Case Study: Distribution and Redistribution of Levomepromazine and its Metabolites in a Fatal Poisoning

REFERENCES

• O'Neill J. and Fountain A. Levomepromazine (Methotrimeprazine) and the last 48 Hours. Hosp Med 1999; 60(8): 564–7.
   PubMed Web of Science ®Google Scholar
• Hals P.A. and Dahl S.G. Metabolism of Levomepromazine in Man. Eur J Drug Metab Pharmacokinet 1995; 20(1): 60–71.
   Google Scholar
• Moffat A.C., Jackson J.V. Moss M.S. and Woddop B. (editors). Clarke's Isolation And Identification of Drugs in Pharmaceuticals, Body Fluids, and Postmortem Materials. 2nd ed. London: Pharmaceutical Press, 1986; 757–758.
   Google Scholar
• Baselt R.C. and Cravey R.H. (editors) Disposition of Toxic Drugs and Chemicals in Man, 4th ed. California: Chemical Toxicology Institute, 1995; 545–546.
   Google Scholar
• Druid H. and Holmgren P. A Compilation of Fatal and Control Concentrations of Drugs in Postmortem Femoral Blood, J.Forensic Sci.1997; 42: 79–87.
   PubMed Web of Science ®Google Scholar
• Stead A.H. and Moffat A.C. A Collection of Therapeutic, Toxic and Fatal Blood Drug Concentrations in Man. Human Toxicol. 1983; 3: 437–64.
   Google Scholar
• Uges D.R.A. Therapeutic and Toxic Drug Concentrations, The Bulletin of the International Association of Forensic Toxicologists.1996; 26(1): Supplement.
   Google Scholar
• Robertson M.D. and Drummer O.H. Postmortem Drug Metabolism by Bacteria, J Forensic Sci.1995; 40: 382–386.
   PubMed Web of Science ®Google Scholar
• Pounder D.J. Postmortem Drug Redistribution—a Toxicological Nightmare, Forensic Sci. Int. 1990; 35(5): 1572–9.
   Google Scholar
• Moriya F. and Hashimoto Y. Redistribution of Basic Drugs Into Cardiac Blood from surrounding Tissues During Early—Stages Postmortem, J. Forensic Sci. 1999; 44: 10–16.
   Google Scholar
• Hilberg T., Rogde S. and Morland J. Postmortem Drug Redistribution—Human Cases Related to Results in Experimental Animals, J. Forensic Sci. 1999; 44: 3–9.
   Google Scholar
• Shepherd M.F. Postmortem Changes and Pharmacokinetics: Review of the Literature and Case Report. Ann Pharmacother. 1992; 26(40): 510–4.
   PubMed Web of Science ®Google Scholar
• Quatrehomme G., Bourret F., Liao Z. and Oilier A. An Experimental Methodology for the Study of Postmortem Changes in Toxic Concentrations of Drugs, using Secobarbital as an Example, J. Forensic Sci. 1994; 39: 1300–4.
   Google Scholar
• Mayer J.M., Kofoed J. and Robinson D.W. Postmortem Changes in Drug Concetrations in the Blood, Proceedings of the 24th International Meeting, The International Association of Forensic Toxicologists, Banff, Alberta, Canada, 1987; 40–47.
   Google Scholar
• Causón R. Validation of Chromatographic Methods in Biomedical Analysis. Viewpoint and Discussion, J. Chromatography B. 1997; 689: 175–180.
   PubMed Web of Science ®Google Scholar
• Bressolle F., Bromet-Petit M. and Audran M. Validation of Liquid Chromatographic and Gas Chromatographic Methods. Application to Pharmacokinetics, J. Chromatography B. 1996; 686: 3–10.
   PubMed Web of Science ®Google Scholar
• Loennechen T., Andersen A., Hals P.A. and Dahl S.G. High Performance Liquid Chromatographic Determination of Levomepromazine (Methotrimeprazine) and its main Metabolites in Serum and Urine, Ther Drug Monit.1990; 12(6): 574–81.
   PubMed Web of Science ®Google Scholar
• Loennechen T.% and Dahl S.G. High Performance Liquid Chromatographic Determination of Levomepromazine (Methotrimeprazine) and its main Metabolites. J Chromatogr 1990; 503(1): 205–15
   PubMed Web of Science ®Google Scholar
• Pawelczyk E. Chemia Leków, PZWL, Warszawa, 1986.
   Google Scholar
• Kostowski W. and Puzyński S., Psychofarmakologia Doś wiadczalna i Kliniczna, PZWL, Warszawa, 1980; 198–260.
   Google Scholar
• Klys M. and Bujak-Gizycka B., Application of Liquid Chromatography with Mass Detection (LC/MS) in the Evaluation of Drug Metabolism in Fatal Poisoning, Acta Poloniae Toxicologica.2000; 8(2): 187–203.
   Google Scholar
• Hilberg T., Morland J. and Bjomeboe A. Postmortem Release of Amitriptyline from the Lungs; Mechanism of Postmortem Drug Redistribution. Forensic Sci Int. 1994; 64(1): 47–55.
   PubMed Web of Science ®Google Scholar
• Robertson M.D. and Drummer O.H. Postmortem Distribution and Redistribution of Nitrobenzodiazepines in Man. J Forensic Sci. 1998; 43(1); 9–13.
   PubMed Web of Science ®Google Scholar
• Langford A.M. and Pounder D.J. Possible Markers for Postmortem Drug Redistribution. J Forensic Sci. 1997; 42(1): 88–92.
   PubMed Web of Science ®Google Scholar
• Jones G.R. Site-Dependent Differences in the Blood Levels of Some Drugs, Proceedings of the 24th International Meeting, the International Association of Forensic Toxicologists. Banff, Alberta, Canada, 1987; 32–39.
   Google Scholar
• Jones G.R. and Pounder D.J. Site Dependence of Drug Concentrations in Postmortem Blood- a Case Study. J. Anal. Toxicol. 1987; 11: 184–190.
   Google Scholar
• Logan B.K. and Smimow D. Postmortem distribution and redistribution of morphine in man. J Forensic Sci. 1996; 41(2): 221–9.
   PubMed Web of Science ®Google Scholar
• Schmidt C. Investigation of the Postmortem Redistribution of Opiates. Proc West Pharmacol Soc. 1996; 39: 27–8.
   PubMedGoogle Scholar