123
Views
0
CrossRef citations to date
0
Altmetric
Pharmaceutical Analysis

Extension of the Temporal Window for the Determination of Alpha-Methylthiofentanyl and Thiofentanyl in Rat Urine by Monitoring the Metabolite Norfentanyl Using Online Solid-Phase Extraction (SPE) Coupled with Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC–MS/MS)

, , , , , & show all
Pages 53-68 | Received 18 Oct 2021, Accepted 04 Jun 2022, Published online: 16 Jun 2022

References

  • Adamowicz, P., Z. Bakhmut, and A. Mikolajczyk. 2020. Screening procedure for 38 fentanyl analogues and five other new opioids in whole blood by liquid chromatography-tandem mass spectrometry. Journal of Applied Toxicology: JAT 40 (8):1033–46. doi:10.1002/jat.3962.
  • Alnouti, Y., K. Srinivasan, D. Waddell, H. Bi, O. Kavetskaia, and A. I. Gusev. 2005. Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma. Journal of Chromatography. A 1080 (2):99–106. doi:10.1016/j.chroma.2005.04.056.
  • Asperger, A., J. Efer, T. Koal, T. Koal, and W. Engewald. 2002. Trace determination of priority pesticides in water by means of high-speed on-line solid-phase extraction–liquid chromatography–tandem mass spectrometry using turbulent-flow chromatography columns for enrichment and a short monolithic column for fast. Journal of Chromatography A 960 (1–2):109–19. doi:10.1016/S0021-9673(01)01392-9.
  • Chang, Y. W., H. T. Yao, Y. S. Chao, and T. K. Yeh. 2007. Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 857 (2):195–201. doi:10.1016/j.jchromb.2007.07.014.
  • Choi, H. S., H. C. Shin, G. Khang, J. M. Rhee, and H. B. Lee. 2001. Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen-phosphorus detection. Journal of Chromatography B, Biomedical Sciences and Applications 765 (1):63–9. doi:10.1016/S0378-4347(01)00405-4.
  • Cole, J. B., and L. S. Nelson. 2017. Controversies and carfentanil: We have much to learn about the present state of opioid poisoning. The American Journal of Emergency Medicine 35 (11):1743–5. doi:10.1016/j.ajem.2017.08.045.
  • Cox, J., K. Mathison, C. Ott, J. DelTondo, J. C. Kraner, A. P. DeCaprio, and L. E. Arroyo-Mora. 2022. Quantitation and validation of 34 fentanyl analogs from liver tissue using a QuEChERS extraction and LC-MS-MS analysis. Journal of Analytical Toxicology 46 (3):232–45. doi:10.1093/jat/bkab009.
  • Cox, J., A. Train, A. Field, C. Ott, J. DelTondo, J. Kraner, K. Bailey, M. Gebhardt, and L. E. Arroyo-Mora. 2021. Quantitation of fentanyl and metabolites from liver tissue using a validated QuEChERS extraction and LC-MS-MS analysis. Journal of Analytical Toxicology 44 (9):957–67. doi:10.1093/jat/bkaa006.
  • Cummings, O. T., J. R. Enders, G. L. McIntire, R. Backer, and A. Poklis. 2016. Fentanyl-norfentanyl concentrations during transdermal patch application: LC-MS-MS urine analysis. Journal of Analytical Toxicology 40 (8):595–600. doi:10.1093/jat/bkw067.
  • da Cunha, K. F., L. C. Rodrigues, M. A. Huestis, and J. L. Costa. 2020. Miniaturized extraction method for analysis of synthetic opioids in urine by microextraction with packed sorbent and liquid chromatography-tandem mass spectrometry. Journal of Chromatography. A 1624:461241. doi:10.1016/j.chroma.2020.461241.
  • Fikarová, K., B. Horstkotte, D. Machián, H. Sklenářová, and P. Solich. 2021. Lab-in-syringe for automated double-stage sample preparation by coupling salting out liquid-liquid extraction with online solid-phase extraction and liquid chromatographic separation for sulfonamide antibiotics from urine. Talanta 221:121427. doi:10.1016/j.talanta.2020.121427.
  • Gardner, M. A., S. Sampsel, W. W. Jenkins, and J. E. Owens. 2015. Analysis of fentanyl in urine by DLLME-GC-MS. Journal of Analytical Toxicology 39 (2):118–25. doi:10.1093/jat/bku136.
  • Ghassabian, S., S. M. Moosavi, Y. G. Valero, K. Shekar, J. F. Fraser, and M. T. Smith. 2012. High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B 903:126–33. doi:10.1016/j.jchromb.2012.07.005.
  • Hedegaard, H., M. Warner, and A. M. J. N. D. B. Minino. 2017. Drug overdose deaths in the United States 1999-2015. NCHS Data Brief (273):1–8.
  • Huhn, A. S., J. G. Hobelmann, G. A. Oyler, and E. C. Strain. 2020. Protracted renal clearance of fentanyl in persons with opioid use disorder. Drug and Alcohol Dependence 214:108147. doi:10.1016/j.drugalcdep.2020.108147.
  • Kang, M., R. Lian, X. Zhang, Y. Li, Y. Zhang, Y. Zhang, W. Zhang, and Z. Ouyang. 2020. Rapid and on-site detection of multiple fentanyl compounds by dual-ion trap miniature mass spectrometry system. Talanta 217:121057. doi:10.1016/j.talanta.2020.121057.
  • Larabi, I. A., M. Martin, I. Etting, G. Pfau, Y. Edel, and J. C. Alvarez. 2020. Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples. Drug Testing and Analysis 12 (9):1298–308. doi:10.1002/dta.2868.
  • Lyu, L., R. Chen, L. Li, H. Duan, Y. Chen, R. Wang, Z. Xu, and Y. Zhang. 2020. Alpha-methylfentanyl and beta-hydroxyfentanyl LC-MS-MS quantification in rat plasma after long-term ethanol exposure. Journal of Analytical Toxicology 44 (8):896–904. doi:10.1093/jat/bkaa114
  • Meyer, M. R., J. Dinger, A. E. Schwaninger, D. K. Wissenbach, J. Zapp, G. Fritschi, and H. H. Maurer. 2011. Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography-linear ion trap-mass spectrometry (LC-MS(n)). )Analytical and Bioanalytical Chemistry 402 (3):1249–55. doi:10.1007/s00216-011-5528-8.
  • O'Donnell, J., R. M. Gladden, B. A. Goldberger, C. L. Mattson, and M. Kariisa. 2020. Notes from the field: Opioid-involved overdose deaths with fentanyl or fentanyl analogs detected - 28 states and the district of Columbia, July 2016-December 2018. MMWR. Morbidity and Mortality Weekly Report 69 (10):271–3. doi:10.15585/mmwr.mm6910a4.
  • Qin, N., P. Xiang, B. Shen, X. Zhuo, Y. Shi, and F. Song. 2019. Application of a validated UHPLC-MS/MS method for 28 fentanyl-analogue and novel synthetic opioids in whole blood in authentic forensic cases. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 1124:82–99. doi:10.1016/j.jchromb.2019.05.025.
  • Sanan, T., and M. Magnuson. 2020. Analysis of per- and polyfluorinated alkyl substances in sub-sampled water matrices with online solid phase extraction/isotope dilution tandem mass spectrometry. Journal of Chromatography. A 1626:461324. doi:10.1016/j.chroma.2020.461324.
  • Shaner, R. L., P. Kaplan, E. I. Hamelin, W. A. Bragg, and R. C. Johnson. 2014. Comparison of two automated solid phase extractions for the detection of ten fentanyl analogs and metabolites in human urine using liquid chromatography tandem mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 962:52–8. doi:10.1016/j.jchromb.2014.05.025.
  • Shanks, K. G., and G. S. Behonick. 2017. Detection of carfentanil by LC-MS-MS and reports of associated fatalities in the USA. Journal of Analytical Toxicology 41 (6):466–72. doi:10.1093/jat/bkx042.
  • Shentu, J., L. Fu, H. Zhou, X. J. Hu, J. Liu, J. Chen, and G. Wu. 2012. Determination of amlodipine in human plasma using automated online solid-phase extraction HPLC-tandem mass spectrometry: Application to a bioequivalence study of Chinese volunteers. Journal of Pharmaceutical and Biomedical Analysis 70:614–8. doi:10.1016/j.jpba.2012.06.014.
  • Sofalvi, S., H. E. Schueler, E. S. Lavins, C. K. Kaspar, I. T. Brooker, C. D. Mazzola, D. Dolinak, T. P. Gilson, and S. Perch. 2017. An LC-MS-MS method for the analysis of carfentanil, 3-methylfentanyl, 2-furanyl fentanyl, acetyl fentanyl, fentanyl and norfentanyl in postmortem and impaired-driving cases. Journal of Analytical Toxicology 41 (6):473–83. doi:10.1093/jat/bkx052.
  • Strano-Rossi, S., I. Alvarez, M. J. Tabernero, P. Cabarcos, P. Fernandez, and A. M. Bermejo. 2011. Determination of fentanyl, metabolite and analogs in urine by GC/MS. Journal of Applied Toxicology : JAT 31 (7):649–54. doi:10.1002/jat.1613.
  • Suzuki, S., T. Inoue, and C. J. Kashima. 1986. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and related compounds. I. Spectrometric and chromatographic analyses of 3-methylfentanyl and alpha-methylfentanyl. Chemical and Pharmaceutical Bulletin 34 (3):1340–3. doi:10.1248/cpb.34.1340.
  • Taghizadeh, M. J., S. J. Hosseini, S. M. Moosavi, and H. Parsa. 2020. Improved method for the total synthesis of thiofentanyl. Journal of Heterocyclic Chemistry doi:10.1002/jhet.3983.
  • Thomasy, S. M., K. R. Mama, and S. D. Stanley. 2008. Comparison of liquid chromatography-mass spectrometry and radioimmunoassay for measurement of fentanyl and determination of pharmacokinetics in equine plasma. Journal of Analytical Toxicology 32 (9):754–9. doi:10.1093/jat/32.9.754.
  • Wang, G., K. Huynh, R. Barhate, W. Rodrigues, C. Moore, C. Coulter, M. Vincent, and J. Soares. 2011. Development of a homogeneous immunoassay for the detection of fentanyl in urine. Forensic Science International 206 (1–3):127–31. doi:10.1016/j.forsciint.2010.07.022.
  • Wilson, N., M. Kariisa, P. Seth, H. Smith, and N. L. Davis. 2020. Drug and opioid-involved overdose deaths - United States, 2017-2018. MMWR. Morbidity and Mortality Weekly Report 69 (11):290–7. doi:10.15585/mmwr.mm6911a4.
  • Zhang, Y., Z. Sheng, Z. Hua, C. Liang, Z. Cai, R. Wang, and Y. Zhang. 2020. Simultaneous separation and determination of 32 fentanyl-related substances, including seven sets of isomeric fentanyl analogues, by ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. Journal of Separation Science 43 (19):3735–47. doi:10.1002/jssc.202000168.
  • Zoorob, M. 2019. Fentanyl shock: The changing geography of overdose in the United States. The International Journal on Drug Policy 70:40–6. doi:10.1016/j.drugpo.2019.04.010.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.