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Annals of Tropical Medicine & Parasitology Volume 73, 1979 - Issue 5
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Original Articles

The concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and ‘double’ dosage in non-immunes: clinical implications

Johan BrohultThe Yekepa Clinical Research and Training Unit of the Liberian Institute for Biomedical Research and Roslagstull Hospital, Department of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
,
Lars RomboThe Yekepa Clinical Research and Training Unit of the Liberian Institute for Biomedical Research and Roslagstull Hospital, Department of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
,
Varsey SirleafThe Yekepa Clinical Research and Training Unit of the Liberian Institute for Biomedical Research and Roslagstull Hospital, Department of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
&
Elias BengtssonThe Yekepa Clinical Research and Training Unit of the Liberian Institute for Biomedical Research and Roslagstull Hospital, Department of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
Pages 401-405 | Received 10 Apr 1979, Published online: 11 Mar 2016

REFERENCES

  • Armstrong, J. C., Asfaha, W., Palmer, T. T., Townley, L. B. & Yigsaw, M. (1976). Chloroquine sensitivity of Plasmodium falciparum in Ethiopia. I. Results of an in vivo test. American Journal of Tropical Medicine and Hygiene, 25, 5–9.
  • Barrett-Connor, E. (1978). Chemoprophylaxis of malaria. Annals of Internal Medicine, 89, 417–418.
  • Bergkvist, Y., Domeij-Nyberg, B., Frisk-Holmberg, M., Hellström, L. & Jansson, F. (1979). Serum concentrations and side-effects in rheumatoid patients treated with chloroquine (Swedish). Lärkartidningen, 76, 725–726.
  • Berliner, R. W., Earle, D. P., Jr., Taggart, I. W., Zubrodi, C. G., Welch, W. I., Conan, N. I., Bauman, E., Scudder, I. T. & Shannon, J. A. (1948). The physiological disposition, antimalarial activity and toxicity of some derivatives of 4-aminoquinoline. Journal of Clinical Investigation, 27, 98–107.
  • Brohult, J., Hedman, P., Rombo, L., Sirleaf, V. & Bengtsson, E. (1979). Habits of malaria chemoprophylaxis and an analysis of breakdowns in a West African mining town. Annals of Tropical Medicine and Parasitology, 73, 327–331.
  • Bruce-Chwatt, L.J. (1970). Resistance of P. falciparum to chloroquine in Africa: true or false? Transactions of the Royal Society of Tropical Medicine and Hygiene, 64, 776–784.
  • Dennis, D. T., Doberstyn, E. B., Sissay, A. & Testar, G. K. (1974). Chloroquine tolerance of Ethiopian strains of P. falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 68, 241–245.
  • Frisk-Holmberg, M., Bergkvist, Y., Domeij-Nyberg, B., Hellström, L. & Jansson, F. (1979). Chloroquine serum concentration and side effects: evidence for dose-dependent kinetics. Clinical Pharmacology and Therapeutics, 25, 345–350.
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  • McChesney, E. W., Banks, W. F., Jr. & McAuliff, J. P. (1962). Laboratory studies of the 4-aminoquinoline antimalarials: II Plasma levels of chloroquine and hydroxychloroquine in an after various dosage regimens. Antibiotics and Chemotherapy, 12, 583–594.
  • McChesney, E. W., Fasco, M. I. & Banks, N. F., Jr. (1967). The metabolism of chloroquine in man during and after repeated oral dosage. Journal of Pharmacology and Experimental Therapeutics, 158, 323–331.
  • McChesney, E. W., Wyzan, H. S. & McAuliff, J. P. (1956). The determination of 4-aminoquinoline antimalarials: evaluation of the induced fluorescence method with specific application to hydroxy-chloroquine analysis. Journal of American Pharmacological Association, 45, 640–645.
  • Olatunde, A. (1977). Chloroquine-resistant Plasmodium falciparum and malaria in Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 71, 80–81.
  • Palmer, T. T., Townley, L. B., Yigsaw, M. & Armstrong, J. C. (1976). Chloroquine sensitivity oi Plasmodium falciparum in Ethiopia. II. Results of an in vitro test. American Journal of Tropical Medicine and Hygiene, 25, 10–13.
  • State Of California, Department Of Health (1978). Malaria encounters of a deadly kind. California Morbidity Weekly Report Infectious Diseases Section No. 17, 5.
  • U.S. Department of Health, Education and Welfare (1978). Chloroquine-resistant malaria acquired in Kenya and Tanzania—Denmark, Georgia, New York. Morbidity and Mortality Weekly Report 27, No. 47, 1–2.
  • World Health Organization (1978). Weekly Epidemiological Record, 53, 181–188.

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