High-Performance Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Trospium Chloride in Human Plasma and Its Application in a Bioequivalence Study

REFERENCES

• Albrecht , H. , R. Bruhn , D. Lorenz , P. W. Lücker , and M. Schumacher . 1983 . Pupillometry: A noninvasive pharmacokinetic and pharmacodynamic method to study the action of trospium chloride on smooth muscle . Methods Find. Exp. Clin. Pharmcol. 5 : 585 – 587 .
   PubMed Web of Science ®Google Scholar
• Doroshyenko , O. , A. Jetter , K. P. Odenthal , and U. Fuhr . 2005 . Clinical pharmacokinetics of trospium chloride . Clin. Pharmacokinet. 44 : 701 – 720 .
   PubMed Web of Science ®Google Scholar
• Halaska , M. , G. Ralph , A. Wiedemann , G. Primus , B. Ballering-Brühl , K. Höfner , and U. Jonas . 2003 . Controlled, double-blind, multicentre clinical trial to investigate long-term tolerability and efficacy of trospium chloride in patients with detrusor instability . World J. Urol. 20 : 392 – 399 .
   PubMed Web of Science ®Google Scholar
• Lehtola , T. , O. Lavikainen , and A. Huhtikangas . 1988 . Radioimmunoassay of trospiumchloride, a quaternary tropane derivative . J. Immunoassay 9 : 297 – 307 .
   PubMed Web of Science ®Google Scholar
• Matuszewski , B. K. , M. L. Constanzer , and C. M. Chavez-Eng . 1998 . Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations . Anal Chem. 70 : 882 – 889 .
   PubMed Web of Science ®Google Scholar
• Rovner , E. S. 2004 . Trospium chloride in the management of overactive bladder . Drugs 64 : 2433 – 2446 .
   PubMed Web of Science ®Google Scholar
• Schladitz-Keil , G. , H. Spahn , and E. Mutschler . 1985 . Fluorimetric determination of the quaternary compound trospium and its metabolite in biological material after derivatization with benoxaprofen chloride . J. Chromatogr. 345 : 99 – 110 .
   PubMed Web of Science ®Google Scholar
• Schroder , S. , A. Jetter , M. Zaigler , R. Weyhenmeyer , G. Krumbiegel , W. Wächter , and U. Fuhr . 2004 . Absorption pattern of trospium chloride along the human gastrointestinal tract assessed using local enteral administration . Int. J. Clin. Pharmacol. Ther. 42 : 543 – 549 .
   PubMed Web of Science ®Google Scholar
• Singh-Franco , D. , C. Machado , S. Tuteja , and A. Zapantis . 2005 . Trospium chloride for the treatment of overactive bladder with urge incontinence . Clin. Ther. 27 : 511 – 530 .
   PubMed Web of Science ®Google Scholar
• Spahn , H. , H. Weber , E. Mutschler , and W. Möhrke . 1984 . α-Alkyl-α-arylacetic acid derivatives as fluorescence markers for thin-layer chromatographic and high performace liquid chromatographic assay of amines and alcohols . J Chromatogr. 310 : 167 – 178 .
   PubMed Web of Science ®Google Scholar
• Zinner , N. , M. Gittelman , R. Harris , J. Susset , A. Kanelos , and S. Auerbach (Trospium Study Group) . 2004 . Trospium chloride improves overactive bladder symptoms: A multicenter phase III trial . J. Urol. 171 : 2311 – 2315 .
   PubMed Web of Science ®Google Scholar
• Zinner , N. R. 2005 . Trospium chloride: An anticholinergic quaternary ammonium compound for the treatment of overactive bladder . Expert Opin Pharmacother. 6 : 1409 – 1420 .
   PubMed Web of Science ®Google Scholar