Quercetin ameliorates lipid deposition in primary hepatocytes of the chicken embryo

References

• Abdel-latif, M. A., A. R. Elbestawy, A. H. El-Far, A. E. Noreldin, M. Emam, R. S. Baty, G. M. Albadrani, M. M. Abdel-Daim, and H. S. Abd El-Hamid. 2021. “Quercetin Dietary Supplementation Advances Growth Performance, Gut Microbiota and Intestinal mRNA Expression Genes in Broiler Chickens.” Animals (Basel) 11 (8): 2302. https://doi.org/10.3390/ani11082302.
   PubMedGoogle Scholar
• Amevor, F. K., Z. Cui, Z. Ning, X. du, N. Jin, G. Shu, X. Deng, et al. 2021. “Synergistic Effects of Quercetin and Vitamin E on Egg Production, Egg Quality and Immunity in Aging Breeder Hens.” Poultry Science 100 (12): 101481. https://doi.org/10.1016/j.psj.2021.101481.
   PubMed Web of Science ®Google Scholar
• Arslan, A. S., I. Seven, S. I. Mutlu, G. Arkali, N. Birben, and P. T. Seven. 2022. “Potential Ameliorative Effect of Dietary Quercetin Against Lead-Induced Oxidative Stress, Biochemical Changes and Apoptosis in Laying Japanese Quails.” Ecotoxicology and Environmental Safety 231 (113200): 113200. https://doi.org/10.1016/j.ecoenv.2022.113200.
   PubMedGoogle Scholar
• Cao, P., Y. Wang, C. Zhang, M. A. Sullivan, W. Chen, X. Jing, H. Yu, et al. 2023. “Quercetin Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) via the Promotion of AMPK-Mediated Hepatic Mitophagy.” The Journal of Nutritional Biochemistry 120 (109414). https://doi.org/10.1016/j.jnutbio.2023.109414.
   Google Scholar
• Chen, C., Z. Su, Y. Li, P. Luan, S. Wang, H. Zhang, F. Xiao, et al. 2021. “Estimation of the Genetic Parameters of Traits Relevant to Feed Efficiency: Result from Broiler Lines Divergent for High or Low Abdominal Fat Content.” Poultry Science 100 (2): 461–466. https://doi.org/10.1016/j.psj.2020.10.028.
   PubMed Web of Science ®Google Scholar
• Chen, L., J. Liu, G. Mei, H. Chen, S. Peng, Y. Zhao, P. Yao, and Y. Tang. 2021. “Quercetin and Non-Alcoholic Fatty Liver Disease: A Review Based on Experimental Data and Bioinformatic Analysis.” Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 154 (112314): 112314. https://doi.org/10.1016/j.fct.2021.112314.
   PubMedGoogle Scholar
• Cui, X., D.-W. Qian, S. Jiang, E.-X. Shang, Z.-H. Zhu, and J.-A. Duan. 2018. “Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway.” International Journal of Molecular Sciences 19 (11): 3634. https://doi.org/10.3390/ijms19113634.
   PubMed Web of Science ®Google Scholar
• Cui, Z., N. Jin, F. K. Amevor, G. Shu, X. du, X. Kang, Z. Ning, et al. 2022. “Dietary Supplementation of Salidroside Alleviates Liver Lipid Metabolism Disorder and Inflammatory Response to Promote Hepatocyte Regeneration via PI3K/AKT/Gsk3-β Pathway.” Poultry Science 101 (9): 102034. https://doi.org/10.1016/j.psj.2022.102034.
   PubMed Web of Science ®Google Scholar
• Derakhshanian, H., M. Djalali, A. Djazayery, M. H. Javanbakht, M. Zarei, A. Hekmatdoost, G. Eslamian, S. S. Mirhashemi, and A. R. Dehpour. 2020. “Quercetin Ameliorates Lipid and Apolipoprotein Profile in High-Dose Glucocorticoid Treated Rats.” Arquivos Brasileiros de Cardiologia 115 (1): 102–108. https://doi.org/10.36660/abc.20180397.
   PubMed Web of Science ®Google Scholar
• du, Z.-Q., Y.-Q. Pang, Y. Zhang, L. Wang, R. Zhang, H. Li, and C.-X. Yang. 2022. “Folate Inhibits Lipid Deposition via the Autophagy Pathway in Chicken Hepatocytes.” Poultry Science 102 (2): 102363. https://doi.org/10.1016/j.psj.2022.102363.
   PubMed Web of Science ®Google Scholar
• el-shial, E. M., A. Kabbash, M. El-Aasr, O. A. El-Feky, and S. A. El-Sherbeni. 2023. “Elucidation of Natural Components of Gardenia Thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease.” Molecules 28 (2). https://doi.org/10.3390/molecules28020879.
   PubMed Web of Science ®Google Scholar
• Feng, Y., Y. Li, W. Jiang, Y. Hu, Y. Jia, and R. Zhao. 2021. “GR-Mediated Transcriptional Regulation of m6A Metabolic Genes Contributes to Diet-Induced Fatty Liver in Hens.” Journal of Animal Science and Biotechnology 12 (1): 117. https://doi.org/10.1186/s40104-021-00642-7.
   PubMed Web of Science ®Google Scholar
• He, Y., H. Wang, S. Lin, T. Chen, D. Chang, Y. Sun, C. Wang, et al. 2023. “Advanced Effect of Curcumin and Resveratrol on Mitigating Hepatic Steatosis in Metabolic Associated Fatty Liver Disease via the PI3K/AKT/mTOR and HIF-1/VEGF Cascade.” Biomed Pharmacother 165 (115279): 115279. https://doi.org/10.1016/j.biopha.2023.115279.
   PubMedGoogle Scholar
• Hoek-Van Den Hil, E. F., J. Keijer, A. Bunschoten, J. J. Vervoort, B. Stankova, M. Bekkenkamp, L. Herreman, et al. 2013. “Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice.” Public Library of Science ONE 8 (1): e51588. https://doi.org/10.1371/journal.pone.0051588.
   Google Scholar
• Horton, J. D., J. L. Goldstein, and M. S. Brown. 2002. “SREBPs: Activators of the Complete Program of Cholesterol and Fatty Acid Synthesis in the Liver.” The Journal of Clinical Investigation 109 (9): 1125–1131. https://doi.org/10.1172/JCI0215593.
   PubMed Web of Science ®Google Scholar
• Hu, G.-L., J. Xiong, Y. Liu, H.-J. Yang, L.-L. Hu, P. Chen, X. Wang, et al. 2022. “Effects of Lecithin Supplementation in Feed of Different Fat Levels on Serum Indexes and Liver Health of Laying Hens.” Frontiers in Physiology 13 (892585). https://doi.org/10.3389/fphys.2022.892585.
   Google Scholar
• Hu, X., Y. Wang, A. Sheikhahmadi, X. Li, J. Buyse, H. Lin, and Z. Song. 2019. “Effects of Glucocorticoids on Lipid Metabolism and AMPK in Broiler chickens’ Liver.” Comparative Biochemistry and Physiology Part B: Biochemistry & Molecular Biology 232:23–30. https://doi.org/10.1016/j.cbpb.2019.02.001.
   PubMed Web of Science ®Google Scholar
• Hu, Y., Y. Feng, L. Zhang, Y. Jia, D. Cai, S.-B. Qian, M. du, and R. Zhao. 2020. “GR-Mediated FTO Transactivation Induces Lipid Accumulation in Hepatocytes via Demethylation of m6A on Lipogenic mRnas.” RNA Biology 17 (7): 930–942. https://doi.org/10.1080/15476286.2020.1736868.
   PubMed Web of Science ®Google Scholar
• Kim, M., and B. H. Voy. 2021. “Fighting Fat with Fat: N-3 Polyunsaturated Fatty Acids and Adipose Deposition in Broiler Chickens.” Frontiers in Physiology 12 (755317). https://doi.org/10.3389/fphys.2021.755317.
   Google Scholar
• Krycer, J. R., L. J. Sharpe, W. Luu, and A. J. Brown. 2010. “The Akt-SREBP Nexus: Cell Signaling Meets Lipid Metabolism.” Trends in Endocrinology and Metabolism: TEM 21 (5): 268–276. https://doi.org/10.1016/j.tem.2010.01.001.
   PubMed Web of Science ®Google Scholar
• Leveille, G. A., D. R. Romsos, Y. Yeh, and E. K. o’hea. 1975. “Lipid Biosynthesis in the Chick. A Consideration of Site of Synthesis, Influence of Diet and Possible Regulatory Mechanisms.” Poultry Science 54 (4): 1075–1093.
   PubMed Web of Science ®Google Scholar
• Lindholm, C., P. Batakis, J. Altimiras, and J. Lees. 2022. “Intermittent Fasting Induces Chronic Changes in the Hepatic Gene Expression of Red Jungle Fowl (Gallus Gallus).” BMC Genomics 23 (1): 304. https://doi.org/10.1186/s12864-022-08533-5.
   PubMed Web of Science ®Google Scholar
• Liu, Y., J. Shen, X. Yang, Q. Sun, and X. Yang. 2018. “Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes.” Journal of Agricultural and Food Chemistry 66 (50): 13162–13172. https://doi.org/10.1021/acs.jafc.8b05193.
   PubMed Web of Science ®Google Scholar
• Liu, Y., J. Yang, X. Liu, R. Liu, Y. Wang, X. Huang, Y. Li, R. Liu, and X. Yang. 2023. “Dietary Folic Acid Addition Reduces Abdominal Fat Deposition Mediated by Alterations in Gut Microbiota and SCFA Production in Broilers.” Animal Nutrition 12:54–62. https://doi.org/10.1016/j.aninu.2022.08.013.
   Web of Science ®Google Scholar
• Lu, Y., C. Zhang, Y. Song, L. Chen, X. Chen, G. Zheng, Y. Yang, P. Cao, and Z. Qiu. 2023. “Gallic Acid Impairs Fructose-Driven de Novo Lipogenesis and Ameliorates Hepatic Steatosis via AMPK-Dependent Suppression of SREBP-1/ACC/FASN Cascade.” European Journal of Pharmacology 940 (175457): 175457. https://doi.org/10.1016/j.ejphar.2022.175457.
   PubMedGoogle Scholar
• Lu, Z., X. F. He, B. B. Ma, L. Zhang, J. L. Li, Y. Jiang, G. H. Zhou, and F. Gao. 2019. “Increased Fat Synthesis and Limited Apolipoprotein B Cause Lipid Accumulation in the Liver of Broiler Chickens Exposed to Chronic Heat Stress.” Poultry Science 98 (9): 3695–3704. https://doi.org/10.3382/ps/pez056.
   PubMed Web of Science ®Google Scholar
• Makovicky, P., M. Dudova, E. Tumova, R. Rajmon, and Z. Vodkova. 2011. “Experimental Study of Non-Alcoholic Fatty Liver Disease (NAFLD) on a Model of Starving Chickens: Is Generalization of Steatosis Accompanied by Fibrosis of the Liver Tissue?” Pathology, Research and Practice 207 (3): 151–155. https://doi.org/10.1016/j.prp.2010.12.002.
   PubMed Web of Science ®Google Scholar
• Mellouk, N., C. Rame, A. Barbe, J. Grandhaye, P. Froment, and J. Dupont. 2018. “Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases.” International Journal of Endocrinology 2018 (4579734): 1–19. https://doi.org/10.1155/2018/4579734.
   Google Scholar
• Mi, S., W. Zhu, X. Zhang, Y. Wang, T. Li, and X. Wang. 2023. “Enhanced Hypoglycemic Bioactivity via RAS/Raf-1/MEK/ERK Signaling Pathway by Combining Capsaicin and QUERCETIN from Chili Peppers.” Molecular Nutrition & Food Research 67 (10): e2200577. https://doi.org/10.1002/mnfr.202200577.
   PubMed Web of Science ®Google Scholar
• Montagner, A., A. Polizzi, E. Fouché, S. Ducheix, Y. Lippi, F. Lasserre, V. Barquissau, et al. 2016. “Liver PPARα Is Crucial for Whole-Body Fatty Acid Homeostasis and Is Protective Against NAFLD.” Gut 65 (7): 1202–1214. https://doi.org/10.1136/gutjnl-2015-310798.
   PubMed Web of Science ®Google Scholar
• Pisonero-Vaquero, S., Á. Martínez-Ferreras, M. V. García-Mediavilla, S. martínez-Flórez, A. Fernández, M. Benet, J. L. Olcoz, R. Jover, J. González-Gallego, and S. Sánchez-Campos. 2015. “Quercetin Ameliorates Dysregulation of Lipid Metabolism Genes via the PI3K/AKT Pathway in a Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease.” Molecular Nutrition & Food Research 59 (5): 879–893. https://doi.org/10.1002/mnfr.201400913.
   PubMed Web of Science ®Google Scholar
• Rebollo-Hernanz, M., Y. Aguilera, M. A. Martin-Cabrejas, and E. Gonzalez De Mejia. 2022. “Phytochemicals from the Cocoa Shell Modulate Mitochondrial Function, Lipid and Glucose Metabolism in Hepatocytes via Activation of FGF21/ERK, AKT and mTOR Pathways.” Antioxidants 11 (1): 136. https://doi.org/10.3390/antiox11010136.
   Web of Science ®Google Scholar
• Su, G., R. J. Letcher, R. Farmahin, and D. Crump. 2018. “Photolysis of Highly Brominated Flame Retardants Leads to Time-Dependent Dioxin-Responsive mRNA Expression in Chicken Embryonic Hepatocytes.” Chemosphere 194:352–359. https://doi.org/10.1016/j.chemosphere.2017.11.153.
   PubMed Web of Science ®Google Scholar
• Tachibana, S., K. Sato, Y. Cho, T. Chiba, W. J. Schneider, and Y. Akiba. 2005. “Octanoate Reduces Very Low-Density Lipoprotein Secretion by Decreasing the Synthesis of Apolipoprotein B in Primary Cultures of Chicken Hepatocytes.” Biochimica Et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1737 (1): 36–43. https://doi.org/10.1016/j.bbalip.2005.09.001.
   PubMed Web of Science ®Google Scholar
• Wang, D., X. Li, P. Zhang, Y. Cao, K. Zhang, P. Qin, Y. Guo, et al. 2022. “ELOVL Gene Family Plays a Virtual Role in Response to Breeding Selection and Lipid Deposition in Different Tissues in Chicken (Gallus Gallus).” BMC Genomics 23 (1): 705. https://doi.org/10.1186/s12864-022-08932-8.
   PubMed Web of Science ®Google Scholar
• Wang, M., Y. Mao, B. Wang, S. Wang, H. Lu, L. Ying, and Y. Li. 2020. “Quercetin Improving Lipid Metabolism by Regulating Lipid Metabolism Pathway of Ileum Mucosa in Broilers.” Oxidative Medicine and Cellular Longevity 2020 (8686248): 1–17. https://doi.org/10.1155/2020/8686248.
   Google Scholar
• Yu, J., G. Hu, H. Cao, and X. Guo. 2022. “Quercetin Ameliorates Lipopolysaccharide-Induced Duodenal Inflammation Through Modulating Autophagy, Programmed Cell Death and Intestinal Mucosal Barrier Function in Chicken Embryos.” Animals (Basel) 12 (24): 3524. https://doi.org/10.3390/ani12243524.
   PubMedGoogle Scholar
• Zhang, Y., Q. Fu, T. Wu, K. Liu, Y. Xiao, Q. Liao, X. Qi, Y. Li, and L. Zhou. 2023. “5-Methoxyflavone Ameliorates Non-Alcoholic Fatty Liver Disease Through Targeting the Cytochrome P450 1A1.” Free Radical Biology & Medicine 195:178–191. https://doi.org/10.1016/j.freeradbiomed.2022.12.093.
   PubMed Web of Science ®Google Scholar
• Zhu, L., R. Liao, J. Huang, C. Xiao, Y. Yang, H. Wang, D. He, H. Yan, and C. Yang. 2022. “Lactobacillus Salivarius SNK-6 Regulates Liver Lipid Metabolism Partly via the MiR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens.” Cells 11 (24): 4133. https://doi.org/10.3390/cells11244133.
   PubMed Web of Science ®Google Scholar