Artificial Sweeteners as Urinary Bladder Carcinogens

References

• Clayson , DB . 1967 . Chemicals and environmental carcinogenesis in man . Europ J Cancer , 3 : 405 – 416 .
   PubMedGoogle Scholar
• Boyland , E . 1969 . “ The correlation of experimental carcinogenesis and cancer in man ” . In Progress in Experimental Tumor Research , Edited by: Homburger , F . Vol. 11 , 222 – 234 . Basel, Switzerland : S Karger . in
   Google Scholar
• Hueper , WC . 1969 . Occupational and Environmental Cancers of the Urinary System , 1 – 369 . New Haven, Conn : Yale University Press .
   Google Scholar
• Temkin , IS . 1963 . Industrial Bladder Carcinogenesis , 41 – 66 . New York : Pergamon Press .
   Google Scholar
• Deichmann , WB , MacDonald , WM Coplan , MM . 1958 . Para nítrobiphenyl, a new bladder carcinogen in the dog . ïndustr Med Surg , 27 : 634 – 637 .
   PubMedGoogle Scholar
• Epstein , SS , Hollaender , A Lederberg , J . 1969 . Wisdom of cyclamate ban . Science , 166 : 1575
   PubMedGoogle Scholar
• Bryan , GT and Ertürk , E . 1970 . Production of mouse urinary bladder carcinomas by sodium cyclamate . Science , 167 : 996 – 998 .
   PubMed Web of Science ®Google Scholar
• Price , JM , Biava , CG Oser , BL . 1970 . Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin . Science , 167 : 1131 – 1132 .
   PubMed Web of Science ®Google Scholar
• Egeberg , RO , Steinfeld , JL Frantz , I . 1970 . Report to the secretary of HEW from the medical advisory group on cyclamates . JAMA , 211 : 1358 – 1361 .
   PubMed Web of Science ®Google Scholar
• Conzelman , GM Jr , Moulton , JE Flanders , LE III . 1969 . Induction of transitional cell carcinomas of the urinary bladder in monkeys fed 2-naphthylamine . J Nat Cancer Inst , 42 : 825 – 836 .
   PubMedGoogle Scholar
• Fitzhugh , OG , Nelson , A A and Frawley , JP . 1951 . Comparison of chronic toxicities of synthetic sweetening agents . J Amer Ph/arm Assoc (Sci Ed) , 40 : 583 – 586 .
   Google Scholar
• Sharratt , M , Frazer , AC and Paranjoti , IS . 1966 . Biological effects of Citrus Red No. 2 in the mouse . Food Cosmet Toxic , 4 : 493 – 502 .
   PubMedGoogle Scholar
• Roe , FJC , Levy , LS and Carter , RL . 1970 . Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity . Food Cosmet Toxic , 8 : 135 – 145 .
   PubMedGoogle Scholar
• Dacre , JC . 1965 . Chronic toxicity and carcinogenicity studies on Citrus Red No. 2 . Proc Univ Otago Med School , 43 : 31 – 33 .
   Google Scholar
• Snell , KC . 1965 . “ Spontaneous lesions of the rat ” . In Pathology of Laboratory Animals , Edited by: Ribelin , WE and McCoy , JR . 266 Springfield, Ill : Charles C Thomas Publisher . in, (eds)
   Google Scholar
• Bonser , GM , Bradshaw , L Clayson , DB . 1956 . A further study of the carcinogenic properties of ortho hydroxy-amines and related compounds by bladder implantation in the mouse . Brit J Cancer , 10 : 539 – 546 .
   PubMed Web of Science ®Google Scholar
• Bonser , GM , Boyland , E Busby , ER . 1963 . A further study of bladder implantation in the mouse as a means of detecting carcinogenic activity: Use of crushed paraffin wax or stearic acid as the vehicle . Brit J Cancer , 17 : 127 – 136 .
   PubMed Web of Science ®Google Scholar
• Bryan , GT , Brown , RR and Price , JM . 1964 . Mouse bladder carcinogenicity of certain tryptophan metabolites and other aromatic nitrogen compounds suspended in cholesterol . Cancer Res , 24 : 596 – 602 .
   PubMed Web of Science ®Google Scholar
• Boyland , E , Busby , ER Dukes , CE . 1964 . Further experiments on implantation of materials into the urinary bladder of mice . Brit J Cancer , 18 : 575 – 581 .
   Web of Science ®Google Scholar
• Saffiotti , U , Cefis , F Montesano , R . 1967 . “ Induction of bladder cancer in hamsters fed aromatic amines ” . In Bladder Cancer , Edited by: Lampe , KF . 129 – 135 . Birmingham, Ala : Aesculapius Publishing Co . in, (ed)
   Google Scholar
• Clayson , DB , Lawson , TA and Pringle , JAS . 1967 . The carcinogenic action of 2-aminodiphenylene oxide and 4-aminodiphenyl on the bladder and liver of the C57 × IF mouse . Brit J Cancer , 21 : 755 – 762 .
   PubMed Web of Science ®Google Scholar
• Clayson , DB , Pringle , JAS Bonser , GM . 1968 . The technique of bladder implantation: Further results and an assessment . Brit J Cancer , 22 : 825 – 832 .
   PubMedGoogle Scholar
• Clayson , DB and Bonser , GM . 1965 . The induction of tumours of the mouse bladder epithelium by 4-ethylsulphonylnaphthalene-l-sulphonamide . Brit J Cancer , 19 : 311 – 316 .
   PubMedGoogle Scholar
• Ertürk , E , Atassi , SA Yoshida , O . 1970 . Comparative urinary and gallbladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N[4-(5-nitro-2-furyl)-2-thiazolyl]aeetamide in the dog . J Nat Cancer Inst , 45 : 535 – 542 .
   PubMedGoogle Scholar
• Pamukcu , AM , Olson , C and Price , JM . 1966 . Assay of fractions of bovine urine for carcinogenic activity after feeding bracken fern (Pteris aquilina) . Cancer Res , 26 : 1745 – 1753 .
   PubMed Web of Science ®Google Scholar
• Pamukcu , AM , Price , JM and Bryan , GT . 1970 . Assay of fractions of bracken fern (Pteris aquilina) for carcinogenic activity . Cancer Res , 30 : 902 – 905 .
   PubMed Web of Science ®Google Scholar
• Bryan , GT . 1969 . Role of tryptophan metabolites in urinary bladder cancer . Amer Industr Hyg Assoc J , 30 : 27 – 34 .
   PubMedGoogle Scholar
• Radomski , JL , Deichmann , WB and Brill , E . 1970 . Transitional cell hyperplasia in the bladders of dogs fed tryptophan . Proc Amer Assoc Cancer Res , 11 : 65
   Google Scholar
• Allen , MJ , Boyland , E Dukes , CE . 1957 . Cancer of the urinary bladder induced in mice with metabolites of aromatic amines and tryptophan . Brit J Cancer , 11 : 212 – 228 .
   PubMed Web of Science ®Google Scholar
• Clayson , DB , Jull , JW and Bonser , GM . 1958 . The testing of ortho hydroxy-amines and related compounds by bladder implantation and a discussion of their structural requirements for carcinogenic activity . Brit J Cancer , 12 : 222 – 230 .
   PubMed Web of Science ®Google Scholar
• Bonser , GM , Clayson , DB and Jull , JW . 1963 . The potency of 20-methylcholanthrene relative to other carcinogens on bladder implantation . Brit J Cancer , 17 : 235 – 241 .
   PubMed Web of Science ®Google Scholar
• Irving , CC , Gutmann , HR and Larson , DM . 1963 . Evaluation of the carcinogenicity of aminofluorenols by implantation into the bladder of the mouse . Cancer Res , 23 : 1782 – 1791 .
   PubMedGoogle Scholar
• Bryan , GT and Springberg , PD . 1966 . Role of the vehicle in the genesis of bladder carcinomas in mice by the pellet implantation technic . Cancer Res , 26 : 105 – 109 .
   PubMed Web of Science ®Google Scholar
• Bryan , GT , Ertürk , E and Yoshida , O . 1970 . Production of urinary bladder carcinomas in mice by sodium saccharin . Science , 168 : 1238 – 1240 .
   PubMed Web of Science ®Google Scholar
• Takemura , N . Carcinogenic action of the intermediates of fluorescent whitening agents, 5-nitro-acenaphthene and 5-aminoacenaphthene . Abstracts Tenth International Cancer Congress . pp. 79 Austin, Tex : University of Texas .
   Google Scholar
• Bonser , GM , Clayson , DB and Jull , JW . 1958 . Some aspects of the experimental induction of tumours of the bladder . Brit Med Bull , 14 : 146 – 152 .
   PubMed Web of Science ®Google Scholar
• Bryan , GT . 1969 . Pellet implantation studies of carcinogenic compounds . J Nat Cancer Inst , 43 : 255 – 261 .
   PubMedGoogle Scholar
• Bryan , GT , Morris , CR and Brown , RR . 1965 . Absorption of 14C-labeled 3-hydroxy-L-kynurenine and 3hydroxyanthranilic acid from the mouse urinary bladder under carcinogenic conditions . Cancer Res , 25 : 1432 – 1437 .
   PubMed Web of Science ®Google Scholar
• Bryan , GT and Morris , CR . 1968 . Distribution of 14Clabeled 8-methyl ether of xanthurenic acid in the mouse following bladder luminal, subcutaneous, and intraperitoneal administration under carcinogenic conditions . Cancer Res , 28 : 186 – 191 .
   PubMed Web of Science ®Google Scholar
• Lawson , TA , Dawson , KM and Clayson , DB . 1970 . Acute changes in nucleic acid and protein synthesis in the mouse bladder epithelium induced by three bladder carcinogens . Cancer Res , 30 : 1586 – 1592 .
   PubMed Web of Science ®Google Scholar
• Clayson , DB , Lawson , TA Santana , S . 1965 . Correlation between the chemical induction of hyperplasia and of malignancy in the bladder epithelium . Brit J Cancer , 19 : 297 – 310 .
   PubMedGoogle Scholar
• Radomski , JL and Brill , E . 1970 . Bladder cancer induction by aromatic amines: Role of N-hydroxy metabolites . Science , 167 : 992 – 993 .
   PubMed Web of Science ®Google Scholar
• Clayson , DB and Pringle , JAS . 1966 . The influence of a foreign body on the induction of tumours in the bladder epithelium of the mouse . Brit J Cancer , 20 : 564 – 568 .
   PubMed Web of Science ®Google Scholar
• Wood , M . 1969 . Factors influencing the induction of tumours of the urinary bladder and liver by 2-acety-laminofluorene in the mouse . Europ J Cancer , 5 : 41 – 47 .
   PubMed Web of Science ®Google Scholar
• Rubini , ME . 1969 . More on cyclamates . Amer J Clin Nutr , 22 : 229 – 232 .
   PubMedGoogle Scholar
• Weisburger , JH and Weisburger , EK . 1968 . Food additives and chemical carcinogens: On the concept of zero tolerance . Food Cosmet Toxic , 6 : 235 – 242 .
   PubMedGoogle Scholar