454
Views
18
CrossRef citations to date
0
Altmetric
Immunology, Health and Disease

Baicalin ameliorates Mycoplasma gallisepticum-induced lung inflammation in chicken by inhibiting TLR6-mediated NF-κB signalling

, , , , , & show all
Pages 199-210 | Received 09 Mar 2020, Accepted 30 Aug 2020, Published online: 09 Dec 2020

References

  • Aderem, A., and R. J. Ulevitch. 2000. “Toll-like Receptors in the Induction of the Innate Immune Response.” Nature 406 (6797): 782–787. doi:10.1038/35021228.
  • Adler, H. E. 1960. “Mycoplasma, the Cause of Chronic Respiratory Disease.” Annals of the New York Academy of Sciences 79: 703–712. doi:10.1111/j.1749-6632.1960.tb42745.x.
  • Bai, C., T. Li, Q. Sun, Q. Xin, T. Xu, J. Yu, and L. Wei. 2018. “Protective Effect of Baicalin against Severe Burninduced Remote Acute Lung Injury in Rats.” Molecular Medicine Reports 17 (2): 2689–2694. doi:10.3892/mmr.2017.8120.
  • Balish, M. F., S. Majumder, F. Zappulla, and L. K. Silbart. 2014. “Mycoplasma Gallisepticum Lipid Associated Membrane Proteins Up-regulate Inflammatory Genes in Chicken Tracheal Epithelial Cells via TLR-2 Ligation through an NF-κB Dependent Pathway.” PloS One 9 (11): e112796. doi:10.1371/journal.pone.0112796.
  • Barton, G. M., and R. Medzhitov. 2003. “Toll-like Receptor Signalling Pathways.” Science 300 (5625): 1524–1525. doi:10.1126/science.1085536.
  • Bi, D., and Q. Xu. 1997. “A Study on Pathogenicity of HS Strain of Mycoplasma Gallisepticum.” Chinese Journal of Animal and Poultry Infectious Diseases 5: 24–26.
  • Bi, D., and X. Ji. 1988. “The Isolation and Identification of the Mycoplasma Gallisepticum.” Acta Veterinaria et Zootechnica Sinica 1: 146–148.
  • Brightbill, H. D., D. H. Libraty, S. R. Krutzik, R. B. Yang, J. T. Belisle, J. R. Bleharski, … R. L. Modlin. 1999. “Host Defense Mechanisms Triggered by Microbial Lipoproteins through Toll-like Receptors.” Science 285 (5428): 732–736. doi:10.1126/science.285.5428.732.
  • Bui, T. T., C. H. Piao, C. H. Song, C. H. Lee, H. S. Shin, and O. H. Chai. 2017. “Baicalein, Wogonin, and Scutellaria Baicalensis Ethanol Extract Alleviate Ovalbumin-induced Allergic Airway Inflammation and Mast Cell-mediated Anaphylactic Shock by Regulation of Th1/Th2 Imbalance and Histamine Release.” Anatomy & Cell Biology 50 (2): 124–134. doi:10.5115/acb.2017.50.2.124.
  • Canter, J. A., E. R. Tulman, J. Beaudet, D. H. Lee, M. May, S. M. Szczepanek, and S. J. Geary. 2019. “Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated Mycoplasma Gallisepticum and Low-Pathogenic Avian Influenza A Virus in Chickens.” Infection and Immunity 88 (1). doi:10.1128/IAI.00607-19.
  • Chen, J. J., C. C. Huang, H. Y. Chang, P. Y. Li, Y. C. Liang, J. S. Deng, and G. J. Huang. 2017. “Scutellaria Baicalensis Ameliorates Acute Lung Injury by Suppressing Inflammation in Vitro and in Vivo.” The American Journal of Chinese Medicine 45 (1): 137–157. doi:10.1142/S0192415X17500100.
  • Cheng, P., T. Wang, W. Li, I. Muhammad, H. Wang, X. Sun, … X. Zhang. 2017. “Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-kappaB Pathway.” Frontiers in Pharmacology 8: 547. doi:10.3389/fphar.2017.00547.
  • Cui, L., L. Feng, Z. H. Zhang, and X. B. Jia. 2014. “The Anti-inflammation Effect of Baicalin on Experimental Colitis through Inhibiting TLR4/NF-kappaB Pathway Activation.” International Immunopharmacology 23 (1): 294–303. doi:10.1016/j.intimp.2014.09.005.
  • Deng, J., D. X. Wang, A. L. Liang, J. Tang, and D. K. Xiang. 2017. “Effects of Baicalin on Alveolar Fluid Clearance and alpha-ENaC Expression in Rats with LPS-induced Acute Lung Injury.” Canadian Journal of Physiology and Pharmacology 95 (2): 122–128. doi:10.1139/cjpp-2016-0212.
  • Ding, X. M., L. Pan, Y. Wang, and Q. Z. Xu. 2016. “Baicalin Exerts Protective Effects against Lipopolysaccharide-induced Acute Lung Injury by Regulating the Crosstalk between the CX3CL1-CX3CR1 Axis and NF-kappaB Pathway in CX3CL1-knockout Mice.” International Journal of Molecular Medicine 37 (3): 703–715. doi:10.3892/ijmm.2016.2456.
  • Dong, S. J., Y. Q. Zhong, W. T. Lu, G. H. Li, H. L. Jiang, and B. Mao. 2015. “Baicalin Inhibits Lipopolysaccharide-Induced Inflammation through Signaling NF-kappaB Pathway in HBE16 Airway Epithelial Cells.” Inflammation 38 (4): 1493–1501. doi:10.1007/s10753-015-0124-2.
  • Feng, L., N. Yang, C. Li, G. Tian, J. Wang, Z. B. Dong, … L. Q. Di. 2018. “Pudilan Xiaoyan Oral Liquid Alleviates LPS-induced Respiratory Injury through Decreasing Nitroxidative Stress and Blocking TLR4 Activation along with NF-KappaB Phosphorylation in Mice.” Journal of Ethnopharmacology 214: 292–300. doi:10.1016/j.jep.2017.07.009.
  • Garmyn, A., M. Vereecken, K. De Gussem, W. Depondt, F. Haesebrouck, and A. Martel. 2019. “Efficacy of Tylosin and Tilmicosin against Experimental Mycoplasma Gallisepticum Infection in Chickens.” Avian Diseases 63 (2): 359–365. doi:10.1637/11991-110818-Reg.1.
  • Gaunson, J. E., C. J. Philip, K. G. Whithear, and G. F. Browning. 2000. “Lymphocytic Infiltration in the Chicken Trachea in Response to Mycoplasma Gallisepticum Infection.” Microbiology 146 (Pt 5): 1223–1229. doi:10.1099/00221287-146-5-1223.
  • Gong, W. Y., J. F. Wu, B. J. Liu, H. Y. Zhang, Y. X. Cao, J. Sun, … J. C. Dong. 2014. “Flavonoid Components in Scutellaria Baicalensis Inhibit Nicotine-induced Proliferation, Metastasis and Lung Cancer-associated Inflammation in Vitro.” International Journal of Oncology 44 (5): 1561–1570. doi:10.3892/ijo.2014.2320.
  • Hao, H., H. Gufu, F. Lei, L. Dang, and Y. Zhongliang. 2012. “Baicalin Suppresses Expression of TLR2/4 and NF-kappaB in Chlamydia Trachomatis-infected Mice.” Immunopharmacology and Immunotoxicology 34 (1): 89–94. doi:10.3109/08923973.2011.580756.
  • Henderson, B., S. Poole, and M. Wilson. 1996. “Bacterial Modulins: A Novel Class of Virulence Factors Which Cause Host Tissue Pathology by Inducing Cytokine Synthesis.” Microbiological Reviews 60 (2): 316–341. doi:10.1128/MMBR.60.2.316-341.1996.
  • Himly, M., D. N. Foster, I. Bottoli, J. S. Iacovoni, and P. K. Vogt. 1998. “The DF-1 Chicken Fibroblast Cell Line: Transformation Induced by Diverse Oncogenes and Cell Death Resulting from Infection by Avian Leukosis Viruses.” Virology 248 (2): 295–304. doi:10.1006/viro.1998.9290.
  • Hu, F., C. Zhao, D. Bi, W. Tian, J. Chen, J. Sun, and X. Peng. 2016. “Mycoplasma Gallisepticum (HS Strain) Surface Lipoprotein pMGA Interacts with Host Apolipoprotein A-I during Infection in Chicken.” Applied Microbiology and Biotechnology 100 (3): 1343–1354. doi:10.1007/s00253-015-7117-9.
  • Hu, S. 2005. “Studies on Cloning and Expressing of Major Antigenic Genes of Avian Influenza Virus Subtype H9N2 and Mycoplasma Gallisepticum HS Strain.” Doctorate, Huazhong Agricultural University.
  • Hu, S., X. Wang, S. Lu, J. Zhang, Z. Li, Q. Xu, M. Liu, and D. Bi. 2015. “The Immunity of Mycoplasma Gallisepticum Strain HS Recombinant Adhesion Protein rpMGA1.2.” Chinese Journal of Preventive Veterinary Medicine 37 (3): 225–228.
  • Hui, R. K., and F. C. Leung. 2015. “Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus.” PloS One 10 (6): e0111771. doi:10.1371/journal.pone.0111771.
  • Into, T., K. Kiura, M. Yasuda, H. Kataoka, N. Inoue, A. Hasebe, … K. Shibata. 2004. “Stimulation of Human Toll-like Receptor (TLR) 2 and TLR6 with Membrane Lipoproteins of Mycoplasma Fermentans Induces Apoptotic Cell Death after NF-kappa B Activation.” Cellular Microbiology 6 (2): 187–199. doi:10.1046/j.1462-5822.2003.00356.x.
  • Ishfaq, M., C. Chen, J. Bao, W. Zhang, Z. Wu, J. Wang, and Y. Liu. 2019. “Baicalin Ameliorates Oxidative Stress and Apoptosis by Restoring Mitochondrial Dynamics in the Spleen of Chickens via the Opposite Modulation of NF-kappaB and Nrf2/HO-1 Signaling Pathway during Mycoplasma Gallisepticum Infection.” Poultry Science 98: 6296–6310. doi:10.3382/ps/pez406.
  • Ishfaq, M., W. Zhang, W. Hu, S. Waqas Ali Shah, Y. Liu, J. Wang, Z. Wu, I. Ahmad, and J. Li. 2019. “Antagonistic Effects of Baicalin on Mycoplasma gallisepticum-Induced Inflammation and Apoptosis by Restoring Energy Metabolism in the Chicken Lungs.” Infection and Drug Resistance 12: 3075–3089. doi:10.2147/IDR.S223085.
  • Levisohn, S., and S. H. Kleven. 2000. “Avian Mycoplasmosis (Mycoplasma Gallisepticum).” Revue Scientifique Et Technique 19 (2): 425–442. doi:10.20506/rst.19.2.1232.
  • Li, J., Z. Qiao, W. Hu, W. Zhang, S. W. A. Shah, and M. Ishfaq. 2019. “Baicalin Mitigated Mycoplasma Gallisepticum-induced Structural Damage and Attenuated Oxidative Stress and Apoptosis in Chicken Thymus through the Nrf2/HO-1 Defence Pathway.” Veterinary Research 50 (1): 83. doi:10.1186/s13567-019-0703-6.
  • Lu, Z., D. Xie, Y. Chen, E. Tian, I. Muhammad, X. Chen, … J. Li. 2017. “TLR2 Mediates Autophagy through ERK Signaling Pathway in Mycoplasma Gallisepticum-infected RAW264.7 Cells.” Molecular Immunology 87: 161–170. doi:10.1016/j.molimm.2017.04.013.
  • Majumder, S., and L. K. Silbart. 2015. “Interaction of Mycoplasma Gallisepticum with Chicken Tracheal Epithelial Cells Contributes to Macrophage Chemotaxis and Activation.” Infection and Immunity 84 (1): 266–274. doi:10.1128/IAI.01113-15.
  • Meng, Y., J. Huo, W. Lu, X. Wang, J. Zhang, and W. Wang. 2012. “Modulation of P1 and EGF Expression by Baicalin.” International Journal of Molecular Sciences 14 (1): 146–157. doi:10.3390/ijms14010146.
  • Mohammed, H. O., T. E. Carpenter, and R. Yamamoto. 1987. “Economic Impact of Mycoplasma Gallisepticum and M. Synoviae in Commercial Layer Flocks.” Avian Diseases 31 (3): 477–482.
  • Orzechowska, B. U., G. Wrobel, E. Turlej, B. Jatczak, M. Sochocka, and R. Chaber. 2020. “Antitumor Effect of Baicalin from the Scutellaria Baicalensis Radix Extract in B-acute Lymphoblastic Leukemia with Different Chromosomal Rearrangements.” International Immunopharmacology 79: 106114. doi:10.1016/j.intimp.2019.106114.
  • Peng, L. Y., M. Yuan, K. Song, J. L. Yu, J. H. Li, J. N. Huang, … H. Q. Shen. 2019. “Baicalin Alleviated APEC-induced Acute Lung Injury in Chicken by Inhibiting NF-kappaB Pathway Activation.” International Immunopharmacology 72: 467–472. doi:10.1016/j.intimp.2019.04.046.
  • Peng, L. Y., M. Yuan, Z. M. Wu, K. Song, C. L. Zhang, Q. An, … H. Q. Shen. 2019. “Anti-bacterial Activity of Baicalin against APEC through Inhibition of Quorum Sensing and Inflammatory Responses.” Scientific Reports 9 (1): 4063. doi:10.1038/s41598-019-40684-6.
  • Qiu, G., Y. Rui, J. Zhang, L. Zhang, S. Huang, Q. Wu, … J. Li. 2017. “Macrolide-Resistance Selection in Tibetan Pigs with a High Load of Mycoplasma Hyopneumoniae.” Microbial Drug Resistance. doi:10.1089/mdr.2017.0254.
  • Razin, S. 1997. “The Minimal Cellular Genome of Mycoplasma.” Indian Journal of Biochemistry & Biophysics 34 (1–2): 124–130.
  • Rottem, S., and Y. Naot. 1998. “Subversion and Exploitation of Host Cells by Mycoplasmas.” Trends in Microbiology 6 (11): 436–440. doi:10.1016/S0966-842X(98)01358-4.
  • Sherwani, M. A., K. Yang, A. Jani, R. A. Abed, A. K. Taufique, T. G. Dosunmu, and N. Yusuf. 2018. “Protective Effect of Baicalin against TLR4-mediated UVA-induced Skin Inflammation.” Photochemistry and Photobiology. doi:10.1111/php.13021.
  • Shi, L., Q. G. Wu, J. C. Zhang, G. M. Yang, W. Liu, and Z. F. Wang. 2020. “Mechanism of Shuang Huang Lian Oral Liquid for Treatment of Mycoplasma Pneumonia in Children on Network Pharmacology.” Combinatorial Chemistry & High Throughput Screening. doi:10.2174/1386207323666200514073428.
  • Shimizu, T., Y. Kida, and K. Kuwano. 2005. “A Dipalmitoylated Lipoprotein from Mycoplasma Pneumoniae Activates NF-kappa B through TLR1, TLR2, and TLR6.” Journal of Immunology 175 (7): 4641–4646. doi:10.4049/jimmunol.175.7.4641.
  • Tian, W., C. Zhao, Q. Hu, J. Sun, and X. Peng. 2016. “Roles of Toll-like Receptors 2 and 6 in the Inflammatory Response to Mycoplasma Gallisepticum Infection in DF-1 Cells and in Chicken Embryos.” Developmental and Comparative Immunology 59: 39–47. doi:10.1016/j.dci.2016.01.008.
  • Vogl, G., A. Plaickner, S. Szathmary, L. Stipkovits, R. Rosengarten, and M. P. Szostak. 2008. “Mycoplasma Gallisepticum Invades Chicken Erythrocytes during Infection.” Infection and Immunity 76 (1): 71–77. doi:10.1128/IAI.00871-07.
  • Wan, Q., H. Wang, X. Han, Y. Lin, Y. Yang, L. Gu, … Y. Yang. 2014. “Baicalin Inhibits TLR7/MYD88 Signaling Pathway Activation to Suppress Lung Inflammation in Mice Infected with Influenza A Virus.” Biomedical Reports 2 (3): 437–441. doi:10.3892/br.2014.253.
  • Winner, F., R. Rosengarten, and C. Citti. 2000. “In Vitro Cell Invasion of Mycoplasma Gallisepticum.” Infection and Immunity 68 (7): 4238–4244. doi:10.1128/IAI.68.7.4238-4244.2000.
  • Wu, S. C., X. L. Chu, J. Q. Su, Z. Q. Cui, L. Y. Zhang, Z. J. Yu, … Z. J. Zhang. 2018. “Baicalin Protects Mice against Salmonella Typhimurium Infection via the Modulation of Both Bacterial Virulence and Host Response.” Phytomedicine 48: 21–31. doi:10.1016/j.phymed.2018.04.063.
  • Wu, Z., C. Chen, Y. Miao, Y. Liu, Q. Zhang, R. Li, and J. Li. 2019. “Baicalin Attenuates Mycoplasma gallisepticum-Induced Inflammation via Inhibition of the TLR2-NF-kappaB Pathway in Chicken and DF-1 Cells.” <![cdata[infection and Drug Resistance]]> 12: 3911–3923. doi:10.2147/IDR.S231908.
  • Wu, Z., L. Ding, J. Bao, Y. Liu, Q. Zhang, J. Wang, and J. Li. 2019. “Co-infection of Mycoplasma Gallisepticum and Escherichia Coli Triggers Inflammatory Injury Involving the IL-17 Signaling Pathway.” Frontiers in Microbiology 10: 2615. doi:10.3389/fmicb.2019.02615.
  • Xu, F., J. Lin, W. Cui, Q. Kong, Q. Li, L. Li, … J. Dong. 2018. “Scutellaria Baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-kappaB Pathway in Cigarette Smoke Mediated-COPD Rats Model.” Evidence-Based Complementary and Alternative Medicine 2018: 1281420. doi:10.1155/2018/1281420.
  • Yang, X., Q. Zhang, Z. Gao, C. Yu, and L. Zhang. 2018. “Baicalin Alleviates IL-1beta-induced Inflammatory Injury via Down-regulating miR-126 in Chondrocytes.” Biomedicine and Pharmacotherapy 99: 184–190. doi:10.1016/j.biopha.2018.01.041.
  • Yao, L., J. W. Zhang, B. Wang, M. J. Sui, and W. M. Wang. 2016. “Repair Effect of Qinbai Qingfei Concentrated Pellets to AEC- of Rats Infected by Mycoplasmal Pneumonia.” Zhongguo Zhong Yao Za Zhi. Zhongguo Zhongyao Zazhi. China Journal of Chinese Materia Medica 41 (8): 1493–1497. doi:10.4268/cjcmm20160821.
  • Yin, Y. D., R. Wang, C. Zhuo, H. Wang, M. G. Wang, C. M. Xie, … Y. N. Liu. 2017. “Macrolide-resistant Mycoplasma Pneumoniae Prevalence and Clinical Aspects in Adult Patients with Community-acquired Pneumonia in China: A Prospective Multicenter Surveillance Study.” Journal of Thoracic Disease 9 (10): 3774–3781. doi:10.21037/jtd.2017.09.75.
  • Yu, Y., Y. Chen, Y. Wang, Y. Li, L. Zhang, and J. Xin. 2018. “TLR2/MyD88/NF-kappaB Signaling Pathway Regulates IL-1beta Production in DF-1cells Exposed to Mycoplasma Gallisepticum LAMPs.” Microbial Pathogenesis 117: 225–231. doi:10.1016/j.micpath.2018.02.037.
  • Zhang, Q., M. J. Lenardo, and D. Baltimore. 2017. “30 Years of NF-kappaB: A Blossoming of Relevance to Human Pathobiology.” Cell 168 (1–2): 37–57. doi:10.1016/j.cell.2016.12.012.
  • Zhang, X., Z. Liao, Y. Wu, Y. Yan, S. Chen, S. Lin, … Q. Xie. 2020. “gga-microRNA-375 Negatively Regulates the Cell Cycle and Proliferation by Targeting Yes-associated Protein 1 in DF-1 Cells.” Experimental and Therapeutic Medicine 20 (1): 530–542. doi:10.3892/etm.2020.8711.
  • Zhang, Y., and Y. Zhang. 2016. “Toll-like Receptor-6 (TLR6) Deficient Mice are Protected from Myocardial Fibrosis Induced by High Fructose Feeding through Anti-oxidant and Inflammatory Signaling Pathway.” Biochemical and Biophysical Research Communications 473 (2): 388–395. doi:10.1016/j.bbrc.2016.02.111.
  • Zhao, Y., K. Zhang, M. Zou, Y. Sun, and X. Peng. 2018. “gga-miR-451 Negatively Regulates Mycoplasma Gallisepticum (HS Strain)-Induced Inflammatory Cytokine Production via Targeting YWHAZ.” International Journal of Molecular Sciences 19 (4): 1191. doi:10.3390/ijms19041191.
  • Zhao, Y., M. Zou, Y. Sun, K. Zhang, and X. Peng. 2019. “gga-miR-21 Modulates Mycoplasma Gallisepticum (HS strain)-Induced Inflammation via Targeting MAP3K1 and Activating MAPKs and NF-kappaB Pathways.” Veterinary Microbiology 237: 108407. doi:10.1016/j.vetmic.2019.108407.
  • Zhao, Y., Y. Hou, K. Zhang, B. Yuan, and X. Peng. 2017. “Identification of Differentially Expressed miRNAs through High-throughput Sequencing in the Chicken Lung in Response to Mycoplasma Gallisepticum HS.” Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics 22: 146–156. doi:10.1016/j.cbd.2017.04.004.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.