Interpretation of Postmortem Dextromethorphan Concentrations—a Review of Case Data and the Literature

REFERENCES

• Goodman & Gilman's. The Pharmacological Basis of Therapeutics. Goodman Gilman A., Rail T.W., Nies A.S. and Taylor P., (eds), 8th ed., Pergamon Press, New York, 1990; 518.
   Google Scholar
• Uges D.R.A. Therapeutic and Toxic Drug Concentrations. Bulletin of The International Association of Forensic Toxicologists. 1996; 26(1) supp., 1–34.
   Google Scholar
• Winek C.L. Drug and Chemical Blood-Level Data 1994. In: Winek's Toxicology Annual and Chapter 72 in: Tedeschi, Eckert and Tedeschi, Editors, Forensic Medicine III.
   Google Scholar
• Schadel M., Wu D., Otton S.V., Kalow W. and Sellers E.M. Pharmacokinetics of Dextromethorphan and Metabolites in Humans: Influence of CYP2D6 Phenotype and Quinidine Inhibition. J. Clin. Psychopharmacol. 1995; 15: 263–269.
   PubMed Web of Science ®Google Scholar
• Christmore D.S., Kelly R.C. and Doshier L.A. Improved Recovery and Stability of Ethanol in Automated Headspace Analysis, J. Forensic Sci. 1984; 29: 1038–1044.
   Google Scholar
• Mortimer O., Lindstrom B., Laureil H., Bergman U. and Rane A. Dextromethorphan: Polymorphic Serum Pattern of the O-demethylated and Didemethylated Metabolites in Man. Br. J. Clin. Pharmacol. 1989; 27: 223–227.
   PubMed Web of Science ®Google Scholar
• Vetticaden S.J., Cabana B.E., Prasad V.K., Purich E.D., Jonkman J.H., de Zeeuw R., Ball L., Leeson L.J. and Braun R.L. Phenotypic Differences in Dextromethorphan Metabolism. Pharm. Res. 1989; 6: 13–19.
   PubMedGoogle Scholar
• Chen Z.R., Somogyi A.A. and Bochner F. Simultaneous Determination of Dextromethorphan and Three Metabolites in Plasma and Urine Using High-Performance Liquid Chromatography with Application to Their Disposition in Man. Ther. Drug Monit. 1990; 12: 97–104.
   PubMed Web of Science ®Google Scholar
• Jacqz-Aigrain E. and Cresteil T. Cytochrome P450-Dependent Metabolism of Dextromethorphan: Fetal and Adult Studies. Dev. Pharmacol. Ther. 1992; 18: 161–168.
   PubMedGoogle Scholar
• Jacqz-Aigrain E., Funck-Brentano C. and Cresteil T. CYP2D6- and CYP3A-Dependent Metabolism of Dextromethorphan in Humans. Pharmacogenetics 1993; 3: 197–204.
   PubMedGoogle Scholar
• Capon D.A., Bochner F., Kerry N., Mijkus G., Danz C. and Somogyi A.A. The Influence of CYP2D6 Polymorphism and Quinidine on the Disposition and Antitussive Effect of Dextromethorphan in Humans. Clin. Pharmacol. Ther. 1996; 60: 295–307.
   PubMed Web of Science ®Google Scholar
• Schmider J., Greenblatt D.J., Fogelman S.M., von Moltke L.L. and Shader R.I. Metabolism of Dextromethorphan In Vitro: Involvement of Cytochromes P450 2D6 and 3A3/4 With a Possible Role of 2E1. Biopharm. Drug Dispos. 1997; 18: 227–240.
   PubMed Web of Science ®Google Scholar
• Ducharme J., Abdullah S. and Wainer I.W. Dextromethorphan as an In Vivo Probe for the Simultaneous Determination of CYP2D6 and CYP3A Activity. J. Chromatogr. B. Biomed. Appl. 1996; 678: 113–128.
   PubMedGoogle Scholar
• Jones D.R., Gorski J.C., Haehner B.D., O'Mara E.M. Jr. and Hall S.D. Determination of Cytochrome P450 3A4/5 Activity in Vivo with Dextromethorphan N-Demethylation. Clin. Pharmacol. Ther. 1996; 60: 374–384.
   PubMedGoogle Scholar
• Jones D.R., Gorski J.C., Hamman M.A., and Hall S.D. Quantification of Dextromethorphan and Metabolites: A Dual Phenotypic Marker for Cytochrome P450 3A4/5 and 2D6 Activity., J. Chromatogr. B. Biomed. Appl. 1996; 678: 105–111.
   PubMedGoogle Scholar
• Jurima-Romet M., Foster B.C., Casley W.L., Rode A., Vloshinsky P., Huang H.S. and Geertsen S. CYP2D6-Related Oxidation Polymorphism in a Canadian Inuit Population. Can. J. Physiol. Pharmacol. 1997; 75: 165–172.
   PubMed Web of Science ®Google Scholar
• Szekely J.I., Sharpe L.G. and Jaffe J.H. Induction of Phencyclidine-like Behavior in Rats by Dextrorphan But Not Dextromethorphan. Pharmacol. Biochem. Behav. 1991; 40: 381–386.
   PubMed Web of Science ®Google Scholar
• Murray T.F. and Leid M.E. Interaction of Dextroorotatory Opioids with Phencyclidine Recognition Sites in Rat Brain Membranes. Life Sci. 1984; 34: 1899–1911.
   PubMedGoogle Scholar
• Tortella F.C., Pellicano M. and Bowery N.G. Dextromethorphan and Neuromodulation: Old Drug Coughs Up New Activities. Trends Pharmacol. Sci. 1989; 10: 501–507.
   PubMed Web of Science ®Google Scholar
• Arnold G.L., Griebel M.L., Valentine J.L., Koroma D.M. and Kearns G.L. Dextromethorphan in Nonketotic Hyperglycinaemia: Metabolic Variation Confounds the Dose-response Relationship. J. Inherit. Metab. Dis. 1977; 20: 28–38.
   Google Scholar
• Silvasti M., Karttunen P., Tukianien H., Kokkonen P., Hanninen U. and Nykanen S. Pharmacokinetics of Dextromethorphan and Dextrorphan: A Single Dose Comparison of Three Preparations in Human Volunteers. Int. J. Clin. Pharmacol. Ther. Toxicol. 1987; 25: 493–497.
   PubMedGoogle Scholar
• Duche J.C., Querol-Ferrer V., Barre J., Mesangeau M. and Tillement, J.P. Dextromethorphan O-Demethylation and Dextrorphan Glucuronidation in a French Population. Int. J. Clin. Pharmacol. Ther. Toxicol. 1993; 31: 392–398.
   PubMed Web of Science ®Google Scholar
• de Zeeuw R.A. and Jonkman J.H.G. Genetic Differences in Oxidative Drug Metabolism. In Proceedings of the International Association of Forensic Toxicologists, Groningen, NL, 1988; 53–64.
   Google Scholar
• Rammer L., Holmgren P. and Sandler H. Fatal Intoxication by Dextromethorphan: A Report on Two Cases. Forensic Sci. Int. 1988; 37: 233–236.
   PubMed Web of Science ®Google Scholar
• Pender E.S. and Parks B.R. Toxicity with Dextromethorphan-containing Preparations: A Literature Review and Report of Two Additional Cases. Pediatr. Emerg. Care 1991; 7: 163–165.
   PubMedGoogle Scholar
• Bem J.L. and Peck R. Dextromethorphan. An Overview of Safety Issues. Drug Saf. 1992; 7: 190–199.
   PubMed Web of Science ®Google Scholar
• Hinsberger A., Sharma V. and Mazmanian D. Cognitive Deterioration From Long-term Abuse of Dextromethorphan: A Case Report. J. Psychiatry Neurosci. 1994; 19: 375–377.
   PubMed Web of Science ®Google Scholar
• Sovner R. and Wolfe J. Interaction Between Dextromethorphan and Monoamine Oxidase Inhibitor Therapy with Isocarboxazid. N. Engl. J. Med. 1988; 319: 1671.
   PubMed Web of Science ®Google Scholar
• Skop B.P., Finkelstein J.A., Mareth T.R., Magoon M.R., Brown T.M. The Serotonin Syndrome Associated with Paroxetine, an Over-the-counter Cold Remedy, and Vascular Disease. Am. J. Emerg. Med. 1994; 12: 642–644.
   PubMed Web of Science ®Google Scholar
• Prouty R.W. and Anderson, W.H. The Forensic Science Implications of Site and Temporal Influences on Postmortem Blood-Drug Concentrations. J. Forensic Sci. 1990; 35: 243–270.
   PubMed Web of Science ®Google Scholar
• Dalpe-Scott M., DeGouffe M., Garbutt, D. and Drost, M. A Comparison of drug concentrations in postmortem cardiac and peripheral blood in 320 cases. Can. Soc. Forensic Sci. J. 1995; 28: 113–121.
   Google Scholar