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Nutrition & Metabolism

Ameliorative effects of L-carnitine and vitamin E (α-tocopherol) on haematological and serum biochemical parameters in White Leghorn cockerels given ochratoxin A contaminated feed

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Pages 471-477 | Accepted 11 Feb 2013, Published online: 05 Jul 2013

REFERENCES

  • Abidin , Z. , Khatoon , A. and Numan , M. 2011 . Mycotoxins in broilers: pathological alterations induced by aflatoxins and ochratoxins, diagnosis and determination, treatment and control of mycotoxicosis . World Poultry Science Journal , 67 : 485 – 496 .
  • Ahmad , F.U.D. , Saleemi , M.K. , Khan , M.Z. , Khan , A. , Muhammad , F. , Hassan , Z.U. , Khatoon , A. , Bhatti , S.A. , Abbass , R.Z. , Rizvi , F. and Ahmed , I. 2012 . Effects of ochratoxin A feeding in white Leghorn cockerels on haematological and serum biochemical parameters and its amelioration with silymarin and vitamin E . Pakistan Veterinary Journal , 32 : 520 – 524 .
  • Aved , I.A.M. , Dafella , R. , Yogi , A.F. and Adam , S.E.I. 1991 . Effect of ochratoxin A on Lohaman type chicks . Veterinary and Human Toxicology , 33 : 357 – 360 .
  • Bayman , P. , Baker , J.L. , Doster , M.A. , Michailides , T.J. and Mahoney , N.E. 2002 . Ochratoxin production by the Aspergillus ochraceus group and Aspergillus alliaceus . Applied and Environmental Microbiology , 68 : 2326 – 2329 .
  • Benjamin , M.M. 1978 . Outline of Veterinary Clinical Pathology , 2nd ed , Ames Iowa : The Iowa State University Press .
  • Borzecki , A. , Borzecka , H. , Sobieszek-Dzillba , U. , Wilqat , E. and Sieklucka-Dziuba , M. 2001 . Vitamin E influence on selected parameters in rats after ochratoxin A intoxication . Annales Universitatis Mariae Curie-Sklodowska , 56 : 231 – 235 .
  • Cieglar , A. , Fennell , D.L. , Mintzlaff , H.J. and Leistner , L. 1972 . Ochratoxin synthesis by Penicillium species . Die Naturwissenshaften , 59 : 365 – 366 .
  • Creppy , E.E. , Lungnier , A.A.J. , Beck , G. , Roschenthaler , R. and Dirheimer , G. 1979 . Action of ochratoxin A on cultured hepatoma cells: reversion of inhibition by phenylalanine . FEBS Letters , 104 : 287 – 290 .
  • Denli , M. , Blandon , J.C. , Guynot , M.E. , Salado , S. and Perez , J.F. 2008 . Efficacy of a new ochratoxin-binding agent (Ocra Tox) to counteract the deleterious effects of ochratoxin A in laying hens . Poultry Science , 87 : 2266 – 2272 .
  • Doerr , J.A. and Huff , R.B. 1980 . Interactive effects of aflatoxin and ochratoxin A on blood constituents in broiler chickens . Poultry Science , 59 : 1600 – 1602 .
  • Dua , K. 2004 . “ Veterinary Ethics and Jurisprudence ” . In New Delhi , India : Kalyani Publishers .
  • Elaroussi , M.A. , Mohamed , F.R. , El Barkouky , E.M. , Atta , A.M. , Abdou , A.M. and Hatab , M.H. 2006 . Experimental ochratoxicosis in broiler chickens . Avian Pathology , 35 : 263 – 269 .
  • Elaroussi , M.A. , Mohamed , F.R. , Elgendy , M.S. , El Barkouky , E.M. , Abdou , A.M. and Hatab , M.H. 2008 . Ochratoxicosis in broiler chickens: functional and histological changes in target organs . International Journal of Poultry Science , 7 : 414 – 422 .
  • Ferrari , R. , Ceconi , C. , Cargnoni , A. , Pasini , E. , Boffa , G.M. , Curello , S. and Visioli , O. 1991 . The effect of propionyll-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondria . Cardiovascular Drugs Therapy , 5 : 57 – 65 .
  • Hassan , Z.U. , Khan , M.Z. , Khan , A. and Javed , I. 2010 . Pathological responses of White Leghorn breeder hens kept on ochratoxin A contaminated feed . Pakistan Veterinary Journal , 30 : 118 – 123 .
  • Hassan , Z.U. , Khan , M.Z. , Khan , A. , Javed , I. , Sadique , U. and Hameed , M.R. 2012 . Effect of ochratoxin A (OTA)-contaminated feed on several health and economic parameters in white leghorn cockerels . Pakistan Veterinary Journal , 32 : 35 – 40 .
  • Hesseltine , C.W. , Vandegraft , E.I. , Fennell , D.L. , Smith , M.C. and Shotwell , O.L . 1972 . Aspergilli as ochratoxin producers . Mycologia , 64 : 539 – 550 .
  • Hoehler , D. and Marquardt , R.R. 1996 . Influence of vitamins E and C on the toxic effects of ochratoxin A and T-2 toxin in chicks . Poultry Science , 75 : 1508 – 1515 .
  • Huff , W.E. , Doerr , J.A. and Hamilton , P.B. 1979 . Decreased glycogen mobilization during ochratoxicosis in broiler chickens . Applied and Environmental Microbiology , 37 : 122 – 126 .
  • Huff , W.E. , Kubena , L.F. and Harvey , R.B. 1988 . Progression of ochratoxicosis in broiler chickens . Poultry Science , 67 : 1139 – 1146 .
  • Huff , W.E. , Kubena , L.F. , Harvey , R.B. and Phillip , T.D. 1992 . Efficacy of hydrated sodium calcium aluminosillicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin A . Poultry Science , 71 : 64 – 69 .
  • Kalorey , D.R. , Kurkure , N.V.S. , Ramgaonkar , J.S. , Sakhare , P.S. , Warke , S. and Nigot , N.K. 2005 . Effect of polyherbal feed supplement “Growell” during induced aflatoxicosis, ochratoxicosis and combined mycotoxicosis in broilers . Asian-Australian Journal of Animal Sciences , 18 : 375 – 383 .
  • Kopple , J.D. , Ding , H. , Letoha , A. , Iveanyi , B. , Qing , D.P.Y. , Dux , L. , Wang , H.Y. and Sonkodi , S. 2002 . L-carnitine ameliorates Gentamicin-induced renal injury in rats . Nephrology, Dialysis, Transplantation , 17 : 2122 – 2131 .
  • Koynarski , V. , Stoev , S. , Grozeva , N. , Mirtcheva , T. , Daskalov , H. , Mitev , J. and Mantle , P. 2007 . Experimental coccidiosis provoked by Eimeria accervulina in chicks simultaneously fed on ochratoxin A contaminated diet . Research in Veterinary Science , 82 : 225 – 231 .
  • Manning , R.O. and Waytt , R.D. 1984 . Toxicity of Aspergillus ochraceus contaminated wheat and different chemical forms of ochratoxin A in broiler chicks . Poultry Science , 63 : 458 – 465 .
  • Mir , M.S. and Dwivedi , P. 2008 . Pathology of induced ochratoxicosis-A in rabbits (Oryctolagus cuniculus . Sher-e- Kashmir University of Agricultural Sciences and Technology-Jammu Journal of Research , 10 : 99 – 111 .
  • Mohiuddin , S.M. , Warasi , S.M.A. and Reddy , M.V. 1993 . Haematological and biochemical changes in experimental ochratoxicosis in broiler chicken . Indian Veterinary Journal , 70 : 613 – 617 .
  • Packer , L. 1991 . Protective role of vitamin E in biological system . American Journal of Clinical Nutrition , 53 : 1050 – 1055 .
  • Page , R.K. , Stewart , G. , Wyatt , R. , Bush , P. , Fletcher , O.J. and Brown , J. 1980 . Influence of low levels of ochratoxin A on egg production, egg-shell stains, and serum uric-acid levels in leghorn-type hens . Avian Diseases , 24 : 777 – 780 .
  • Peckham , J.C. , Doupnik , B.J. and Jones , O.J. 1971 . Acute toxicity of ochratoxins A and B in chicks . Applied Microbiology , 21 : 492 – 494 .
  • Prasanna , K. , Sharma , A.K. , Dwivedi , P. , Satheesh , C.C. and Telang , A.G. 2007 . Pathogenesis of ochratoxin A induced nephropathy in rats with special reference to oxidative damage, cytokine profile and ultrastructural changes . Indian Journal of Veterinary Pathology , 31 : 1 – 10 .
  • Ramadevi , N.R. , Gopal Naidu , R. and Ravikumar , P. 2000 . An assessment of the protective effect of bentonite on ochratoxicosis in broiler with reference to certain haematological profile . Indian Veterinary Journal , 77 : 303 – 306 .
  • Sakhare , P.S. , Harne , S.D. , Kalorey , D.R. , Warke , S.R. , Bhandarkar , A.G. and Kurkure , N.V. 2007 . Effect of toxiroak® polyherbal feed supplement during induced aflatoxicosis, ochratoxicosis and combined mycotoxicosis in broilers . Veterinarski Archiv , 77 : 129 – 146 .
  • Sandhu , B.S. , Singh , B. and Brar , R.S. 1998 . Haematological and biochemical studies in broiler chicks fed ochratoxin and inoculated with inclusion body hepatitis virus, singly and in concurrence . Veterinary Research Communication , 22 : 335 – 346 .
  • Sawale , G.K. , Ravikanth , R.C. , Maini , S. and Rekhe , D.S. 2009 . Experimental mycotoxicosis in layer induced by ochratoxin A and its amelioration with herbomineral toxin binder “Toxiroak” . International Journal of Poultry Sciences , 8 : 798 – 803 .
  • Sawarkar , A.R. , Sonkusale , P.M. , Kurkure , N.V. , Jangade , C.R. , Maini , S. and Ravikanth , K. 2011 . Experimental afla and ochratoxin induced mixed mycotoxicosis in broilers and its amelioration with herbomineral toxin binder “Toxiroak Gold” . International Journal of Poultry Sciences , 10 : 560 – 566 .
  • Sener , G. , Paskaloglu , K. , Satiroglu , H. , Alican , I. , Kacmaz , A. and Sakarcan , A. 2004 . L-Carnitine ameliorates oxidative damage due to chronic renal failure in rats . Journal of Cardiovascular Pharmacology , 43 : 698 – 705 .
  • Shlosberg , A. , Elkin , N. , Malkinson , M. , Orgad , U. , Hanji , V. , Bogin , E. , Weisman , Y. , Meroz , M. and Bock , R. 1997 . Severe hepatopathy in geese and broilers associated with ochratoxin in their feed . Mycopathologia , 138 : 71 – 76 .
  • Stoev , S.D. , Anguelov , G. , Ivanov , I. and Pavlov , D. 2000 . Influence of OA and an extract of artichoke on the vaccinal immunity and health in broiler chicks . Experimental and Toxicologic Pathology , 52 : 43 – 55 .
  • Subramanian , R. , Plehn , S. , Noonan , J. , Schmidt , M. and Shug , A.L. 1987 . Free radical-mediated damage during myocardial ischemia and reperfusion and protection by carnitine esters . Zeitschrift fur Kardiologie , 76 : 41 – 45 .
  • Trenk , H.L. , Butz , M.E. and Chu , F.S. 1971 . Production of ochratoxins in different cereal products by aspergillus ochraceus . Applied Microbiology , 21 : 1032 – 1035 .
  • Wang , G.H. , Xue , C.Y. , Chen , F. , Ma , Y.L. , Zhang , X.B. , Bi , Y.Z. and Cao , Y.C. 2009 . Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler chickens . Poultry Science , 88 : 504 – 510 .

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