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Annals of Tropical Medicine & Parasitology Volume 64, 1970 - Issue 3
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Original Articles

The metabolism of niridazole (AMBILHARR) in man

I. Investigations on patients suffering from clinically mild forms of Schistosoma haematobium and Schistosoma mansoni infection

J. W. Faigle From the Chemical Research Laboratories of the Pharmaceutical Division, CIBA Ltd., Basle, Switzerland, and the Blair Research Laboratory and the University Medical School, Salisbury, Rhodesia
,
D. M. Blair From the Chemical Research Laboratories of the Pharmaceutical Division, CIBA Ltd., Basle, Switzerland, and the Blair Research Laboratory and the University Medical School, Salisbury, Rhodesia
,
V. De V. Clarke From the Chemical Research Laboratories of the Pharmaceutical Division, CIBA Ltd., Basle, Switzerland, and the Blair Research Laboratory and the University Medical School, Salisbury, Rhodesia
,
L. A. G. Davidson From the Chemical Research Laboratories of the Pharmaceutical Division, CIBA Ltd., Basle, Switzerland, and the Blair Research Laboratory and the University Medical School, Salisbury, Rhodesia
,
D. C. Dukes From the Chemical Research Laboratories of the Pharmaceutical Division, CIBA Ltd., Basle, Switzerland, and the Blair Research Laboratory and the University Medical School, Salisbury, Rhodesia
&
H. Keberle From the Chemical Research Laboratories of the Pharmaceutical Division, CIBA Ltd., Basle, Switzerland, and the Blair Research Laboratory and the University Medical School, Salisbury, Rhodesia
Pages 373-382 | Received 21 Jul 1969, Published online: 15 Mar 2016

REFERENCES

  • Blair, D. M., and Clarke, V. De V. (1966). Field trials with CIBA 32,644-Ba in Rhodesia. Acta trop., Suppl. 9, 145.
  • Clarke, V. De V. and Blair, D. M. (1966). Trials with Ambilhar (CIBA 32,644-Ba) in the treatment of bilharziasis in Rhodesia. Cent. Afr. J. Med., 12, 64.
  • Clarke, V. De V. and Blair, D. M. (1969). Dosage scheme and dosage response of niridazole in schistosomiasis. Ann N. Y. Acad. Sci., 160, 645.
  • Faigle, J. W., Coutinho, A. D., Keberle, H., and Trindade Barretto, F. (1970). The metabolism of niridazole (AmbilharR) in man. II. Investigations on patients suffering from clinically advanced forms of Schistosoma mansoni infection. Arm. trop. Med. Parasit., 64, 383.
  • Faigle, J. W., Coutinho, A. D., and Trindade Barretto, F. and Keberle, H. (1966). The metabolic fate of CIBA 32, 644-Ba. Acta trop., Suppl. 9, 8.
  • Faigle, J. W., Coutinho, A. D., and Trindade Barretto, F. and Keberle, H. (1969a). Metabolism of niridazole in various species including man. Ann. N.Y. Acad. Sci. 160, 544.
  • Faigle, J. W., Coutinho, A. D., and Trindade Barretto, F. and Keberle, H. (1969b). Synthesis of 14C-labelled 2-aminothiazole, 2-amino-5-nitrothiazole, 2-chloro-5-nitrothiazole and 1-(5-nitro-2-thiazolyl)-2-imidazolidinone (active substance of AmbilharR). J. Labelled Comp., 5, 173.
  • Fontanilles, F. (1969). Risks versus benefits in antischistosomal therapy. Ann. N. Y. Acad. Sci., 160, 811.
  • Hess, R., Faigle, J. W., and Lambert, C. (1966). Selective uptake of an antibilharzial nitrothiazole compound by Schistosoma mansoni. Nature, Lond., 210, 964.
  • Kalberer, F., and Rutschmann, J. (1961). Eine Schnellmethode zur Bestimmung von Tritium, Radiokohlenstoff und Radioschwefel in beliebigem organischem Probenmaterial mittels des Flüssigkeits-Scintillations-Zählers. Helv. chim. Acta., 44, 1956.
  • Lambert, C. R. (1966b). Nouveau traitement des schistosomiases et de l'amibiase, le CIBA 32,644-Ba. Acta trop., 23, 1.
  • Lambert, C. R. (1966b). Transaminases et rôle du filtre hépatique lors du traitement au CIBA 32, 644-Ba. Acta trop., Suppl. 9, 28.
  • Lambert, C. R. Wilhelm, M., Striebel, H., Kradolfer, F., and Schmidt, P. (1964). Eine neue gegen Bilharziose und Amoebiase wirksame Verbindung. Experientia, 20, 452.
  • Martins Da Rocha, R., and Gil, F. B. (1966). Essais préliminaires sur l'élimination du CIBA 32,644-Ba marqué C14. Acta trop., Suppl. 9, 23.
  • Wilhelm, M., Marquardt, F. H., Meier, KD., and Schmidt, P. (1966). Synthese und Abbau von 1-(5- Nitro-2-thiazolyl)-2-imidazolidinon und Derivaten. Helv. chim. Acta., 49, 452.

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