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Mass Spectrometry

Rapid Determination of Formaldehyde, Acetaldehyde and Acrolein in Electronic Cigarette Aerosols by Direct Mass Spectrometry with Evaluation of the Toxicity

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Pages 331-346 | Received 05 Jan 2020, Accepted 30 Apr 2020, Published online: 24 May 2020

References

  • Bekki, K., S. Uchiyama, K. Ohta, Y. Inaba, H. Nakagome, and N. Kunugita. 2014. Carbonyl compounds generated from electronic cigarettes. International Journal of Environmental Research and Public Health 11 (11):11192–200. doi:10.3390/ijerph111111192.
  • Brenton, A. G., and A. R. Godfrey. 2010. Accurate mass measurement: terminology and treatment of data. Journal of the American Society for Mass Spectrometry 21 (11):1821–35. doi:10.1016/j.jasms.2010.06.006.
  • Chi, Y., Y. Feng, S. Wen, H. Lu, Z. Yu, W. Zhang, G. Sheng, and J. Fu. 2007. Determination of carbonyl compounds in the atmosphere by DNPH derivatization and LC-ESI-MS/MS detection. Talanta 72 (2):539–45. doi:10.1016/j.talanta.2006.11.018.
  • Conklin, D. J., M. A. Ogunwale, Y. Chen, W. S. Theis, M. H. Nantz, X.-A. Fu, L.-C. Chen, D. W. Riggs, P. Lorkiewicz, A. Bhatnagar, et al. 2018. Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Science and Technology 52 (11):1219–32. doi:10.1080/02786826.2018.1500013.
  • Coresta method. 2018. Determination of Selected Carbonyls in Mainstream Cigarette Smoke by High Performance Liquid Chromatography – No.74.
  • Deng, C., and X. Zhang. 2004. A simple, rapid and sensitive method for determination of aldehydes in human blood by gas chromatography/mass spectrometry and solid-phase microextraction with on-fiber derivatization. Rapid Communications in Mass Spectrometry 18 (15):1715–20. doi:10.1002/rcm.1544.
  • Elghawi, U. M., and A. M. Mayouf. 2014. Carbonyl emissions generated by a (SI/HCCI) engine from winter grade commercial gasoline. Fuel 116:109–15. doi:10.1016/j.fuel.2013.07.124.
  • Feng, L., C. J. Musto, and K. S. Suslick. 2010. A simple and highly sensitive colorimetric detection method for gaseous formaldehyde. Journal of the American Chemical Society 132 (12):4046–7. doi:10.1021/ja910366p.
  • Fujioka, K., and T. Shibamoto. 2006. Determination of toxic carbonyl compounds in cigarette smoke. Environmental Toxicology 21 (1):47–54. doi:10.1002/tox.20153.
  • Geiss, O., I. Bianchi, and J. Barrero-Moreno. 2016. Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours. International Journal of Hygiene and Environmental Health 219 (3):268–77. doi:10.1016/j.ijheh.2016.01.004.
  • Ghislain, M., N. Costarramone, J. ‐M. Sotiropoulos, T. Pigot, R. Van Den Berg, S. Lacombe, and M. Le Bechec. 2019. Direct analysis of aldehydes and carboxylic acids in the gas phase by negative ionization SIFT‐MS: Quantification and modeling of ion‐molecule reactions. Rapid Communications in Mass Spectrometry 33 (21):1623–34. doi:10.1002/rcm.8504.
  • Giokas, D. L., G. Z. Tsogas, and A. G. Vlessidis. 2009. On-line derivatization coupled to flow injection permanganate chemiluminescence detection of total carbonyl compounds in natural waters and drinking water. Analytica Chimica Acta. 651 (2):188–95. doi:10.1016/j.aca.2009.08.028.
  • Goniewicz, M. L., J. Knysak, M. Gawron, L. Kosmider, A. Sobczak, J. Kurek, A. Prokopowicz, M. Jablonska-Czapla, C. Rosik-Dulewska, C. Havel, et al. 2014. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tobacco Control 23 (2):133–9. doi:10.1136/tobaccocontrol-2012-050859.
  • Hileman, B. 1984. Formaldehyde: Assessing the risk. Environmental Science & Technology 18 (7):216–21. doi:10.1021/es00125a603.
  • Hutzler, C., M. Paschke, S. Kruschinski, F. Henkler, J. Hahn, and A. Luch. 2014. Chemical hazards present in liquids and vapors of electronic cigarettes. Archives of Toxicology 88 (7):1295–308. doi:10.1007/s00204-014-1294-7.
  • Jakober, C. A., M. J. Charles, M. J. Kleeman, and P. G. Green. 2006. LC − MS Analysis of carbonyl compounds and their occurrence in diesel emissions. Analytical Chemistry 78 (14):5086–93. doi:10.1021/ac060301c.
  • Jiang, C.-Y., S.-H. Sun, Q.-D. Zhang, J.-H. Liu, J.-X. Zhang, Y.-L. Zong, and J.-P. Xie. 2013. Fast determination of 3-ethenylpyridine as a marker of environmental tobacco smoke at trace level using direct atmospheric pressure chemical ionization tandem mass spectrometry. Atmospheric Environment 67:1–7. doi:10.1016/j.atmosenv.2012.10.052.
  • Jiang, C.-Y., S.-H. Sun, Q.-D. Zhang, Y.-P. Ma, H. Wang, J.-X. Zhang, Y.-L. Zong, and J.-P. Xie. 2013. Application of direct atmospheric pressure chemical ionization tandem mass spectrometry for on-line analysis of gas phase of cigarette mainstream smoke. International Journal of Mass Spectrometry 353:42–8. doi:10.1016/j.ijms.2013.05.033.
  • Kolliker, S., M. Oehme, and C. Dye. 1998. Structure elucidation of 2,4-Dinitrophenylhydrazone derivatives of carbonyl compounds in ambient air by HPLC/MS and multiple MS/MS using atmospheric chemical ionization in the negative ion mode. Analytical Chemistry 70 (9):1979–85. doi:10.1021/ac9709458.
  • Kosmider, L., A. Sobczak, M. Fik, J. Knysak, M. Zaciera, J. Kurek, and M. L. Goniewicz. 2014. Carbonyl compounds in electronic cigarette vapors: Effects of nicotine solvent and battery output voltage. Nicotine & Tobacco Research 16 (10):1319–26. doi:10.1093/ntr/ntu078.
  • Koziel, J., and J. Pawliszyn. 2001. Air sampling and analysis of volatile organic compounds with solid phase microextraction. Journal of the Air & Waste Management Association ( Association 51 (2):173–84. doi:10.1080/10473289.2001.10464263.
  • Lee, C.-Y., C.-M. Chiang, Y.-H. Wang, and R.-H. Ma. 2007. A self-heating gas sensor with integrated NiO thin-film for formaldehyde detection. Sensors and Actuators B: Chemical 122 (2):503–10. doi:10.1016/j.snb.2006.06.018.
  • Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping, Products 2019. Accessed December, 2019. https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html.
  • Pang, X., A. C. Lewis, and M. Ródenas-García. 2013. Microfluidic lab-on-a-chip derivatization for gaseous carbonyl analysis. Journal of Chromatography A 1296:93–103. doi:10.1016/j.chroma.2013.04.066.
  • Rankin, G. D., H. Wingfors, O. Uski, L. Hedman, B. Ekstrand-Hammarstrom, J. Bosson, and M. Lundback. 2019. The toxic potential of a fourth-generation E-cigarette on human lung cell lines and tissue explants. Journal of Applied Toxicology 39 (8):1143–54. doi:10.1002/jat.3799.
  • Szulejko, J. E., and K.-H. Kim. 2015. Derivatization techniques for determination of carbonyls in air. TrAC Trends in Analytical Chemistry 64:29–41. doi:10.1016/j.trac.2014.08.010.
  • Tang, M-s, X.-R. Wu, H.-W. Lee, Y. Xia, F.-M. Deng, A. L. Moreira, L.-C. Chen, W. C. Huang, and H. Lepor. 2019. Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proceedings of the National Academy of Sciences 116 (43):21727–31. 11321. doi:10.1073/pnas.1911321116.
  • Tayyarah, R., and G. A. Long. 2014. Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air. Regulatory Toxicology and Pharmacology 70 (3):704–10. doi:10.1016/j.yrtph.2014.10.010.
  • Tobacco Trade Standard of China. 2008. Cigarettes–determination of major carbonyls in mainstream cigarette smoke-High performance liquid chromatographic method. YC/T 254–2008.
  • Witkowski, B., and T. Gierczak. 2013. Analysis of alpha-acyloxyhydroperoxy aldehydes with electrospray ionization-tandem mass spectrometry (ESI-MS(n)). Journal of Mass Spectrometry 48 (1):79–88. doi:10.1002/jms.3130.
  • Zhang, S., H. Chen, A. Wang, Y. Liu, H. Hou, and Q. Hu. 2018. Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro. Environmental Science and Pollution Research 25 (25):25306–14. doi:10.1007/s11356-018-2584-z.
  • Zhang, Y., W. Zhao, D. Wang, H. Zhang, G. Chai, Q. Zhang, B. Lu, S. Sun, and J. Zhang. 2019. Direct analysis of carbonyl compounds by mass spectrometry with double-region atmospheric pressure chemical ionization. Analytical Chemistry 91 (9):5715–21. doi:10.1021/acs.analchem.8b05834.

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