Mechanism of Action of a New Toxin from Gonyaulax Tamarensis on Nerve Membranes

References

• Kao , C. Y. 1966 . Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena . Pharmacol. Rev. , 18 : 997 – 1049 .
   PubMed Web of Science ®Google Scholar
• Schantz , E. J. , Lynch , J. M. , Vayvada , G. , Matsumoto , K. and Rapoport , H. 1966 . The purification and characterization of the poison produced by Gonyaulax catanella in axenic culture . Biochemistry , 5 : 1191 – 1195 .
   PubMed Web of Science ®Google Scholar
• Narahashi , T. , Moore , J. W. and Scott , W. R. 1964 . Tetrodotoxin blockage of sodium conductance increase in lobster giant axons . J. Gen. Physiol. , 47 : 965 – 974 .
   PubMed Web of Science ®Google Scholar
• Hille , B. 1968 . Pharmacological modifications of the sodium channels of frog nerve . J. Gen. Physiol. , 51 : 199 – 219 .
   PubMedGoogle Scholar
• Nakamura , Y. , Nakajima , S. and Grundfest , H. 1965 . The action of tetrodotoxin on electrogenic components of squid giant axons . J. Gen. Physiol. , 48 : 985 – 996 .
   Google Scholar
• Narahashi , T. 1972 . Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes . Federation Proc. , 31 : 1124 – 1132 .
   PubMedGoogle Scholar
• Cuervo , L. A. and Adelman , W. J. Jr. 1970 . Equilibrium and kinetic properties of the interaction between tetrodotoxin and the excitable membrane of the squid giant axon . J. Gen. Physiol. , 55 : 309 – 335 .
   PubMedGoogle Scholar
• Narahashi , T. , Anderson , N. C. and Moore , J. W. 1967 . Comparison of tetrodotoxin and procaine in internally perfused squid giant axons . J. Gen. Physiol. , 50 : 1413 – 1428 .
   PubMedGoogle Scholar
• Narahashi , T. 1971 . “ Neurophysiological basis for drug action. Ionic mechanism, site of action and active form in nerve fibers ” . In Biophysics and Physiology of Excitable Membranes , Edited by: Adelman , W. J. Jr. 423 – 462 . New York : Van Nostrand Reinhold Co. .
   Google Scholar
• Narahashi , T. 1972 . “ Pharmacological characterization of axonal and end-plate membranes ” . In Perspectives in Membrane Biophysics , Edited by: Agin , D. P. 245 – 298 . New York : Gordon & Breach .
   Google Scholar
• Narahashi , T. and Anderson , N. C. 1967 . Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons . Toxicol. Appl. Pharmacol. , 10 : 529 – 547 .
   PubMedGoogle Scholar
• Wang , C. M. , Narahashi , T. and Scuka , M. 1972 . Mechanism of negative temperature coefficient of nerve blocking action of allethrin . J. Pharmacol. Exp. Therap. , 182 : 442 – 453 .
   PubMedGoogle Scholar
• Adelman , W. J. Jr. and Taylor , R. E. 1961 . Leakage current rectification in the squid giant axon . Nature , 190 : 883 – 885 .
   PubMedGoogle Scholar