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International Journal of Neuroscience Volume 131, 2021 - Issue 6
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Original Articles

Repolarization of glioblastoma macrophage cells using non-agonistic Dectin-1 ligand encapsulating TLR-9 agonist: plausible role in regenerative medicine against brain tumor

Rohit Kumar Tiwaria Department of Biosciences, Integral University, Lucknow, IndiaView further author information
,
Sarika Singhb Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow, IndiaView further author information
,
Chhedi Lal Guptaa Department of Biosciences, Integral University, Lucknow, IndiaView further author information
,
Pratibha Pandeyc Department of Bioengineering, Integral University, Lucknow, IndiaView further author information
,
Vipendra Kumar Singhd Environmental Carcinogenesis Laboratory, Food Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, IndiaView further author information
,
Uzma Sayyeda Department of Biosciences, Integral University, Lucknow, IndiaView further author information
,
Rafia Shekha Department of Biosciences, Integral University, Lucknow, IndiaView further author information
&
Preeti Bajpaia Department of Biosciences, Integral University, Lucknow, India;e Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University, Motihari, BiharCorrespondence[email protected] [email protected]
View further author information
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Pages 591-598 | Received 31 Aug 2019, Accepted 15 Mar 2020, Published online: 19 Apr 2020

References

  • Dunn GP, Rinne ML, Wykosky J, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev. 2012;26(8):756–784.
  • Masui K, Cloughesy TF, Mischel PS. Molecular pathology in adult high‐grade gliomas: from molecular diagnostics to target therapies. Neuropathol Appl Neurobiol. 2012;38(3):271–291.
  • Gupta A, Dwivedi T. A simplified overview of World Health Organization classification update of central nervous system tumors 2016. J Neurosci Rural Pract. 2017;08(04):629–641.
  • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005;308(5726):1314–1318.
  • Ghosh A, Chaudhuri S. Microglial action in glioma: a boon turns bane. Immunol Lett. 2010;131(1):3–9.
  • Watters JJ, Schartner JM, Badie B. Microglia function in brain tumors. J Neurosci Res. 2005;81(3):447–455.
  • Bowman RL, Joyce JA. Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma. Immunotherapy. 2014;6(6):663–666.
  • Mieczkowski J, Kocyk M, Nauman P, et al. Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma. Oncotarget. 2015;6(32):33077.
  • Roesch S, Rapp C, Dettling S, et al. When immune cells turn bad—tumor-associated microglia/macrophages in glioma. IJMS. 2018;19(2):436.
  • Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci. 2016;19(1):20–27.
  • Alizadeh D, White EE, Sanchez TC, et al. Immunostimulatory CpG on carbon nanotubes selectively inhibits migration of brain tumor cells. Bioconjug Chem. 2018;29(5):1659–1668.
  • Leng L, Jiang T, Zhang Y. TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. J Clin Neurosci. 2012;19(1):75–80.
  • Wang C, Cao S, Yan Y, et al. TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients. BMC Cancer. 2010;10(1):415.
  • Kobiyama K, Aoshi T, Narita H, et al. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Nat Acad Sci USA. 2014;111(8):3086–3091.
  • Takeda Y, Shimada N, Kaneko K, et al. Ternary complex consisting of DNA, polycation, and a natural polysaccharide of schizophyllan to induce cellular uptake by antigen presenting cells. Biomacromolecules. 2007;8(4):1178–1186.
  • Fatima F, Bajpai P, Pathak N, et al. Antimicrobial and immunomodulatory efficacy of extracellularly synthesized silver and gold nanoparticles by a novel phosphate solubilizing fungus Bipolaris tetramera. BMC Microbiol. 2015;15(1):52.
  • Pandey P, Sayyed U, Tiwari RK, et al. Hesperidin induces ROS-mediated apoptosis along with cell cycle arrest at G2/M phase in human gall bladder carcinoma. Nutr Cancer. 2019;71(4):676–687.
  • Xin H, Jiang X, Gu J, et al. Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. Biomaterials. 2011;32(18):4293–4305.
  • Liou GY, Storz P. Reactive oxygen species in cancer. Free Rad Res. 2010;44(5):479–496.
  • Pistollato F, Bremer-Hoffmann S, Basso G, et al. Targeting glioblastoma with the use of phytocompounds and nanoparticles. Targ Oncol. 2016;11(1):1–16.
  • Betzer O, Shilo M, Opochinsky R, et al. The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study. Nanomedicine. 2017;12(13):1533–1546.
  • Zhao Y, Wang Y, Ran F, et al. A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics. Sci Rep. 2017;7(1):4131.
  • Goodridge HS, Reyes CN, Becker CA, et al. Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’. Nature. 2011;472(7344):471–475.
  • Andaloussi AE, Sonabend AM, Han Y, et al. Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumors. Glia. 2006;54(6):526–535.
  • Wu SY, Watabe K. The roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease. Front Biosci. 2017;22(10):1805–1829.
  • Martin-Cordero C, Jose Leon-Gonzalez A, Manuel Calderon-Montano J, et al. Pro-oxidant natural products as anticancer agents. CDT. 2012;13(8):1006–1028.
  • Su BC, Pan CY, Chen JY. Antimicrobial peptide TP4 induces ROS-mediated necrosis by triggering mitochondrial dysfunction in wild-type and mutant p53 glioblastoma cells. Cancers. 2019;11(2):171.

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