Exploring Chemical Profiles and Bioactivities of Harungana madagascariensis Lam. ex Poir. Leaves and Stem Bark Extracts: A New Source of Procyanidins

References

• Ahangarpour, A., M. Sayahi, and M. Sayahi. 2019. The antidiabetic and antioxidant properties of some phenolic phytochemicals: A review study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13:854–7. doi: 10.1016/j.dsx.2018.11.051.
   PubMed Web of Science ®Google Scholar
• Allgrove, J., and G. Davison. 2014. Chapter 19 - Dark chocolate/cocoa polyphenols and oxidative stress. In Polyphenols in human health and disease, ed. R. R. Watson, V. R. Preedy, and S. Zibadi, 241-51. San Diego, CA: Academic Press.
   Google Scholar
• Antia, B. S., B. N. Ita, and U. E. Udo. 2015. Nutrient composition and in vitro antioxidant properties of Harungana madagascariensis stembark extracts. Journal of Medicinal Food 18(5):609–14. doi: 10.1089/jmf.2014.0084.
   PubMed Web of Science ®Google Scholar
• Azizuddin, A. M. Khan, and M. I. Choudhary. 2011. Tyrosinase inhibitory potential of natural products isolated from various medicinal plants. Natural Product Research 25(7):750–3.
   PubMed Web of Science ®Google Scholar
• Biapa, P. C., G. A. Agbor, J. E. Oben, and J. Y. Ngogang. 2008. Phytochemical studies and antioxidant properties of four medicinal plants used in Cameroon. African Journal of Traditional, Complementary and Alternative Medicines 4(4):495–500. doi: 10.4314/ajtcam.v4i4.31243.
   Google Scholar
• Biapa, P. C., H. Nya, Ş. Matei, J. E. O. Bâlici, and J. Y. Ngogang. 2013. Protective effects of stem bark of Harungana madgascariensis on the red blood cell membrane. BMC Complementary and Alternative Medicine 13(1):98. doi: 10.1186/1472-6882-13-98.
   PubMed Web of Science ®Google Scholar
• Borges, L. L., S. F. Alves, B. L. Sampaio, E. C. Conceição, M. T. F. Bara, and J. R. Paula. 2013. Environmental factors affecting the concentration of phenolic compounds in Myrcia tomentosa leaves. Revista Brasileira de Farmacognosia 23(2):230–8. doi: 10.1590/S0102-695X2013005000019.
   Google Scholar
• Brudzynski, K., and D. Miotto. 2011. Honey melanoidins: Analysis of the compositions of the high molecular weight melanoidins exhibiting radical-scavenging activity. Food Chemistry 127(3):1023–30. doi: 10.1016/j.foodchem.2011.01.075.
   PubMed Web of Science ®Google Scholar
• Chang, T. 2009. An updated review of tyrosinase inhibitors. International Journal of Molecular Sciences 10(6):2440–75. doi: 10.3390/ijms10062440.
   PubMed Web of Science ®Google Scholar
• Cos, P., T. D. Bruyne, N. Hermans, S. Apers, D. V. Berghe, and A. J. Vlietinck. 2004. Proanthocyanidins in health care: Current and new trends. Current Medicinal Chemistry 11(10):1345–59. doi: 10.2174/0929867043365288.
   PubMed Web of Science ®Google Scholar
• Dutta, S., and S. Ray. 2018. Comparative assessment of total phenolic content and in vitro antioxidant activities of bark and leaf methanolic extracts of Manilkara hexandra (Roxb.) Dubard. Journal of King Saud University-Science. doi: 10.1016/j.jksus.2018.09.015.
   Web of Science ®Google Scholar
• Gocer, H., F. Topal, M. Topal, M. Kucuk, D. Teke, I. Gulcin, S. H. Alwasel, and C. T. Supuran. 2016. Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin. Journal of Enzyme Inhibition and Medicinal Chemistry 31(3):441–7. doi: 10.3109/14756366.2015.1036051.
   PubMed Web of Science ®Google Scholar
• Hanamura, T., E. Uchida, and H. Aoki. 2008. Skin-lightening effect of a polyphenol extract from acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation. Bioscience, Biotechnology, and Biochemistry 72(12):3211–18. doi: 10.1271/bbb.80421.
   PubMed Web of Science ®Google Scholar
• Hashim, S. N. N. S., L. J. Schwarz, R. I. Boysen, Y. Yang, B. Danylec, and M. T.W. Hearn. 2013. Rapid solid-phase extraction and analysis of resveratrol and other polyphenols in red wine. Journal of Chromatography A 1313:284–90. doi: 10.1016/j.chroma.2013.06.052.
   PubMed Web of Science ®Google Scholar
• Iqbal, E., K. A. Salim, and L. B. L. Lim. 2015. Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam. Journal of King Saud University - Science 27(3):224–32. doi: 10.1016/j.jksus.2015.02.003.
   Google Scholar
• Iwalewa, E. O., I. O. Adewale, B. J. Taiwo, T. Arogundade, A. Osinowo, O. M. Daniyan, and G. E. Adetogun. 2008. Effects of Harungana madagascariensis stem bark extract on the antioxidant markers in alloxan induced diabetic and carrageenan induced inflammatory disorders in rats. Journal of Complementary and Integrative Medicine 5(1):1–18. doi: 10.2202/1553-3840.1088.
   Google Scholar
• Iwalewa, E. O., M. M. Suleiman, L. K. Mdee, and J. N. Eloff. 2009. Antifungal and antibacterial activities of different extracts of Harungana madagascariensis stem bark. Pharmaceutical Biology 47(9):878–85. doi: 10.1080/13880200903029316.
   Web of Science ®Google Scholar
• Kengni, F., S. P. C. Fodouop, D. S. Tala, M. N. Djimeli, C. Fokunang, and D. Gatsing. 2016. Antityphoid properties and toxicity evaluation of Harungana madagascariensis Lam (Hypericaceae) aqueous leaf extract. Journal of Ethnopharmacology 179:137–45. doi: 10.1016/j.jep.2015.12.037.
   PubMed Web of Science ®Google Scholar
• Kim, Y., J. E. Chung, M. Kurisawa, H. Uyama, and S. Kobayashi. 2004. New tyrosinase inhibitors, (+)-catechin − aldehyde polycondensates. Biomacromolecules 5(2):474–9. doi: 10.1021/bm034320x.
   PubMed Web of Science ®Google Scholar
• Kouam, S. F., B. T. Ngadjui, K. Krohn, P. Wafo, A. Ajaz, and M. I. Choudhary. 2005. Prenylated anthronoid antioxidants from the stem bark of Harungana madagascariensis. Phytochemistry 66(10):1174–9. doi: 10.1016/j.phytochem.2005.03.022.
   PubMed Web of Science ®Google Scholar
• Lemma, M. T., A. M. Ahmed, M. T. Elhady, H. T. Ngo, T. L.-H. Vu, T. K. Sang, E. Campos-Alberto, A. Sayed, S. Mizukami, K. Na-Bangchang, et al. 2017. Medicinal plants for in vitro antiplasmodial activities: A systematic review of literature. Parasitology International 66(6):713–20. doi: 10.1016/j.parint.2017.09.002.
   PubMed Web of Science ®Google Scholar
• Lesjak, M., I. Beara, N. Simin, D. Pintać, T. Majkić, K. Bekvalac, D. Orčić, and N. Mimica-Dukić. 2018. Antioxidant and anti-inflammatory activities of quercetin and its derivatives. Journal of Functional Foods 40:68–75. doi: 10.1016/j.jff.2017.10.047.
   Web of Science ®Google Scholar
• Llorent-Martínez, E. J., G. Zengin, D. Lobine, L. Molina-García, A. Mollica, and M. F. Mahomoodally. 2018. Phytochemical characterization, in vitro and in silico approaches for three Hypericum species. New Journal of Chemistry 42(7):5204–14. doi: 10.1039/C8NJ00347E.
   Web of Science ®Google Scholar
• Moronkola, D. O., S. O. Yeboah, R.R.T. Majinda, E. Yeboah, C. G. Fru, and P. M. Osamudiamen. 2018. Antioxidant properties of the methanol extracts of leaf, stem, fruit and seed of Nigerian Harungana madagascariensis, an Hypericaceae (Gutiferae). European Journal of Pharmaceutical and Medical Research 5(9):123–7.
   Google Scholar
• Moulari, B., Y. Pellequer, H. Lboutounne, C. Girard, J-P. Chaumont, J. Millet, and F. Muyard. 2006. Isolation and in vitro antibacterial activity of astilbin, the bioactive flavanone from the leaves of Harungana madagascariensis Lam. ex Poir. (Hypericaceae). Journal of Ethnopharmacology 106(2):272–8. doi: 10.1016/j.jep.2006.01.008.
   PubMed Web of Science ®Google Scholar
• Mpiana, P. T., V. Mudogo, D. S. T. Tshibangu, E. K. Kitwa, A. B. Kanangila, J. B. S. Lumbu, K. N. Ngbolua, E. K. Atibu, and M. K. Kakule. 2008. Antisickling activity of anthocyanins from Bombax pentadrum, Ficus capensis and Ziziphus mucronata: Photodegradation effect. Journal of Ethnopharmacology 120(3):413–18. doi: 10.1016/j.jep.2008.09.012.
   PubMed Web of Science ®Google Scholar
• Ndjakou, L. B., S. Ngouela, E. Re, F. F. Boyom, F. Tantangmo, G. R. F. Tchouya, E. Tsamo, J. Gut, P. J. Rosenthal, and J. D. Connolly. 2007. Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis (Hypericaceae). Chemical & Pharmaceutical Bulletin 55(3):464–7. doi: 10.1248/cpb.55.464.
   PubMed Web of Science ®Google Scholar
• Ndjakou, L. B., C. Vonthron-Senecheau, R. Fongang Soh, F. Tantangmo, S. Ngouela, M. Kaiser, E. Tsamo, R. Anton, and B. Weniger. 2007. In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants. Journal of Ethnopharmacology 111(1):8–12. doi: 10.1016/j.jep.2006.10.036.
   PubMed Web of Science ®Google Scholar
• Nimenibo-Uadia, R., and K. Nwachukwu. 2017. Biochemical evaluation of Harungana madagascariensis lam aqueous leaf extract in diabetic rats. British Journal of Pharmaceutical Research 5(2):1–11. doi: 10.9734/BJPR/2017/31987.
   Google Scholar
• Ochwang’i, D. O., C. N. Kimwele, J. A. Oduma, P. K. Gathumbi, S. G. Kiama, and T. Efferth. 2018. Cytotoxic activity of medicinal plants of the Kakamega County (Kenya) against drug-sensitive and multidrug-resistant cancer cells. Journal of Ethnopharmacology 215:233–40. doi: 10.1016/j.jep.2018.01.004.
   PubMed Web of Science ®Google Scholar
• Okoli, A. S., M. I. Okeke, C. U. Iroegbu, and P. U. Ebo. 2002. Antibacterial activity of Harungana madagascariensis leaf extracts. Phytotherapy Research 16(2):174–79. doi: 10.1002/ptr.991.
   PubMed Web of Science ®Google Scholar
• Onajobi, I. B., A. Adhikari, S. Hussain, K. Javaid, O. E. Fagade, and I. A. Oladosu. 2016. New alpha-glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam. Natural Product Research 30(22):2507–13. doi: 10.1080/14786419.2015.1115998.
   PubMed Web of Science ®Google Scholar
• Oyenihi, A. B., and C. Smith. 2019. Are polyphenol antioxidants at the root of medicinal plant anti-cancer success? Journal of Ethnopharmacology 229:54–72. doi: 10.1016/j.jep.2018.09.037.
   PubMed Web of Science ®Google Scholar
• Roleira, F. M., E. J. Tavares-da-Silva, C. L. Varela, S. C. Costa, T. Silva, J. Garrido, and F. Borges. 2015. Plant derived and dietary phenolic antioxidants: Anticancer properties. Food Chemistry 183:235–58. doi: 10.1016/j.foodchem.2015.03.039.
   PubMed Web of Science ®Google Scholar
• Ruiz, D., J. Egea, M. I. Gil, and F. A. Tomás-Barberán. 2005. Characterization and quantitation of phenolic compounds in new apricot (Prunus armeniaca L.) varieties. Journal of Agricultural and Food Chemistry 53(24):9544–52. doi: 10.1021/jf051539p.
   PubMed Web of Science ®Google Scholar
• Si, Y. X., S. J. Yin, S. Oh, Z. J. Wang, S. Ye, L. Yan, J. M. Yang, Y. D. Park, J. Lee, and G. Y. Qian. 2012. An integrated study of tyrosinase inhibition by rutin: Progress using a computational simulation. Journal of Biomolecular Structure and Dynamics 29(5):999–1012. doi: 10.1080/073911012010525028.
   PubMed Web of Science ®Google Scholar
• Su, X. Z., and L. H. Miller. 2015. The discovery of artemisinin and the Nobel Prize in Physiology or Medicine. Science China Life Sciences 58(11):1175–9. doi: 10.1007/s11427-015-4948-7.
   PubMed Web of Science ®Google Scholar
• Suganthy, N., and K. P. Devi. 2016. In vitro antioxidant and anti-cholinesterase activities of Rhizophora mucronata. Pharmaceutical Biology 54(1):118–29. doi: 10.3109/13880209.2015.1017886.
   PubMed Web of Science ®Google Scholar
• Tankeo, S. B., F. Damen, L. P. Sandjo, I. Celik, P. Tane, and V. Kuete. 2016. Antibacterial activities of the methanol extracts, fractions and compounds from Harungana madagascariensis Lam. ex Poir. (Hypericaceae). Journal of Ethnopharmacology 190:100–5. doi: 10.1016/j.jep.2016.06.005.
   PubMed Web of Science ®Google Scholar
• Thabti, I., W. Elfalleh, N. Tlili, M. Ziadi, M. G. Campos, and A. Ferchichi. 2014. Phenols, flavonoids, and antioxidant and antibacterial activity of leaves and stem bark of Morus species. International Journal of Food Properties 17(4):842–54. doi: 10.1080/10942912.2012.660722.
   Web of Science ®Google Scholar
• Tona, L., K. Kambu, N. Ngimbi, K. Cimanga, and A. J. Vlietinck. 1998. Antiamoebic and phytochemical screening of some Congolese medicinal plants. Journal of Ethnopharmacology 61(1):57–65. doi: 10.1016/S0378-8741(98)00015-4.
   PubMed Web of Science ®Google Scholar
• Uysal, S., G. Zengin, M. Locatelli, M. B. Bahadori, A. Mocan, G. Bellagamba, E. D. Luca, A. Mollica, and A. Aktumsek. 2017. Cytotoxic and enzyme inhibitory potential of two Potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition. Frontiers in Pharmacology 8:290. doi: 10.3389/fphar.2017.00290.
   PubMed Web of Science ®Google Scholar
• Ye, M., Y. Yan, and D. Guo. 2005. Characterization of phenolic compounds in the Chinese herbal drug Tu‐Si‐Zi by liquid chromatography coupled to electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 19(11):1469–84. doi: 10.1002/rcm.1944.
   PubMed Web of Science ®Google Scholar
• Zanwar, A. A., S. L. Badole, P. S. Shende, M. V. Hegde, and S. L. Bodhankar. 2014. Chapter 21 - Antioxidant role of catechin in health and disease. In Polyphenols in human health and disease,ed. R. R. Watson, V. R. Preedy, and S. Zibadi, 267-71. San Diego, CA: Academic Press.
   Google Scholar
• Zengin, G., G. Bulut, A. Mollica, C. M. Nancy Picot-Allain, and M. F. Mahomoodally. 2018. In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—An endemic folk medicinal plant. Computational Biology and Chemistry 73:120–6. doi: 10.1016/j.compbiolchem.2018.02.010.
   PubMed Web of Science ®Google Scholar
• Zhang, L., C. Virgous, and H. Si. 2019. Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals. The Journal of Nutritional Biochemistry 69:19–30. doi: 10.1016/j.jnutbio.2019.03.009.
   PubMed Web of Science ®Google Scholar
• Zhang, L., Y. Wang, D. Li, C.T. Ho, J. Li, and X. Wan. 2016. The absorption, distribution, metabolism and excretion of procyanidins. Food & Function 7(3):1273–81. doi: 10.1039/C5FO01244A.
   PubMed Web of Science ®Google Scholar