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Original Articles

The amoebicidal activity and toxicity of natural emetine, (±)-2-dehydroemetine and (−)-2-dehydroemetine

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Pages 455-461 | Received 05 Jun 1968, Published online: 15 Mar 2016

REFERENCES

  • Brossi, A., Brener, Z., Pellegrino, J., Stohler, H., and Frey, J. R. (1960). Stereospezifität der Wirkung von Emetin. Experientia, 16, 64.
  • González De Cossío, A. (1960). Electrocardiographic changes under therapy with Ro 1–9334, a synthetic racemic 2-dehydroemetine. Revta Inst. Med. trop. S. Paulo, 2, 313.
  • Herrero, J., Brossi, A., Faust, M., and Frey, J. R. (1960). Preliminary experimental and clinical results with a new synthetic emetine-like compound. Ann. Biochem. Exp. Med., 20, Suppl., 475.
  • Neal, R. A. (1951). Some observations on the variation of virulence and response to chemotherapy of strains of Entamoeba histolytica in Rats. Trans. R. Soc. Trop. Med. Hyg., 44, 439.
  • Piller, M., and Stohler, H. (1963). Experimented Grundlagen der Amöbiasisbehandlung mit Dehydro-Emetin. Praxis, 52, 273.
  • Powell, S. J. (1967). The cardiotoxicity of systemic amebicides: a comparative electrocardiographic study. Am. J. trop. Med. Hyg., 16, 447.
  • Powell, S. J. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. (1962). Dehydroemetine in amebic dysentery and amebic liver abscess. Ibid., 11, 607.
  • Powell, S. J. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. (1965a). The treatment of acute amoebic dysentery: trials of dehydroemetine, of dehydroemetine-bismuth-iodide, and of dehydroemetine and dehydroemetine-bismuthiodide in combination. Ann. trop. Med. Parasit., 59, 205.
  • Powell, S. J. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. Wilmot, A. J., MacLeod, I. N., and Elsdon-Dew, R. (1965b). Dehydroemetine in the treatment of amoebic liver abscess. Ibid., 59, 208.
  • Powell, S. J. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. Wilmot, A. J., MacLeod, I. N., and Elsdon-Dew, R. Wilmot, A. J., MacLeod, I. N., and Elsdon-Dew, R. (1965c). A comparative trial of dehydroemetine, emetine hydrochloride and chloroquine in the treatment of amoebic liver abscess. Ibid., 59, 496.
  • Powell, S. J. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. MacLeod, I., Wilmot, A. J., and Elsdon-Dew, R. Wilmot, A. J., MacLeod, I. N., and Elsdon-Dew, R. Wilmot, A. J., MacLeod, I. N., and Elsdon-Dew, R. Wilmot, A. J., MacLeod, I. N., and Elsdon-Dew, R. (1967). A comparative trial of dehydroemetine and emetine hydrochloride in identical dosage in amoebic liver abscess. Ibid., 61, 26.
  • Schwartz, D. E., and Herrero, J. (1965). Comparative pharmacokinetic studies of dehydroemetine and emetine in guinea pigs using spectrofluorometric and radiometric methods. Am. J. trop. Med. Hyg., 14, 78.
  • Thompson, P. E., and Reinertson, J. W. (1951). Chemotherapy of amebic hepatitis in hamsters with emetine, chloroquine, amodiaquin (Camoquin), quinacrine and other drugs. Am. J. trop. Med., 31, 707.
  • Vakil, B. J., Shah. S. C., and Moses, J. M. (1967). The comparative value of dehydroemetine and emetme in amebiasis. J. Ass. Physns India, 15, 223.
  • Whittaker, N. (1969). The synthesis of emetine and related compounds. Pt. IX: The use of Wittig-type reagents in the synthesis of 2,3-dehydroemetine. J. chem. Soc., (c), 94.

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