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Original Articles

Dissociation Constants and Solubilities of Bases of Anti-Malarial Compounds

I.—Quinine; II.—Atebrin

Pages 43-69 | Received 08 Dec 1936, Published online: 23 Mar 2016

REFERENCES

General

  • Auerbach, F., and Smolczyk, E. (1924). Zur Theorie und Praxis der electrometrischen Sauretitration. Ztsch. f. Physikal. Chem., 110, 65.
  • Bredig, G. (1894). Über die Affinitatsgrossen der Basen. Ibid., 13, 289.
  • CHANDLER, E. E. (1908). The ionization constants of the second hydrogen ion of dibasic acids. Jl. Amer. Chem. Soc., 30, 694.
  • Clark, W. M. (1928). The determination of hydrogen ions. 3rd ed. Lond.
  • Denham, H. G. (1908). The electrometric determination of the hydrolysis of salts. Jl. Chem. Soc., 93, 41.
  • Enklaar, J. E. (1912). Die Neutralisationskurve und Dissociations-Konstanten von Schwefelsaure und Citronensaure. Ztsch. f. Physikal. Chem., 80, 617.
  • Farmer, R. C., and Warth, F. J. (1904). The affinity constants of aniline and its derivatives. Jl. Chem. Soc., 85, 1713.
  • Findlay, A. (1933). Introduction to physical chemistry. Lond.
  • Gane, R., and Incold, C. K. (1928). Electrometric titration curves of dibasic acids. Pt. I: Normal acids. Jl. Chem. Soc., 1594.
  • Gilbert, F. L. (1924). The electrometric titration of hydrazine and its salts. Jl. Amer. Chem. Soc., 46, 2648.
  • Hastings, A. B., and van Slyke, D. D. (1922). The determination of the three dissociation constants of citric acid. Jl. Biol. Chem., 58, 269.
  • Jeffery, G. H., and Vogel, A. I. (1934). The dissociation constants of organic acids. Jl. Chem. Soc., 1101.
  • Kolthoff, I. M. and Furman, N. H. (1925). Die Dissociationskonstante, das Loslichkeitsprodukt und die Titrierbarkeit von Alkaloiden. Biochem. Ztsch., 162, 289.
  • Kolthoff, I. M. (1926). Indicators, p. 13. Lond.
  • Mauss, H., and Mietzsch, F. (1933). Atebrin, ein neues Heilmittel gegen Malaria. Klin. Woch., 12, 1276.
  • McCOY, H. N. (1908). Two new methods for the determination of the secondary ionization constants of dibasic acids. Jl. Amer. Chem. Soc., 30, 688.
  • Prideaux, E. B. R., and Gilbert, F. L. (1927). The application of the hydrogen electrode to organic bases; piperidine and its use as an alkaline buffer. Jl. Chem. Soc., 2164.
  • Pugh, W. (1929). Germanium. Pt. V: The hydrolysis of sodium germanate and the dissociation constants of germanic acid. Ibid., 1994.
  • Schmidt, J. (1932). A textbook of organic chemistry. (English ed.). Lond.
  • Schulemann, W. (1932). Synthetic anti-malarial preparations. Proc. Roy. Soc. Med., 25, 897.
  • Sidgwick, N. V. (1927). The electronic theory of valency. Lond.
  • Veley, V. H. (1908a). The affinity constants of bases as determined by the aid of methyl orange. Jl. Chem. Soc., 93, 652, 2122.
  • Vogel, A. I. (1929). The dissociation constants of organic acids. Pt. I: The primary dissociation constants of some alkyl malonic acids. Ibid., 1476.

Quinine

  • Arnall, J. (1920). The determination of the relative strengths of some nitrogen bases of the aromatic series and of some alkaloids. Jl. Chem. Soc., 117, 835.
  • Barratt, J. O. W. (1910). Über die Konstanten der ersten und zweiten Dissoziations des Chinins. Ztsch. f. Electrochem., 16, 130.
  • Berthelot and Gaudechon (1903). Recherches sur les alkaloides des quinquinas: quinine et quinidine. C. R. Acad. Sci., 136, 128.
  • Bredig, G. (1894). See under General.
  • Colson and Darzens (1893). Constants thermiques de quelques bases polyatomique. C. R. Acad. Sci., 118, 250.
  • Fischl, V., and Schlossberger, H. (1933). Handbook of chemotherapy. Baltimore.
  • Kolthoff, J. M. (1925). See under GENERAL.
  • Manz (1904). Physik, chem. Untersuch, über Alkaloide. Dissertation, Stuttgart. (Quoted by Kolthoff, 1925.)
  • Masucci, P., and Moffat, M. I. (1923). The hydrogen-ion concentration of some U.S.P. products. Jl. Amer. Pharm. Assoc., 12, 609.
  • McGill, J. M. (1922). The use of the newer indicators in titrations of alkaloids. Jl. Amer. Chem. Soc., 44, 2156.
  • Oettincen, W. F. von (1933). The therapeutic agents of the quinoline group. New York.
  • Rabe, P., Huntenburg, W., Schultze, A., and Volger, G. (1931). Die Totalsynthese der China-Alkaloide, Hydrochinin und Hydrochinidin. Ber. Dent. Chem. Gesellsch., 64, 2487.
  • Rohde, G., and Antonaz, A. (1907). Beitrage zur Kenntnis der Chinaalkaloide. Ibid., 40, 2329.
  • Salamonsen (1895). (Quoted by Veley, 1908b.) Ned. Tydsch. Pharm., 7, 195, 225.
  • Schoorl, N. (1922). Le titrage d'alcaloïdes du quinquina et de leurs sels. Rec. Trav. Chim. des Pays-Ba., 41, 228.
  • Veley, V. H. (1908A). The affinity of certain alkaloids for hydrochloric acid. Jl. Chem. Soc., 93, 2114.
  • Veley, V. H. (1909). The affinity values of certain alkaloids. Ibid., 95, 758.

ATEBRIN

  • Mauss, H., and Mietzsch, F. See under General.
  • Mietzsch, F., and Mauss, H. (1934). Gegen Malaria wirksame Acridinverbindungen. Ztsch. f. Angew. Chem., No. 37, 633.
  • Schulemann, W. (1935). Die Wirkung der synthetisch dargestellten gegen Malaria wirksamen Arzneistoffe. Riv. Malar., 14, Suppl. I, 33.

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