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Annals of Tropical Medicine & Parasitology Volume 86, 1992 - Issue 4
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Original Articles

The in vitro and in vivo antimalarial activity of some Mannich bases derived from 4-(7′-trifluoromethyl-1′,5′-naphthyridin-4′-ylamino)phenol, 2-(7′-trifluoromethyl-quinolin-4′-ylamino)phenol, and 4′-chloro-5-(7″-trifluoromethylquinolin-4″-ylamino)biphenyl-2-ols

G. B. BarlinDivision of Neuroscience, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT, 2601, Australia
,
Chuenjit JiravinyuDivision of Neuroscience, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT, 2601, Australia
,
G. A ButcherDepartment of Zoology, Australian National University, Canberra, Australia
,
Barbara KoteckaArmy Malaria Research Unit, Milpo, Ingleburn, New South Wales, 2174, Australia
&
K. RieckmannArmy Malaria Research Unit, Milpo, Ingleburn, New South Wales, 2174, Australia
Pages 323-331 | Received 01 Jul 1991, Accepted 26 May 1992, Published online: 15 Nov 2016

REFERENCES

  • Barlin, G. B. & Jiravinyu, C. (1990a). Potential antimalarials. X. Di-Mannich bases of 4-(7′-trifluoro-methyl-1′,5′-naphthyridin-4′-ylamino)phenol and N-(4′-diethylamino-1′-methylbutyl)-7-trifluoro- methyl-1,5-naphthyridin-4-amine. Australian Journal of Chemistry, 43, 1175–1181.
  • Barlin, G. B. & Jiravinyu, C. (1990b). Potential antimalarials. XI. 4′-Chloro-3-(substituted amino)methyl-5-(7-trifluoromethylquinolin-4-ylamino)biphenyl-2-ols. Australian Journal of Chemistry, 43, 1301–1307.
  • Barlin, G. B. & Jiravinyu, C. (1990c). Potential antimalarials. XII. 4-Chloro-3-(substituted amino)methyl-5-7-bromo (and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]biphenyl-2-ols and 4-chloro-3-(substituted amino)methyl-5-(7-trifluoromethylquinazolin-4-ylamino)biphenyl-2-ols. Australian Journal of Chemistry, 43, 1367–1373.
  • Barlin, G. B. & Yan, J.-H. (1989). Potential antimalarials VIII. Mono- and di-Mannich bases of 2-(7′-trifluoromethylquinolin-4′-ylamino)phenol via 2-nitrophenols. Australian Journal of Chemistry, 42, 2191–2199.
  • Chen, P., Lamont, G., Elliot, T., Kidson, C., Brown, G., Mitchell, G., Stace, J. & Alpers, M. (1980). Plasmodium falciparum stains from Papua New Guinea; culture characteristics and drug sensitivity. Southeast Asian Journal of Tropical Medicine and Public Health, 11, 435–440.
  • Cowden, W. B., Butcher, G. A., Hunt, N. H., Clarke, I. A. & Yoneda, F. (1987). Antimalarial activity of a riboflavin analogue against Plasmodium vinckei in vivo and Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene, 37, 495–500.
  • Desjardins, R. E., Canfield, C. J., Haynes, J. D. & Chulay, J. D. (1979). Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy, 16, 710–718.
  • Peters, W., Irare, S. G., Ellis, D. C., Warhurst, D. C. & Robinson, B. L. (1984). The chemotherapy of rodent malaria. XXXVIII. Studies on the activity of three new antimalarials (WR 194,965, WR 228,258 and WR 225, 448) against rodent and human malaria parasites (Plasmodium berghei and P. falciparum). Annals of Tropical Medicine and Parasitology, 78, 567–579.
  • Peters, W. & Robinson, B. L. (1984). The chemotherapy of rodent malaria, XXXVII. The in vivo action of two Mannich bases, WR 194,965 and WR 228,258 and an 8-aminoquinoline WR 225,448. Annals of Tropical Medicine and Parasitology, 78, 561–565.
  • Rieckmann, K. H., Sax, L. J., Campbell, G. H. & Mrema, J. E. (1978). Drug sensitivity of Plasmodium falciparum. An in vitro microtechnique. Lancet, i, 22–23.
  • Schmidt, L. H., Vaughan, D., Mueller, D., Crosby, R. & Hamilton, R. (1977). Activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 11, 826–843.
  • Scott, H. V., Tan, W.-L. & Barlin, G. B. (1987). Antimalarial activity of Mannich bases derived from 4-(7′-bromo-1′,5′naphthyridin-4′-ylamino)phenol and 4-(7′-trifluoromethylquinolin-4′-ylamino)phenol against Plasmodium falciparum in vitro. Annals of Tropical Medicine and Parasitology, 81, 85–93.
  • Scott, H. V., Tan, W.-L. & Barlin, G. B. (1988). The in vitro and in vivo antimalarial activity of some Mannich bases derived from 4–7′-bromo (and chloro)-1′,5′-naphthyridin-4′-ylamino)phenol and 4-(7′-trifluoromethylquinolin-4′-ylamino]phenol. Annals of Tropical Medicine and Parasitology, 82, 127–134.
  • Thaithong, S. & Beale, G. H. (1981). Resistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests. Transactions of the Royal Society of Tropical Medicine and Hygiene, 75, 271–273.
  • Werbel, L. M., Cook, P. D., Elslager, E. F., Hung, J. H., Johnson, J. L., Kesten, S. J., McNamara, D. J., Ortwine, D. F. & Worth, D. F. (1986). Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-(7-chloro-4-quinolinyl)amino]-3-(alkylamino)methyl]1,1′-biphenyl]-2-ols and Nω-oxides. Journal of Medicinal Chemistry, 29, 924–939.

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