173
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

MiR-195 alleviates oxygen–glucose deprivation/reperfusion-induced cell apoptosis via inhibition of IKKα-mediated NF-κB pathway

, &
Pages 755-764 | Received 30 Dec 2019, Accepted 28 Mar 2020, Published online: 19 Apr 2020

References

  • Rodrigo R, Fernandez-Gajardo R, Gutierrez R, et al. Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord Drug Targets. 2013;12(5):698–714.
  • Fagan SC. Stroke is one of the most common and undertreated diseases in the world, and ischemic stroke makes up more than 85% of all strokes. Introduction. Pharmacotherapy. 2010;30(7, part 2):49s–50s.
  • Ruan L, Wang B, ZhuGe Q, et al. Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Res. 2015;1623:166–173.
  • Martinez B, Peplow PV. Blood microRNAs as potential diagnostic markers for hemorrhagic stroke. Neur Regen Res. 2017;12(1):13–18.
  • Jolana L, Kamil D. The role of microRNA in ischemic and hemorrhagic stroke. Curr Drug Deliv. 2017;14(6):816–831.
  • Eyileten C, Wicik Z, De Rosa S, et al. MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke-A comprehensive review and bioinformatic analysis. Cells. 2018;7(12):249.
  • Du K, Zhao C, Wang L, Wang Y, et al. MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1. Aging (Albany, NY). 2019; 11(9):2762–2786.
  • Cai Wei D, Chen S, Chen X, et al. MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4. Life Sci. 2019; 231:116517.
  • Yu W, Liang X, Li X, et al. MicroRNA-195: a review of its role in cancers. Onco Targets Ther. 2018;11:7109–7123.
  • Yang G, Liu Z, Wang L, et al. MicroRNA-195 protection against focal cerebral ischemia by targeting CX3CR1. J Neurosurg. 2019;131(5):1347–1682.
  • Cheng HY, Wang YS, Hsu PY, Chen CY, Liao YC, et al. miR-195 has a potential to treat ischemic and hemorrhagic stroke through neurovascular protection and neurogenesis. Mol Ther Methods Clin Dev. 2019;13:121–132.
  • Li Q, Tian Z, Wang M, et al. Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPARgamma/Nrf2/NF-kappaB signaling pathway. Int Immunopharmacol. 2019; 66:309–316.
  • Lv Y, Liu W, Ruan Z, et al. Myosin IIA regulated tight junction in oxygen glucose-deprived brain endothelial cells via activation of TLR4/PI3K/Akt/JNK1/2/14-3-3epsilon/NF-kappaB/MMP9 signal transduction pathway. Cell Mol Neurobiol. 2019;39(2):301–319.
  • Fann DY, Lim YA, Cheng YL, Lok KZ, et al. Evidence that NF-kappaB and MAPK signaling promotes NLRP inflammasome activation in neurons following ischemic stroke. Mol Neurobiol. 2018;55(2):1082–1096.
  • Zhang X, Zhu XL, Ji BY, Cao X, Yu LJ, et al. LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. J Neuroinflamm. 2019; 16(1):75.
  • Liu L, Cen J, Man Y, et al. Transplantation of human umbilical cord blood mononuclear cells attenuated ischemic injury in MCAO rats via inhibition of NF-kappaB and NLRP3 inflammasome. Neuroscience. 2018;369:314–324.
  • Liu W, Wang X, Zheng Y, et al. Electroacupuncture inhibits inflammatory injury by targeting the miR-9-mediated NF-kappaB signaling pathway following ischemic stroke. Mol Med Rep. 2016;13(2):1618–1626.
  • Guo D, Ma J, Li T, et al. Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-kappaB pathway by targeting FOXO3. Exp Cell Res. 2018;369(1):34–42.
  • Wang M, Jiang YM, Xia LY, et al. LncRNA NKILA upregulation mediates oxygen glucose deprivation/re-oxygenation-induced neuronal cell death by inhibiting NF-kappaB signaling. Biochem Biophys Res Commun. 2018;503(4):2524–2530.
  • Gu N, Wang J, Di Z, et al. The effects of intelectin-1 on antioxidant and angiogenesis in HUVECs exposed to oxygen glucose deprivation. Front Neurol. 2019;10:383.
  • Yang S, Jin H, Zhu Y, et al. Diverse functions and mechanisms of pericytes in ischemic stroke. Curr Neuropharmacol. 2017;15(6):892–905.
  • Li G, Morris-Blanco KC, Lopez MS, et al. Impact of microRNAs on ischemic stroke: from pre- to post-disease. Prog Neurobiol. 2018;163–164:59–78.
  • Wang X, Sun ZJ, Wu JL, et al. Naloxone attenuates ischemic brain injury in rats through suppressing the NIK/IKKalpha/NF-kappaB and neuronal apoptotic pathways. Acta Pharmacol Sin. 2019;40(2):170–179.
  • Guzik A, Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn). 2017;23(1, Cerebrovascular Disease):15–39.
  • Zhang X, Liu Z, Shu Q, et al. LncRNA SNHG6 functions as a ceRNA to regulate neuronal cell apoptosis by modulating miR-181c-5p/BIM signalling in ischaemic stroke. J Cell Mol Med. 2019;23(9):6120–6130.
  • Mendell JT, Olson EN. MicroRNAs in stress signaling and human disease. Cell. 2012;148(6):1172–1187.
  • Sohrabji F, Selvamani A. Sex differences in miRNA as therapies for ischemic stroke. Neurochem Int. 2019;127:56–63.
  • He XW, Shi YH, Liu YS, et al. Increased plasma levels of miR-124-3p, miR-125b-5p and miR-192-5p are associated with outcomes in acute ischaemic stroke patients receiving thrombolysis. Atherosclerosis. 2019;289:36–43.
  • Zhang A, Qian Y, Qian J. MicroRNA-152-3p protects neurons from oxygen-glucose-deprivation/reoxygenation-induced injury through upregulation of Nrf2/ARE antioxidant signaling by targeting PSD-93. Biochem Biophys Res Commun. 2019;517(1):69–76.
  • Yong YX, Yang H, Lian J, et al. Up-regulated microRNA-199b-3p represses the apoptosis of cerebral microvascular endothelial cells in ischemic stroke through down-regulation of MAPK/ERK/EGR1 axis. Cell Cycle. 2019;18(16):1868–1881.
  • Song J, Yoon SR, Kim OY. miR-Let7A controls the cell death and tight junction density of brain endothelial cells under high glucose condition. Oxid Med Cell Longev. 2017;2017:1–10.
  • Sun SC. The non-canonical NF-kappaB pathway in immunity and inflammation. Nat Rev Immunol. 2017;17(9):545–558.
  • Zhang F, Yan C, Wei C, et al. Vinpocetine inhibits NF-kappaB-dependent inflammation in acute ischemic stroke patients. Transl Stroke Res. 2018;9(2):174–184.
  • Shen J, Cheng J, Zhu S, et al. Regulating effect of baicalin on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis. Int Immunopharmacol. 2019;73:193–200.
  • Tang X, Sun L, Wang G, et al. RUNX1: a regulator of NF-kB signaling in pulmonary diseases. Curr Protein Pept Sci. 2018;19(2):172–178.
  • Qi J, Rong Y, Wang L, et al. Rab7b overexpression-ameliorated ischemic brain damage following tMCAO involves suppression of TLR4 and NF-kappaB p65. J Mol Neurosci. 2019;68(2):163–170.
  • Chen Z, Xiang Y, Bao B, et al. Simvastatin improves cerebrovascular injury caused by ischemia‑reperfusion through NF‑κB‑mediated apoptosis via MyD88/TRIF signaling. Mol Med Rep. 2018;18(3):3177–3184.
  • Zhu JR, Lu HD, Guo C, et al. Berberine attenuates ischemia-reperfusion injury through inhibiting HMGB1 release and NF-kappaB nuclear translocation. Acta Pharmacol Sin. 2018;39(11):1706–1715.
  • Chen A, Xu Y, Yuan J. Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat. Int j Dev Neurosci. 2018;69(1):106–111.
  • Yang Y, Zhang N, Wang S, et al. MicroRNA-155 regulates inflammatory response in ischemic cerebral tissues through autophagy. Curr Neurovasc Res. 2018;15(2):103–110.
  • Jickling GC, Ander BP, Zhan X, et al. microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS One. 2014;9(6):e99283.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.