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BIOSENSORS

Graphene-Based Optical and Electrochemical Biosensors: A Review

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Pages 1-17 | Received 16 May 2012, Accepted 17 Jun 2012, Published online: 21 Dec 2012

REFERENCES

  • Allen , M. J. , V. C. Tung , and R. B. Kaner . 2010 . Honeycomb carbon: A review of graphene . Chem. Rev. 110 : 132 – 145 .
  • Alwarappan , S. , C. Liu , A. Kumar , and C.-Z. Li . 2010 . Enzyme-doped graphene nanosheets for enhanced glucose biosensing . J. Phys. Chem. C 114 : 12920 – 12924 .
  • Ambrosi , A. , A. Bonanni , Z. Sofer , J. S. Cross , and M. Pumera . 2011 . Electrochemistry at chemically modified graphenes . Chem. Eur. J. 17 : 10763 – 10770 .
  • Baby , T. T. , S. S. J. Aravind , T. Arockiadoss , R. B. Rakhi , and S. Ramaprabhu . 2010 . Metal decorated graphene nanosheets as immobilization matrix for amperometric glucose biosensor . Sens. Actuators B 145 : 71 – 77 .
  • Balapanuru , J. , J. X. Yang , S. Xiao , Q. Bao , M. Jahan , L. Polavarapu , J. Wei , Q. H. Xu , and K. P. Loh . 2010 . A graphene oxide-organic dye ionic complex with DNA-sensing and optical-limiting properties . Angew. Chem. Int. Ed. 49 : 6549 – 6553 .
  • Balasubramanian , K. , and M. Burghard . 2006 . Biosensors based on carbon nanotubes . Anal. Bioanal. Chem. 385 : 452 – 468 .
  • Bo , Y. , W. Wang , J. Qi , and S. Huang . 2011 . A DNA biosensor based on graphene paste electrode modified with Prussian blue and chitosan . Analyst 136 : 1946 – 1951 .
  • Bonanni , A. , and M. Pumera . 2011 . Graphene platform for hairpin-DNA-based impedimetric genosensing . ACS Nano 5 : 2356 – 2361 .
  • Bong , S. , Y. R. Kim , I. Kim , S. Woo , S. Uhm , J. Lee , and H. Kim . 2010 . Graphene supported electrocatalysts for methanol oxidation . Electrochem. Commun. 12 : 129 – 131 .
  • Chang , D. W. , G. J. Sohn , L. Dai , and J. B. Baek . 2011 . Reversible adsorption of conjugated amphiphilic dendrimers onto reduced graphene oxide (rGO) for fluorescence sensing . Soft Matter 7 : 8352 – 8357 .
  • Chang , H. , L. Tang , Y. Wang , J. Jiang , and J. Li . 2010. Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection. Anal. Chem. 82: 2341–2346.
  • Chang , H. , X. Wu , C. Wu , Y. Chen , H. Jiang , and X. Wang . 2011 . Catalytic oxidation and determination of β-NADH using self-assembly hybrid of gold nanoparticles and graphene . Analyst 136 : 2735 – 2740 .
  • Chen , D. , L. Tang , and J. Li . 2010 . Graphene-based materials in electrochemistry . Chem. Soc. Rev. 39 : 3157 – 3180 .
  • Chen , J. L. , X. P. Yan , K. Meng , and S. F. Wang . 2011 . Graphene oxide based photoinduced charge transfer label-free near-infrared fluorescent biosensor for dopamine . Anal. Chem. 83 : 8787 – 8793 .
  • Chen , Q. , W. Wei , and J. M. Lin . 2011 . Homogeneous detection of concanavalin A using pyrene-conjugated maltose assembled graphene based on fluorescence resonance energy transfer . Biosens. Bioelectron. 26 : 4497 – 4502 .
  • Chen , Y. , Y. Li , D. Sun , D. Tian , J. Zhang , and J. J. Zhu . 2011 . Fabrication of gold nanoparticles on bilayer graphene for glucose electrochemical biosensing . J. Mater. Chem. 21 : 7604 – 7611 .
  • Choi , B. G. , J. Im , H. S. Kim , and H. S. Park . 2011 . Flow-injection amperometric glucose biosensors based on graphene/Nafion hybrid electrodes . Electrochim. Acta 56 : 9721 – 9726 .
  • Choi , B. G. , H. S. Park , T. J. Park , M. H. Yang , J. S. Kim , S. Y. Jang , N. S. Heo , S. Y. Lee , J. Kong , and W. H. Hong . 2010 . Solution chemistry of self-assembled graphene nanohybrids for high-performance flexible biosensors . ACS Nano 4 : 2910 – 2918 .
  • Choi , B. G. , H. S. Park , M. H. Yang , Y. M. Jung , S. Y. Lee , W. H. Hong , and T. J. Park . 2010 . Microwave-assisted synthesis of highly water-soluble graphene towards electrical DNA sensor . Nanoscale 2 : 2692 – 2697 .
  • Dey , R. S. , and C. R. Raj . 2010 . Development of an amperometric cholesterol biosensor based on graphene-Pt nanoparticle hybrid material . J. Phys. Chem. C 114 : 21427 – 21433 .
  • Dong , H. , W. Gao , F. Yan , H. Ji , and H. Ju . 2010 . Fluorescence resonance energy transfer between quantum dots and graphene oxide for sensing biomolecules . Anal. Chem. 82 : 5511 – 5517 .
  • Du , D. , Z. Zou , Y. Shin , J. Wang , H. Wu , M. H. Engelhard , J. Liu , I. A. Aksay , and Y. Lin . 2010 . Sensitive immunosensor for cancer biomarker based on dual signal amplification strategy of graphene sheets and multienzyme functionalized carbon nanospheres . Anal. Chem. 82 : 2989 – 2995 .
  • Dubertret , B. , M. Calame , and A. J. Libchaber . 2001 . Single-mismatch detection using gold-quenched fluorescent oligonucleotides . Nat. Biotechnol. 19 : 365 – 370 .
  • Eda , G. , Y. Y. Lin , C. Mattevi , H. Yamaguchi , H. A. Chen , I. Chen , C. W. Chen , and M. Chhowalla . 2010 . Blue photoluminescence from chemically derived graphene oxide . Adv. Mater. 22 : 505 – 509 .
  • Feng , D. , Y. Zhang , T. Feng , W. Shi , X. Li , and H. Ma . 2011 . A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2 . Chem. Commun. 47 : 10680 – 10682 .
  • Geim , A. K. , and K. S. Novoselov . 2007 . The rise of graphene . Nature Mater. 6 : 183 – 191 .
  • Gu , X. , G. Yang , G. Zhang , D. Zhang , and D. Zhu . 2011 . A new fluorescence turn-on assay for trypsin and inhibitor screening based on graphene oxide . ACS Appl. Mater. Interfaces 3 : 1175 – 1179 .
  • Guo , S. , D. Wen , Y. Zhai , S. Dong , and E. Wang . 2010 . Platinum nanoparticle ensemble-on-graphene hybrid nanosheet: one-pot, rapid synthesis, and used as new electrode material for electrochemical sensing . ACS Nano 4 : 3959 – 3968 .
  • Guo , Y. , L. Deng , J. Li , S. Guo , E. Wang , and S. Dong . 2011 . Hemin-graphene hybrid nanosheets with intrinsic peroxidase-like activity for label-free colorimetric detection of single-nucleotide polymorphism . ACS Nano 5 : 1282 – 1290 .
  • Ha , T. , T. Enderle , D. F. Ogletree , D. S. Chemla , P. R. Selvin , and S. Weiss . 1996. Probing the interaction between two single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor. Proc. Natl. Acad. Sci. USA 93: 6264–6268.
  • Han , J. , Y. Zhuo , Y. Q. Chai , L. Mao , Y.-L. Yuan , and R. Yuan . 2011 . Highly conducting gold nanoparticles-graphene nanohybrid films for ultrasensitive detection of carcinoembryonic antigen . Talanta 85 : 130 – 135 .
  • He , S. , B. Song , D. Li , C. Zhu , W. Qi , Y. Wen , L. Wang , S. Song , H. Fang , and C. Fan . 2010 . A graphene nanoprobe for rapid, sensitive, and multicolor fluorescent DNA analysis . Adv. Funct. Mater. 20 : 453 – 459 .
  • He , Y. , Q. Sheng , J. Zheng , M. Wang , and B. Liu . 2011 . Magnetite-graphene for the direct electrochemistry of hemoglobin and its biosensing application . Electrochim. Acta 56 : 2471 – 2476 .
  • Hirsch , A. 2010 . The era of carbon allotropes . Nature Mater. 9 : 868 – 871 .
  • Huang , K. J. , D. J. Niu , J. Y. Sun , and J. J. Zhu . 2011 . An electrochemical amperometric immunobiosensor for label-free detection of α -fetoprotein based on amine-functionalized graphene and gold nanoparticles modified carbon ionic liquid electrode . J. Electroanal. Chem. 656 : 72 – 77 .
  • Huang , X. , Z. Yin , S. Wu , X. Qi , Q. He , Q. Zhang , Q. Yan , F. Boey , and H. Zhang . 2011 . Graphene-based materials: synthesis, characterization, properties, and applications . Small 7 : 1876 – 1902 .
  • Huang , Y. , X. Dong , Y. Liu , L. J. Li , and P. Chen . 2011 . Graphene-based biosensors for detection of bacteria and their metabolic activities . J. Mater. Chem. 21 : 12358 – 12362 .
  • Husale , B. S. , S. Sahoo , A. Radenovic , F. Traversi , P. Annibale , and A. Kis . 2010 . ssDNA binding reveals the atomic structure of graphene . Langmuir 26 : 18078 – 18082 .
  • Jung , J. H. , D. S. Cheon , F. Liu , K. B. Lee , and T. S. Seo . 2010 . A graphene oxide based immuno-biosensor for pathogen detection . Angew. Chem. Int. Ed. 49 : 5708 – 5711 .
  • Kamat , P. V. 2010 . Graphene-based nanoarchitectures. Anchoring semiconductor and metal nanoparticles on a two-dimensional carbon support . J. Phys. Chem. Lett. 1 : 520 – 527 .
  • Kang , X. , J. Wang , H. Wu , I. A. Aksay , J. Liu , and Y. Lin . 2009 . Glucose Oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing . Biosens. Bioelectron. 25 : 901 – 905 .
  • Keeley , G. P. , A. O'Neill , N. McEvoy , N. Peltekis , J. N. Coleman , and G. S. Duesberg . 2010 . Electrochemical ascorbic acid sensor based on DMF-exfoliated graphene . J. Mater. Chem. 20 : 7864 – 7869 .
  • Kuila , T. , S. Bose , P. Khanra , A. K. Mishra , N. H. Kim , and J. H. Lee . 2011 . Recent advances in graphene-based biosensors . Biosens. Bioelectron. 26 : 4637 – 4678 .
  • Li , F. , Y. Huang , Q. Yang , Z. Zhong , L. Wang , S. Song , and C. Fan . 2010 . A graphene-enhanced molecular beacon for homogeneous DNA detection . Nanoscale 2 : 1021 – 1026 .
  • Li , H. , and L. J. Rothberg . 2004 . DNA sequence detection using selective fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles . Anal. Chem. 76 : 5414 – 5417 .
  • Li , H. , Q. Wei , J. He , T. Li , Y. Zhao , Y. Cai , B. Du , Z. Qian , and M. Yang . 2011 . Electrochemical immunosensors for cancer biomarker with signal amplification based on ferrocene functionalized iron oxide nanoparticles . Biosens. Bioelectron. 26 : 3590 – 3595 .
  • Li , L. , Z. Du , S. Liu , Q. Hao , Y. Wang , Q. Li , and T. Wang . 2010 . A novel nonenzymatic hydrogen peroxide sensor based on MnO2/graphene oxide nanocomposite . Talanta 82 : 1637 – 1641 .
  • Liang , J. , Z. Chen , L. Guo , and L. Li . 2011 . Electrochemical sensing of L-histidine based on structure-switching DNAzymes and gold nanoparticle-graphene nanosheet composites . Chem. Commun. 47 : 5476 – 5478 .
  • Lim , C. X. , H. Y. Hoh , P. K. Ang , and K. P. Loh . 2010. Direct voltammetric detection of DNA and pH sensing on epitaxial graphene: an insight into the role of oxygenated defects. Anal. Chem. 82: 7387–7393.
  • Liu , F. , J. Y. Choi , and T. S. Seo . 2010 . Graphene oxide arrays for detecting specific DNA hybridization by fluorescence resonance energy transfer . Biosens. Bioelectron. 25 : 2361 – 2365 .
  • Liu , K. , J. Zhang , G. Yang , C. Wang , and J. J. Zhu . 2010 . Direct electrochemistry and electrocatalysis of hemoglobin based on poly (diallyldimethylammonium chloride) functionalized graphene sheets/room temperature ionic liquid composite film . Electrochem. Commun. 12 : 402 – 405 .
  • Liu , M. , H. Zhao , S. Chen , H. Yu , Y. Zhang , and X. Quan . 2011 . Label-free fluorescent detection of Cu (II) ions based on DNA cleavage-dependent graphene-quenched DNAzymes . Chem. Commun. 47 : 7749 – 7751 .
  • Liu , M. , H. Zhao , X. Quan , S. Chen , and X. Fan . 2010 . Distance-independent quenching of quantum dots by nanoscale-graphene in self-assembled sandwich immunoassay . Chem. Commun. 46 : 7909 – 7911 .
  • Liu , S. , J. Tian , L. Wang , Y. Luo , W. Lu , and X. Sun . 2011 . Self-assembled graphene platelet-glucose oxidase nanostructures for glucose biosensing . Biosens. Bioelectron. 26 : 4491 – 4496 .
  • Liu , Y. , D. Yu , C. Zeng , Z. Miao , and L. Dai . 2010 . Biocompatible graphene oxide-based glucose biosensors . Langmuir 26 : 6158 – 6160 .
  • Loh , K. P. , Q. Bao , G. Eda , and M. Chhowalla . 2010 . Graphene oxide as a chemically tunable platform for optical applications . Nature Chem. 2 : 1015 – 1024 .
  • Lu , C. H. , J. Li , X. L. Zhang , A. X. Zheng , H. H. Yang , X. Chen , and G. N. Chen . 2011 . General approach for monitoring peptide-protein interactions based on graphene-peptide complex . Anal. Chem. 83 : 7276 – 7282 .
  • Lu , C. H. , H. H. Yang , C. L. Zhu , X. Chen , and G. N. Chen . 2009 . A graphene platform for sensing biomolecules . Angew. Chem. Int. Ed. 48 : 4785 – 4787 .
  • Lu , C. H. , C. L. Zhu , J. Li , J. J. Liu , X. Chen , and H. H. Yang . 2010 . Using graphene to protect DNA from cleavage during cellular delivery . Chem. Commun. 46 : 3116 – 3118 .
  • Lu , L. M. , H. B. Li , F. Qu , X.-B. Zhang , G.-L. Shen , and R.-Q. Yu . 2011 . In situ synthesis of palladium nanoparticle-graphene nanohybrids and their application in nonenzymatic glucose biosensors . Biosens. Bioelectron. 26 : 3500 – 3504 .
  • Lu , W. , Y. Luo , G. Chang , and X. Sun . 2011 . Synthesis of functional SiO2-coated graphene oxide nanosheets decorated with Ag nanoparticles for H2O2 and glucose detection . Biosens. Bioelectron. 26 : 4791 – 4797 .
  • Maxwell , D. J. , J. R. Taylor , and S. Nie . 2002 . Self-assembled nanoparticle probes for recognition and detection of biomolecules . J. Am. Chem. Soc. 124 : 9606 – 9612 .
  • Moyano , D. F. , and V. M. Rotello . 2011 . Nano meets biology: Structure and function at the nanoparticle interface . Langmuir 27 : 10376 – 10385 .
  • Neto , A. H. C. 2010 . The carbon new age . Mater. Today 13 : 12 – 17 .
  • Niemeyer , C. M. 2001 . Nanoparticles, proteins, and nucleic acids: Biotechnology meets materials science . Angew. Chem. Int. Ed. 40 : 4128 – 4158 .
  • Novoselov , K. S. , A. K. Geim , S. V. Morozov , D. Jiang , Y. Zhang , S. V. Dubonos , I. V. Grigorieva , and A. A. Firsov . 2004 . Electric field effect in atomically thin carbon films . Science 306 : 666 – 669 .
  • Ping , J. , Y. Wang , K. Fan , J. Wu , and Y. Ying . 2011 . Direct electrochemical reduction of graphene oxide on ionic liquid doped screen-printed electrode and its electrochemical biosensing application . Biosens. Bioelectron. 28 : 204 – 209 .
  • Pu , Y. , Z. Zhu , D. Han , H. Liu , J. Liu , J. Liao , K. Zhang , and W. Tan . 2011 . Insulin-binding aptamer-conjugated graphene oxide for insulin detection . Analyst 136 : 4138 – 4140 .
  • Pumera , M. 2011. Graphene in biosensing. Mater. Today 14: 308–315.
  • Ratinac , K. R. , W. Yang , J. J. Gooding , P. Thordarson , and F. Braet . 2011 . Graphene and related materials in electrochemical sensing . Electroanal. 23 : 803 – 826 .
  • Ray , P. C. , G. K. Darbha , A. Ray , J. Walker , and W. Hardy . 2007 . Gold nanoparticle based FRET for DNA detection . Plasmonics 2 : 173 – 183 .
  • Roy , S. , N. Soin , R. Bajpai , D. S. Misra , J. A. McLaughlin , and S. S. Roy . 2011 . Graphene oxide for electrochemical sensing applications . J. Mater. Chem. 21 : 14725 – 14731 .
  • Sapsford , K. E. , L. Berti , and I. L. Medintz . 2006 . Materials for fluorescence resonance energy transfer analysis: beyond traditional donor-acceptor combinations . Angew. Chem. Int. Ed. 45 : 4562 – 4588 .
  • Selvin , P. R. 2000 . The renaissance of fluorescence resonance energy transfer . Nat. Struct. Biol. 7 : 730 – 734 .
  • Shan , C. , H. Yang , D. Han , Q. Zhang , A. Ivaska , and L. Niu . 2009 . Water-soluble graphene covalently functionalized by biocompatible poly-L-lysine . Langmuir 25 : 12030 – 12033 .
  • Shan , C. , H. Yang , D. Han , Q. Zhang , A. Ivaska , and L. Niu . 2010a . Electrochemical determination of NADH and ethanol based on ionic liquid-functionalized graphene . Biosens. Bioelectron. 25 : 1504 – 1508 .
  • Shan , C. , H. Yang , D. Han , Q. Zhang , A. Ivaska , and L. Niu . 2010b . Graphene/AuNPs/chitosan nanocomposites film for glucose biosensing . Biosens. Bioelectron. 25 : 1070 – 1074 .
  • Shao , Y. , J. Wang , H. Wu , J. Liu , I. A. Aksay , and Y. Lin . 2010 . Graphene based electrochemical sensors and biosensors: a review . Electroanal. 22 : 1027 – 1036 .
  • Sheng , L. , J. Ren , Y. Miao , J. Wang , and E. Wang . 2011 . PVP-coated graphene oxide for selective determination of ochratoxin A via quenching fluorescence of free aptamer . Biosens. Bioelectron. 26 : 3494 – 3499 .
  • Song , W. , D. W. Li , Y. T. Li , Y. Li , and Y.-T. Long . 2011 . Disposable biosensor based on graphene oxide conjugated with tyrosinase assembled gold nanoparticles . Biosens. Bioelectron. 26 : 3181 – 3186 .
  • Song , Y. , Y. Chen , L. Feng , J. Ren , and X. Qu . 2011 . Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity . Chem. Commun. 47 : 4436 – 4438 .
  • Song , Y. , K. Qu , C. Zhao , J. Ren , and X. Qu . 2010 . Graphene oxide: intrinsic peroxidase catalytic activity and its application to glucose detection . Adv. Mater. 22 : 2206 – 2210 .
  • Su , B. , J. Tang , J. Huang , H. Yang , B. Qiu , G. Chen , and D. Tang . 2010 . Graphene and nanogold-functionalized immunosensing interface with enhanced sensitivity for one-step electrochemical immunoassay of alpha-fetoprotein in human serum . Electroanal. 22 : 2720 – 2728 .
  • Sun , W. , X. Qi , Y. Chen , S. Liu , and H. Gao . 2011 . Application of chitosan/Fe3O4 microsphere-graphene composite modified carbon ionic liquid electrode for the electrochemical detection of the PCR product of soybean Lectin gene sequence . Talanta 87 : 106 – 112 .
  • Sun , X. , Z. Liu , K. Welsher , J. T. Robinson , A. Goodwin , S. Zaric , and H. Dai . 2008 . Nano-graphene oxide for cellular imaging and drug delivery . Nano Res. 1 : 203 – 212 .
  • Tang , Z. , H. Wu , J. R. Cort , G. W. Buchko , Y. Zhang , Y. Shao , I. A. Aksay , J. Liu , and Y. Lin . 2010 . Constraint of DNA on functionalized graphene improves its biostability and specificity . Small 6 : 1205 – 1209 .
  • Wan , Y. , Z. Lin , D. Zhang , Y. Wang , and B. Hou . 2011 . Impedimetric immunosensor doped with reduced graphene sheets fabricated by controllable electrodeposition for the non-labelled detection of bacteria . Biosens. Bioelectron. 26 : 1959 – 1964 .
  • Wan , Y. , Y. Wang , J. Wu , and D. Zhang . 2011 . Graphene oxide sheet-mediated silver enhancement for application to electrochemical biosensors . Anal. Chem. 83 : 648 – 653 .
  • Wang , G. , G. Zhang , H. Huang , and L. Wang . 2011. Graphene-Prussian blue/gold nanoparticles based electrochemical immunoassay of carcinoembryonic antigen. Anal. Methods 3: 2082–2087.
  • Wang , J. 2005 . Carbon-nanotube based electrochemical biosensors: a review . Electroanal. 17 : 7 – 14 .
  • Wang , J. , and M. Musameh . 2003 . Carbon nanotube/teflon composite electrochemical sensors and biosensors . Anal. Chem. 75 : 2075 – 2079 .
  • Wang , K. , H. N. Li , J. Wu , C. Ju , J. J. Yan , Q. Liu , and B. Qiu . 2011 . TiO2-decorated graphene nanohybrids for fabricating an amperometric acetylcholinesterase biosensor . Analyst 136 : 3349 – 3354 .
  • Wang , K. , Q. Liu , Q. M. Guan , J. Wu , H. N. Li , and J. J. Yan . 2011 . Enhanced direct electrochemistry of glucose oxidase and biosensing for glucose via synergy effect of graphene and CdS nanocrystals . Biosens. Bioelectron. 26 : 2252 – 2257 .
  • Wang , L. , X. Liu , X. Hu , S. Song , and C. Fan . 2006 . Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers . Chem. Commun. 3780 – 3782 .
  • Wang , Y. , Y. Li , L. Tang , J. Lu , and J. Li . 2009 . Application of graphene-modified electrode for selective detection of dopamine . Electrochem. Commun. 11 : 889 – 892 .
  • Wang , Y. , Z. Li , D. Hu , C.-T. Lin , J. Li , and Y. Lin . 2010 . Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells . J. Am. Chem. Soc. 132 : 9274 – 9276 .
  • Wang , Y. , Z. Li , J. Wang , J. Li , and Y. Lin . 2011 . Graphene and graphene oxide: biofunctionalization and applications in biotechnology . Trends Biotechnol. 29 : 205 – 212 .
  • Wang , Y. , Y. Shao , D. W. Matson , J. Li , and Y. Lin . 2010 . Nitrogen-doped graphene and its application in electrochemical biosensing . ACS Nano 4 : 1790 – 1798 .
  • Wang , Y. , S. Zhang , D. Du , Y. Shao , Z. Li , J. Wang , M. H. Engelhard , J. Li , and Y. Lin . 2011 . Self assembly of acetylcholinesterase on a gold nanoparticles-graphene nanosheet hybrid for organophosphate pesticide detection using polyelectrolyte as a linker . J. Mater. Chem. 21 : 5319 – 5325 .
  • Wei , H. , B. Li , J. Li , E. Wang , and S. Dong . 2007 . Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes . Chem. Commun. 3735 – 3737 .
  • Wei , Q. , Y. Zhao , B. Du , D. Wu , Y. Cai , K. Mao , H. Li , and C. Xu . 2011 . Nanoporous ptru alloy enhanced nonenzymatic immunosensor for ultrasensitive detection of microcystin-LR . Adv. Funct. Mater. 21 : 4193 – 4198 .
  • Wu , C. , Y. Zhou , X. Miao , and L. Ling . 2011 . A novel fluorescent biosensor for sequence-specific recognition of double-stranded DNA with the platform of graphene oxide . Analyst 136 : 2106 – 2110 .
  • Wu , H. , J. Wang , X. Kang , C. Wang , D. Wang , J. Liu , I. A. Aksay , and Y. Lin . 2009 . Glucose biosensor based on immobilization of glucose oxidase in platinum nanoparticles/graphene/chitosan nanocomposite film . Talanta 80 : 403 – 406 .
  • Wu , J. F. , M. Q. Xu , and G. C. Zhao . 2010 . Graphene-based modified electrode for the direct electron transfer of Cytochrome c and biosensing . Electrochem. Commun. 12 : 175 – 177 .
  • Xu , C. , J. Wang , L. Wan , J. Lin , and X. Wang . 2011 . Microwave-assisted covalent modification of graphene nanosheets with hydroxypropyl-β-cyclodextrin and its electrochemical detection of phenolic organic pollutants . J. Mater. Chem. 21 : 10463 – 10471 .
  • Xu , H. , H. Dai , and G. Chen . 2010 . Direct electrochemistry and electrocatalysis of hemoglobin protein entrapped in graphene and chitosan composite film . Talanta 81 : 334 – 338 .
  • Xu , Y. , A. Malkovskiy , and Y. Pang . 2011 . A graphene binding-promoted fluorescence enhancement for bovine serum albumin recognition . Chem. Commun. 47 : 6662 – 6664 .
  • Xu , Y. , L. Zhao , H. Bai , W. Hong , C. Li , and G. Shi . 2009 . Chemically converted graphene induced molecular flattening of 5, 10, 15, 20-tetrakis (1-methyl-4-pyridinio) porphyrin and its application for optical detection of cadmium (ii) ions . J. Am. Chem. Soc. 131 : 13490 – 13497 .
  • Yang , J. , S. Deng , J. Lei , H. Ju , and S. Gunasekaran . 2011. Electrochemical synthesis of reduced graphene sheet-AuPd alloy nanoparticle composites for enzymatic biosensing. Biosens. Bioelectron. 29: 159–166.
  • Yang , M. H. , B. G. Choi , T. J. Park , N. S. Heo , W. H. Hong , and S. Y. Lee . 2011 . Site-specific immobilization of gold binding polypeptide on gold nanoparticle-coated graphene sheet for biosensor application . Nanoscale 3 : 2950 – 2956 .
  • Yang , R. , J. Jin , Y. Chen , N. Shao , H. Kang , Z. Xiao , Z. Tang , Y. Wu , Z. Zhu , and W. Tan . 2008 . Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization . J. Am. Chem. Soc. 130 : 8351 – 8358 .
  • Yang , R. , Z. Tang , J. Yan , H. Kang , Y. Kim , Z. Zhu , and W. Tan . 2008 . Noncovalent assembly of carbon nanotubes and single-stranded DNA: an effective sensing platform for probing biomolecular interactions . Anal. Chem. 80 : 7408 – 7413 .
  • Yang , W. , K. R. Ratinac , S. P. Ringer , P. Thordarson , J. J. Gooding , and F. Braet . 2010 . Carbon nanomaterials in biosensors: should you use nanotubes or graphene? Angew. Chem. Int. Ed. 49 : 2114 – 2138 .
  • Yue , R. , Q. Lu , and Y. Zhou . 2011 . A novel nitrite biosensor based on single-layer graphene nanoplatelet–protein composite film . Biosens. Bioelectron. 26 : 4436 – 4441 .
  • Zeng , Q. , J. S. Cheng , X. F. Liu , H.-T. Bai , and J.-H. Jiang . 2011 . Palladium nanoparticle/chitosan-grafted graphene nanocomposites for construction of a glucose biosensor . Biosens. Bioelectron. 26 : 3456 – 3463 .
  • Zhang , J. , J. Lei , R. Pan , Y. Xue , and H. Ju . 2010 . Highly sensitive electrocatalytic biosensing of hypoxanthine based on functionalization of graphene sheets with water-soluble conducting graft copolymer . Biosens. Bioelectron. 26 : 371 – 376 .
  • Zhang , Q. , Y. Qiao , F. Hao , L. Zhang , S. Wu , Y. Li , J. Li , and X. M. Song . 2010 . Fabrication of a biocompatible and conductive platform based on a single-stranded DNA/graphene nanocomposite for direct electrochemistry and electrocatalysis . Chem. Eur. J. 16 : 8133 – 8139 .
  • Zhang , Q. , S. Wu , L. Zhang , J. Lu , F. Verproot , Y. Liu , Z. Xing , J. Li , and X.-M. Song . 2011 . Fabrication of polymeric ionic liquid/graphene nanocomposite for glucose oxidase immobilization and direct electrochemistry . Biosens. Bioelectron. 26 : 2632 – 2637 .
  • Zhang , Y. , R. Yuan , Y. Chai , W. Li , X. Zhong , and H. Zhong . 2011 . Simultaneous voltammetric determination for DA, AA and based on graphene/poly-cyclodextrin/MWCNTs nanocomposite platform . Biosens. Bioelectron. 26 : 3977 – 3980 .
  • Zhao , J. , G. Chen , L. Zhu , and G. Li . 2011 . Graphene quantum dots-based platform for the fabrication of electrochemical biosensors . Electrochem. Commun. 13 : 31 – 33 .
  • Zhao , X. H. , R. M. Kong , X. B. Zhang , H. M. Meng , W.-N. Liu , W. Tan , G.-L. Shen , and R.-Q. Yu . 2011 . Graphene-DNAzyme based biosensor for amplified fluorescence “turn-on” detection of Pb2+ with a high selectivity . Anal. Chem. 83 : 5062 – 5066 .
  • Zheng , J. , Y. He , Q. Sheng , and H. Zhang . 2011 . DNA as a linker for biocatalytic deposition of Au nanoparticles on graphene and its application in glucose detection . J. Mater. Chem. 21 : 12873 – 12879 .
  • Zhou , K. , Y. Zhu , X. Yang , and C. Li . 2011 . Preparation and application of mediator-free H2O2 biosensors of graphene-Fe3O4 composites . Electroanal. 23 : 862 – 869 .
  • Zhou , K. , Y. Zhu , X. Yang , J. Luo , C. Li , and S. Luan . 2010 . A novel hydrogen peroxide biosensor based on Au-graphene-HRP-chitosan biocomposites . Electrochim. Acta 55 : 3055 – 3060 .
  • Zhou , M. , Y. Zhai , and S. Dong . 2009 . Electrochemical sensing and biosensing platform based on chemically reduced graphene oxide . Anal. Chem. 81 : 5603 – 5613 .
  • Zhu , Z. , R. Yang , M. You , X. Zhang , Y. Wu , and W. Tan . 2010 . Single-walled carbon nanotube as an effective quencher . Anal. Bioanal. Chem. 396 : 73 – 83 .

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