Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury induced by traumatic brain injury – via endothelial nitric oxide synthase pathway regulation

References

• Feigin VL, Theadom A, Barker-Collo S, et al. Incidence of traumatic brain injury in New Zealand: a population-based study. Lancet Neurol. 2013;12:53–64.
   PubMed Web of Science ®Google Scholar
• Alluri H, Wiggins-Dohlvik K, Davis, ML, et al. Blood-brain barrier dysfunction following traumatic brain injury. Metab Brain Dis. 2015;30:1093–1104.
   PubMed Web of Science ®Google Scholar
• Lo EH, Rosenberg GA. The neurovascular unit in health and disease: introduction. Stroke. 2009;40 (3):S2–S3.
   PubMed Web of Science ®Google Scholar
• Lan R, Xiang J, Zhang Y, et al. PI3K/Akt pathway contributes to neurovascular unit protection of xiao-xu-ming decoction against focal cerebral ischemia and reperfusion injury in rats. Evid Based Complement Alternat Med. 2013;2013:459467.
   PubMed Web of Science ®Google Scholar
• Tao XG, Shi JH, Hao SY, et al. Protective effects of calpain inhibition on neurovascular unit injury through downregulating nuclear factor-κB-related inflammation during traumatic brain injury in mice. Chin Med J (Engl). 2017;130:187–198.
   PubMed Web of Science ®Google Scholar
• Bouzat P, Millet A, Boue Y, et al. Changes in brain tissue oxygenation after treatment of diffuse traumatic brain injury by erythropoietin. Crit Care Med. 2013;41:1316–1324.
   PubMed Web of Science ®Google Scholar
• Lok J, Wang XS, Xing CH, et al. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015;21:304–308.
   PubMed Web of Science ®Google Scholar
• Jullienne A, Badaut J. Molecular contributions to neurovascular unit dysfunctions after brain injuries: lessons for target-specific drug development. Future Neurol. 2013;8:677–689.
   PubMedGoogle Scholar
• Khan M, Im YB, Shunmugavel A, et al. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation. 2009;6:32.
   PubMed Web of Science ®Google Scholar
• Cherian L, Hlatky R, Robertson CS. Nitric oxide in traumatic brain injury. Brain Pathol. 2014;14:195–201.
   Web of Science ®Google Scholar
• Hall ED, Wang JA, Miller DM. Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury. Exp Neurol. 2012;238:176–182.
   PubMed Web of Science ®Google Scholar
• Rochette L, Lorin J, Zeller M, et al. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets? Pharmacol Ther. 2013;140:239–257.
   PubMed Web of Science ®Google Scholar
• Lu J, Wu DB, Zheng YL, et al. NGF-Dependent activation of TrkA pathway: a mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice. Brain Pathol. 2010;20:952–965.
   PubMed Web of Science ®Google Scholar
• Lu J, Wu DM, Zheng ZH, et al. Troxerutin protects against high cholesterol-induced cognitive deficits in mice. Brain. 2011;134:783–797.
   PubMed Web of Science ®Google Scholar
• Lu JDM. Wu, YL. Zheng Y, et al. Troxerutin counteracts domoic acid-induced memory deficits in mice by inhibiting CCAAT/enhancer binding protein β-mediated inflammatory response and oxidative stress. J Immunol. 2013;190:3466–3479.
   PubMed Web of Science ®Google Scholar
• Mellou F, Loutrari H, Stamatis H, et al. Enzymatic esterification of flavonoids with unsaturated fatty acids: effect of the novel esters on vascular endothelial growth factor release from K562 cells. Process Biochem. 2006;41:2029–2034.
   Web of Science ®Google Scholar
• Jang JW, Lee JK, Hur H, et al. Rutin improves functional outcome via reducing the elevated matrix metalloproteinase-9 level in a photothrombotic focal ischemic model of rats. J Neurol Sci. 2014;339:75–80.
   PubMed Web of Science ®Google Scholar
• Kim H, Kong H, Choi B, et al. Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. Pharmac Res. 2005;22:1499–1509.
   PubMed Web of Science ®Google Scholar
• Gu XH, Xu LJ, Liu ZQ, et al. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease. Behav Brain Res. 2016;311:309–321.
   PubMed Web of Science ®Google Scholar
• Gupta R, Singh M, Sharma A. Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. Pharmacol Res. 2003;48:209–215.
   PubMed Web of Science ®Google Scholar
• Agrawal R, Noble E, Tyagi E, et al. Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation. Biochim Biophys Acta. 2015;1852:862–872.
   PubMed Web of Science ®Google Scholar
• Kumar A, Rinwa P, Dhar H. Possible nitric oxide modulation in the protective effects of rutin against experimental head trauma-induced cognitive deficits: behavioral, biochemical, and molecular correlate. J Surg Res. 2014;188:268–279.
   PubMed Web of Science ®Google Scholar
• Machawal L, Kumar A. Possible involvement of nitric oxide mechanism in the neuroprotective effect of rutin against immobilization stress induced anxiety like behaviour, oxidative damage in mice. Pharmacol Rep. 2014;66:15–21.
   PubMed Web of Science ®Google Scholar
• Feeney DM, Boyeson MG, Linn RT, et al. Responses to cortical injury: I. methodology and local effects of contusions in the rat. Brain Res. 2011;211:66–67.
   Web of Science ®Google Scholar
• Wei W, Wang H, Yong W, et al. Alpha lipoic acid inhibits neural apoptosis via a mitochondrial pathway in rats following traumatic brain injury. Neurochem Int. 2015;87:85–91.
   PubMed Web of Science ®Google Scholar
• Flierl MA, Stahel PF, Beauchamp KM, et al. Mouse closed head injury model induced by a weight-drop device. Nat Protoc. 2009;4:1328–1337.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zou H, Zhang Q, et al. Effects of Xiaoshuan enteric-coated capsule on neurovascular functions assessed by quantitative multiparametric MRI in a rat model of permanent cerebral ischemia. BMC Complement Altern Med. 2016;16:198.
   PubMed Web of Science ®Google Scholar
• Zhuang Z, Zhou ML, You WC, et al. Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci. 2012;13:47.
   PubMed Web of Science ®Google Scholar
• Zhao H, Wu H, He J, et al. Frontal cortical mitochondrial dysfunction and mitochondria-related β-amyloid accumulation by chronic sleep restriction in mice. Neuroreport. 2016;27:916–922.
   PubMed Web of Science ®Google Scholar
• Du H, Guo L, Yan S, et al. Early deficits in synaptic mitochondria in an Alzheimer’s disease mouse model. Proc Natl Acad Sci USA. 2010;107:18670–18675.
   PubMed Web of Science ®Google Scholar
• Yemisci M, Gursoy-Ozdemir Y, Vural A, et al. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med. 2009;15: 1031–1037.
   PubMed Web of Science ®Google Scholar
• Dong S, Tong X, Li J, et al. Total flavonoid of Litsea coreana leve exerts anti-oxidative effects and alleviates focal cerebral ischemia/reperfusion injury. Neural Regener Res. 2013;8:3193–3202.
   PubMed Web of Science ®Google Scholar
• Zhai X, Ding Y, Wang Q, et al. Rutin acid ameliorates neural apoptosis induced by traumatic brain injury via mitochondrial pathways in mice. Neuroimmunomodulation. 2016;23:179–187.
   PubMed Web of Science ®Google Scholar
• Khan MM, Ahmad A, Ishrat T, et al. Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res. 2009;1292:123–135.
   PubMed Web of Science ®Google Scholar
• Zhu W, Khachi S, Hao Q, et al. Upregulation of EMMPRIN after permanent focal cerebral ischemia. Neurochem Int. 2008;52:1086–1091.
   PubMed Web of Science ®Google Scholar
• Meng XE, Zhang Y, Li YN, et al. Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury. Genet Mol Res. 2016;15:15016933.
   Web of Science ®Google Scholar
• Voigt C, Donat CK, Hartig W, et al. Effect of leukotriene inhibitors on evolution of experimental brain contusions. Neuropathol Appl Neurobiol. 2012;38:354–366.
   PubMed Web of Science ®Google Scholar
• Khan M, Sakakima H, Dhammu TS, et al. S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J Neuroinflammation. 2011;8:78.
   PubMed Web of Science ®Google Scholar
• Zhao Z, Nelson AR, Betsholtz C, et al. Establishment and dysfunction of the blood-brain barrier. Cell. 2015;163:1064–1078.
   PubMed Web of Science ®Google Scholar
• Thal SC, Luh C, Schaible EV, et al. Volatile anesthetics influence blood-brain barrier integrity by modulation of tight junction protein expression in traumatic brain injury. PLoS One. 2012;7:e50752.
   PubMed Web of Science ®Google Scholar
• Wang XY, Song MM, Bi SX, et al. MRI dynamically evaluates the therapeutic effect of recombinant human MANF on ischemia/reperfusion injury in rats. Int J Mol Sci. 2016;17:1476.
   PubMed Web of Science ®Google Scholar
• Ugusman A, Zakaria Z, Chua KH, et al. Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells. Sci World J. 2014;2014:169370.
   Web of Science ®Google Scholar