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Original Articles

Studies on Synthetic Antimalarial Drugs

IX.—The Excretion of 2-p-Chlorophenylguanidino-4-β-Diethylaminoethylamino-6-Methylpyrimidine (3349) in Human Urine

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Pages 197-207 | Received 15 Nov 1945, Published online: 22 Mar 2016

REFERENCES

  • Adams, A. R. D., and Sanderson, G. (1945a), Studies on synthetic antimalarial drugs. III: A preliminary investigation of the therapeutic action of 3349 on acute attacks of benign tertian malaria. Ann. Trop. Med. & Parasitol. Vol, 89, 165.
  • Adams, A. R. D., and Sanderson, G. (1945b). Studies on synthetic antimalarial drugs. IV: A preliminary investigation of the therapeutic action of 3349 on acute attacks of malignant tertian malaria. Ibid. Vol, 39, 169.
  • Anderson, C. E., Cornatzer, W. E., and Andrews, J. C. (1943). Role of the liver in the metabolic destruction of quinine. Jl. Pharmacol. Vol, 79, 62.
  • Andrews, J. C., and Anderson, C. E. (1943). The absorption of quinine sulfate and quinine dihydrochloride from isolated intestinal loops of dogs. Ibid. Vol, 78, 346.
  • Behre, J. A. (1940). A modified salicylaldehyde method for the determination of acetone bodies in blood and urine. Jl. Biol. Chem. Vol, 136, 25.
  • Berenblum, I., and Schoental, R. (1942). Metabolic products of 3: 4-benzpyrene. Nature, 149, 439.
  • Bernhard, K. (1939). Stoffwechsel mit Dekahydro- und Tetrahvdro-chinolin und -isochinolin sowie Dekahydro- chinaldin. Ztschr. Phys. Chem. Vol, 258, 96.
  • Bispham, W. N. (1941). Toxic reactions following the use of atabrine in malaria. Amer. Jl. Trop. Med. Vol, 21, 455.
  • Blixenkrone-Moller, N. (1938). Über den Abbau von Ketonenkörpern. Ztschr. Phys. Chem. Vol, 253, 261.
  • Brentano, C., and Markees, S. (1936). Exogene bzw. alimentäre Ketonkörperbildung aus Fettsäuren. Ztschr. Ges. Exp. Med. Vol, 99, 498.
  • Cason, J., and Fieser, L. F. (1940). Synthesis of 4’: 8′-dihydroxy-1: 2: 5: 6-dibenzanthracene and its relation to products of metabolism of the hydrocarbon. Jl. Amer. Chem. Soc. Vol, 62, 2681.
  • Chalmers, J. G., and Crowfoot, D. (1941). The elimination of 3: 4-benzpyrene from the animal body after subcutaneous injection. Biochem. Jl. Vol, 85, 1270.
  • Dearborn, E. H., Kelsey, F. E., Oldham, F. K., and Geiling, E. M. K. (1943). The accumulation and excretion of atabrine. Jl. Pharmacol. Vol, 78, 120.
  • Deichmann, W. (1943). The quantitative estimation of glucuronates in urine. Jl. Lab. & Clin. Med. Vol, 28, 770.
  • Dobriner, K., Rhoads, C. P., and Lavin, G. I. (1942). The detection, isolation and biological effects of the metabolites of 1: 2: 5: 6-dibenzanthracene. Cancer Res. Vol, 2, 95.
  • Farinaud, E., Lataste, C., Baccialone, L., and Canet, J. (1939). Rapports entre la concentration sanguine et l'élimination urinaire de la quinacrine. C.R. Soc. Biol. Paris, 180, 623.
  • Findlay, G. M., and Stevenson, A. C. (1944). Investigations in the chemotherapy of malaria in West Africa. II: Malaria suppression—quinine and mepacrine. Ann. Trop. Med. & Parasitol. Vol, 38, 168.
  • Fisher, R. A. (1938). Statistical methods for research workers. 7th ed. Lond.: Oliver & Boyd.
  • Hanson, S. W. F., Mills, G. T., and Williams, R. T. (1944). A study of the determination of glucuronic acid by the naphthoresorcinol reaction with the photoelectric absorptiometer. Biochem. Jl. Vol, 38, 274.
  • Hartmann, H., and Zila, L. (1918). Das Schicksal des Chinins im Organismus. Arch. Exp. Path. u. Pharmak. Vol, 88, 221.
  • Hawk, P. B., and Bergeim, O. (1938). Practical physiological chemistry. 11th ed. Lond.: J. & A. Churchill.
  • Hecht, G. (1933). Pharmakologisches über Atebrine. Arch. Exp. Path. u. Pharmak. Vol, 170, 328.
  • Herrick, J. B., and Irons, E. E. (1906). Chronic acetanilide poisoning. Jl. Amer. Med. Assoc. Vol, 46, 351.
  • Jaffe, M., and Hilbert, P. (1888). Ueber Acetanilid und Acettoluid und ihr Verhalten im thierischen Stoff-wechsel. Ztschr. Phys. Chem. Vol, 12, 295.
  • James, G. V. (1940). The isolation of some oxidation products of sulphanilamide from urine. Biochem. Jl. Vol, 34, 640.
  • Jordi, A., and Leuthard, F. (1939). Sulfatbestimmungen im Urin zur Fruhdiagnose der Benzolgiftung. Helv. Med. Acta, 6, 652.
  • Kehar, N. D. (1935). Observations on the absorption and excretion of atebrin. Rec. Malar. Surv. India, 5, 393.
  • Kemal, H. (1927). Beitrag zur Kenntnis der Schicksale des Isopropylalkohols im menschlichen Organismus. Biochem. Ztschr. Vol, 187, 461.
  • Loughlin, E. H., Bennett, R. H., Santora, E., and Muttucci, S. (1943). Clinical toxicity of atabrine dihydrochloride. War Med. Vol, 4, 272.
  • Maughan, G. B., Evelyn, K. A., and Browne, J. S. L. (1938). A method for the quantitative estimation of glucuronic acid and conjugated glucuronides. Jl. Biol. Chem. Vol, 126, 567.
  • Ratish, H. D., and Bullowa, J. G. M. (1943). Determination of glucuronic acid in biological media. Arch. Biochem. Vol, 2, 381.
  • Rose, F. L., and Bevan, H. G. L. (1944). A new coupling component and simplified method for the estimation of sulphanilamide drugs. Biochem. Jl. Vol, 38, 116.
  • Rothkopf, H. (1936). Über die Ausschiedung organischer Dämpfe in der Atemluft. Ztschr. Ges. Exp. Med. Vol, 99, 464.
  • Sammons, H. G., and Williams, R. T. (1941). The metabolism of vanillin and vanillic acid in the rabbit. Biochem. Jl. Vol, 85, 1175.
  • Scudi, J. V. (1940). On the urinary excretion of ‘free’ sulfapvridine. Science, 91, 486.
  • Scudi, J. V. Ratish, H. D., and Bullowa, J. G. M. (1939). Increased glycuronate excretion following administration of sulfapyridine. Ibid. Vol, 89, 516.
  • Shelswell, J., and Williams, R. T. (1940). Ethereal sulphate formation in the rabbit after administration of sulphanilamide. Biochem. Jl. Vol, 34, 528.
  • Simici, D., Dimitriu, C. C., and Cimino-Berenger, E. (1937). Recherches sur l'élimination des hydrates de carbone par l'estomac chez le chien, l'homme normal et chez les diabétiques. Bull. Acad. Méd. Roumanie, 4, 530.
  • Spinks, A. (1945). Studies on synthetic antimalarial drugs. VII: Turbidimetric determination of 2-p-chloro-phenylguanidino-4-β-diethylaminoethylamino-6-methylpyrimidine (3349). Ann. Trop. Med. & Parasitol. Vol, 39, 182.
  • Spinks, A. and Tottey, M. M. (1945). Studies on synthetic antimalarial drugs. VIII: Colorimetric determination of 2-p-chlorophenylguanidino-4-β-diethylaminoethylamino-6-methylpyrimidine (3349). Ibid. Vol, 39, 190.
  • Stroud, S. W. (1939). Preliminary investigation of the metabolism of stilbene. Nature, 144, 245.
  • Tropp, C., and Weise, W. (1933). Untersuchungen über die Ausschiedung von Atebrin durch Harn und Faeces. Arch. Exp. Path, u Pharmak. Vol, 170, 339.
  • Vigliani, E. C. (1938). Medical prevention of chronic benzene intoxication with special reference to urinary sulphates. Chem. Abstr. Vol, 32, 2645.
  • Wiley, F. H. (1938). The metabolism of β-naphthylamine. Jl. Biol. Chem. Vol, 124, 627.
  • Williams, R. T. (1945). The metabolism of sulphanilamide, metanilamide and orthanilamide. Biochem. Jl. Vol, 39, proceedings.

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