203
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients

, , , , &
Pages 49-54 | Received 28 Feb 2018, Accepted 17 Jul 2018, Published online: 22 Nov 2018

References

  • Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689–701.
  • Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 2013;12:483–497.
  • Huijts M, Duits A, Van Oostenbrugge RJ, et al. Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients. Front Aging Neurosci. 2013;5:72.
  • Koga H, Yuzuriha T, Yao H, et al. Quantitative MRI findings and cognitive impairment among community dwelling elderly subjects. J Neurol Neurosurg Psychiatry. 2002;72:737–741.
  • Staals J, Booth T, Morris Z, et al. Total MRI load of cerebral small vessel disease and cognitive ability in older people. Neurobiol Aging. 2015;36:2806–2811.
  • Song TJ, Kim J, Song D, et al. Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke. J Clin Neurol. 2017;13:187–195.
  • Arba F, Inzitari D, Ali M, et al. Small vessel disease and clinical outcomes after IV rt-PA treatment. Acta Neurol Scand. 2017;136:72–77.
  • Tang W, Chen Y, Lu J, et al. Microbleeds and post-stroke emotional lability. J Neurol, Neurosurg Psychiatry. 2009;80:1082–1086.
  • Gouveri E, Papanas N, Hatzitolios A, et al. Hypovitaminosis D and peripheral arterial disease: emerging link beyond cardiovascular risk factors. Eur J Intern Med. 2012;23:674–681.
  • Leung RY, Han Y, Sing C-W, et al. Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese. Thrombosis Haemostasis. 2017;117:158–63.
  • Kunadian V, Ford GA, Bawamia B, et al. Vitamin D deficiency and coronary artery disease: a review of the evidence. Am Heart J 2014;167:283–91.
  • Chung PW, Park KY, Kim JM, et al. 25-hydroxyvitamin D status is associated with chronic cerebral small vessel disease. Stroke. 2015;46:248–251.
  • Michos ED, Carson KA, Schneider AL, et al. Vitamin D and subclinical cerebrovascular disease: the atherosclerosis risk in communities brain magnetic resonance imaging study. JAMA Neurol. 2014;71:863–871.
  • Staals J, Makin SD, Doubal FN, et al. Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology. 2014;83:1228–1234.
  • Zhang X, Tang Y, Xie Y, et al. Total magnetic resonance imaging burden of cerebral small‐vessel disease is associated with post-stroke depression in patients with acute lacunar stroke. Eur J Neurol. 2017;24:374–380.
  • Xiao L, Lan W, Sun W, et al. Chronic kidney disease in patients with lacunar stroke: association with enlarged perivascular spaces and total magnetic resonance imaging burden of cerebral small vessel disease. Stroke. 2015;46:2081–2086.
  • Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369:11–19.
  • Wang Z, van Veluw S, Wong A, et al. Risk factors and cognitive relevance of cortical cerebral microinfarcts in patients with ischemic stroke or transient ischemic attack. Stroke. 2016;47:2450–2455.
  • Fazekas F, Chawluk JB, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol. 1987;149:351–356.
  • Klarenbeek P, van Oostenbrugge RJ, Lodder J, et al. Higher ambulatory blood pressure relates to enlarged Virchow-Robin spaces in first-ever lacunar stroke patients. J Neurol. 2013;260:115–121.
  • McGreevy C, Williams D. New insights about vitamin D and cardiovascular disease: a narrative review. Ann Intern Med. 2011;155:820–826.
  • Brøndum-Jacobsen P, Nordestgaard B, Schnohr P, et al. 25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis. Ann Neurol. 2013;73:38–47.
  • Christakos S, Dhawan P, Verstuyf A, et al. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 2016;96:365–408.
  • Bouillon R, Carmeliet GV, erlinden Lv, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008;29:726–776.
  • Buell J, Dawson-Hughes B, Scott T, et al. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010;74:18–26.
  • Prager J, Thomas C, Ankenbrandt W, et al. Association of white matter hyperintensities with low serum 25-hydroxyvitamin D levels. AJNR Am J Neuroradiol. 2014;35:1145–1149.
  • Suda S, Kanamaru T, Okubo S, et al. Urinary albumin-to-creatinine ratio is associated with white matter lesions severity in first-ever stroke patients. J Neurol Sci. 2017, 373:258–262.
  • Shi ZS, Loh Y, Liebeskind DS, et al. Leukoaraiosis predicts parenchymal hematoma after mechanical thrombectomy in acute ischemic stroke. Stroke, 2012, 43:1806–1811.
  • Al Mheid I, Patel R, Murrow J, et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol. 2011;58:186–192.
  • Pilz S, Tomaschitz A, Drechsler C, et al. Vitamin D supplementation: a promising approach for the prevention and treatment of strokes. Curr Drug Targets. 2011 12:88–96.
  • Hassan A, Hunt B, O'Sullivan M, et al. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain. 2004;127:212–219.
  • Nezu T, Hosomi N, Aoki S, et al. Endothelial dysfunction is associated with the severity of cerebral small vessel disease. Hypertens Res. 2015;38:291–297.
  • Del Brutto O, Sedler M, Mera R, et al. The association of ankle-brachial index with silent cerebral small vessel disease: results of the Atahualpa Project. Int J Stroke. 2015;10:589–593.
  • Balden R, Selvamani A, Sohrabji F. Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology. 2012;153:2420–2435.
  • Holick MF. Vitamin D deficiency. N Engl j Med. 2007;2007:266–281.
  • Rouhl RP, Damoiseaux JG, Lodder J, et al. Vascular inflammation in cerebral small vessel disease. Neurobiol of Agi. 2012;33:1800–1806.
  • Kassi E, Adamopoulos C, Basdra E, et al. Role of vitamin D in atherosclerosis. Circulation. 2013;128:2517–2531.
  • Klarenbeek P, van Oostenbrugge RJ, Rouhl RP, et al. Ambulatory blood pressure in patients with lacunar stroke: association with total MRI burden of cerebral small vessel disease. Stroke. 2013;44:2995–2999.
  • Lewis J, Elder P. Serum 25-OH vitamin D2 and D3 are stable under exaggerated conditions. Clin Chem. 2008;54:1931–1932.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.