Conductometric Determination of N-acetylcysteine in Pharmaceutical Formulations Using Copper(II) Sulphate as Titrant

REFERENCES

• Alvarez-Coque , M.C.G. , Hernández , M.J.M. , Camañas , R.M.V. , and Mongay , C. 1989 . Spectrophotometric determination of N-acetylcysteine in drug formulations with o-phthalaldehyde and isoleucine . Analyst , 114 : 975 – 977 .
   Web of Science ®Google Scholar
• Banica , F.G. , Moreira , J.C. , and Fogg , A.G. 1994 . Application of catalytica stripping voltammetry for the determination of orgânica sulfur-compounds at a hanging mercury drop electrode: Behavior of cysteine, custine and N-acetylcysteine in the presence of nickel íon . Analyst , 119 : 309 – 318 .
   Web of Science ®Google Scholar
• Bittencount , C.F. 1977 . Farmacopeia Brasileira, , 3rd ed . São Paulo : Atheneu Editora , 406 – 407 .
   Google Scholar
• Borgstrom , L. , Kagedal , B. , and Paulsen , O. 1986 . Pharmacokinetics of N-acetylcysteine in man . Eur. J. Clin. Pharmacol. , 31 : 217 – 222 .
   PubMed Web of Science ®Google Scholar
• de Flora , S. , Bennicellik , C. , and Camoirano , A. 1985 . In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and or mutagenic compounds . Carcinogenesis , 6 : 1735 – 1745 .
   PubMed Web of Science ®Google Scholar
• do Carmo , D.R. , da Silva , R.M. and Stradiotto , N.R. 2003 . Electrocatalytic and voltammetric determination of sulfhydryl compounds through iron nitroprusside modified graphite paste electrode . J. Braz. Chem. Soc. , 14 : 616 – 620 .
   Web of Science ®Google Scholar
• Du , H.X. , Li , Y.H. , and Lu , J.R. 2001 . Investigation on the chemiluminescence reaction of luminol-H2O2-S2-/R-SH system . Anal. Chim. Acta , 448 : 79 – 83 .
   Web of Science ®Google Scholar
• Garcia-Molina , F. , Penalver , M.J. , Rodriguez-Lopez , J.N. , Garcia-Canovas , F. , and Tudela , J. 2005 . Enzymatic method with polyphenol oxidase for the determination of cysteine and N-acetylcysteine . J. Agr. Food Chem. , 53 : 6183 – 6189 .
   PubMed Web of Science ®Google Scholar
• Kolar , M. and Dobcnik , D. 2003 . Chemically prepared silver electrode for determination of N-acetyl-L-cysteine by flow-injection potentiometry . Pharmazie , 58 : 25 – 28 .
   PubMed Web of Science ®Google Scholar
• Kuruganti , P.A. , Luchéis , P.A. , and Wurster , R.D. 2002 . Mitogen activated protein kinase activation and oxidant signaling in astrocytoma cells . J. Neurooncol. , 44 : 213 – 221 .
   Web of Science ®Google Scholar
• Raggi , M.A. , Cavrini , V. , and Di Petra , A.M. 1982 . Colorimetric determination of acetylcysteine, penicillamine, and mercaptopropinnylglycine in pharmaceutical dosage forms . J. Pharm. Sci. , 71 : 1384 – 1386 .
   PubMed Web of Science ®Google Scholar
• Sastry , C.S.P. , Srinivas , K.R. , and Prasad , K.M.M. K. 1996 . Spectrophotometric determination of bio-active compounds in commercial samples with nitrous acid and cresyl fast violet acetate . Anal. Lett. , 29 : 1329 – 1349 .
   Web of Science ®Google Scholar
• Sanchez-Pedreño , C. , Albero , M.I. , Garcia , M.S. , and Rodenas , V. 1992 . Determination of N-acetylcysteine in pharmaceutical samples by flow-injection . Analyst , 117 : 925 – 928 .
   Web of Science ®Google Scholar
• The United States Pharmacopeia Convention, , 2000. 24th ed . The United States Pharmacopeia, Rockville , MD : pp. 296 – 298 .
   Google Scholar