DDE blood levels and health of a unique rural population of African American females residing in the Mississippi Delta of the United States of America

References

• Petit, S.D., 2021, ToxPoint: Health disparities, COVID-19, and owning our share. Toxicological Sciences 179, 147–148. doi: 10.1093/toxsci/kfaa175.
   PubMed Web of Science ®Google Scholar
• August, L.M., Faust, J.B., Cushing, L., Zeise, L. and Alexeeff, G.V., 2012, Methodological considerations in screening for cumulative environmental health impacts: Lessons learned from a pilot study in California. International Journal of Environmental Research and Public Health 9, 3069–3084. doi: 10.3390/ijerph9093069.
   PubMed Web of Science ®Google Scholar
• Gaither, C.J., Afrin, S., Garcia-Menendez, F., Odman, M.T., Huang, R. and Goodrick, S., et al., 2019, African American exposure to prescribed fire smoke in Georgia, USA. International Journal of Environmental Research and Public Health 16, 3079. doi: 10.3390/ijerph16173079.
   PubMed Web of Science ®Google Scholar
• Ma, J., Li, Y.-F., Harner, T. and Cao, Z., 2007, Assessing the relationship between extensive use of organochlorine pesticides and cooling trend during the mid-20th century in the southeastern United States. Environmental Science & Technology 41, 7209–7214. doi: 10.1021/es0617744.
   PubMed Web of Science ®Google Scholar
• Attaran, A., Roberts, D.R., Curtis, C.F. and Kilama, W.L., 2000, Balancing risks on the backs of the poor. Nature medicine 6, 729–731. doi: 10.1038/77438.
   PubMed Web of Science ®Google Scholar
• Saffell, C.L., 2000, When did king cotton move his throne (and has it moved back)? Agricultural history 74, 293–308. doi: 10.1215/00021482-74.2.293.
   Web of Science ®Google Scholar
• Meek, E.C., Jones, D.D., Crow, J.A., Wills, R.A., Cooke III, W.H. and Chambers, J.E., 2019, Association of serum levels of p,p’-Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi. Journal of Toxicology and Environmental Health, Part A 82(6), 387–400. doi: 10.1080/15287394.2019.1610678.
   PubMed Web of Science ®Google Scholar
• Lee, D.-H., Steffes, M.W., Sjödin, A., Jones, R.S., Needham, L.L. and Jacobs Jr, D.R., 2011, Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes. Public Library of Science ONE 6, e15977, 20 11. doi: 10.1371/journal.pone.0015977.
   Google Scholar
• Lee, D.-H., Lee, I.K., Song, K., Steffes, M., Toscano, W. and Baker, B.A., et al., 2006, A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes results from the National Health and Examination Survey 1999–2002. Diabetes Care 29, 1638–1644. doi: 10.2337/dc06-0543.
   PubMed Web of Science ®Google Scholar
• Taylor, K.W., Novak, R.F., Anderson, H.A., Birnbaum, L.S., Blystone, C. and DeVito, M., et al., 2013, Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: A national toxicology program workshop review. Environmental Health Perspectives 121, 774–783. doi: 10.1289/ehp.1205502.
   PubMed Web of Science ®Google Scholar
• Ha, M.H., Lee, D.-H. and Jacobs Jr, D.R., 2007, Association between serum concentrations of persistent organic pollutants and self-reported cardiovascular disease prevalence: Results from the National Health and Nutrition Examination Survey, 1999–2002. Environmental Health Perspectives 115, 1204–1209. doi: 10.1289/ehp.10184.
   PubMed Web of Science ®Google Scholar
• Sergeev, A.V. and Carpenter, D.O., 2005, Hospitalization rates for coronary heart disease in relation to residence near areas contaminated with persistent organic pollutants and other pollutants. Environmental Health Perspectives 113, 756–761. doi: 10.1289/ehp.7595.
   PubMed Web of Science ®Google Scholar
• Lee, Y.M., Bae, S.G., Lee, S.H., Jacobs Jr, D.R. and Lee, D.H., 2013, Persistent organic pollutants and hyperuricemia in the U.S. general population. Atherosclerosis 230, 1–5. doi: 10.1016/j.atherosclerosis.2013.06.012.
   PubMed Web of Science ®Google Scholar
• Chae, D.H., Clouston, S., Hatzenbuehler, M.L., Kramer, M.R., Cooper, H.L.F. and Wilson, S.M., et al., 2015, Association between an internet-based measure of area racism and black mortality. Public Library of Science ONE 10(4), e0122963. doi: 10.1371/journal.pone.0122963.
   Google Scholar
• Cardel, M.I., Chi, X., Min, Y., Sims, M., Musani, S.K. and Dulin, A., et al., 2021, Experiences of discrimination are associated with worse metabolic syndrome severity among African Americans in the Jackson Heart Study. Annals of Behavioral Medicine 55, 266–279. doi: 10.1093/abm/kaaa050.
   PubMed Web of Science ®Google Scholar
• Chen, Z., Lloyd, D., Zhou, Y.H., Chiu, W.A., Wright, F.A. and Rusyn, I., 2021, Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon concentrations data. Toxicological Sciences 179(1), 108–120. doi: 10.1093/toxsci/kfaa166.
   PubMed Web of Science ®Google Scholar
• Costa, L.G., Vitalone, A., Cole, T.B. and Furlong, C.E., 2005, Modulation of paraoxonase (PON1) activity. Biochemical Pharmacology 69, 541–550. doi: 10.1016/j.bcp.2004.08.027.
   PubMed Web of Science ®Google Scholar
• Boesch-Saadatmandi, C., Egert, S., Schrader, C., Coumoul, X., Barouki, R. and Muller, M.J., et al., 2010, Effect of quercetin on paraoxonase 1 activity--studies in cultured cells, mice and humans. Journal of Physiology and Pharmacology 61, 99–105.
   PubMed Web of Science ®Google Scholar
• Abbott, C.A., Mackness, M.I., Kumar, S., Boulton, A.J. and Durrington, P.N., 1995, Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins. Arteriosclerosis, thrombosis, and vascular biology 15, 1812–1818. doi: 10.1161/01.ATV.15.11.1812.
   PubMed Web of Science ®Google Scholar
• Rosenblat, M., Sapir, O. and Aviram, M., 2008, Glucose inactivates paraoxonase 1 (PON1) and displaces it from high density lipoprotein (HDL) to a free PON1 form, In: B. Mackness, M. Mackness, M. Aviram and G. Paragh (Eds) The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (Dordrecht: Springer), pp. 35–49.
   Google Scholar
• Grzegorzewska, A.E., Adamska, P., Iwańczyk‑skalska, E., Ostromecka, K., Niepolski, L. and Marcinkowski, W., et al., 2021, Paraoxonase 1 concerning dyslipidaemia, cardiovascular diseases, and mortality in hemodialysis patients. Scientific reports 11, 6773. doi: 10.1038/s41598-021-86231-0.
   PubMed Web of Science ®Google Scholar
• Chambers, J.E. and Chambers, H.W., 1990, Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats. Toxicology and Applied Pharmacology 103, 420–429. doi: 10.1016/0041-008X(90)90315-L.
   PubMed Web of Science ®Google Scholar
• U.S. News and World Report, 2020, Healthiest Communities. Available online at: http://www.usnews.com/news/healthiest-communities/mississippi/humphreys-county
   Google Scholar
• Stribling, W., How rural hospitals are working together to keep from closing. Daily Journal 148(225), 1A. 22 Nov 2021.
   Google Scholar
• Statistical Atlas, 2022, Occupations in Humphreys County, Mississippi. Available online at: https://statisticalatlas.com/county-subdivision/Mississippi/Humphreys-County/Humphreys-District-4/Occupations
   Google Scholar
• Fenske, R.A., Kissel, J.C., Lu, C., Kalman, D.A., Simcox, N.J. and Allen, E.H., et al., 2000, Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 108, 515–520. doi: 10.1289/ehp.00108515.
   PubMed Web of Science ®Google Scholar
• Tamaro, C.M., Smith, M.N., Workman, T., Griffith, W.C., Thompson, B. and Faustman, E.M., 2018, Characterization of organophosphate pesticides in urine and home environment dust in an agricultural community. Biomarkers 23, 174–187. doi: 10.1080/1354750X.2017.1395080.
   PubMed Web of Science ®Google Scholar
• U.S. Census Bureau, 1950, Census of population preliminary counts. Available online at: https://www2.census.gov/library/publications/decennial/1950/pc-02/pc-2-27.pdf 2021.
   Google Scholar
• U.S. Census Bureau, 2019, Population estimates. Available online at: https://www.census.gov/quickfacts/fact/table/humphreyscountymississippi/holmescountymississippi/POP060210 2021.
   Google Scholar
• USEPA (United States Environmental Protection Agency), 1998, Method 3545A: Pressurized Fluid Extraction (PFE). Available online at: https://www.epa.gov/homelandsecurity-research/method-3545a-sw-846-pressurized-fluidextraction-pfe
   Google Scholar
• USEPA (United States Environmental Protection Agency), 2007, Method 8018B: Organochlorine Pesticides by Gas Chromatography. Available online at: https://www.epa.gov/sites/default/files/2015-12/documents/8081b.pdf
   Google Scholar
• Eden, P.R., Meek, E.C., Wills, R.W., Olsen, E.V., Crow, J.A. and Chambers, J.E., 2016, Association of type 2 diabetes mellitus with plasma organochlorine compound concentrations. Journal of Exposure Science & Environmental Epidemiology 26, 207–213. doi: 10.1038/jes.2014.69.
   PubMed Web of Science ®Google Scholar
• Richter, R.J. and Furlong, C.E., 1999, Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 9, 745–753. doi: 10.1097/00008571-199912000-00009.
   PubMedGoogle Scholar
• Davis, K.A., Crow, J.A., Chambers, H.W., Meek, E.C. and Chambers, J.E., 2009, Racial differences in paraoxonase-1 (PON1): A factor in the health of Southerners? Environmental Health Perspectives 117, 1226–1231. doi: 10.1289/ehp.0900569.
   PubMed Web of Science ®Google Scholar
• Coombes, R.H., Crow, J.A., Dail, M.B., Chambers, H.W., Wills, R.W. and Bertolet, B.D., et al., 2011, Relationship of human paraoxonase-1 (PON1) serum activity and genotype with atherosclerosis in individuals from the deep South. Pharmacogenetics and Genomics 21, 867–875. doi: 10.1097/FPC.0b013e32834cebc6.
   PubMed Web of Science ®Google Scholar
• McDaniel, C.Y., Dail, M.B., Wills, R.W., Chambers, H.W. and Chambers, J.E., 2014, Paraoxonase 1 polymorphisms within a Mississippi USA population as possible biomarkers of enzyme activities associated with disease susceptibility. Biochemical Genetics 52, 509–523. doi: 10.1007/s10528-014-9663-8.
   PubMed Web of Science ®Google Scholar
• Benjamini, Y. and Hochberg, Y., 1995, Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society: Series B (Statistical Methodology) 57, 289–300. doi: 10.1111/j.2517-6161.1995.tb02031.x.
   Web of Science ®Google Scholar
• Zhang, C., Liu, L., Ma, Y. and Li, F., 2018, Using isomeric and metabolic ratios of DDT to identify the sources and fate of DDT in Chinese agricultural topsoil. Environmental Science & Technology 52, 1990–1996. doi: 10.1021/acs.est.7b05877.
   PubMed Web of Science ®Google Scholar
• CDC (Centers for Disease Control and Prevention), 2021, Volume 3: Analysis of pooled serum samples for select chemicals, NHANES 2005-2016, fourth national report on human exposure to environmental chemicals, updated tables. US Dept of Health and Human Services.
   Google Scholar
• Mayo Clinic, 2021, HDL cholesterol: How to boost your ‘good’ cholesterol. Available online at: http://www.mayoclinic.org/diseases-conditions/high-bloodcholesterol/in-depth/hdl-cholesterol/art-20046388
   Google Scholar
• Mayo Clinic, 2022, Triglycerides: Why do they matter? Available online at: https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/triglycerides/art-20048186/mc_id=us&utm_source=newsnetwork&utm_medium=l&utm_content=content&utm_campaign=mayoclinic&geo=national&placementsite=enterprise&cauid=100721
   Google Scholar
• Wolff, M.S., Britton, J.A., Teitelbaum, S.L., Eng, S., Deych, E. and Ireland, K., et al., 2005, Improving organochlorine biomarker models for cancer research. Cancer Epidemiology, Biomarkers and Prevention 14, 2224–2236. doi: 10.1158/1055-9965.EPI-05-0173.
   PubMed Web of Science ®Google Scholar
• Jugan, J., Lind, P.M., Salihovic, S., Stubleski, J., Kärrman, A. and Lind, L., et al., 2020, The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content. Lipids in Health and Disease 19, 249. doi: 10.1186/s12944-020-01417-1.
   PubMed Web of Science ®Google Scholar
• White, U.A., Fitch, M.D., Beyl, R.A., Hellerstein, M.K. and Ravussin, E., 2018, Racial differences in in vivo adipose lipid kinetics in humans. Journal of Lipid Research 59, 1738–1744. doi: 10.1194/jlr.P082628.
   PubMed Web of Science ®Google Scholar
• Metcalf, P.A., Sharrett, A.R., Folsom, A.R., Duncan, B.B., Patsch, W. and Hutchinson, R.G., et al., 1998, African American-white differences in lipids, lipoproteins, and apolipoproteins, by educational attainment, among middle-aged adults: The atherosclerosis risk in communities study. American Journal of Epidemiology 148, 750–760. doi: 10.1093/oxfordjournals.aje.a009696.
   PubMed Web of Science ®Google Scholar
• Ward, A.B., Dail, M.B. and Chambers, J.E., 2016, In vitro effect of DDE exposure on the regulation of lipid metabolism and secretion in McA-RH7777 hepatocytes: A potential role in dyslipidemia which may increase the risk of type 2 diabetes mellitus. Toxicology in Vitro 37, 9–14. doi: 10.1016/j.tiv.2016.08.011.
   PubMed Web of Science ®Google Scholar
• Albrink, M.J. and Man, E.B., 1958, Serum triglycerides in health and diabetes. Diabetes 7, 194–201. doi: 10.2337/diab.7.3.194.
   PubMed Web of Science ®Google Scholar
• Voorspoels, S., Covaci, A., Maervoet, J. and Schepens, P., 2002, Relationship between age and levels of organochlorine contaminants in human serum of a Belgian population. Bulletin of Environmental Contamination and Toxicology 69, 22–29. doi: 10.1007/s00128-002-0004-y.
   PubMed Web of Science ®Google Scholar
• Hue, O., Marcotte, J., Berrigan, F., Simoneau, M., Dore´, J. and Marceau, P., et al., 2007, Plasma concentration of organochlorine compounds is associated with age and not obesity. Chemosphere 67, 1463–1467. doi: 10.1016/j.chemosphere.2006.10.033.
   PubMed Web of Science ®Google Scholar
• CDC (Centers for Disease Control and Prevention), 2020, Prevalence of obesity and severe obesity among adults: United States, 2017-2018. National Center for Health Statistics Data Brief No. 360.
   Google Scholar
• CDC (Centers for Disease Control and Prevention), 2021, Diabetes tests. Available online at: https://www.cdc.gov/diabetes/basics/getting-tested/html
   Google Scholar
• Kim, S.-A., Kim, K.-S., Lee, Y.-M., Jacobs, D.R. and Lee, D.-H., 2015, Associations of organochlorine pesticides and polychlorinated biphenyls with total, cardiovascular, and cancer mortality in elders with differing fat mass. Environmental Research 138, 1–7. doi: 10.1016/j.envres.2015.01.021.
   PubMed Web of Science ®Google Scholar
• Lee, D.-H., Porta, M., Jacobs Jr, D.R. and Vandenberg, L.N., 2014, Chlorinated persistent organic pollutants, obesity, and Type 2 diabetes. Endocrine Reviews 35, 557–601. doi: 10.1210/er.2013-1084.
   PubMed Web of Science ®Google Scholar
• Scheen, A.J., 2005, Diabetes mellitus in the elderly: Insulin resistance and/or impaired insulin secretion? Diabetes Metabolism 31, 5S27–34. doi: 10.1016/S1262-3636(05)73649-1.
   PubMed Web of Science ®Google Scholar
• Furlong, C.E., Richter, R.J., W-F, L., Brophy, V.H., Carlson, C. and Reider, M., et al., 2008, The functional consequences of polymorphisms in the human PON1 gene, In: B. Mackness, M. Mackness, M. Aviram and G. Paragh (Eds) The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (Dordrecht: Springer), pp. 267–281.
   Google Scholar
• Mackness, B., Mackness, M.I., Arrol, S., Turkie, W. and Durrington, P.N., 1998, Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification. Federation of European Biochemical Societies Letters 423, 57–60. doi: 10.1016/S0014-5793(98)00064-7.
   PubMed Web of Science ®Google Scholar
• Lee, D.-H., Steffes, M.W., Sjödin, A., Jones, R.S., Needham, L.L. and Jacobs Jr, D.R., 2010, Low dose of some persistent organic pollutants predicts type 2 diabetes: A nested case–control study. Environmental Health Perspectives 118, 1235–1242. doi: 10.1289/ehp.0901480.
   PubMed Web of Science ®Google Scholar
• Carpenter, D.O., 2008, Environmental contaminants as risk factors for developing diabetes. Reviews on Environmental Health 23, 59–74. doi: 10.1515/REVEH.2008.23.1.59.
   PubMedGoogle Scholar
• Howell III, G. and Mangum, L., 2011, Exposure to bioaccumulative organochlorine compounds alters adipogenesis, fatty acid uptake, and adipokine production in NIH3T3-L1 cells. Toxicology in Vitro 25, 394–402. doi: 10.1016/j.tiv.2010.10.015.
   PubMed Web of Science ®Google Scholar
• Howell III, G.E., Meek, E., Kilic, J., Mohns, M., Mulligan, C. and Chambers, J.E., 2014, Exposure to p,p′-dichlorodiphenyldichloroethylene (DDE) induces fasting hyperglycemia without insulin resistance in male C57BL/6H mice. Toxicology 320, 6–14. doi: 10.1016/j.tox.2014.02.004.
   PubMed Web of Science ®Google Scholar
• Howell, G.E., Mulligan, C., Meek, E. and Chambers, J.E., 2015, Effect of chronic p,p´-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice. Toxicology 328, 112–122. doi: 10.1016/j.tox.2014.12.017.
   PubMed Web of Science ®Google Scholar
• Mangum, L.H., Howell III, G.E. and Chambers, J.E., 2015, Exposure to p,p′-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation. Toxicology Lettersrs 238, 65–71. doi: 10.1016/j.toxlet.2015.07.009.
   PubMed Web of Science ®Google Scholar
• Mangum, L.H., Crow, J.A., Stokes, J.V., Howell III, G.E., Ross, M.K. and Pruett, S.B., et al., 2016, Exposure to p,p′-DDE alters macrophage reactivity and increases macrophage numbers in adipose stromal vascular fraction. Toxicological Sciences 150, 169–177. doi: 10.1093/toxsci/kfv315.
   PubMed Web of Science ®Google Scholar
• Ward, A.B., Dail, M.B. and Chambers, J.E., 2021, In vitro effect of DDE exposure on the regulation of B-TC-6 pancreatic beta cell insulin secretion: A potential role in beta cell dysfunction and type 2 diabetes mellitus. Toxicology Mechanisms and Methods 31, 667–673. doi: 10.1080/15376516.2021.1950251.
   PubMed Web of Science ®Google Scholar
• Pauza, A.G., Thakkar, P., Tasic, T., Felippe, I., Bishop, P. and Greenwood, M.P., et al., 2022, GLP1R attenuates sympathetic response to high glucose via carotid body inhibition. Circulation Research 130, 694–707. doi: 10.1161/CIRCRESAHA.121.319874.
   PubMed Web of Science ®Google Scholar