Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy

References

• Shankar-Hari M, Harrison DA, Rubenfeld GD, et al. Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database. Br J Anaesth. 2017;119(4):626–636.
   PubMed Web of Science ®Google Scholar
• Sonneville R, Verdonk F, Rauturier C, et al. Understanding brain dysfunction in sepsis. Ann Intensive Care. 2013;3(1):15.
   PubMed Web of Science ®Google Scholar
• Orhun G, Tüzün E, Özcan PE, et al. Association between inflammatory markers and cognitive outcome in patients with acute brain dysfunction due to sepsis. Noro Psikiyatr Ars. 2019;56(1):63–70.
   PubMedGoogle Scholar
• van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet. 2010;375(9716):773–775.
   PubMed Web of Science ®Google Scholar
• Annane D, Sharshar T. Cognitive decline after sepsis. Lancet Respir Med. 2015;3(1):61–69.
   PubMed Web of Science ®Google Scholar
• Orhun G, Tüzün E, Bilgiç B, et al. Brain volume changes in patients with acute brain dysfunction due to sepsis. Neurocrit Care. 2020;32(2):459–468.
   PubMed Web of Science ®Google Scholar
• Hosokawa K, Gaspard N, Su F, et al. Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review. Crit Care. 2014;18(6):674.
   PubMed Web of Science ®Google Scholar
• Orhun G, Esen F, Özcan PE, et al. Neuroimaging findings in sepsis-induced brain dysfunction: Association with clinical and laboratory findings. Neurocrit Care. 2019; 30(1):106–117.
   PubMed Web of Science ®Google Scholar
• Gisslén M, Heslegrave A, Veleva E, et al. CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection. Neurol Neuroimmunol Neuroinflamm. 2019;6(1):e512.
   PubMed Web of Science ®Google Scholar
• Zetterberg H. Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis. Acta Neurol Scand. 2017;136 (Suppl 201):15–17.
   PubMed Web of Science ®Google Scholar
• Li W, Chang H, Wu W, et al. Increased CSF soluble TREM2 concentration in patients with neurosyphilis. Front Neurol. 2020;11:62.
   PubMed Web of Science ®Google Scholar
• Casey CP, Lindroth H, Mohanty R, et al. Postoperative delirium is associated with increased plasma neurofilament light. Brain. 2020;143(1):47–54.
   PubMed Web of Science ®Google Scholar
• Alirezaei Z, Pourhanifeh MH, Borran S, et al. Neurofilament light chain as a biomarker, and correlation with magnetic resonance imaging in diagnosis of CNS-related disorders. Mol Neurobiol. 2020;57(1):469–491.
   PubMed Web of Science ®Google Scholar
• Ehler J, Petzold A, Wittstock M, et al. The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study. PLoS One. 2019;14(1):e0211184.
   PubMed Web of Science ®Google Scholar
• Fields JA, Spencer B, Swinton M, et al. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018;147(6):784–802.
   PubMed Web of Science ®Google Scholar
• Brosseron F, Traschütz A, Widmann CN, et al. Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease. Alzheimers Res Ther. 2018;10(1):25.
   PubMed Web of Science ®Google Scholar
• Redaelli V, Salsano E, Colleoni L, et al. Frontotemporal dementia and chorea associated with a compound heterozygous TREM2 mutation. JAD. 2018;63(1):195–201.
   Web of Science ®Google Scholar
• Sheng L, Chen M, Cai K, et al. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. FASEB J. 2019;33(9):10425–10442.
   PubMed Web of Science ®Google Scholar
• Casati M, Ferri E, Gussago C, et al. Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer’s disease. Eur J Neurol. 2018;25(6):805–810.
   PubMed Web of Science ®Google Scholar
• Tan YJ, Ng ASL, Vipin A, et al. Higher peripheral TREM2 mRNA levels relate to cognitive deficits and hippocampal atrophy in Alzheimer’s disease and amnestic mild cognitive impairment. JAD. 2017;58(2):413–423.
   Google Scholar
• Dellinger RP, Levy MM, Rhodes A, The Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup*, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2013;39(2):165–228.
   PubMed Web of Science ®Google Scholar
• Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA. 2001;286(21):2703–2710.
   PubMed Web of Science ®Google Scholar
• Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002; 166(10):1338–1344.
   PubMed Web of Science ®Google Scholar
• Hirsch LJ, LaRoche SM, Gaspard N, et al. American clinical neurophysiology society’s standardized critical care EEG terminology: 2012 version. J Clin Neurophysiol. 2013;30(1):1–27.
   PubMed Web of Science ®Google Scholar
• Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198.
   PubMed Web of Science ®Google Scholar
• Mioshi E, Dawson K, Mitchell J, et al. The Addenbrooke’s cognitive examination revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriat Psychiatry. 2006;21(11):1078–1085.
   PubMed Web of Science ®Google Scholar
• Heming N, Mazeraud A, Verdonk F, et al. Neuroanatomy of sepsis-associated encephalopathy. Crit Care. 2017;21(1):65.
   PubMed Web of Science ®Google Scholar
• Esen F, Orhun G, Ozcan PE, et al. Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis. Intensive Care Med Exp. 2017;5(1):1.
   PubMedGoogle Scholar
• Zhuang X, Yu Y, Jiang Y, et al. Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. Int Immunopharmacol. 2020; 81(106287):106287.
   PubMed Web of Science ®Google Scholar
• Halaas NB, Henjum K, Blennow K, et al. CSF sTREM2 and tau work together in predicting increased temporal lobe atrophy in older adults. Cereb Cortex. 2020;30(4):2295–2306.
   PubMed Web of Science ®Google Scholar
• Falcon C, Monté-Rubio GC, Grau-Rivera O, et al. CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals. Neuroimage Clin. 2019; 23(101801):101801.
   PubMed Web of Science ®Google Scholar
• Lerche S, Wurster I, Röben B, et al. CSF NFL in a longitudinally assessed PD cohort: Age effects and cognitive trajectories. Mov Disord. 2020;35(7):1138–1144.
   Google Scholar
• Guan YF, Huang GB, Xu MD, et al. Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula. Brain Behav Immun. 2020;S0889-1591(20):30136–30137.
   Google Scholar
• Zhang L, Verwer RWH, Lucassen PJ, et al. Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features. J Psychiatr Res. 2020;125:66–74.
   PubMed Web of Science ®Google Scholar
• Montalbetti L, Ratti MT, Greco B, et al. Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes. Funct Neurol. 2005;20(2):71–75.
   PubMed Web of Science ®Google Scholar