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Meta-analysis

Intravenous sodium valproate in status epilepticus: review and Meta-analysis

ORCID Icon, , ORCID Icon, , &
Pages 70-84 | Received 17 Sep 2019, Accepted 09 Feb 2020, Published online: 02 Mar 2020

References

  • Hesdorffer DC, Logroscino G, Cascino G, et al. Incidence of status epilepticus in Rochester, Minnesota, 1965–1984. Neurology. 1998;50(3):735–741.
  • DeLorenzo RJ, Pellock JM, Towne AR, et al. Epidemiology of status epilepticus. J Clin Neurophysiol. 1995;12(4):316–325.
  • Coeytaux A, Jallon P, Galobardes B, et al. Incidence of status epilepticus in French-speaking Switzerland: (EPISTAR). Neurology. 2000;55(5):693–697.
  • Knake S, Rosenow F, Vescovi M, et al. Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia. 2001;42(6):714–718.
  • Vignatelli L, Rinaldi R, Galeotti M, et al. Epidemiology of status epilepticus in a rural area of northern Italy: a 2-year population-based study. Eur J Neurol. 2005;12(11):897–902.
  • Logroscino G, Hesdorffer DC, Cascino GD, et al. Long-term mortality after a first episode of status epilepticus. Neurology. 2002;58(4):537–541.
  • Wu YW, Shek DW, Garcia PA, et al. Incidence and mortality of generalized convulsive status epilepticus in California. Neurology. 2002;58(7):1070–1076.
  • Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia. 1999;40(1):120–122.
  • Trinka E, Cock H, Rossetti A, et al. A definition and classification of status epilepticus—Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015;56(10):1515–1523.
  • Trinka E, Kälviäinen R. 25 years of advances in the definition, classification and treatment of status epilepticus. Seizure. 2017;44:65–73.
  • Trinka E, Höfler J, Leitinger M, et al. Pharmacotherapy for status epilepticus. Drugs. 2015;75(13):1499–1521.
  • Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol. 2008;38(6):377–390.
  • Holtkamp M. Pharmacotherapy for refractory and super-refractory status epilepticus in adults. Drugs. 2018;78(3):307–326.
  • Leppik IE, Derivan AT, Homan RW, et al. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA. 1983;249(11):1452–1454.
  • Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998;339(12):792–798.
  • Silbergleit R, Durkalski V, Lowenstein D, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366(7):591–600.
  • Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001;345(9):631–637.
  • Zaccara G, Perucca E. Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs. Epileptic Disord. 2014;16(4):409–431.
  • Seif-Eddeine H, Treiman DM. Problems and controversies in status epilepticus: a review and recommendations. Expert Rev Neurother. 2011;11(12):1747–1758.
  • Meierkord H, Boon P, Engelsen B, et al. EFNS guideline on the management of status epilepticus. Eur J Neurol. 2010;17(3):348–355.
  • Grover EH, Nazzal Y, Hirsch LJ. Treatment of convulsive status epilepticus. Curr Treat Options Neurol. 2016;18(3):11.
  • Trinka E. What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam? Epilepsia. 2009;50(Suppl 12):40–43.
  • Vajda FJ, Symington GR, Bladin PF. Rectal valproate in intractable status epilepticus. Lancet. 1977;12(1(8007):359–360.
  • Vajda FJ, Mihaly GW, Miles JL, et al. Rectal administration of sodium valproate in status epilepticus. Neurology. 1978;28(9):897–899.
  • Viani F, Jussi MI, Germano M, et al. Rectal administration of sodium valproate for neonatal and infantile status epilepticus. Dev Med Child Neurol. 2008;26(5):678–679.
  • Venkataraman V, Wheless JW. Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients. Epilepsy Res. 1999;35(2):147–153.
  • Sinha S, Naritoku DK. Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology. 2000;55(5):722–724.
  • Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs. 2002;16(10):695–714.
  • Ramsay RE, Cantrell D, Collins SD, et al. Safety and tolerance of rapidly infused Depacon. A randomized trial in subjects with epilepsy. Epilepsy Res. 2003;52(3):189–201.
  • Wheless JW, Vazquez BR, Kanner AM, et al. Rapid infusion with valproate sodium is well tolerated in patients with epilepsy. Neurology. 2004;63(8):1507–1508.
  • Limdi NA, Knowlton RK, Cofield SS, et al. Safety of rapid intravenous loading of valproate. Epilepsia. 2007;48(3):478–483.
  • Morton LD, O’Hara KA, Coots BP, et al. Safety of rapid intravenous valproate infusion in pediatric patients. Pediatr Neurol. 2007;36(2):81–83.
  • Brigo F, Storti M, Del Felice A, et al. IV Valproate in generalized convulsive status epilepticus: a systematic review. Eur J Neurol. 2012;19(9):1180–1191.
  • Liu X, Wu Y, Chen Z, et al. A systematic review of randomized controlled trials on the theraputic effect of intravenous sodium valproate in status epilepticus. Int J Neurosci. 2012;122(6):277–283.
  • Trinka E, Höfler J, Zerbs A, et al. Efficacy and safety of intravenous valproate for status epilepticus: a systematic review. CNS Drugs. 2014;28(7):623–639.
  • Brigo F, Bragazzi N, Nardone R, et al. Direct and indirect comparison meta-analysis of levetiracetam versus phenytoin or valproate for convulsive status epilepticus. Epilepsy Behav. 2016;64(Pt A):110–115.
  • Yasiry Z, Shorvon SD. The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: a meta-analysis of published studies. Seizure. 2014;23(3):167–174.
  • Brigo F, Igwe SC, Nardone R, et al. A common reference-based indirect comparison meta-analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus. Epileptic Disord. 2013;15(3):314–323.
  • Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions version 5.1.0. London, UK: Cochrane; 2011.
  • Neville BG, Chin RF, Scott RC. Childhood convulsive status epilepticus: epidemiology, management and outcome. Acta Neurol Scand. 2007;115(s186):21–24.
  • Guo Y, Yu L, He B, et al. Aetiological features of elderly patients with newly diagnosed symptomatic epilepsy in Western China. Biomed Res Int. 2018;2018:1–6. eCollection 2018.
  • Gavaghan DJ, Moore AR, McQuay HJ. An evaluation of homogeneity tests in meta-analysis in pain using simulations of patient data. Pain. 2000;85(3):415–424.
  • Higgins JP, Thompson SG, Deeks JJ. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–560.
  • Khajeh A, Yaghoubinia F, Yaghoubi S, et al. Comparison of the effect of phenobarbital versus sodium valproate in management of children with status epilepticus. Iran J Child Neurol. Autumn. 2018;12(4):85–93.
  • Amiri-Nikpour MR, Nazarbaghi S, Eftekhari P, et al. Sodium valproate compared to phenytoin in treatment of status epilepticus. Brain Behav. 2018;8(5):e00951.
  • Su Y, Liu G, Tian F, et al. Phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A prospective randomized controlled trial in China. CNS Drugs. 2016;30(12):1201–1207.
  • Chitsaz A, Mehvari J, Salari M, et al. A comparative assessment the efficacy of intravenous infusion of sodium valproate and phenytion in the treatment of status epilepticus. Int J Prev Med. 2013;4(Suppl 2):S216–S21.
  • Malamiri RA, Ghaempanah M, Khosroshahi N, et al. Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. Eur J Paediatr Neurol. 2012;16(5):536–541.
  • Gilad R, Izkovitz N, Dabby R, et al. Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. Act Neurol Scand. 2008;118(5):296–300.
  • Mehta V, Singhi P, Singhi S. Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. J Child Neurol. 2007;22(10):1191–1197.
  • Agarwal P, Kumar N, Chandra R, et al. Randomized study of intravenous valproate and phenytoin in status epilepticus. Seizure. 2007;16(6):527–532.
  • Nene D, Mundlamuri RC, Satishchandra P, et al. Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study. Seizure. 2019;65:111–117.
  • Misra UK, Dubey D, Kalita J. Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study. Epilepsy Behav. 2017;76:110–113.
  • Mundlamuri RC, Sinha S, Subbakrishna DK, et al. Management of generalised convulsive status epilepticus (SE): A prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam–Pilot study. Epilepsy Res. 2015;114:52–58.
  • Chen WB, Gao R, Su YY, et al. Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. Eur J Neurol. 2011;18(12):1391–1396.
  • Misra UK, Kalita J, Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology. 2006;67(2):340–342.
  • Kalita J, Nair PP, Misra UK. A clinical, radiological and outcome study of status epilepticus from India. J Neurol. 2010;257(2):224–229.
  • Tripathi M, Vibha D, Choudhary N, et al. Management of refractory status epilepticus at a tertiary care centre in a developing country. Seizure. 2010;19(2):109–111.
  • Tiamkao S, Sawanyawisuth K, Chancharoen A. The efficacy of intravenous sodium valproate and phenytoin as the first-line treatment in status epilepticus: a comparison study. BMC Neurol. 2013;13(1):98.
  • Alvarez V, Januel JM, Burnand B, et al. Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam. Epilepsia. 2011;52(7):1292–1296.
  • İşgüder R, Güzel O, Ceylan G, et al. A comparison of intravenous levetiracetam and valproate for the treatment of refractory status epilepticus in children. J Child Neurol. 2016;31(9):1120–1126.
  • Misra UK, Dubey D, Kalita J. A randomized controlled trial of lacosamide versus sodium valproate in status epilepticus. Epilepsia. 2017;58(5):919–919.
  • Brophy GM, Neurocritical Care Society Status Epilepticus Guideline Writing Committee, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012;17(1):3–23.
  • Brigo F, Bragazzi NL, Lattanzi S, et al. A critical appraisal of randomized controlled trials on intravenous phenytoin in convulsive status epilepticus. Eur J Neurol. 2018;25(3):451–463. Epub 2018 Jan 24.
  • Zhou B, Huang Y, Wang J, et al. The aetiology of convulsive status epilepticus: a study of 258 cases in Western China. Seizure. 2014;23(9):717–721. Epub 2014 Jun 5.
  • Leitinger M, Trinka E, Giovannini G, et al. Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes. Epilepsia. 2019;60(1):53–62. Epub 2018 Nov 26.
  • Brigo F, Del Giovane C, Nardone R, et al. Intravenous antiepileptic drugs in adults with benzodiazepine-resistant convulsive status epilepticus: A systematic review and network meta-analysis. Epilepsy Behav. 2019;101:106466. : [Epub ahead of print]
  • Hanada T, Ido K, Kosasa T. Effect of perampanel, a novel AMPA antagonist, on benzodiazepine-resistant status epilepticus in a lithium-pilocarpine rat model. Pharmacol Res Perspect. 2014;2(5):e00063. Epub 2014 Jul 15.
  • Brigo F, Lattanzi S, Rohracher A, et al. Perampanel in the treatment of status epilepticus: A systematic review of the literature. Epilepsy Behav. 2018;86:179–186. Epub 2018 Jul 31.
  • ClinicalTrials.gov. Study to evaluate bioavailability of a single 12 mg dose of perampanel for three intravenous infusion durations relative to a single 12 mg perampanel oral tablet in healthy subjects. 2017. https://clinicaltrials.gov/ct2/show/ NCT03376997. Last update posted September 7, 2018.
  • Leo A, Giovannini G, Russo E, et al. The role of AMPA receptors and their antagonists in status epilepticus. Epilepsia. 2018;59(6):1098–1108. Epub 2018 Apr 17.
  • Rohracher A, Kalss G, Neuray C, et al. Perampanel in patients with refractory and super-refractory status epilepticus in a neurological intensive care unit: A single-center audit of 30 patients. Epilepsia. 2018;59(Suppl 2):234–242. Epub 2018 Jul 25.
  • Nicolas JM, Hannestad J, Holden D, et al. Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action. Epilepsia. 2016;57(2):201–209. Epub 2015 Dec 10.
  • Niquet J, Suchomelova L, Thompson K, et al. Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. Epilepsia. 2017;58(7):1199–1207. Epub 2017 Jun 9.
  • Brigo F, Lattanzi S, Nardone R, et al. Intravenous Brivaracetam in the treatment of status epilepticus: A systematic review. CNS Drugs. 2019;33(8):771–781.

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