Advanced search
Publication Cover
International Journal of Neuroscience Volume 113, 2003 - Issue 7
Submit an article Journal homepage
96
Views
70
CrossRef citations to date
0
Altmetric
Research Article

AUTOLOGOUS ADULT BONE MARROW STEM CELL TRANSPLANTATION IN AN ANIMAL MODEL OF HUNTINGTON'S DISEASE: BEHAVIORAL AND MORPHOLOGICAL OUTCOMES

LAURENT LESCAUDRON INSERM UMR 437, Institut de Transplantation et de Recherche en Transplantation, CHU Hôtel Dieu and Service de Physiologie Animale, Faculté des Sciences et des Techniques, Université de Nantes, France; and Brain Research and Integrative Neuroscience Center, Department of Psychology, Central Michigan University, Mt. Pleasant, Michigan, USA
,
DIVYA UNNI Brain Research and Integrative Neuroscience Center, Department of Psychology, Central Michigan University, Mt. Pleasant, Michigan, USA
&
GARY L. DUNBAR Brain Research and Integrative Neuroscience Center, Department of Psychology, Central Michigan University, Mt. Pleasant, Michigan, USA
Pages 945-956 | Published online: 07 Jul 2009

  • Bachoud-Levi, A. C., Remy, P., Nguyen, J. P., Brugieres, P., Lefaucheur, J. P., Bourdet, C, Baudic, S., Gaura, V., Maison, P., Haddad, B., Boisse, M. F., Grandmougin, T., Jeny, R., Bartolomeo, P., Dalla Barba, G., Degos, J. D., Lisovoski, F., Ergis, A. M., Pailhous, E., Cesaro, P., Hantraye, P., & Peschanski, M. (2000). Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet, 356, 1975-1979.
  • Boheler, K. R., & Fiszman, M. Y. (1999). Can exogenous stem cells be used in transplantation? Cells Tissues and Organs, 65(3-4), 237-245.
  • Brazelton, T. R., Fabio, M., Rossi, V., Keshet, G. L., & Blau, H. M. (2000). From marrow to brain: Expression of Neuronal Phenotypes in adult mice. Science, 290, 1775-1779.
  • Butters, N., Salmon, D., & Heindel, W. C. (1994). Specificity of the memory deficits associated with basal ganglia dysfunction. Revue Neurologique, 150(8-9), 530-567.
  • Diamond, R., White, R. F., Myers, R. H., Mastromauro, C., Koroshetz, W. J., Butters, N., Rothstein, D. M., Moss, M. B., & Vasterling, J. (1992). Evidence of presymptomatic cognitive decline in Huntington's disease. Journal of Clinical and Experimental Neuropsychology, 14(6), 961-975.
  • Ekblom, M., Fassler, R., Tomasini-Johansson, B., Nilsson, K., & Ekblorn, P. (1993). Downregulation of tenascin expression by glucocorticoids in bone marrow stromal cells and in fibroblasts. Journal of Cellular Biology. 123, 1037-1045.
  • Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J., Aldrich, S., Lisberg, A.,Low, W. C., Largaespada, D. A., & Verfaillie, C. (2002). Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 418(6893), 41-49.
  • Freeman, T. B., Cicchetti, F., Hauser, R. A., Deacon, T. W., Li, X. J., Hersch, S. M., Nauert, G. M., Sanberg, P. R., Kordower, J. H., Saporta, S., & Isacson, O. (2000). Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceeding of National Academy of Sciences U.S.A., 97(25), 13877-13882.
  • Lawrence, A. D., Sahakian, B. J., Hodges J. R., Rosser, A. E., Lange, K. W., & Robbins, T. W. (1996). Executive and mnemonic functions in early Huntington's disease. Brain, 119, 1633-1645.
  • Lev, P. R., Marta, R. F., Vassalu, P., & Molinas, P. C. (2002). Variation of PDGR, TGFbeta, and bFGF levels in essential thrombocythemia patients treated with anagrehde. American Journal of Hematology, 70, 85-91.
  • Mahmood, A., Lu, D., Yi, L., Chen, J. L., & Chopp, M. (2001). Intracranial bone marrow transplantation after traumatic brain injury improving functional outcome in adult rats. Journal of Neurosurgery, 94(4), 589-595.
  • Maysinger, D., Berezovskaya, O., & Fedoroff, S. (1996). The hematopoietic cytokine colony stimulating factor 1 is also a growth factor in the CNS: (II). Microencapsulated CSF1 and LM-IO cells as delivery systems. Experimental Neurology, 1141, 47-56.
  • Mehlier, M. R, Rozental, R., Dougherty, M., Spray, D. C., & Kessler, J. A. (1993). Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature, 362, 62-65.
  • Mezey, E., Chandross, K. J., Harta, G., Maki, R. A., & McKercher, S. R. (2000). Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow. Science, 290(5497), 1779-1782.
  • Moore, M. A. (2002). Cytokine and chemokine networks influencing stern cell proliferation, differentiation, and marrow homing. Journal of Cellular Biochemistry, Supplement 38, 29-38.
  • Nardi, N. B., & Alfonso, Z. Z. (1999). The hematopoietic stroma. Brazilian Journal of Medicine and Biological Research, 32(5), 601-609.
  • Priller, J., Persons, D. A., Klett, F.F., Kempermann, G., Kreutzberg, G. W., & Dirnagl, U. (2001). Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. Journal of Cellular Biology, 155, 733-738.
  • Prockop, D. J. (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science, 276(5309), 71-74.
  • Sanchez-Ramos, J., Song, S., Cardozo-Pelaez, F., Hazzi, C., Stedeford, T., Willing A., Freeman, T. B., Saporta, S., Janssen, W., Patel, N., Cooper, D. R., & Sandberg, P. R. (2000). Adult bone marrow stromal cells differentiate into neural cells in vitro. Experimental Neurology, 164, 247-256.
  • Shear, D. A., Dong, J., Haik-Creguer, K., Bazzett, T. J., Albin, R. L., & Dunbar, G. L. (1998). Chronic administration of quinolinic acid in the rat striatum causes spatial learning deficits in a radial arm water maze task. Experimental Neurology, 150, 305-311.
  • Shiwach, R. (1994). Psychopathology in Huntington's disease patients. Acta Psychiatrica Scandinavica, 90(4), 241-246.
  • Woodbury, D., Schwarz, E. J., Prockop, D. J., & Black, I. B. (2000). Adult rat and human bone marrow stromal cells differentiate into neurons. Journal of Neuroscience Research, 61, 364-370.
  • Zhao, L. R., Duan, W. M., Reyes, M., Keene, D., Verfaillie, C. M., & Low, W. C. (2002). Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Experimental Neurology, 174, 11-20.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.