Identification of Nitrogen Mustard Chemical Warfare Agents in Sand by Gas Chromatography–Mass Spectrometry (GC-MS) in a Military Deployable Laboratory

References

• Ansell, S. M. 2015. Hodgkin lymphoma: Diagnosis and treatment. Mayo Clinic Proceedings 90 (11):1574–83. doi:10.1016/j.mayocp.2015.07.005.
   PubMed Web of Science ®Google Scholar
• Barrioulet, M. P., A. Guérin, and M. L. Kuitunen. 2017. Chapter 2. Soil samples. In Recommended operating procedures for analysis in the verification of chemical disarmament, 2nd ed., 175–86. Helsinki, Finland: The Ministry of Foreign Affairs of Finland.
   Google Scholar
• Brevett, C. A. S., K. B. Sumpter, J. Pence, R. G. Nickol, B. E. King, C. V. Giannaras, and H. D. Durst. 2009. Evaporation and degradation of VX on silica sand. The Journal of Physical Chemistry C 113 (16):6622–33. doi:10.1021/jp8111099.
   Web of Science ®Google Scholar
• Chua, H.-C., H.-S. Lee, and M.-T. Sng. 2006. Screening of nitrogen mustards and their degradation products in water and decontamination solution by liquid chromatography-mass spectrometry. Journal of Chromatography A 1102 (1–2):214–23. doi:10.1016/j.chroma.2005.10.066.
   PubMed Web of Science ®Google Scholar
• Cummings, J., A. MacLellan, J. F. Smyth, and P. B. Farmer. 1991. Determination of reactive nitrogen mustard anticancer drugs in plasma by high-performance liquid chromatography using derivatization. Analytical Chemistry 63 (15):1514–19. doi:10.1021/ac00015a004.
   PubMed Web of Science ®Google Scholar
• Goodman, L. S., M. W. Wintrobe, W. Dameshek, M. J. Goodman, A. Gilman, and M. T. McLennan. 1946. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. Journal of the American Medical Association 132:126–32. doi:10.1001/jama.1946.02870380008004.
   PubMed Web of Science ®Google Scholar
• Jan, Y.-H., D. E. Heck, D. L. Laskin, and J. D. Laskin. 2020. DNA damage signaling in the cellular responses to mustard vesicants. Toxicology Letters 326:78–82. doi:10.1016/j.toxlet.2020.03.008.
   PubMed Web of Science ®Google Scholar
• Jung, H., and S. Choi. 2017. Behavior of sulfur mustard in sand, concrete, and asphalt matrices: Evaporation, degradation, and decontamination. Journal of Environmental Science and Health A: Toxic/Hazardous Substances & Environmental Engineering 52 (12):1121–25. doi:10.1080/10934529.2017.1342498.
   PubMed Web of Science ®Google Scholar
• Jung, H., and S. Choi. 2018. VX evaporation and degradation from urban land surfaces. Environmental Engineering Science 35 (6):645–53. doi:10.1089/ees.2017.0342.
   Web of Science ®Google Scholar
• Jung, H., and K. C. Lim. 2016. Fate and degradation of the chemical warfare agent soman on sands. Environmental Chemistry Letters 14 (3):367–72. doi:10.1007/s10311-016-0575-1.
   Web of Science ®Google Scholar
• Klener, P., and L. Donner. 1975. Trichlortriethylamine (TS-160 Spofa) in combination chemotherapy of malignant lymphomas. Neoplasma 22 (1):55–62.
   PubMed Web of Science ®Google Scholar
• Lee, J. Y., Z. H. Lee, and Z. G. Byun. 2012. Characterization and study of piperazinium salts, degradation products of nitrogen mustards by nuclear magnetic resonance spectroscopy and liquid chromatography–mass spectrometry. Journal of Chromatography A 1227:163–73.
   PubMed Web of Science ®Google Scholar
• Lind, M. J. 2016. Principles of systemic anticancer therapy. Oncology 44 (1):20–24.
   Google Scholar
• Munro, N. B., S. S. Talmage, G. D. Griffin, L. C. Waters, A. P. Watson, J. F. King, and V. Hauschild. 1999. The sources, fate, and toxicity of chemical warfare agent degradation products. Environmental Health Perspectives 107 (12):933–74. doi:10.1289/ehp.99107933.
   PubMed Web of Science ®Google Scholar
• Nagashima, H., T. Kondo, T. Nagoya, T. Ikeda, N. Kurimata, S. Unoke, and Y. Seto. 2015. Identification of chemical warfare agents from vapor samples using a field-portable capillary gas chromatography/membrane-interfaced electron ionization quadrupole mass spectrometry instrument with tri-bed concentrator. Journal of Chromatography A 1406:279–90. doi:10.1016/j.chroma.2015.06.011.
   PubMed Web of Science ®Google Scholar
• Otsuka, M., H. Miyaguchi, and M. Uchiyama. 2020. Analysis of nitrogen mustard degradation products via post-pentafluorobenzoylation liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1625:461306. doi:10.1016/j.chroma.2020.461306.
   PubMed Web of Science ®Google Scholar
• Pantazides, B. G., J. Quiñones-González, D. M. Rivera Nazario, B. S. Crow, J. W. Perez, T. A. Blake, and R. C. Johnson. 2019. A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts. Journal of Chromatography B 1121:9–17. doi:10.1016/j.jchromb.2019.05.005.
   PubMed Web of Science ®Google Scholar
• Qadah, D. T. D., and J. H. Aldstadt. 2018. Determination of aromatic arsines in environmental solids by direct thermal desorption gas chromatography. Analytical Letters 51 (9):1321–34. doi:10.1080/00032719.2017.1379531.
   Web of Science ®Google Scholar
• Reddy, T. J., U. V. R. V. Saradhi, S. Prabhakar, and M. Vairamani. 2004. Trace level detection and identification of chemicals related to the Chemical weapons convention from complex organic samples. Journal of Chromatography A 1038 (1–2):225–30. doi:10.1016/j.chroma.2004.03.028.
   PubMed Web of Science ®Google Scholar
• Rozsypal, T. 2022. Development of a method for the derivatization of ethanolamines and its application to sand samples. Journal of the Serbian Chemical Society 87 (2):233–45. doi:10.2298/JSC210312047R.
   Web of Science ®Google Scholar
• Sinha Roy, K., D. R. Goud, B. Chandra, and D. K. Dubey. 2018. Efficient extraction of sulfur and nitrogen mustards from nonpolar matrix and an investigation on their sorption behavior on silica. Analytical Chemistry 90 (14):8295–99. doi:10.1021/acs.analchem.8b02157.
   PubMed Web of Science ®Google Scholar
• Sousa, R. B., P. F. P. M. Alves, S. F. Cavalcante, L. B. Bernardo, C. C. Barros, C. N. Ferreira, and A. L. S. Lima. 2014. Identification of sulfur and nitrogen mustards by GC/FPD/NPD-MS. Revista Virtual de Química 6 (3):601–31. doi:10.5935/1984-6835.20140039.
   Google Scholar
• Sridhar, L., R. Karthikraj, V. V. S. Lakshmi, N. P. Raju, and S. Prabhakar. 2014. Rapid screening of N-oxides of chemical warfare agents degradation products by ESI-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 406 (21):5235–41. doi:10.1007/s00216-014-7623-0.
   PubMed Web of Science ®Google Scholar
• Tewari-Singh, N., and R. Agarwal. 2016. Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure: Silibinin to counteract skin injury by mustards. Annals of the New York Academy of Sciences 1374 (1):184–92. doi:10.1111/nyas.13099.
   PubMed Web of Science ®Google Scholar
• Tørnes, J. A., A. M. Opstad, and B. A. Johnsen. 1991. Use of solid-phase extraction in determination of chemical warfare agents: Part II. Determination of chemical warfare agents in samples from a battlefield environment. International Journal of Environmental Analytical Chemistry 44 (4):227–31. doi:10.1080/03067319108027555.
   Web of Science ®Google Scholar
• Willison, S. A. 2012. Wipe selection for the analysis of surface materials containing chemical warfare agent nitrogen mustard degradation products by ultra-high pressure liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1270:72–79. doi:10.1016/j.chroma.2012.11.013.
   PubMed Web of Science ®Google Scholar