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Research Articles

Naringin prevents the reduction of the number of neurons and the volume of CA1 in a scopolamine-induced animal model of Alzheimer’s disease (AD): a stereological study

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Pages 364-371 | Received 03 May 2022, Accepted 30 Jun 2022, Published online: 18 Oct 2022

References

  • Zhao D, Liu J, Wang M, et al. Epidemiology of cardiovascular disease in China: current features and implications. Nat Rev Cardiol. 2019;16(4):203–212.
  • Mizuno K, Wakai M, Takeda A, et al. Medial temporal atrophy and memory impairment in early stage of Alzheimer’s disease: an MRI volumetric and memory assessment study. J Neurol Sci. 2000;173(1):18–24.
  • Galton CJ, Patterson K, Graham K, et al. Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology. 2001;57(2):216–225.
  • Rajmohan R, Reddy PH. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. J Alzheimers Dis. 2017;57(4):975–999.
  • Zhang F, Jiang L. Neuroinflammation in Alzheimer’s disease. Neuropsychiatr Dis Treat. 2015;11:243–256.
  • Webers A, Heneka MT, Gleeson PA. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer’s disease. Immunol Cell Biol. 2020;98(1):28–41.
  • Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer’s disease. Neuron. 2014 May 21;82(4):756–771.
  • Tu S, Okamoto SI, Lipton SA, et al. Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease. Mol Neurodegener. 2014;9(1):48–12.
  • Jahanshahi M, Nikmahzar E, Sayyahi A. Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease. Iran J Basic Med Sci. 2020;23(1):86–92.
  • Jahanshahi M, Gorgani NE. S. Taurine can decrease phosphorylated tau protein levels in Alzheimer’s model rats’ brains. Kathmandu Univ Med J. 2021;19(74):200–204.
  • Gorgani S, Jahanshahi M, Elyasi L. Taurine prevents passive avoidance memory impairment, accumulation of amyloid-β plaques, and neuronal loss in the hippocampus of scopolamine-treated rats. Neurophysiology. 2019;51(3):171–179.
  • San Tang K. The cellular and molecular processes associated with scopolamine-induced memory deficit: a model of Alzheimer’s biomarkers. Life Sci. 2019;233:116695.
  • Rahman M, Bajgai J, Fadriquela A, et al. Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges. Molecules. 2021;26(17):5327.
  • Atanasov AG, Zotchev SB, Dirsch VM, et al. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20(3):200–216.
  • Palhares RM, Gonçalves Drummond M, dos Santos Alves Figueiredo Brasil B, et al. Medicinal plants recommended by the world health organization: DNA barcode identification associated with chemical analyses guarantees their quality. PLoS One. 2015;10(5):e0127866.
  • Martillanes S, Rocha-Pimienta J, Delgado-Adámez J. Agrifood by-products as a source of phytochemical compounds. Descriptive food science. London: IntechOpen; 2018. p. 43–58.
  • Bayir AG, Kiziltan HS, Kocyigit A. Plant family, carvacrol, and putative protection in gastric cancer dietary interventions in gastrointestinal diseases. Amsterdam, Netherlands: Elsevier; 2019. p. 3–18.
  • Koes RE, Quattrocchio F, Mol JN. The flavonoid biosynthetic pathway in plants: function and evolution. Bioessays. 1994;16(2):123–132.
  • Chaves JO, De Souza MC, Da Silva LC, et al. Extraction of flavonoids from natural sources using modern techniques. Front Chem. 2020;8:507887.
  • Alam MA, Subhan N, Rahman MM, et al. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr. 2014;5(4):404–417.
  • Chen R, Qi QL, Wang M-T, et al. Therapeutic potential of naringin: an overview. Pharm Biol. 2016;54(12):3203–3210.
  • Kempuraj D, Thangavel R, Natteru P, et al. Neuroinflammation induces neurodegeneration. J Neurol Neurosurg Spine. 2016;1(1):1003.
  • Lyman M, Lloyd DG, Ji X, et al. Neuroinflammation: the role and consequences. Neurosci Res. 2014;79:1–12.
  • Chen WW, Zhang X, Huang WJ. Role of neuroinflammation in neurodegenerative diseases. Mol Med Rep. 2016;13(4):3391–3396.
  • Ahmed S, Khan H, Aschner M, et al. Therapeutic potential of naringin in neurological disorders. Food Chem Toxicol. 2019;132:110646.
  • Jang H, Jeong KH, Kim SR. Naringin attenuates granule cell dispersion in the dentate gyrus in a mouse model of temporal lobe epilepsy. Epilepsy Res. 2016;123:6–10.
  • Gaur V, Aggarwal A, Kumar A. Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. Eur J Pharmacol. 2009;616(1–3):147–154.
  • Kumar A, Prakash A, Dogra S. Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. Food Chem Toxicol. 2010;48(2):626–632.
  • Altunkaynak BZ, Onger ME, Altunkaynak ME, et al. A brief introduction to stereology and sampling strategies: basic concepts of stereology. Neuroquantology. 2011;10(1):31–43.
  • Thomsen JS, Laib A, Koller B, et al. Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. J Microsc. 2005;218(Pt 2):171–179.
  • Brown DL. Bias in image analysis and its solution: unbiased stereology. J Toxicol Pathol. 2017;30(3):183–191.
  • Howard V, Reed M. Unbiased stereology: three-dimensional measurement in microscopy. New York (NY): Garland Science; 2004.
  • Sayyahi A, Jahanshahi M, Amini H, et al. Vitamin E can compensate the density of M1 receptors in the hippocampus of scopolamine-treated rats. Folia Neuropathol. 2018;56(3):215–228.
  • Sachdeva AK, Chopra K. Naringin mitigate okadaic acid-induced cognitive impairment in an experimental paradigm of Alzheimer’s disease. J Funct Foods. 2015;19:110–125.
  • Sarkala HB, Jahanshahi M, Dolatabadi LK, et al. Effect of G-CSF on the spatial arrangement of CA1 hippocampal pyramidal neurons after brain ischemia in the male rats. J Chem Neuroanat. 2019;98:80–86.
  • Gundersen H, Bagger P, Bendtsen T, et al. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS. 1988;96(10):857–881.
  • Gundersen H, Bendtsen TF, Korbo L, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988;96(5):379–394.
  • Kristiansen SLB, Nyengaard JR. Digital stereology in neuropathology. APMIS. 2012;120(4):327–340.
  • Glaser J, Greene G, Hendricks SS f Biological research: with a focus on neuroscience. London: MBF Press; 2007.
  • Brown DL. Practical stereology applications for the pathologist. Vet Pathol. 2017;54(3):358–368.
  • More SV, Kumar H, Cho D-Y, et al. Toxin-induced experimental models of learning and memory impairment. Int J Mol Sci. 2016;17(9):1447.
  • Seifhosseini S, Jahanshahi M, Moghimi A, et al. The effect of scopolamine on avoidance memory and hippocampal neurons in male wistar rats. Basic Clin Neurosci. 2011;3(1):9–15.
  • Kola PK, Akula A, NissankaraRao LS, et al. Protective effect of naringin on pentylenetetrazole (PTZ)-induced kindling; possible mechanisms of antikindling, memory improvement, and neuroprotection. Epilepsy Behav. 2017;75:114–126.
  • Rajesh K, Kumar KP, Kotaiah S, et al. Studies on nootropic activity of rutin and naringin on scopolamine induced amnesia in rats using morris water maze task. World J Pharm Pharm Sci. 2014;3(7):1770–1776.
  • Yang W, Ma J, Liu Z, et al. Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats. Neurol Sci. 2014;35(5):741–751.
  • West MJ, Kawas CH, Martin LJ, et al. The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Ann NY Acad Sci. 2000;908(1):255–259.
  • Rössler M, Zarski R, Bohl J, et al. Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer’s disease. Acta Neuropathol. 2002;103(4):363–369.
  • Bobinski M, De Leon MJ, Tarnawski M, et al. Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain Res. 1998;805(1–2):267–269.
  • Schaeffer EL, Catanozi S, West MJ, et al. Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice. Ann Anat. 2017;209:51–60.
  • Bartsch T, Döhring J, Rohr A, et al. CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness. Proc Natl Acad Sci USA. 2011;108(42):17562–17567.
  • Perry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol. 2010;6(4):193–201.
  • Regen F, Hellmann-Regen J, Costantini E, et al. Neuroinflammation and Alzheimer’s disease: implications for microglial activation. Curr Alzheimer Res. 2017;14(11):1140–1148.
  • Yao K, Zu H-b Microglial polarization: novel therapeutic mechanism against Alzheimer’s disease. Inflammopharmacology. 2020;28(1):95–110.
  • Srinivasan S, Vinothkumar V, Murali R. Antidiabetic efficacy of citrus fruits with special allusion to flavone glycosides. Bioactive food as dietary interventions for diabetes. 2th ed. Amsterdam, Netherlands: Elsevier; 2019. p. 335–346.
  • Bharti S, Rani N, Krishnamurthy B, et al. Preclinical evidence for the pharmacological actions of naringin: a review. Planta Med. 2014;80(6):437–451.
  • Yu KU, Jang IS, Kang KH, et al. Metabolism of saikosaponin c and naringin by human intestinal bacteria. Arch Pharm Res. 1997;20(5):420–424.
  • Yang Z, Kuboyama T, Tohda C. Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression. Phytother Res. 2019;33(4):1114–1121.
  • Golechha M, Chaudhry U, Bhatia J, et al. Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol Pharm Bull. 2011;34(3):360–365.
  • Okuyama S, Nakashima T, Nakamura K, et al. Inhibitory effects of auraptene and naringin on astroglial activation, tau hyperphosphorylation, and suppression of neurogenesis in the hippocampus of streptozotocin-induced hyperglycemic mice. Antioxidants. 2018;7(8):109.
  • Gopinath K, Sudhandiran G. Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. Neuroscience. 2012;227:134–143.

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