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Annals of Tropical Medicine & Parasitology Volume 80, 1986 - Issue 4
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Original Articles

The chemotherapy of onchocerciasis XI A double-blind comparative study of ivermectin, diethylcarbamazine and placebo in human onchocerciasis in Northern Ghana

K. AwadziOnchocerciasis Chemotherapeutic Research Centre, Tamale Hospital, Ghana
,
K. Y. DadzieOnchocerciasis Control Programme, P.O. Box 549, Ouagadougou, Burkina-Faso
,
H. Schulz-KeyTropenmedizinisches Institut, Wilhelmstrasse 31, 7400 Tübingen 1, F.R.G.
,
H. M. GillesDepartment of Tropical Medicine, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
,
A. J. FulfordStatistics Unit, Department of Tropical Paediatrics, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
&
M. A. AzizMerck Sharpe and Dohme Research Laboratories, P.O. Box 2000, Rahway, New Jersey07065, U.S.A.
Pages 433-442 | Received 18 Dec 1985, Published online: 15 Nov 2016

REFERENCES

  • Awadzi, K. (1980). The chemotherapy of onchocerciasis II. Quantitation of the clinical reaction to microfilaricides. Annals of Tropical Medicine and Parasitology, 74, 189–197.
  • Awadzi, K. (1984). Drugs for filariasis. In Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics. American Society for Pharmacology and Experimental Therapeutics, pp. 606–628. Rockville: Pike.
  • Awadzi, K. & Gilles, H. M. (1980). The chemotherapy of onchocerciasis IV. Further trials with metrifonate. Annals of Tropical Medicine and Parasitology, 74, 355–362.
  • Awadzi, K., Roulet, H. & Bell, D. R. (1980). The chemotherapy of onchocerciasis V. A standard method for the determination of microfilarial densities in skin snips. Annals of Tropical Medicine and Parasitology, 74, 363–366.
  • Awadzi, K., Orme, M. L. E., Breckenridge, A. M. & Gilles, H. M. (1982). The chemotherapy of onchocerciasis IX. The effect of prednisone plus cyproheptadine on the Mazzotti reaction. Annals of Tropical Medicine and Parasitology, 76, 547–555.
  • Awadzi, K., Dadzie, K. Y., Schulz-Key, H., Haddock, D. R. W., Gilles, H. M. & Aziz, M. A. (1985). The chemotherapy of onchocerciasis X. An assessment of four single dose treatment regimes of MK-933 (ivermectin) in human onchocerciasis. Annals of Tropical Medicine and Parasitology, 79, 63–78.
  • Aziz, M. A., Diallo, S., Diop, I. M., Lariviere, M. & Porta, M. (1982a). Efficacy and tolerance ofivermectin in human onchocerciasis. Lancet, ii, 171–173.
  • Aziz, M. A., Diallo, S., Lariviere, M., Diop, I. M., Porta, M. & Gazotte, P. (1982a) Ivermectin in onchocerciasis. Lancet, ii, 1456–1457.
  • Coulaud, J. P., Lariviere, M., Gervais, M. C., Gaxotte, P., Aziz, A., Deloul, A. M. & Cerac, J. (1983). Traitement de l'onchocercose humaine par l'ivermectin. Bulletin de la Societé de Pathologie Exotique, 76, 681–688.
  • Coulaud, J. P., Lariviere, M., Aziz, M. A., Gervais, M. C., Gaxotte, P., Deloul, A. M. & Cenac, J. (1984). Ivermectin in onchocerciasis. Lancet, ii, 526–527.
  • Greene, B. M., Taylor, H. R., Cupp, E. W. Murphy, R. P., White, A. T., Aziz, M. A., Schulz-Key, H., D'anna, S. A., Newland, H. S., Goldschmidt, L. P., Auer, A., Hanson, A. P., Freeman, V., Reber, E. W. & Williams, P. N. (1985). Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. New England Journal of Medicine, 313, 133–138.
  • Lariviere, M., Vingtain, P., Aziz, M. A., Beauvais, B., Weimann, D., Derouin, F., Ginoux, J., Schulz-Key, H., Gaxotte, P., Basset, D. & Sarfati, C. (1985). Double-blind study of ivermectin and diethylcarbamazine in African onchocerciasis patients with ocular involvement. Lancet, ii, 174–177.
  • Schulz-Key, H., Jean, B. & Albeiz, E. J. (1980). Investigations on female Onchocerca volvulus for the evaluation of drug trials. Tropenmedizin und Parasitologie, 31, 34–40.
  • Schulz-Key, H. & Karam, M. (1984). Quantitative assessment of microfilariae and adults of Onchocerca volvulus in ethanol-fixed biopsies and nodules. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 157–159.
  • Taylor, H. R., Awadzi, K., George, T., Schulz-Key, H. & Murphy, R. P. (1985). Fluorescein angiographic studies of mebendazole treatment for onchocerciasis. Tropenmedizine und Parasitologie, 36, 7–11.

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