Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway

References

• Zhao Y, Cai J, Liu Z, et al. Nanocomposites inhibit the formation, mitigate the neurotoxicity, and facilitate the removal of β-amyloid aggregates in Alzheimer's disease mice. Nano Lett. 2019; 19(2):674–683.
   PubMed Web of Science ®Google Scholar
• Alzheimer’s A. Alzheimer’s disease facts and figures. Alzheimers Dement. 2015;11(3):332–384.
   PubMed Web of Science ®Google Scholar
• Chan KY, Wang W, Wu JJ, Liu L, Theodoratou E, Car J, Middleton L, Russ TC, Deary IJ, Campbell H, et al. Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990-2010: a systematic review and analysis. Lancet. 2013; 381(9882):2016–2023.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yang J, Liu C, et al. Pseudoginsenoside-F11 alleviates cognitive deficits and Alzheimer's disease-type pathologies in SAMP8 mice . Pharmacol Res. 2019; 139:512–523.
   PubMed Web of Science ®Google Scholar
• Yuan C, Guo X, Zhou Q, et al. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice . Biochim Biophys Acta Mol Basis Dis. 2019; 1865(1):161–180.
   PubMed Web of Science ®Google Scholar
• Jia J, Wei C, Chen S, et al. The cost of Alzheimer's disease in China and re-estimation of costs worldwide . Alzheimers Dement. 2018; 14(4):483–491.
   PubMed Web of Science ®Google Scholar
• Li F, Chen S, Wei C, et al. Monetary costs of Alzheimer's disease in China: protocol for a cluster-randomised observational study . BMC Neurol. 2017; 17(1):15
   PubMed Web of Science ®Google Scholar
• Yang Y, Xin X, Fu X, et al. Expression pattern of human SERPINE2 in a variety of human tumors. Oncol Lett. 2018; 15(4):4523–4530.
   PubMed Web of Science ®Google Scholar
• Pagliara V, Adornetto A, Mammi M, et al. Protease Nexin-1 affects the migration and invasion of C6 glioma cells through the regulation of urokinase Plasminogen Activator and Matrix Metalloproteinase-9/2. Biochim Biophys Acta. 2014; 1843(11):2631–2644.
   PubMed Web of Science ®Google Scholar
• Mirante O, Price M, Puentes W, et al. Endogenous protease nexin-1 protects against cerebral ischemia. Int J Mol Sci. 2013; 14(8):16719–16731.
   PubMed Web of Science ®Google Scholar
• Wagner SL, Geddes JW, Cotman CW, et al. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Proc Natl Acad Sci USA. 1989; 86(21):8284–8288.
   PubMed Web of Science ®Google Scholar
• Vaughan PJ, Su J, Cotman CW, et al. Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer’s disease. Brain Res. 1994; 668(1-2):160–170.
   PubMed Web of Science ®Google Scholar
• Vaillant C, Valdivieso P, Nuciforo S, et al. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PloS ONE. 2015; 10(4):e0124870
   PubMed Web of Science ®Google Scholar
• Xin X, Ding Y, Yang Y, et al. Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling. Blood Cancer J. 2018; 8(2):24
   PubMed Web of Science ®Google Scholar
• McKee CM, Xu D, Cao Y, et al. Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. J Clin Invest. 2012; 122(11):4025–4036.
   PubMed Web of Science ®Google Scholar
• Hung YH, Chang SH, Huang CT, et al. Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons. Mol Neurobiol. 2016; 53(2):793–809.
   PubMed Web of Science ®Google Scholar
• He P, Staufenbiel M, Li R, et al. Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice. Hum Mol Genet. 2014; 23(24):6512–6527.
   PubMed Web of Science ®Google Scholar
• Ma J, Gao Y, Jiang L, et al. Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice. Oncotarget. 2017; 8(17):27676–27692.
   PubMedGoogle Scholar
• Sun Y, Zhang JR, Chen S. Suppression of Alzheimer’s disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway. Exp Ther Med. 2017; 14(6):5267–5274.
   PubMed Web of Science ®Google Scholar
• Orlans FB. Ethical decision making about animal experiments. Ethics Behav. 1997; 7(2):163–171.
   PubMed Web of Science ®Google Scholar
• Yao ZG, Zhang L, Liang L, et al. The effect of PN-1, a traditional Chinese prescription, on the learning and memory in a transgenic mouse model of Alzheimer’s disease. Evidence-Based Complementary Altern Med. 2013; 2013:1–12.
   Web of Science ®Google Scholar
• Xia H, Wu L, Chu M, et al. Effects of breviscapine on amyloid beta 1–42 induced Alzheimer's disease mice: A HPLC-QTOF-MS based plasma metabonomics study. J Chromatogr B Analyt Technol Biomed Life Sci. 2017; 1057:92–100.
   PubMed Web of Science ®Google Scholar
• Zhang C, Xie L, Guan F, et al. 3H-1,2-dithiole-3-thione protects PC12 cells against amyloid beta 1–42 (Aβ1–42) induced apoptosis via activation of the ERK1/2 pathway. Life Sci. 2018; 213:74–81.
   PubMed Web of Science ®Google Scholar
• Koh EJ, Kim KJ, Choi J, et al. Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1–42 (Aβ1–42) induced neurotoxicity in PC12 cells. Neurosci Lett. 2018; 673:33–38.
   PubMed Web of Science ®Google Scholar
• Smith-Swintosky VL, Zimmer S, Fenton JW, 2nd, et al. Opposing actions of thrombin and protease nexin-1 on amyloid beta-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons. J Neurochem. 1995;65(3):1415–1418. :
   PubMed Web of Science ®Google Scholar
• Sun L, Guo C, Liu D, et al. Protective effects of bone morphogenetic protein 7 against amyloid-beta induced neurotoxicity in PC12 cells. Neuroscience. 2011; 184:151–163.
   PubMed Web of Science ®Google Scholar
• Lee MH, Shih YH, Lin SR, et al. Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation . Alzheimers Dement (N Y)). 2017; 3(2):189–204.
   PubMedGoogle Scholar
• Lino MM, Atanasoski S, Kvajo M, et al. Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush. J Neurosci. 2007; 27(14):3677–3685.
   PubMed Web of Science ®Google Scholar
• Azoulay S, Terry S, Chimingqi M, et al. Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression. J Pathol. 2008; 216(4):460–470.
   PubMed Web of Science ®Google Scholar
• Kumaran A, Ho CC, Hwang LS. Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease. J Food Drug Anal. 2018; 26(1):172–181.
   PubMed Web of Science ®Google Scholar