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Annals of Tropical Medicine & Parasitology Volume 86, 1992 - Issue 5
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Original Articles

The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials

W. PetersDepartment of Medical Parasitology, London School of Hygiene and Tropical Medicine, Winches Farm, 395 Hatfield Road, St. AlbansAL4 OXQ, U.K.
&
B. L. RobinsonDepartment of Medical Parasitology, London School of Hygiene and Tropical Medicine, Winches Farm, 395 Hatfield Road, St. AlbansAL4 OXQ, U.K.
Pages 455-465 | Received 11 Feb 1992, Accepted 01 May 1992, Published online: 15 Nov 2016

REFERENCES

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  • Childs, G. E., Hausler, B., Milhous, W., Chen, C., Wimonwattrawatee, T., Pooyindee, N. & Boudreau, E. F. (1988). In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene, 38, 24–29.
  • Churchill, F. C., Patchen, L. C., Campbell, C. C., Schwartz, I. K., Nguyen-dinh, P. & Dickinson, C. M. (1985). Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans. Life Sciences, 36, 53–62.
  • Fu, S. & Xiao, S-H. (1991) Pyronaridine: a new antimalarial drug. Parasitology Today, 7, 310–313.
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  • Peters, W., Davies, E. E. & Robinson, B. L. (1975a). The chemotherapy of rodent malaria. XXIII Causal prophylaxis, part II: practical experience with Plasmodium yoelii nigeriensis in drug screening. Annals of Tropical Medicine and Parasitology, 69, 311–328.
  • Peters, W., Portus, J. H. & Robinson, B. L. (1975b) The chemotherapy of rodent malaria. XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity. Annals of Tropical Medicine and Parasitology, 69, 155–171.
  • Peters, W. & Robinson, B. L. (1984). The chemotherapy of rodent malaria. XXXVII. The in vivo action of two Mannich bases, WR 194,965 and WR 228,258 and an 8-aminoquinoline WR 225,448. Annals of Tropical Medicine and Parasitology, 78, 561–565.
  • Pussard, E., Verdier, F., Blayo, M.-C. & Pocidalo, J.-J. (1985). Bio-transformation de l'amodiaquine et prophylaxie du paludisme à Plasmodium falciparum. Comptes Rendus de l' Academie de Science, Paris, Série III, 301, 383–385.
  • Pussard, E., Verdier, F., Faurisson, F., Clavier, F., Simon, F. & Gaudebout, C. (1988). Disposition of amopyroquine in rats and rabbits and in vitro activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 32, 568–572.
  • Shao, B.-R., Ye, X.-Y. & Zheng, H. (1982). Development of pyronaridine resistance in Plasmodium berghei. Acta Pharmacologica Sinica, 17, 566–571.
  • Shao, B.-R., Ye, X.-Y. & Zheng, H. (1985). Stability of drug resistance of pyronaridine-resistant line of Plasmodium berghei. Acta Pharmacologica Sinica, 6, 183–185.
  • Warsame, M., Wernsdorfer, W. H., Payne, D. & Björkman, A. (1991). Positive relationship between the response of Plasmodium falciparum to chloroquine and pyronaridine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85, 570–571.
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  • World Health Organization (1984). Advances in Malaria Chemotherapy. Technical Report Series No. 711. Geneva: WHO.

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