Advanced search
Publication Cover
International Journal of Neuroscience Volume 112, 2002 - Issue 10
Submit an article Journal homepage
22
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Brief Clinical Report DOES LONG-TERM USE OF VALPROATE CAUSE WEIGHT GAIN IN PREPUBERTAL EPILEPTIC CHILDREN?

HÜSEYIN ÇAKSEN Department of Pediatrics Faculty of Medicine Yüzüncü Yil University Van, Turkey
,
GÜLHIS DEDA Department of Pediatrics Faculty of Medicine Ankara University Ankara, Turkey
&
MERIH BERBEROGLU Department of Pediatrics Faculty of Medicine Ankara University Ankara, Turkey
Pages 1183-1189 | Published online: 07 Jul 2009

  • Aicardi, J., Bax, M., Gillberg, C. & Ogier. H. (1998). Diseases of nervous system in childhood. Lonon: Mac Keith Press.
  • Breum, I., Astrup, A., Grain, L., Andersen, T., Slokholm, K. H., Christensen. N. J., Werdelin, L., & Madsen, J. (1992). Metabolic changes during treatment with valproate in humans: Implication for untoward weight gain. Metabolisum. 41, 666-670.
  • Brodersen, R., Jorgensen, N., Vorum, H., & Krukow, N. (1991). Valproate and palmilate binding to human serum albumin: An hypothesis on obesity. Molecular Pharmacology. 37, 704-709.
  • Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., & Caro, J. F. (1996). Serum immunoreactive leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, 334, 292-295.
  • Corman, C. L., Leung, N. M., & Guberman, A. H. (1997). Weight gain in epileptic patients during treatment with valproic acid: A retrospcetive study. Cannadian Journal of Neurological Science, 24, 240-244.
  • Covanis, A., Gupta, A. K., & Jeavons, PM. (1982). Sodium valproate: Monotherapy and polytherapy. Epilepsia, 23, 693-720.
  • Demir, E., & Aysun, S. (2000). Weight gain associated with valproate in childhood. Pediatric Neurology, 22, 361-364.
  • Dinesen, H., Gram, L., Andersen, T., & Dam, M. (1984). Weight gain during treatment with valproate. Acta Neurologica Scandiavica, 69, 65-69.
  • Easter, D., O'Bryan-Tear, C. G., & Verity, C. (1997). Weight gain with valproate or carhamazopine--a reappraisal. Seizare. 6, 121-125.
  • Egger, J., & Brett, E.M. (1981). Effects of sodium valproate in 100 children with special reference to weight. British Medical Journal (Clinical Research), 283, 577-581.
  • Haslant, R. H. A. (2000). The nervous system. In R. E Behrman, R. M. Kliegman, & H. B. Jenson (Eds.). Testbook of pediutrics (16th ed., pp 1793-1866). Philadelphia: WB Saunders Co.
  • Isojarvi, J. L., Laatikainen, T. J., Knip, M., Pakarinen, A. J., Jantunen, K. T., & Myllyla, V. V. (1996). Obesity and endocrine diseases in women taking valproate for epilepsy. Annals of Neurology, 39, 579-584
  • Isojarvi, J. L, Laatikainen, T. J., Pakarinen, A. J., Jumunen, K. T., & Myllyla, V. V. (1993). Polycystic osaries and hyperandrogenism in women taking valproate for epilepsy. New England Journal of Medicine, 329, 1383-1388.
  • Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei. H., Kim, S., Laflone, R., Ranganathan, S., et al. (1995). Leptin levels in human and rodent: Measurement of plasma leptin and oh RNA in obese and weight-reduced subjects. Nature Meicine, 1, 1155-1161.
  • Mantzoros, C., S., & Moscho, S. J. (1998). Leptin: In search of rolets) in human physiology and pathophysiology. Clinial Endocrinology, 49, 551-567.
  • Marshall, W. A., & Tanner, J. M. (1969). Variations in pattern of pubertal changes in girls. Archives of Diseases in Childhood. 44, 291-303.
  • Novak, G. P., Maytal, J., Alsbansky, A., Eviatar, L., Sy-Khu, R., & Siddique, Q. (1999). Risk of excessive weight gain in epileptic children treated with valproate. Journal of Child Neurology, 14, 490-495.
  • Rogiers, V., Vandenberghe, Y., & Vercruysse, A. (1985). Inhibition of gluconcogenesis by sodium valproate and its metabolites in rat hepatocytes. Xeaobiotica, 15, 759-765.
  • Verrotti, A., Basciani, F., Morresi, S., de Martino, M., Morgese, G., & Chiarelli, F. (1999). Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. Neurology, 53, 230-232.
  • Vorum, H., Gram, L., & Honore, B. (1993). Valproate and palntitate binding to serum albumin in valproate-treated patients: Relation to obesity. Epilepxy Research, 16, 55-64.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.