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Original Articles

The Absorption and Excretion of Paludrine in the Human Subject

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Pages 493-506 | Received 15 Oct 1946, Published online: 22 Mar 2016

REFERENCES

  • Adams, A. R. D., Maegraith, B. G., King, J. D., Townshend, R. H., Davey, T. H., and Havard, R. E. (1945). Studies on synthetic antimalarial drugs. XIII: Results of a preliminary investigation of the therapeutic action of 4888 (Paludrine) on acute attacks of benign tertian malaria. Ann. Trop. Med. & Parasitol, 39, 225.
  • Annegers, J. H., Snapp, F. E., Paskind, L., Ivy, A. C., and Atkinson, J. C. (1943). Retention of atabrine in animal body: excretion in bile and urine and effect on cholic acid output. War Med., Chicago, 4, 176.
  • Armored Medical Research Laboratory, Fort Knox, Kentucky (1943). Investigation of the effects of activity and environment on atabrine therapy.
  • Army Malaria Research Unit (1944). Mepacrine plasma concentration and B.T. malaria. I: Relapses after treatment with mepacrine. Rep. MLA 48 to Malar. Comm., Med. Res. Court.
  • Army Malaria Research Unit (1945). Factors affecting the excretion of mepacrine in the urine. Ann. Trop. Med. & Parasitol., 39, 53.
  • Army Malaria Research Unit (1946a). Mepacrine in animal tissues. Ibid., 40, 173.
  • Army Malaria Research Unit (1946b). Distribution of mepacrine in blood. Ibid., 40, 181.
  • Army Malaria Research Unit (1946c). Blood and plasma concentrations of mepacrine in subjects taking suppressive and therapeutic dosages. Ibid., 40, 472.
  • Bernardbeig and Caujolle, F. (1935). Sur l'élimination de la quinine par la bile. Bull. Acad. Méd., 113, 147.
  • Chen, G. and Geiling, E. K. M. (1944). Observations bearing on the mechanism of the elimination of quinine and atabrine from the circulation and tissues. Jl. Pharmacol., 82, 120.
  • Fairley, N. H. (1945). Chemotherapeutic suppression and prophylaxis in malaria: an experimental investigation undertaken by medical research teams in Australia. Trans. Roy. Soc. Trop. Med. & Hyg., 88, 311.
  • Farinaud, E., Baccialone, L., Lataste, C., and Nguyen-Van-Lien (1937). Recherches préliminaires sur l'élimination de la quinacrine chez le malade paludéen. Bull. Soc. Path. Exot., 30, 791.
  • Hecht, G. (1933). Pharmakologisches über Atebrin. Arch. f. Exp. Path. u. Pharmak., 170, 328.
  • Henry, A. J., and Grindley, D. N. (1945). The adsorption-fluorescence estimation of mepacrine and stilbamidine. Ann. Trop. Med. & Parasitol., 39, 1.
  • Maegraith, B. G., Adams, A. R. D., King, J. D., Tottey, Mary M., Rigby, D. J., and Sladden, R. A. (1946). Paludrine in the treatment of malaria. Brit. Med. Jl., 1, 903.
  • Maegraith, B. G., Adams, A. R. D., King, J. D., Tottey, Mary M., Rigby, D. J., and Sladden, R. A. Townshend, R. H., Davey, T. H., and Havard, R. E. (1945). Studies on synthetic antimalarial drugs. XIV: Results of a preliminary investigation of the therapeutic action of 4888 (Paludrine) on acute attacks of malignant tertian malaria. Ann. Trop. Med. & Parasitol., 39, 232.
  • Maegraith, B. G., Adams, A. R. D., King, J. D., Tottey, Mary M., Rigby, D. J., and Sladden, R. A. Townshend, R. H., Davey, T. H., and Havard, R. E. and Havard, R. E. (1945). Prolonged administration of mepacrine: effects on volunteers. Lancet, 249, 141.
  • Ramsden, W., Lipkin, I. J., and Whitley, E. (1918). On quinine in animal tissues and liquids, with methods for its estimation. Ann. Trop. Med. & Parasitol., 12, 223.
  • Shannon, J. A. (1943). On the use of atabrine in the treatment of malaria: memo, to Committee of Medical Research Office of Scientific Research and Development, July, 1943.
  • Shannon, J. A. Earle, D. P., Brodie, B. B., Taggart, J. V., Berliner, R. W., Et Al. (1944). The pharmacological basis for the rational use of atabrine in the treatment of malaria. Jl. Pharmacol., 81, 307.
  • Spinks, A. (in the press). Studies on synthetic antimalarial drugs. XVIII: The absorption, distribution and excretion of Paludrine in experimental animals. Ann. Trop. Med. & Parasitol.
  • Spinks, A. and Tottey, Mary M. (1945a). Studies on synthetic antimalarial drugs. IX: The excretion of 2-p- chlorophenylguanidino-4-β-diethylaminoethylamino-6-methylpyrimidine (3349) in human urine. Ibid., 39, 197.
  • Spinks, A. and Tottey, Mary M. (1945b). Unpublished report.
  • Spinks, A. and Tottey, Mary M. (1946a). Studies on synthetic antimalarial drugs. XV: Hvdrolytic determination of Paludrine. Ann. Trop. Med. & Parasitol., 40, 101.
  • Spinks, A. and Tottey, Mary M. (1946b). Studies on synthetic antimalarial drugs. XVI: The absorption, distribution and excretion of 2-p-chlorophenylguanidino-4-β-diethylaminoethylamino-6-methylpyrimidine (3349) in experimental animals. Ibid., 40, 145.

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