392
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats– exploring the comparable benefits of choline and DHA or environmental enrichment

, & ORCID Icon
Pages 1066-1077 | Received 08 Jun 2019, Accepted 15 May 2020, Published online: 04 Jun 2020

References

  • Khan AN, Raine BL, Donovan M, et al. Iv. the cognitive implications of obesity and nutrition in childhood. Monogr Soc Res Child Dev. 2014;79(4):51–71.
  • Kd M, Lj E, Jm H, et al. Health effects of overweight and obesity in 195 countries over 25 years. Yearb Paediatr Endocrinol. 2017;377(1):13–27.
  • Seth A, Sharma R. Childhood obesity. Indian J Pediatr. 2013;80(4):309–317.
  • Wang C, Chan JSY, Ren L, et al. Obesity reduces cognitive and motor functions across the lifespan. Neural Plast. 2016;2016:2473081–2473013.
  • Poly C, Massaro JM, Seshadri S, et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham offspring cohort. Am J Clin Nutr. 2011;94(6):1584–1591.
  • Castaño A, Drachman BM, Judge D, et al. Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs. Heart Fail Rev. 2015;20(2):163–178.
  • Li W, Li B, Lv J, et al. Choline supplementation improves the lipid metabolism of intrauterine-growth-restricted pigs. Asian-Australas J Anim Sci. 2018;31(5):686–695.
  • da Costa KA, Rai KS, Craciunescu CN, et al. Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- Mouse. J Biol Chem. 2010;285(2):1008–1015.
  • Shang T, Liu L, Zhou J, et al. Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. Lipids Health Dis. 2017;16(1):1–13.
  • Kempermann G, Gast D, Gage FH. Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol. 2002;52(2):135–143.
  • Lestaevel P, Airault F, Racine R, et al. Influence of environmental enrichment and depleted uranium on behaviour, cholesterol and acetylcholine in apolipoprotein e-deficient mice. J Mol Neurosci. 2014;53(3):469–479.
  • Thomas Rajarethnem H, Megur Ramakrishna Bhat K, Jc M, et al. Combined supplementation of choline and docosahexaenoic acid during pregnancy enhances neurodevelopment of fetal hippocampus. Neurol Res Int. 2017;2017:1–9.
  • Roland B, Jürgen S, Cornelius BL. High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity. 2012;15(4):798–808.
  • Thomas RH, Bhat KMR, Gopalkrishnan SK, et al. Neurocognitive developmental outcomes in early adolescent rats prenatally exposed to choline and docosahexaenoic acid. JCDR. 2018;12(1):KC01–KC05.
  • Fabel K, Wolf SA, Ehninger D, et al. Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice. Front Neurosci. 2009;3:1–7.
  • Fernández-Alfonso MS, Olmo N, Del Valladolid-Acebes I, et al. High-fat diets impair spatial learning in the radial-arm maze in mice. Neurobiol Learn Mem. 2011;95(1):80–85.
  • Beker M, Dallı T, Elibol B. Thymoquinone can improve neuronal survival and promote neurogenesis in rat hippocampal neurons. Mol Nutr Food Res. 2018;62(5):1700768–1700710.
  • Finer N. Medical consequences of obesity. Med. [United Kingdom]. 2015;43(2):88–93.
  • Del Olmo N, Ruiz-Gayo M. Influence of high-fat diets consumed during the juvenile period on hippocampal morphology and function. Front Cell Neurosci. 2018;12:439.
  • Micháliková D, Kaprinay BT, Lipták B, et al. Effect of high-fat-fructose diet on synaptic plasticity in hippocampus and lipid profile of blood serum of rat: Pharmacological possibilities of affecting risk factors. Eur Pharm J. 2018;65(2):12–16.
  • Raubenheimer PJ, Nyirenda MJ, Walker BR. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes. 2006;55(7):2015–2020.
  • Levy JR, Clore JN, Stevens W. Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in fischer 344 rats. Hepatology. 2004;39(3):608–616.
  • Duarte F, Araujo H, Duarte A, et al. The effects of exercise modalities on adiposity in obese rats. Clinics (Sao Paulo). 2012;67(12):1469–1477.
  • Prado Lima MG, Schimidt HL, Garcia A, et al. Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity. Proc Natl Acad Sci USA. 2018;115(10):E2403–E2409.
  • La C, Linortner P, Bernstein JD, et al. Hippocampal CA1 subfield predicts episodic memory impairment in Parkinson’s disease. NeuroImage: Clinical. 2019;23:101824.
  • Martínez-Moreno A, Rivera-Olvera A, Escobar ML. BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner. Neurobiol Learn Mem. 2020;167:107125.
  • Hainmueller T, Bartos M. Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories. Nat Rev Neurosci. 2020;21(3):153–168.
  • Vaderav R, Velichety S, Jetty R. Effect of high cholesterol diet and stress on CA1 & CA3 regions of hippocampus. IJNBD. 2014;1(1):1–38.
  • Lindqvist A, Mohapel P, Bouter B, et al. High-fat diet impairs hippocampal neurogenesis in male rats. Eur J Neurol. 2006;13(12):1385–1388.
  • Stangl D, Thuret S. Impact of diet on adult hippocampal neurogenesis. Genes Nutr. 2009;4(4):271–282.
  • Thirumangalakudi L, Prakasam A, Zhang R, et al. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008;106(1):475–485.
  • Wu H, Liu Q, Kalavagunta PK, et al. Normal diet vs high fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice. Metab Brain Dis. 2018;33(1):177–190.
  • Khedr SA, Elmelgy AA, El-Kharashi OA, et al. Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(4):407–422.
  • Nam SM, Kim JW, Kwon HJ, et al. Differential effects of low- and high-dose zinc supplementation on synaptic plasticity and neurogenesis in the hippocampus of control and high-fat diet-fed mice. Neurochem Res. 2017;42(11):3149–3159.
  • Craciunescu CN, Albright CD, Mar M, et al. Cell mitosis in developing mouse hippocampus 1, 2. Environ Heal. 2003;133(11):3614–3618.
  • Nagata T, Yaguchi T, Nishizaki T. DL- and PO-phosphatidylcholines as a promising learning and memory enhancer. Lipids Health Dis. 2011;10(1):25.
  • Korsmo HW, Jiang X, Caudill MA. Choline: Exploring the growing science on its benefits for moms and babies. Nutrients. 2019;11(8):1823.
  • Al Rajabi A, Castro GSF, da Silva RP, et al. Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet. J Nutr. 2014;144(3):252–257.
  • Mukherjee PK, Chawla A, Loayza MS, et al. Docosanoids are multifunctional regulators of neural cell integrity and fate: Significance in aging and disease. Prostaglandins Leukot Essent Fatty Acids. 2007;77(5–6):233–238.
  • Mun JG, Legette LL, Ikonte CJ, et al. Choline and DHA in maternal and infant nutrition: Synergistic implications in brain and eye health. Nutrients. 2019;11(5):1125.
  • Bernhard W, Böckmann K, Maas C, et al. Combined choline and DHA supplementation: a randomized controlled trial. Eur J Nutr. 2020;59(2):729–739.
  • Zainuddin MSA, Thuret S. Nutrition, adult hippocampal neurogenesis and mental health. Br Med Bull. 2012;103(1):89–114.
  • Goes TC, Antunes FD, Teixeira-Silva F. Environmental enrichment for adult rats: Effects on trait and state anxiety. Neurosci Lett. 2015;584:93–96.
  • Kleim JA, Jones TA, Schallert T. Motor enrichment and the induction of plasticity before or after brain injury. Neurochem Res. 2003;28(11):1757–1769.
  • Speisman RB, Kumar A, Rani A, et al. Environmental enrichment restores neurogenesis and rapid acquisition in aged rats. Neurobiol Aging. 2013;34(1):263–274.
  • Kazlauckas V, Pagnussat N, Mioranzza S, et al. Enriched environment effects on behavior, memory and BDNF in low and high exploratory mice. Physiol Behav. 2011;102(5):475–480.
  • Zhang TY, Keown CL, Wen X, et al. Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus. Nat Commun. 2018;9(1):298.
  • Nakandakari SCBR, Muñoz VR, Kuga GK, et al. Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice. Brain Behav Immun. 2019;79:284–293.
  • Guaraldi M, Shea TB. A high-fat and high-cholesterol diet potentiates oxidative damage in hippocampus of mice lacking apolipoprotein E. Open Neurol J. 2018;12(1):12–18.
  • Khazen T, Hatoum OA, Ferreira G, et al. Acute exposure to a high-fat diet in juvenile male rats disrupts hippocampal-dependent memory and plasticity through glucocorticoids. Sci Rep. 2019;9(1):12270.
  • Boitard C, Maroun M, Tantot F, et al. Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids. J Neurosci. 2015;35(9):4092–4103.
  • Sampedro-Piquero P, Álvarez-Suárez P, Moreno-Fernández RD, et al. Environmental enrichment results in both brain connectivity efficiency and selective improvement in different behavioral tasks. Neuroscience. 2018; 388:374–383.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.