Endurance and resistance training mitigate the negative consequences of depression on synaptic plasticity through different molecular mechanisms

References

• Haenisch B, Bonisch H. Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters. Pharmacol Ther. 2011;129(3):352–368.
   PubMed Web of Science ®Google Scholar
• Hamon M, Blier P. Monoamine neurocircuitry in depression and strategies for new treatments. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45:54–63.
   PubMed Web of Science ®Google Scholar
• Anacker C, Cattaneo A, Musaelyan K, et al. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc Natl Acad Sci USA. 2013;110(21):8708–8713.
   PubMed Web of Science ®Google Scholar
• 4. Nifosi F, Toffanin T, Follador H, et al. Reduced right posterior hippocampal volume in women with recurrent familial pure depressive disorder. Psychiatry Res. 2010;184(1):23–28.
   PubMed Web of Science ®Google Scholar
• Varea E, Guirado R, Gilabert-Juan J, et al. Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients. J Psychiatr Res. 2012;46(2):189–197.
   PubMed Web of Science ®Google Scholar
• Cobb JA, Simpson J, Mahajan GJ, et al. Hippocampal volume and total cell numbers in major depressive disorder. J Psychiatr Res. 2013;47(3):299–306.
   PubMed Web of Science ®Google Scholar
• Kotloski RJ, Sutula TP. Environmental enrichment: evidence for an unexpected therapeutic influence. Exp Neurol. 2015;264:121–126.
   PubMed Web of Science ®Google Scholar
• Kuhn M, Hoger N, Feige B, et al. Fear extinction as a model for synaptic plasticity in major depressive disorder. PLoS One. 2014;9(12):e115280.
   PubMed Web of Science ®Google Scholar
• Gornicka-Pawlak E, Jablonska A, Chylinski A, et al. Housing conditions influence motor functions and exploratory behavior following focal damage of the rat brain. Acta Neurobiol Exp (Wars). 2009;69(1):62–72.
   PubMed Web of Science ®Google Scholar
• Um HS, Kang EB, Leem YH, et al. Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model. Int J Mol Med. 2008;22(4):529–539.
   PubMed Web of Science ®Google Scholar
• Uysal N, Tugyan K, Kayatekin BM, et al. The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory. Neurosci Lett. 2005;383(3):241–245.
   PubMed Web of Science ®Google Scholar
• Lu J, Xu Y, Hu W, et al. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neurosci Lett. 2014;573:13–18.
   PubMed Web of Science ®Google Scholar
• Heyman E, Gamelin FX, Goekint M, et al. Intense exercise increases circulating endocannabinoid and BDNF levels in humans–possible implications for reward and depression. Psychoneuroendocrinology. 2012;37(6):844–851.
   PubMed Web of Science ®Google Scholar
• Shin MS, Jeong HY, An DI, et al. Treadmill exercise facilitates synaptic plasticity on dopaminergic neurons and fibers in the mouse model with Parkinson's disease. Neurosci Lett. 2016;621:28–33.
   PubMed Web of Science ®Google Scholar
• Best JR, Chiu BK, Liang Hsu C, et al. Long-term effects of resistance exercise training on cognition and brain volume in older women: results from a randomized controlled trial. J Int Neuropsychol Soc. 2015;21(10):745–756.
   PubMed Web of Science ®Google Scholar
• Suijo K, Inoue S, Ohya Y, et al. Resistance exercise enhances cognitive function in mouse. Int J Sports Med. 2013;34(4):368–375.
   PubMed Web of Science ®Google Scholar
• Shen J, Zhang J, Deng M, et al. The antidepressant effect of Angelica sinensis extracts on chronic unpredictable mild stress-induced depression is mediated via the upregulation of the BDNF signaling pathway in rats. Evid Based Complement Alternat Med. 2016;2016:1.
   Web of Science ®Google Scholar
• Fahey B, Barlow S, Day JS, et al. Interferon-alpha-induced deficits in novel object recognition are rescued by chronic exercise. Physiol Behav. 2008;95(1-2):125–129.
   PubMed Web of Science ®Google Scholar
• Slattery DA, Cryan JF. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc. 2012;7(6):1009–1014.
   PubMed Web of Science ®Google Scholar
• Pavlides C, Ogawa S, Kimura A, et al. Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices. Brain Res. 1996;738(2):229–235.
   PubMed Web of Science ®Google Scholar
• D'Aquila PS, Peana AT, Carboni V, et al. Exploratory behaviour and grooming after repeated restraint and chronic mild stress: effect of desipramine. Eur J Pharmacol. 2000;399(1):43–47.
   PubMed Web of Science ®Google Scholar
• Leventhal AM, Francione Witt C, Zimmerman M. Associations between depression subtypes and substance use disorders. Psychiatry Res. 2008;161(1):43–50.
   PubMed Web of Science ®Google Scholar
• Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology. 2005;52(2):90–110.
   PubMed Web of Science ®Google Scholar
• Willner P, Mitchell PJ. The validity of animal models of predisposition to depression. Behav Pharmacol. 2002;13(3):169–188.
   PubMed Web of Science ®Google Scholar
• Olson RL, Brush CJ, Ehmann PJ, et al. A randomized trial of aerobic exercise on cognitive control in major depression. Clin Neurophysiol. 2017;128(6):903–913.
   PubMed Web of Science ®Google Scholar
• Cassilhas RC, Viana VA, Grassmann V, et al. The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc. 2007;39(8):1401–1407.
   PubMed Web of Science ®Google Scholar
• Vythilingam M, Heim C, Newport J, et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry. 2002;159(12):2072–2080.
   PubMed Web of Science ®Google Scholar
• Zahorodna A, Tokarski K, Bijak M. Electrophysiologic tests for testing the effects of antidepressant drugs and corticosterone on reactivity of serotonin receptors in the hippocampus]. Postepy Hig Med Dosw. 2000;54(3):391–401.
   PubMedGoogle Scholar
• Xu L, Anwyl R, Rowan MJ. Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature. 1997;387(6632):497–500.
   PubMed Web of Science ®Google Scholar
• de Almeida AA, Gomes da Silva S, Lopim GM, et al. Resistance exercise reduces seizure occurrence, attenuates memory deficits and restores BDNF signaling in rats with chronic epilepsy. Neurochem Res. 2017;42(4):1230–1239.
   PubMed Web of Science ®Google Scholar
• Blanpied TA, Scott DB, Ehlers MD. Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron. 2002;36(3):435–449.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang C, Vincent J, et al. Pharmacological modulation of AMPA receptor surface diffusion restores hippocampal synaptic plasticity and memory in Huntington's disease. Nat Commun. 2018;9(1):4272.
   Web of Science ®Google Scholar
• Perreault ML, Jones-Tabah J, O'Dowd BF, et al. A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol. 2013;16(02):477–483.
   PubMed Web of Science ®Google Scholar
• Evergren E, Benfenati F, Shupliakov O. The synapsin cycle: a view from the synaptic endocytic zone. J Neurosci Res. 2007;85(12):2648–2656.
   PubMed Web of Science ®Google Scholar
• Fykse EM, Takei K, Walch-Solimena C, et al. Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins. J Neurosci. 1993;13(11):4997–5007.
   PubMed Web of Science ®Google Scholar
• Cassilhas RC, Lee KS, Fernandes J, et al. Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience. 2012;202:309–317.
   PubMed Web of Science ®Google Scholar
• Cho Y, Hazen BC, Russell AP, et al. Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem. 2013;288(35):25207–25218.
   PubMed Web of Science ®Google Scholar
• Hayashi Y, Shi SH, Esteban JA, et al. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science. 2000;287(5461):2262–2267.
   PubMed Web of Science ®Google Scholar