Characterization of Liver Failure by the Analysis of Exhaled Breath by Extractive Electrospray Ionization Mass Spectrometry (EESI-MS): A Pilot Study

References

• Arasaradnam, R. P., M. McFarlane, K. Ling, S. Wurie, N. O'Connell, C. U. Nwokolo, K. D. Bardhan, J. Skinner, R. S. Savage, and J. A. Covington. 2016. Breathomics-exhaled volatile organic compound analysis to detect hepatic encephalopathy: A pilot study. Journal of Breath Research 10 (1):016012. doi:10.1088/1752-7155/10/1/016012.
   PubMed Web of Science ®Google Scholar
• Arroyo, V., R. Moreau, R. Jalan, and P. Ginès. 2015. Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis. Journal of Hepatology 62 (1 Suppl):S131–S143. doi:10.1016/j.jhep.2014.11.045.
   PubMed Web of Science ®Google Scholar
• Beccaria, M., T. R. Mellors, J. S. Petion, C. A. Rees, M. Nasir, H. K. Systrom, J. W. Sairistil, M. A. Jean-Juste, V. Rivera, K. Lavoile, et al. 2018. Preliminary investigation of human exhaled breath for tuberculosis diagnosis by multidimensional gas chromatography—Time of flight mass spectrometry and machine learning. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1074–1075:46–50. doi:10.1016/j.jchromb.2018.01.004.
   PubMed Web of Science ®Google Scholar
• Boots, A. W., J. J. Van Berkel, J. W. Dallinga, A. Smolinska, E. F. Wouters, and F. J. van Schooten. 2012. The versatile use of exhaled volatile organic compounds in human health and disease. Journal of Breath Research 6 (2):027108. doi:10.1088/1752-7155/6/2/027108.
   PubMed Web of Science ®Google Scholar
• Chen, H., A. Wortmann, W. Zhang, and R. Zenobi. 2007. Rapid in vivo fingerprinting of nonvolatile compounds in breath by extractive electrospray ionization quadrupole time-of-flight mass spectrometry. Angewandte Chemie (International ed. in English) 46 (4):580–3. doi:10.1002/anie.200602942.
   PubMed Web of Science ®Google Scholar
• Chen, E. Q., F. Zeng, L. Y. Zhou, and H. Tang. 2015. Early warning and clinical outcome prediction of acute-on-chronic hepatitis B liver failure. World Journal of Gastroenterology 21 (42):11964–73. doi:10.3748/wjg.v21.i42.11964.
   PubMed Web of Science ®Google Scholar
• Covington, J. A., L. Wedlake, J. Andreyev, N. Ouaret, M. G. Thomas, C. U. Nwokolo, K. D. Bardhan, and R. P. Arasaradnam. 2012. The detection of patients at risk of gastrointestinal toxicity during pelvic radiotherapy by electronic nose and FAIMS: A pilot study. Sensors (Basel, Switzerland) 12 (10):13002–18. doi:10.3390/s121013002.
   PubMed Web of Science ®Google Scholar
• Dadamio, J., S. Van den Velde, W. Laleman, P. Van Hee, W. Coucke, F. Nevens, and M. Quirynen. 2012. Breath biomarkers of liver cirrhosis. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 905:17–22. doi:10.1016/j.jchromb.2012.07.025.
   PubMed Web of Science ®Google Scholar
• Eng, K., Alkhouri, N. F. Cikach, N. Patel, C. Yan, D. Grove, R. Lopez, E. Rome, R. A. Dweik. 2015. Analysis of breath volatile organic compounds in children with chronic liver disease compared to healthy controls. Journal of Breath Research 9 (2):026002. doi:10.1088/1752-7155/9/2/026002.
   PubMed Web of Science ®Google Scholar
• Hanouneh, I. A., N. N. Zein, F. Cikach, L. Dababneh, D. Grove, N. Alkhouri, R. Lopez, and R. A. Dweik. 2014. The breathprints in patients with liver disease identify novel breath biomarkers in alcoholic hepatitis. Clinical Gastroenterology and Hepatology 12 (3):516–23. doi:10.1016/j.cgh.2013.08.048.
   PubMed Web of Science ®Google Scholar
• Hauschild, A. C., T. Frisch, J. I. Baumbach, and J. Baumbach. 2015. Carotta: Revealing hidden confounder markers in metabolic breath profiles. Metabolites 5 (2):344–63. doi:10.3390/metabo5020344.
   PubMed Web of Science ®Google Scholar
• Hu, B., S. Yang, M. Li, H. Gu, and H. Chen. 2011. Direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry. The Analyst 136 (18):3599–601. doi:10.1039/c1an15410a.
   PubMed Web of Science ®Google Scholar
• Li, L., Z. Wu, W. Ma, Y. Yu, and Y. Chen. 2001. Changes in intestinal microflora in patients with chronic severe hepatitis. Chinese Medical Journal 114 (8):869–72.
   PubMed Web of Science ®Google Scholar
• Liang, X., S. Bi, W. Yang, L. Wang, G. Cui, F. Cui, Y. Zhang, J. Liu, X. Gong, Y. Chen, et al. 2009. Epidemiological serosurvey of hepatitis B in China-declining HBV prevalence due to hepatitis B vaccination. Vaccine 27 (47):6550–7. doi:10.1016/j.vaccine.2009.08.048.
   PubMed Web of Science ®Google Scholar
• Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Severe Liver Diseases and Artificial Liver Group, and Chinese Society of Hepatology. 2013. Diagnostic and treatment guidelines for liver failure (2012 version). Zhonghua Gan Zang Bing Za Zhi 21 (3):177–83.
   PubMedGoogle Scholar
• McGill, M. R. 2016. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI Journal 15:817–28. doi:10.17179/excli2016-800.
   PubMed Web of Science ®Google Scholar
• Mieth, M., J. K. Schubert, T. Gröger, B. Sabel, S. Kischkel, P. Fuchs, D. Hein, R. Zimmermann, and W. Miekisch. 2010. Automated needle trap heart-cut GC/MS and needle trap comprehensive two-dimensional GC/TOF-MS for breath gas analysis in the clinical environment. Analytical Chemistry 82 (6):2541–51. doi:10.1021/ac100061k.
   PubMed Web of Science ®Google Scholar
• Nitti, M., M. A. Pronzato, U. M. Marinari, and C. Domenicotti. 2008. PKC signaling in oxidative hepatic damage. Molecular Aspects of Medicine 29 (1–2):36–42. doi:10.1016/j.mam.2007.09.001.
   PubMed Web of Science ®Google Scholar
• Obermeier, J., P. Trefz, J. Happ, J. K. Schubert, H. Staude, D. C. Fischer, and W. Miekisch. 2017. Exhaled volatile substances mirror clinical conditions in pediatric chronic kidney disease. PLoS ONE 12 (6):e0178745. doi:10.1371/journal.pone.0178745.
   PubMed Web of Science ®Google Scholar
• Pan, S., Y. Tian, M. Li, J. Zhao, L. Zhu, W. Zhang, H. Gu, H. Wang, J. Shi, X. Fang, et al. 2015. Quantitative detection of nitricoxide in exhaled human breath by extractive electrospray ionization mass spectrometry. Scientific Reports 5 (1):8725. doi:10.1038/srep08725.
   PubMed Web of Science ®Google Scholar
• Pijls, K. E., A. Smolinska, D. M. Jonkers, J. W. Dallinga, A. A. Masclee, G. H. Koek, and F. van Schooten. 2016. A profile of volatile organic compounds in exhaled air as a potential non-invasive biomarker for liver cirrhosis. Scientific Reports 6 (1):19903. doi:10.1038/srep19903.
   PubMed Web of Science ®Google Scholar
• Safari, Z., and P. Gérard. 2019. The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD). Cellular and Molecular Life Sciences : CMLS 76 (8):1541–58. doi:10.1007/s00018-019-03011-w.
   PubMed Web of Science ®Google Scholar
• Schwenger, K. J., N. Clermont-Dejean, and J. P. Allard. 2019. The role of the gut microbiome in chronic liver disease: The clinical evidence revised. JHEP Reports 1 (3):214–26. doi:10.1016/j.jhepr.2019.04.004.
   PubMedGoogle Scholar
• Smolinska, A., A. C. Hauschild, R. R. Fijten, J. W. Dallinga, J. Baumbach, and F. J. van Schooten. 2014. Current breathomics-a review on data pre-processing techniques and machine learning inmetabolomics breath analysis. Journal of Breath Research 8 (2):027105. doi:10.1088/1752-7155/8/2/027105.
   PubMed Web of Science ®Google Scholar
• Van den Berg, R. A., H. C. Hoefsloot, J. A. Westerhuis, A. K. Smilde, and M. J. Van der Werf. 2006. Centering, scaling, and transformations: Improving the biological information content of metabolomics data. BMC Genomics 7 (1):142. doi:10.1186/1471-2164-7-142.
   PubMed Web of Science ®Google Scholar
• Van den Velde, S., F. Nevens, P. Van Hee, D. van Steenberghe, and M. Quirynen. 2008. GC-MS analysis of breath odor compounds in liver patients. Journal of Chromatography B. 875 (2):344–8. doi:10.1016/j.jchromb.2008.08.031.
   PubMed Web of Science ®Google Scholar
• Verdam, F. J., J. W. Dallinga, A. Driessen, C. de Jonge, E. J. C. Moonen, J. B. N. van Berkel, J. Luijk, N. D. Bouvy, W. A. Buurman, S. S. Rensen, et al. 2013. Non-alcoholic steatohepatitis: A non-invasive diagnosis by analysis of exhaled breath. Journal of Hepatology 58 (3):543–8. doi:10.1016/j.jhep.2012.10.030.
   PubMed Web of Science ®Google Scholar
• Wang, C., Y. Feng, M. Wang, X. Pi, H. Tong, Y. Wang, L. Zhu, and E. Li. 2015. Volatile organic metabolites identify patients with mesangial proliferative glomerulonephritis, IgA nephropathy and normal Controls. Scientific Reports 5 (1):14744. doi:10.1038/srep14744.
   PubMed Web of Science ®Google Scholar
• Wang, C., M. Li, H. Jiang, H. Tong, Y. Feng, Y. Wang, X. Pi, L. Guo, M. Nie, H. Feng, et al. 2016. Comparative analysis of VOCs in exhaled breath of amyotrophic lateral sclerosis and cervical spondylotic myelopathy patients. Scientific Reports 6 (1):26120. doi:10.1038/srep26120.
   PubMed Web of Science ®Google Scholar
• Westerhuis, J. A., H. C. J. Hoefsloot, S. Smit, D. J. Vis, A. K. Smilde, E. J. J. van Velzen, J. P. M. van Duijnhoven, and F. A. van Dorste. 2008. Assessment of PLSDA cross validation. Metabolomics 4 (1):81–9. doi:10.1007/s11306-007-0099-6.
   Web of Science ®Google Scholar
• Wishart, D. S., Feunang, Y. D. A. Marcu, A. C. Guo, K. Liang, R. Vázquez-Fresno, R. T. Sajed, D. Johnson, C. Li, N. Karu, et al. 2018. HMDB 4.0: The human metabolome database for 2018. Nucleic Acids Research 46 (D1):D608–D617. doi:10.1093/nar/gkx1089.
   PubMed Web of Science ®Google Scholar
• Wlodzimirow, K. A., A. Abu-Hanna, M. J. Schultz, M. A. Maas, L. D. Bos, P. J. Sterk, H. H. Knobel, R. J. Soers, and R. A. Chamuleau. 2014. Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats. Biosensors & Bioelectronics 53:129–34. doi:10.1016/j.bios.2013.09.047.
   PubMed Web of Science ®Google Scholar
• Zuo, W., W. Bai, X. Gan, F. Xu, G. Wen, and W. Zhang. 2019. Detection of Lung Cancer by Analysis of Exhaled Gas Utilizing Extractive Electrospray Ionization-Mass Spectroscopy. Journal of Biomedical Nanotechnology 15 (4):633–46. doi:10.1166/jbn.2019.2719.
   PubMed Web of Science ®Google Scholar