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Original Articles

The effect of nonpharmacologic therapy on global cognitive functions in patients with Alzheimer’s disease: an updated meta-analysis of randomized controlled trials

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Pages 28-44 | Received 30 Jan 2019, Accepted 24 Jun 2019, Published online: 25 Oct 2019

References

  • 2015 Alzheimer's disease facts and figures. Alzheimers Dement. 2015;11:332–384.
  • 2016 Alzheimer's disease facts and figures. Alzheimers Dement. 2016;12:459–509.
  • Takizawa C, Thompson PL, van Walsem A, et al. Epidemiological and economic burden of Alzheimer's disease: a systematic literature review of data across Europe and the United States of America. J Alzheimers Dis. 2014;43:1271–1284.
  • Suehs BT, Davis CD, Alvir J, et al. The clinical and economic burden of newly diagnosed Alzheimer's disease in a medicare advantage population. Am J Alzheimers Dis Other Demen. 2013;28:384–392.
  • Benhaberou-Brun D. Alzheimer's disease and the grieving caregiver. Alzheimer's from the point of view of the caregiver. Perspect Infirm. 2014;11:43–45.
  • Black CM, Fillit H, Xie L, et al. Economic burden, mortality, and institutionalization in patients newly diagnosed with Alzheimer's disease. J Alzheimers Dis. 2017;61:185–193.
  • Schwarz S, Froelich L, Burns A. Pharmacological treatment of dementia. Curr Opin Psychiatry. 2012;25:542–550.
  • Cummings J, Reiber C, Kumar P. The price of progress: Funding and financing Alzheimer's disease drug development. Alzheimers Dement. 2018;4:330–343.
  • Schneider LS, Mangialasche F, Andreasen N, et al. Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014. J Intern Med. 2014;275:251–283.
  • Ehret MJ, Chamberlin KW. Current practices in the treatment of Alzheimer disease: where is the evidence after the phase III trials? Clin Therap. 2015;37:1604–1616.
  • Borisovskaya A, Pascualy M, Borson S. Cognitive and neuropsychiatric impairments in Alzheimer's disease: current treatment strategies. Curr Psychiatry Rep. 2014;16:470.
  • Requena C, Maestu F, Campo P, et al. Effects of cholinergic drugs and cognitive training on dementia: 2-year follow-up. Dement Geriatr Cogn Disord. 2006;22:339–345.
  • Tormalehto SM, et al. Use of anti-dementia drugs in relation to change in cognition, behavior, and functioning in Alzheimer's disease over a three-year period: Kuopio ALSOVA study. J Alzheimers Dis. 2015;48:1033–1041.
  • Wang C, Yu J-T, Wang H-F, et al. Non-pharmacological interventions for patients with mild cognitive impairment: a meta-analysis of randomized controlled trials of cognition-based and exercise interventions. J Alzheimers Dis. 2014;42:663–678.
  • Olazaran J, et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010;30:161–178.
  • Anderson JG, Lopez RP, Rose KM, et al. Nonpharmacological strategies for patients with early-stage dementia or mild cognitive impairment: a 10-year update. Res Gerontol Nursing. 2017;10:5–11.
  • McDermott O, Charlesworth G, Hogervorst E, et al. Psychosocial interventions for people with dementia: a synthesis of systematic reviews. Aging Ment Health. 2018;1–11.
  • Yusuf S, Peto R, Lewis J, et al. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Progr Cardiovasc Dis. 1985;27:335–371.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188.
  • Arcoverde C, Deslandes A, Moraes H, et al. Treadmill training as an augmentation treatment for Alzheimer's disease: a pilot randomized controlled study. Arq Neuro-Psiquiatr. 2014;72:190–196.
  • Holthoff VA, Marschner K, Scharf M, et al. Effects of physical activity training in patients with Alzheimer's dementia: results of a pilot RCT study. PLoS One. 2015;10:e0121478.
  • Ohman H, et al. Effects of exercise on cognition: the Finnish Alzheimer disease exercise trial: a randomized, controlled trial. J Am Geriatr Soc. 2016;64:731–738.
  • Rolland Y, Pillard F, Klapouszczak A, et al. Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am Geriatr Soc. 2007;55:158–165.
  • Vreugdenhil A, Cannell J, Davies A, et al. A community-based exercise programme to improve functional ability in people with Alzheimer's disease: a randomized controlled trial. Scand J Caring Sci. 2012;26:12–19.
  • Ahmed MA, Darwish ES, Khedr EM, et al. Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer's dementia. J Neurol. 2012;259:83–92.
  • Cotelli M, Calabria M, Manenti R, et al. Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry. 2011;82:794–797.
  • Lee J, Choi BH, Oh E, et al. Treatment of Alzheimer's disease with repetitive transcranial magnetic stimulation combined with cognitive training: a prospective, randomized, double-blind, placebo-controlled study. J Clin Neurol. 2016;12:57–64.
  • Rabey JM, Dobronevsky E, Aichenbaum S, et al. Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer's disease: a randomized, double-blind study. J Neural Transm. 2013;120:813–819.
  • Zhao J, et al. Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer's disease patients. Oncotarget. 2017;8:33864–33871.
  • Davis RN, Massman PJ, Doody RS. Cognitive intervention in Alzheimer disease: a randomized placebo-controlled study. Alzheimer Dis Assoc Disord. 2001;15:1–9.
  • Jelcic N, Cagnin A, Meneghello F, et al. Effects of lexical-semantic treatment on memory in early Alzheimer disease: an observer-blinded randomized controlled trial. Neurorehabil Neural Repair. 2012;26:949–956.
  • Viola LF, Nunes PV, Yassuda MS, et al. Effects of a multidisciplinary cognitive rehabilitation program for patients with mild Alzheimer's disease. Clinics (Sao Paulo, Brazil). 2011;66:1395–1400.
  • Van Bogaert P, Van Grinsven R, Tolson D, et al. Effects of SolCos model-based individual reminiscence on older adults with mild to moderate dementia due to Alzheimer disease: a pilot study. J Am Med Direct Assoc. 2013;14:e9.528–e529.513.
  • Toshimichi N, Kayano Y. A, Eri T. C, et al. Effects of productive activities with reminiscence in occupational therapy for people with dementia: a pilot randomized controlled study. Hong Kong J Occupat Ther. 2014;24:13e19.
  • Etsuko T1, Katsuko K. Effects of reminiscence group in elderly people with Alzheimer disease and vascular dementia in a community setting. Geriatr Gerontol Int. 2007;7:167–173.
  • Jia Y, Zhang X, Yu J, et al. Acupuncture for patients with mild to moderate Alzheimer’s disease: a randomized controlled trial. BMC Complement Altern Med. 2017;17:556.
  • Chen Z, Wu G, Shi H. M-Cholinoceptors in caudate nucleus participate in originating descending modulation of parafascicular neurons in acupuncture analgesia. Shi Jie Zhen Jiu ZA Zhi. 2018;8:23–27.
  • Cun JY, Chun YU, Jing-Xian H. Effects of “Yiqitiaoxue,fubenpeiyuan” acupunctur method on associative learning in dementia. Chuan Tong Zhong YI Xue ZA Zhi. 2017;11:133–137.
  • Sun L, Li M, Yajie L. Efficacy of acupuncture on Baihui and Dazhui in the treatment of Alzheimer's disease. Zhen Jiu Lin Chuang ZA Zhi. 2016;23:42–43.
  • Giovagnoli AR, Manfredi V, Schifano L, et al. Combining drug and music therapy in patients with moderate Alzheimer's disease: a randomized study. Neurol Sci. 2018;39:1021–1028.
  • Guetin S, et al. Effect of music therapy on anxiety and depression in patients with Alzheimer's type dementia: randomised, controlled study. Dement Geriatr Cogn Disord. 2009;28:36–46.
  • Lyu J, Zhang J, Mu H, et al. The effects of music therapy on cognition, psychiatric symptoms, and activities of daily living in patients with Alzheimer's disease. J Alzheimers Dis. 2018;64:1347–1358.
  • Scheltens P, et al. Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial. Alzheimers Dement. 2010;6:1–10.e1. 1,
  • Akbari E, et al. Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: a randomized, double-blind and controlled trial. Front Aging Neurosci. 2016;8:256.
  • Hulme C, Wright J, Crocker T, et al. Non-pharmacological approaches for dementia that informal carers might try or access: a systematic review. Int J Geriatr Psychiatry. 2010;25:756–763.
  • Kwon C, Lee B, Suh H, et al. Efficacy and safety of auricular acupuncture for cognitive impairment and dementia: a systematic review. Evid Based Complement Alternat Med. 2018;2018:1.
  • Fiorenzato E, Weis L, Falup-Pecurariu C, et al. Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) performance in progressive supranuclear palsy and multiple system atrophy. J Neural Transm. 2016;123:1435–1442.
  • Lowe DA, Balsis S, Benge JF, et al. Adding delayed recall to the ADAS-cog improves measurement precision in mild Alzheimer's disease: implications for predicting instrumental activities of daily living. Psychol Assess. 2015;27:1234–1240.
  • Knopman DS, Petersen RC. Mild cognitive impairment and mild dementia: a clinical perspective. Mayo Clinic Proc. 2014;89:1452–1459.
  • Yu CC, et al. Effects of acupuncture on Alzheimer's disease: evidence from neuroimaging studies. Chin J Integr Med. 2018.
  • Cantone M, Di Pino G, Capone F, et al. The contribution of transcranial magnetic stimulation in the diagnosis and in the management of dementia. Clin Neurophysiol. 2014;125:1509–1532.
  • Nardone R, et al. Transcranial magnetic stimulation (TMS)/repetitive TMS in mild cognitive impairment and Alzheimer's disease. Acta Neurol Scand. 2014;129:351–366.
  • Wassermann EM, Lisanby SH. Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin Neurophysiol. 2001;112:1367–1377.
  • Kim JH, et al. Moderate-intensity exercise induces neurogenesis and improves cognition in old mice by upregulating hippocampal hippocalcin, Otub1, and spectrin-alpha. Mol Neurobiol. 2018. [CrossRef][
  • van der Kleij LA, Petersen ET, Siebner HR, et al. The effect of physical exercise on cerebral blood flow in Alzheimer's disease. NeuroImage Clin. 2018;20:650–654.
  • Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004;85:1694–1704.
  • Beckett MW, Ardern CI, Rotondi MA. A meta-analysis of prospective studies on the role of physical activity and the prevention of Alzheimer's disease in older adults. BMC Geriatr. 2015;15:9.
  • Groot C, Hooghiemstra AM, Raijmakers PGHM, et al. The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials. Ageing Res Rev. 2016;25:13–23.
  • Ohman H, Savikko N, Strandberg TE, et al. Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: a systematic review. Dement Geriatr Cogn Disord. 2014;38:347–365.
  • George EM, Coch D. Music training and working memory: an ERP study. Neuropsychologia. 2011;49:1083–1094.
  • Bermudez P, Zatorre RJ. Differences in gray matter between musicians and nonmusicians. Ann N Y Acad Sci. 2005;1060:395–399.
  • Chang Y-S, Chu H, Yang C-Y, et al. The efficacy of music therapy for people with dementia: A meta-analysis of randomised controlled trials. J Clin Nurs. 2015;24:3425–3440.
  • Li HC, Wang HH, Chou FH, et al. The effect of music therapy on cognitive functioning among older adults: a systematic review and meta-analysis. J Am Med Direct Assoc. 2015;16:71–77.
  • Serrani Azcurra DJ. A reminiscence program intervention to improve the quality of life of long-term care residents with Alzheimer's disease: a randomized controlled trial. Revista Brasileira de Psiquiatria (Sao Paulo, Brazil: 1999). 2012;34:422–433.
  • Spector A, Orrell M, Davies S, et al. Reminiscence therapy for dementia. Cochrane Database Syst Rev. 2000;CD001120.
  • Woods B, Spector A, Jones C, et al. Reminiscence therapy for dementia. Cochrane Database Syst Rev. 2005;CD001120.

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