Advanced search
Publication Cover
Annals of Tropical Medicine & Parasitology Volume 78, 1984 - Issue 1
Journal homepage
3
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Comparison of in vitro and in vivo antimalarial activities of g-phenanthrenecarbinols

G. E. ChildsDivision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC20012, U.S.A.
,
C. LambrosDivision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC20012, U.S.A.
,
J. D. NotschDivision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC20012, U.S.A.
,
C. L. PamplinDivision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC20012, U.S.A.
,
D. E. Davidson Jr.Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC20012, U.S.A.
&
A. AgerRane Laboratory, University of Miami, Miami, FL33142, U.S.A.
Pages 13-20 | Received 01 Oct 1982, Published online: 15 Nov 2016

REFERENCES

  • Canfield, C. J., Hall, A. P., Macdonald, B. S., Newman, D. A. & Shaw, J. A. (1973). Treatment of falciparum malaria from Vietnam with a phenanthrenemethanol (WR 33 063) and a quinolinemethanol (WR 30 090). Antimicrobial Agents and Chemotherapy, 3, 224–227.
  • Canfield, C. J. & Heifer, M. H. (1978). The US Army Drug Development Program. Advances in Pharmacology and Therapeutics, 10, 99–108.
  • Carroll, F. I. & Blackwell, J. T. (1972). Preparation and absolute configuration of the optical isomers of x-(2-piperidyl)-3,6-bis(tri-fluoromethyl)-9-phenanthrenemethanol. Chemistry and Industry, 574–575.
  • Colton, T. (1974). Statistics in Medicine. Little, Brown and Company. Boston.
  • Colwell, W. T., Brown, V., Christie, P., Lange, J., Reech, C., Yamamoto, Y. & Henry, D. W. (1972). Antimalarial arylaminopropanols. Journal of Medicinal Chemistry, 15, 771–775.
  • Desjardins, R. E., Canfield, C. J., Haynes, J. D. & Chulay, J. D. (1979). Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy, 16, 710–718.
  • Kim, K. H., Hansch, C., Fukunaga, J. Y., Steller, E., Jow, Y. C., Craig, P. C. & Page, J. (1979). Quantitative structure-activity relationships in l-aryl-2-(alkylamino)ethanol antimalarials. Journal of Medicinal Chemistry, 22, 336–391.
  • May, E. L. & Mosettig, E. (1946). Attempts to find new antimalarials. XVIII. Amino alcohols of the type-CHOHCN2NR2 derived from 3-bromo-10-acetylphenanthrene. Journal of Organic Chemistry, 11, 627–630.
  • Nodiff, E. A., Saggiomo, A. J., Shinbo, M., Chen, E. H., Otomasu, H., Kondo, Y., Kikuchi, T., Verma, B. L., Matsuura, S., Tanabe, K., Tyagi, M. P. & Morosawa, S. (1972). Antimalarial phenanthrene amino alcohols. 2. Trifluoromethyl-containing 9-phenanthrenemethanols. Journal of Medicinal Chemistry, 15, 775–780.
  • Nodiff, E. A., Saggiomo, A. J., Tanabe, K., Chen, E. H., Shinbo, M., Tyagi, M. P., Koxuka, A., Otomasu, H., Verma, B. L. & Goff, D. (1975). Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrene-methanols. Journal of Medicinal Chemistry, 18, 1011–1019.
  • Nodiff, E. A., Tanabe, K., Seyfried, C., Matsuura, S., Kondo, Y., Chen, E. H. & Tyagi, M. P. (1971). Antimalarial phenanthrene amino alcohols. 1. Fluorine-containing 3- and 6-substituted 9-phenanthrene-methanols. Journal of Medicinal Chemistry, 14, 921–925.
  • Olsen, R. E. (1972). Antimalarial activity and conformation of erythro-and threo-α-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrene-methanol. Journal of Medicinal Chemistry, 15, 207–208.
  • Osdene, T. S., Russell, P. B. & Rane, L. (1967). 2,4,7-Triamino-6-ortho-substituted arylpteridines. A new series of potent antimalarial agents. Journal of Medicinal Chemistry, 10, 431–434.
  • Rinehart, J., Arnold, J. & Canfield, C. J. (1976). Evaluation of two phenanthrenemethanols for antimalarial activity in man: WR 122,455 and WR 171,669. American Journal of Tropical Medicine and Hygiene, 25, 769–774.
  • Rozman, R. S. & Canfield, C. J. (1979). New experimental and antimalarial drugs. Advances in Pharmacology and Chemotherapy, 16, 1-4-3.
  • Schmidt, L. H., Crosby, R., Rasco, J. & Vaughan, D. (1978). Antimalarial activities of various 9-phenanthrenemethanols with special attention to WR 122,455 and WR 171,669. Antimicrobial Agents and Chemotherapy, 14, 292–314.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.