References
- Quintero GC. Advances in cortical modulation of pain. J Pain Res. 2013;6:713–725.
- Turk Dennis C, Swanson Kimberly S, Wilson Hillary D. Psychological aspects of pain. In: Ballantyne JC, Fishman SM, editors. Bonica's management of pain. Baltimore: Lippincott, Williams and Wilkins; 2010. p. 100-120.
- Xie YF, Huo FQ, Tang JS. Cerebral cortex modulation of pain. Acta Pharmacol Sin. 2009;30:31–41.
- Xie YF, Wang J, Huo FQ, et al. Mu but not delta and kappa opioid receptor involvement in ventrolateral orbital cortex opioid-evoked antinociception in formalin test rats. Neuroscience. 2004;126:717–726.
- Xie YF, Zhang S, Chiang CY, et al. Involvement of glia in central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn). Brain Behav Immun. 2007;21:634–641.
- Xie YF. Glial involvement in trigeminal central sensitization. Acta Pharmacol Sin. 2008;29:641–645.
- Ji RR, Chamessian A, Zhang YQ. Pain regulation by non-neuronal cells and inflammation. Science. 2016;354:572–577.
- Salter MW. Cellular neuroplasticity mechanisms mediating pain persistence. J Orofac Pain. 2004;18:318–324.
- Benyamin R, Trescot AM, Datta S et al. Opioid complications and side effects. Pain Phys. 2008;11:S105–S120.
- Wiffen PJ, Wee B, Derry S, et al. Opioids for cancer pain—an overview of Cochrane reviews. Cochrane Database Syst Rev. 2017;7:CD012592.
- Bell RF, Eccleston C, Kalso EA. Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst Rev. 2017;6:CD003351.
- Vadivelu N, Schermer E, Kodumudi V, et al. Role of ketamine for analgesia in adults and children. J Anaesthesiol Clin Pharmacol . 2016;32:298–306.
- Ochoa V, Garcia Perdomo HA. Efficacy of Botulinum toxin A for the treatment of Bladder pain syndrome: a systematic review. Actas Urol Esp. 2018;42:152–162.
- Turnaturi R, Arico G, Ronsisvalle G, et al. Multitarget opioid/non-opioid ligands: a potential approach in pain management. Curr Med Chem. 2016;23:4506–4528.
- Stella N, Schweitzer P, Piomelli D. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997;388:773–778.
- Starowicz K, Di MV. Non-psychotropic analgesic drugs from the endocannabinoid system: "magic bullet" or "multiple-target" strategies? Eur J Pharmacol. 2013;716:41–53.
- Zhang X, Maor Y, Wang JF, et al. Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator. Br J Pharmacol. 2010;160:1583–1594.
- Jardin I, Lopez JJ, Diez R et al. TRPs in pain sensation. Front Physiol. 2017;8:392.
- Sorge RE, Mapplebeck JC, Rosen S et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015;18:1081–1083.
- Yamamoto M, Nishiyama M, Iizuka S et al. Transient receptor potential vanilloid 1-immunoreactive signals in murine enteric glial cells. World J Gastroenterol. 2016;22:9752–9764.
- Rycerz K, Krawczyk A, Jaworska-Adamu J, et al. Immunoreactivity of arcuate nucleus astrocytes in rats after intragastric administration of habanero peppers (Capsicum Chinese Jacq.). Pol J Vet Sci. 2016;19:809–817.
- Nam JH, Park ES, Won SY et al. TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF. Brain. 2015;138:3610–3622.
- Mannari T, Morita S, Furube E, et al. Astrocytic TRPV1 ion channels detect blood-borne signals in the sensory circumventricular organs of adult mouse brains. Glia. 2013;61:957–971.
- Luongo L, Maione S, Di MV. Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions. Eur J Neurosci. 2014;39:401–408.
- Howlett AC, Bidaut-Russell M, Devane WA, et al. The cannabinoid receptor: biochemical, anatomical and behavioral characterization. Trends Neurosci. 1990;13:420–423.
- Pirone A, Lenzi C, Coli A, et al. Preferential epithelial expression of type-1 cannabinoid receptor (CB1R) in the developing canine embryo. Springerplus. 2015;4:804.
- Matias I, Bisogno T, Di MV. Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. Int J Obes. (Lond.). 2006;30(Suppl 1):S7–S12.
- Mukhopadhyay P, Batkai S, Rajesh M et al. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol. 2007;50:528–536.
- Galiegue S, Mary S, Marchand J et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 1995;232:54–61.
- Rajesh M, Mukhopadhyay P, Batkai S et al. CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol. 2007;293:H2210–H2218.
- Fede C, Albertin G, Petrelli L et al. Expression of the endocannabinoid receptors in human fascial tissue. Eur J Histochem. 2016;60:2643.
- Salio C, Doly S, Fischer J, et al. Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord. Neurosci Lett. 2002;329:13–16.
- Hegyi Z, Hollo K, Kis G, et al. Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats. Glia. 2012;60:1316–1329.
- Kovacs A, Bordas C, Biro T et al. Direct presynaptic and indirect astrocyte-mediated mechanisms both contribute to endocannabinoid signaling in the pedunculopontine nucleus of mice. Brain Struct Funct. 2017;222:247–266.
- Devane WA, Axelrod J. Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc Natl Acad Sci USA. 1994;91:6698–6701.
- Basavarajappa BS. Critical enzymes involved in endocannabinoid metabolism. Protein Pept Lett. 2007;14:237–246.
- Nasirinezhad F, Jergova S, Pearson JP, et al. Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. Neuropharmacology. 2015;95:100–109.
- Munawar N, Oriowo MA, Masocha W. Antihyperalgesic activities of endocannabinoids in a mouse model of antiretroviral-induced neuropathic pain. Front Pharmacol. 2017;8:136.
- Tomic MA, Pecikoza UB, Micov AM, et al. The efficacy of eslicarbazepine acetate in models of trigeminal, neuropathic, and visceral pain: the involvement of 5-HT1B/1D serotonergic and CB1/CB2 cannabinoid receptors. Anesth Analg. 2015;121:1632–1639.
- Wilkerson JL, Gentry KR, Dengler EC et al. Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain. 2012;153:1091–1106.
- McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7:e31758.
- Han H, Liang X, Wang J et al. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation. Brain Res. 2017;1663:132–140.
- Wang TC, Wang J, Xu X, et al. Tonic modulation of nociceptive behavior and allodynia by cannabinoid receptors in formalin test in rats. Chin J Physiol. 2015;58:72–78.
- Luongo L, Guida F, Boccella S et al. Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice. CNS Neurol Disord Drug Targets. 2013;12:45–54.
- Krustev E, Muley MM, McDougall JJ. Endocannabinoids inhibit neurogenic inflammation in murine joints by a non-canonical cannabinoid receptor mechanism. Neuropeptides. 2017;64:131–135.
- Almeida RT, Romero TR, Romero MG, et al. Endocannabinoid mechanism for orofacial antinociception induced by electroacupuncture in acupoint St36 in rats. Pharmacol Rep. 2016;68:1095–1101.
- Nozaki C, Markert A, Zimmer A. Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. Eur Neuropsychopharmacol. 2015;25:1388–1396.
- Azim S, Nicholson J, Rebecchi MJ et al. Endocannabinoids and acute pain after total knee arthroplasty. Pain. 2015;156:341–347.
- Gajofatto A. Refractory trigeminal neuralgia responsive to nabiximols in a patient with multiple sclerosis. Mult Scler Relat Disord. 2016;8:64–65.
- Silva GD, Lopes PS, Fonoff ET et al. The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain? J Neuroinflammation. 2015;12:10.
- Malek N, Popiolek-Barczyk K, Mika J, et al. Anandamide, acting via CB2 receptors, alleviates LPS-induced neuroinflammation in rat primary microglial cultures. Neural Plast. 2015;2015:130639.
- Guasti L, Richardson D, Jhaveri M et al. Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. Mol Pain. 2009;5:35.
- Lopez-Rodriguez AB, Siopi E, Finn DP et al. CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice. Cereb Cortex. 2015;25:35–45.
- Fernandez-Trapero M, Espejo-Porras F, Rodriguez-Cueto C et al. Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis. Dis Model Mech. 2017;10:551–558.
- Koszeghy A, Kovacs A, Biro T et al. Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes. Brain Struct Funct. 2015;220:3023–3041.
- Alkaitis MS, Solorzano C, Landry RP, et al. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010;5:e10891.
- Lu C, Liu Y, Sun B et al. Intrathecal injection of JWH-015 attenuates bone cancer pain via time-dependent modification of pro-inflammatory cytokines expression and astrocytes activity in spinal cord. Inflammation. 2015;38:1880–1890.
- Jiang W, Wang Y, Sun W, et al. Morin suppresses astrocyte activation and regulates cytokine release in bone cancer pain rat models. Phytother Res. 2017;31:1298–1304.
- More SV, Park JY, Kim BW et al. Anti-neuroinflammatory activity of a novel cannabinoid derivative by inhibiting the NF-kappaB signaling pathway in lipopolysaccharide-induced BV-2 microglial cells. J Pharmacol Sci. 2013;121:119–130.
- Romero-Sandoval EA, Horvath R, Landry RP et al. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009;5:25.
- Patwardhan AM, Jeske NA, Price TJ, et al. The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA. 2006;103:11393–11398.
- Jeske NA, Patwardhan AM, Gamper N, et al. Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem. 2006;281:32879–32890.
- Marrone MC, Morabito A, Giustizieri M et al. TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nat Commun. 2017;8:15292.
- Doly S, Fischer J, Salio C, et al. The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes. Neurosci Lett. 2004;357:123–126.
- Giordano C, Cristino L, Luongo L et al. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. Cereb Cortex. 2012;22:2495–2518.
- Nerandzic V, Mrozkova P, Adamek P, et al. Peripheral inflammation alters N-arachidonoylphosphatidylethanolamine (20:4-NAPE) induced modulation of nociceptive spinal cord synaptic transmission. Br J Pharmacol. 2018;175:2322–2336.
- Malek N, Mrugala M, Makuch W et al. A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. Pain. 2015;156:890–903.
- Okine BN, Madasu MK, McGowan F et al. N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism. Pain. 2016;157:2687–2696.
- Chen Y, Willcockson HH, Valtschanoff JG. Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain. Exp Neurol. 2009;220:383–390.
- Talbot S, Dias JP, Lahjouji K et al. Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia. J Neuroinflammation. 2012;9:16.
- D’Antoni S, Berretta A, Bonaccorso CM et al. Metabotropic glutamate receptors in glial cells. Neurochem Res. 2008;33:2436–2443.
- Dzamba D, Honsa P, Anderova M. NMDA receptors in glial cells: pending questions. Curr Neuropharmacol. 2013;11:250–262.
- Patneau DK, Wright PW, Winters C et al. Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor. Neuron. 1994;12:357–371.
- Anneser JM, Chahli C, Ince PG, et al. Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2004;63:831–840.
- Conti F, Barbaresi P, Melone M, et al. Neuronal and glial localization of NR1 and NR2A/B subunits of the NMDA receptor in the human cerebral cortex. Cereb Cortex. 1999;9:110–120.
- Sun Y, Zhang W, Liu Y, et al. Intrathecal injection of JWH015 attenuates remifentanil-induced postoperative hyperalgesia by inhibiting activation of spinal glia in a rat model. Anesth Analg. 2014;118:841–853.
- Han J, Kesner P, Metna-Laurent M et al. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. 2012;148:1039–1050.
- Shao Z, Yin J, Chapman K et al. High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature. 2016. DOI:10.1038/nature20613
- Hua T, Vemuri K, Pu M et al. Crystal structure of the human cannabinoid receptor CB1. Cell. 2016;167:750–762.
- Hua T, Vemuri K, Nikas SP et al. Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature. 2017;547:468–471.
- Hassan S, Eldeeb K, Millns PJ, et al. Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation. Br J Pharmacol. 2014;171:2426–2439.