158
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Thyroid hormone levels and structural parameters of thyroid homeostasis are correlated with motor subtype and disease severity in euthyroid patients with Parkinson’s disease

ORCID Icon, , , , , & ORCID Icon show all
Pages 346-356 | Received 29 Aug 2019, Accepted 09 Mar 2020, Published online: 24 Mar 2020

References

  • Heisters D. Parkinson’s: symptoms, treatments and research. Br J Nurs. 2011;20(9):548–554.
  • Hindle JV. Ageing, neurodegeneration and Parkinson’s disease. Age Ageing. 2010;39(2):156–161. Mar
  • Elbaz A, Moisan F. Update in the epidemiology of Parkinson's disease. Curr Opin Neurol. 2008;21(4):454–460.
  • Crosiers D, Theuns J, Cras P, et al. Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypes. J Chem Neuroanat. 2011;42(2):131–141.
  • Motherwell MS, Zuo L. The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease. Gene. 2013;532(1):18–23.
  • Bonuccelli U, D'Avino C, Caraccio N, et al. Thyroid function and autoimmunity in Parkinson’s disease: a study of 101 patients. Parkinsonism Relat Disord. 1999;5(1–2):49–53. Apr
  • de Rijk MC, Breteler MM, Graveland GA, et al. Prevalence of Parkinson’s disease in the elderly: the Rotterdam study. Neurology. 1995;45(12):2143–2146. Dec
  • Li TM. Hypothyroidism in elderly people. Geriatr Nurs. 2002;23(2):88–93. Mar-Apr
  • Prakash KM, Kek PC. Hyperthyroidism “masked” the levodopa response in newly diagnosed Parkinson’s disease patients. Parkinsonism Relat Disord. 2010;16(10):691–692. Dec
  • Trivalle C, Doucet J, Chassagne P, et al. Differences in the signs and symptoms of hyperthyroidism in older and younger patients. J Am Geriatr Soc. 1996;44(1):50–53. Jan
  • Novakova L, Haluzik M, Jech R, et al. Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation. Neuro Endocrinol Lett. 2011;32(4):437–441.
  • Schaefer S, Vogt T, Nowak T, et al. Pituitary function and the somatotrophic system in patients with idiopathic Parkinson’s disease under chronic dopaminergic therapy. J Neuroendocrinol. 2007;20(1):104–109.
  • Vogel HP, Ketsche R. Effect of hypoglycaemia, TRH and levodopa on plasma growth hormone, prolactin, thyrotropin and cortisol in Parkinson’s disease before and during therapy. J Neurol. 1986;233(3):149–152. Jun
  • Tandeter H, Levy A, Gutman G, et al. Subclinical thyroid disease in patients with Parkinson’s disease. Arch Gerontol Geriatr. 2001;33(3):295–300.
  • Kim HT, Edwards MJ, L, Narsimhan R, et al. Hyperthyroidism exaggerating parkinsonian tremor: a clinical lesson. Parkinsonism Relat Disord. 2005;11(5):331–332. Aug
  • Aziz NA, Pijl H, Frolich M, et al. Diurnal secretion profiles of growth hormone, thyrotrophin and prolactin in Parkinson’s disease. J Neuroendocrinol. 2011;23(6):519–524. Jun
  • Umehara T, Matsuno H, Toyoda C, et al. Thyroid hormone level is associated with motor symptoms in de novo Parkinson’s disease. J Neurol. 2015;262(7):1762–1768. Jul
  • Hoermann R, Midgley JE, Larisch R, et al. Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment. Front Endocrinol. 2015;6(177).
  • Hoermann R, Larisch R, Dietrich JW, et al. Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method. Eur J Endocrinol. 2016;174(6):735–743. Jun
  • Dietrich JW, Landgrafe-Mende G, Wiora E, et al. Calculated parameters of thyroid homeostasis: emerging tools for differential diagnosis and clinical research. Front Endocrinol. 2016;7:57.
  • Spiegel J, Hellwig D, Samnick S, et al. Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease. J Neural Transm. 2007;114(3):331–335.
  • Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967;17(5):427–442.
  • Jostel A, Ryder WD, Shalet SM. The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index. Clin Endocrinol. 2009;71(4):529–534. Oct
  • Pohlenz J, Weiss RE, Macchia PE, et al. Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta gene. J Clin Endocrinol Metab. 1999;84(11):3919–3928.
  • Dietrich JW, Landgrafe G, Fotiadou EH, Tsh, et al. Key actors in thyroid homeostasis. J Thyroid Res. 2012;2012:1–29.
  • Dickson DW, Fujishiro H, Orr C, et al. Neuropathology of non-motor features of Parkinson disease. Parkinsonism Relat Disord. 2009;15(3):S1–S5.
  • Tian YY, Jiang B, An LJ, et al. Neuroprotective effect of catalpol against MPP(+)-induced oxidative stress in mesencephalic neurons. Eur J Pharmacol. 2007;568(1–3):142–148.
  • Flower TR, Chesnokova LS, Froelich CA, et al. Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson’s disease. J Mol Biol. 2005;351(5):1081–1100.
  • Guo S, Yan J, Yang T, et al. Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson’s disease through inhibition of ROS-NO pathway. Biol Psychiatry. 2007;62(12):1353–1362.
  • Shulga A, Rivera C. Interplay between thyroxin, BDNF and GABA in injured neurons. Neuroscience. 2013;239:241–252.
  • Pasqualetti G, Pagano G, Rengo G, et al. Subclinical hypothyroidism and cognitive impairment: systematic review and meta-analysis. J Clin Endocrinol Metab. 2015;100(11):4240–4248. Nov
  • Villanueva I, Sanchez Pacheco-Rosado ACJ. The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid Med Cell Longev. 2013;2013(218145):1–15.
  • Berger JR, Kelley RE. Thyroid function in Parkinson disease. Neurology. 1981;31(1):93–95.
  • Munhoz RP, Teive HA, Troiano AR, et al. Parkinson’s disease and thyroid dysfunction. Parkinsonism Relat Disord. 2004;10(6):381–383.
  • Ahmed OM, Ahmed RG, El-Gareib AW, et al. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II-the developmental pattern of neurons in relation to oxidative stress and antioxidant defense system. Int J Dev Neurosci. 2012;30(6):517–537.
  • Rao G, Verma R, Mukherjee A, et al. Melatonin alleviates hyperthyroidism induced oxidative stress and neuronal cell death in hippocampus of aged female golden hamster, Mesocricetus auratus. Exp Gerontol. 2016;82:125–130.
  • Erem C, Suleyman AK, Civan N, et al. The effect of L-thyroxine replacement therapy on ischemia-modified albumin and malondialdehyde levels in patients with overt and subclinical hypothyroidism. Endocr Res. 2016;41(4):350–360.
  • Obradovic M, Gluvic Z, Sudar-Milovanovic E, et al. Nitric oxide as a marker for levo-thyroxine therapy in subclinical hypothyroid patients. CVP. 2016;14(3):266–270.
  • Mancini A, Di Segni C, Raimondo S, et al. Thyroid hormones, oxidative stress, and inflammation. Mediators Inflamm. 2016;2016:1–12. 2016:6757154.
  • Kimber J, Watson L, Mathias CJ. Neuroendocrine responses to levodopa in multiple system atrophy (MSA). Mov Disord. 1999;14(6):981–987.
  • Crespi F, Keane PE, Morre M. In vivo evaluation by differential pulse voltammetry of the effect of thyrotropin-releasing hormone (TRH) on dopaminergic and serotoninergic synaptic activity in the striatum and nucleus accumbens of the rat. Exp Brain Res. 1986;62(2):329–334.
  • Cantuti-Castelvetri I, Hernandez LF, Keller-McGandy CE, et al. Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats. PLoS One. 2010;5(11):e13861.
  • Matsui H, Udaka F, Oda M, et al. Metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease also decreases at thyroid. Ann Nucl Med. 2005;19(3):225–229.
  • Melander A, Ericson LE, Sundler F, et al. Sympathetic innervation of the mouse thyroid and its significance in thyroid hormone secretion. Endocrinology. 1974;94(4):959–966.
  • Cardinali DP, Vacas MI, Gejman PV. The sympathetic superior cervical ganglia as peripheral neuroendocrine centers. J Neural Transm. 1981;52(1-2):1–21.
  • D, Tredici K, Hawkes CH, Ghebremedhin E, et al. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease. Acta Neuropathol. 2010;119(6):703–713.
  • Orimo S, Uchihara T, Nakamura A, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson’s disease. Brain. 2008;131(3):642–650.
  • Timiras PS, Nzekwe EU. Thyroid hormones and nervous system development. Biol Neonate. 1989;55(6):376–385.
  • Ganguli M, Burmeister LA, Seaberg EC, et al. Association between dementia and elevated TSH: a community-based study. Biol Psychiatry. 1996;40(8):714–725.
  • Tan ZS, Beiser A, Vasan RS, et al. Thyroid function and the risk of Alzheimer disease: the Framingham Study. Arch Intern Med. 2008;168(14):1514–1520.
  • Volpato S, Guralnik JM, Fried LP, et al. Serum thyroxine level and cognitive decline in euthyroid older women. Neurology. 2002;58(7):1055–1061.
  • van Osch LA, Hogervorst E, Combrinck M, et al. Low thyroid-stimulating hormone as an independent risk factor for Alzheimer disease. Neurology. 2004;62(11):1967–1971.
  • Wahlin A, Bunce D, Wahlin TB. Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age. Psychoneuroendocrinology. 2005;30(7):625–637.
  • Wahlin A, Wahlin TB, Small BJ, et al. Influences of thyroid stimulating hormone on cognitive functioning in very old age. J Gerontol B Psychol Sci Soc Sci. 1998;53(4):P234–9.
  • van Boxtel MP, Menheere PP, Bekers O, et al. Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology. 2004;29(7):891–898.
  • Lindeman RD, Schade DS, LaRue A, et al. Subclinical hypothyroidism in a biethnic, urban community. J Am Geriatr Soc. 1999;47(6):703–709.
  • Luboshitzky R, Oberman AS, Kaufman N, et al. Prevalence of cognitive dysfunction and hypothyroidism in an elderly community population. Isr J Med Sci. 1996;32(1):60–65.
  • Johannessen AC, Boye A, Pakkenberg H. Thyroid function in patients with Parkinson’s disease. Acta Neurol Scand. 1987;75(5):364–365.
  • Lorefalt B, Ganowiak W, Palhagen S, et al. Factors of importance for weight loss in elderly patients with Parkinson’s disease. Acta Neurol Scand. 2004;110(3):180–187.
  • Hoermann R, Eckl W, Hoermann C, et al. Complex relationship between free thyroxine and TSH in the regulation of thyroid function. Eur J endocrinol. 2010;162(6):1123–1129.
  • Clark PM, Holder RL, Haque SM, et al. The relationship between serum TSH and free T4 in older people. J Clin Pathol. 2012;65(5):463–465.
  • Rothacker K, Hadlow NC, Wardrop R, et al. editors. The relationship between TSH and free T4 is not log-linear and diffffers between genders and age groups. The Annual Scientifific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology; 2012 Proceedings of the ASN Events.
  • Koulouri O, Auldin MA, Agarwal R, et al. Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine. Clin Endocrinol. 2011;74(6):744–749.
  • Chatzitomaris A, Hoermann R, Midgley JE, et al. Thyroid allostasis-adaptive responses of thyrotropic feedback control to conditions of strain, stress, and developmental programming. Front Endocrinol. 2017;8(163).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.