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International Journal of Neuroscience Volume 131, 2021 - Issue 3
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Original Articles

Elevated serum mitochondrial DNA in females and lack of altered platelet mitochondrial methylation in patients with Parkinson´s disease

Amit SharmaDepartment of Neurology, University Clinic Bonn, Bonn, Germany; ;Department of Ophthalmology, University Hospital Bonn, Bonn, Germany; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2216-5389View further author information
ORCID Icon,
Simon T. SchaeferDepartment of Anesthesiology, University Hospital, LMU Munich, Munich, Germany; View further author information
,
Chanachai Sae-LeeHuman Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; ;Research Division, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; View further author information
,
Hyang-Min ByunHuman Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; View further author information
&
Ullrich WüllnerDepartment of Neurology, University Clinic Bonn, Bonn, Germany; ;German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyCorrespondence[email protected]
View further author information
Pages 279-282 | Received 12 Dec 2019, Accepted 22 Feb 2020, Published online: 11 Mar 2020

References

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  • Pyle A, Anugrha H, Kurzawa-Akanbi M, et al. Reduced mitochondrial DNA copy number is a biomarker of Parkinson’s disease. Neurobiol Aging. 2016; 38:216 e217–216 e210.
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  • Sharma A, Kaut O, Pavlova A, et al. Skewed X-chromosome inactivation and XIST locus methylation levels do not contribute to the lower prevalence of Parkinson’s disease in females. Neurobiol Aging. 2017; 57:248 e241–248 e245.
  • Sharma A, Osato N, Liu H, et al. Common genetic variants associated with Parkinson’s disease display widespread signature of epigenetic plasticity. Sci Rep. 2019; 9(1):18464.
  • Kaut O, Sharma A, Schmitt I, et al. DNA methylation of imprinted loci of autosomal chromosomes and IGF2 is not affected in Parkinson’s disease patients’ peripheral blood mononuclear cells. Neurol Res. 2017; 39(3):281–284.
  • Baccarelli AA, Byun HM. Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease. Clin Epigenet. 2015;7(1):44.
  • Mechta M, Ingerslev LR, Fabre O, et al. Evidence Suggesting Absence of Mitochondrial DNA Methylation. Front Genet. 2017; 8:166.
  • Schafer ST, Franken L, Adamzik M, et al. Mitochondrial DNA. An endogenous trigger for immune paralysis. Anesthesiology. 2016; 124(4):923–933.

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