 113 : 199 – 206 .
  • Rudewicz , P. and Straub , K. M. 1986 . Rapid structure elucidation of catecholamine conjugates with tandem mass spectrometry . Anal. Chem. , 58 : 2928 – 2934 .
  • Somani , S. M. and Khalique , A. 1986 . Distribution and pharmacokinetics of physostigmine in rat after intramuscular administration . Fundam. Appl. Toxicol. , 6 : 327 – 334 .
  • Somani , S. M. and Khalique , A. 1987 . Pharmacokinetics and pharmacodynamics of physostigmine in the rat after intravenous administration . Drug Metab. Dispos. , 15 : 627 – 633 .
  • Thal , L. J. , Lasker , B. , Sharpless , N. S. , Bobotas , G. , Schor , J. M. and Nigalye , A. 1989 . A plasma physostigmine concentrations after controlled‐release oral administration . Arch. Neurol. , 46 : 13 – 16 .
  • Tuovinen , K. , Kaliste‐Korhonen , E. , Raushel , F. M. and Hanninen , O. 1999 . Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication . Toxicology , 134 : 169 – 178 .
  • Yu , X. , Cui , D. and Davis , M. R. 1999 . Identification of in vitro metabolites of indinavir by ‘‘Intelligent automated LC‐MS/MS’' (INTAMS) utilizing triple quadrupole tandem mass spectrometry . J. Am. Soc. Mass Spectrom. , 10 : 175 – 183 .

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