Dexmedetomidine alleviates sevoflurane-induced neuroinflammation and neurocognitive disorders by suppressing the P2X4R/NLRP3 pathway in aged mice

References

• Evered L, Silbert B, Knopman DS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018. Br J Anaesth. 2018;121(5):1005–1012.
   PubMed Web of Science ®Google Scholar
• Inouye SK, Marcantonio ER, Kosar CM, et al. The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimers Dement. 2016;12(7):766–775.
   PubMed Web of Science ®Google Scholar
• Daiello LA, Racine AM, Yun Gou R, et al. Postoperative delirium and postoperative cognitive dysfunction: overlap and divergence. Anesthesiology. 2019;131(3):477–491.
   PubMed Web of Science ®Google Scholar
• Lv G, Li C, Wang W, et al. Silencing SP1 alleviated sevoflurane-induced POCD development via cholinergic anti-inflammatory pathway. Neurochem Res. 2020;45(9):2082–2090.
   PubMed Web of Science ®Google Scholar
• Yu X, Zhang F, Shi J. Effect of sevoflurane treatment on microglia activation, NF-kB and MAPK activities. Immunobiology. 2019;224(5):638–644.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Wang Y, Yao R, et al. Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period. J Neuroinflammation. 2017;14(1):6–16.
   PubMed Web of Science ®Google Scholar
• Shi M, Miao S, Gu T, et al. Dexmedetomidine for the prevention of emergence delirium and postoperative behavioral changes in pediatric patients with sevoflurane anesthesia: a double-blind, randomized trial. Drug Des Dev Ther. 2019;13:897–905.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li M, Cui E, et al. Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors. Mol Med Rep. 2021;23(1):1–8.
   PubMed Web of Science ®Google Scholar
• Xu S, Gao R, Chen L. Dexmedetomidine regulates sevoflurane-induced neurotoxicity through the miR-330-3p/ULK1 axis. J Biochem Mol Toxicol. 2021;35(12):e22919.
   Web of Science ®Google Scholar
• Zabala A, Vazquez-Villoldo N, Rissiek B, et al. P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis. EMBO Mol Med. 2018;10(8):1–20.
   PubMed Web of Science ®Google Scholar
• Illes P, Rubini P, Ulrich H, et al. Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS. Cells. 2020;9(5):1108–1123.
   PubMed Web of Science ®Google Scholar
• Molnár K, Nógrádi B, Kristóf R, et al. Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury. J Neuroinflammation. 2022;19(1):1–22.
   PubMed Web of Science ®Google Scholar
• Milner MT, Maddugoda M, Götz J, et al. The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease. Curr Opin Immunol. 2021;68:116–124.
   PubMed Web of Science ®Google Scholar
• Yuan H, Lu B, Ji Y, et al. Role of P2X4/NLRP3 pathway-mediated neuroinflammation in perioperative neurocognitive disorders. Mediators Inflamm. 2022;2022:6355805.
   PubMed Web of Science ®Google Scholar
• Xie X, Shen Z, Hu C, et al. Dexmedetomidine ameliorates postoperative cognitive dysfunction in aged mice. Neurochem Res. 2021;46(9):2415–2426.
   PubMed Web of Science ®Google Scholar
• Ling KK, Jackson M, Alkam D, et al. Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis. Neurobiol Dis. 2018;114:174–183.
   PubMed Web of Science ®Google Scholar
• Meng B, Li X, Lu B, et al. The investigation of hippocampus-dependent cognitive decline induced by anesthesia/surgery in mice through integrated behavioral Z-Scoring. Front Behav Neurosci. 2020;13:1–13.
   Web of Science ®Google Scholar
• Tay TL, Savage JC, Hui CW, et al. Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol. 2017;595(6):1929–1945.
   PubMed Web of Science ®Google Scholar
• Wang Z, Meng S, Cao L, et al. Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment. J Neuroinflammation. 2018;15(1):1–12.
   PubMed Web of Science ®Google Scholar
• Wu Z, Zhang Y, Zhang Y, et al. Sirtuin 2 inhibition attenuates sevoflurane-induced learning and memory deficits in developing rats via modulating microglial activation. Cell Mol Neurobiol. 2020;40(3):437–446.
   PubMed Web of Science ®Google Scholar
• Xu Y, Gao G, Sun X, et al. ATPase inhibitory factor 1 is critical for regulating sevoflurane-induced microglial inflammatory responses and caspase-3 activation. Front Cell Neurosci. 2021;15:1–13.
   Web of Science ®Google Scholar
• Qiu Z, Lu P, Wang K, et al. Dexmedetomidine inhibits neuroinflammation by altering microglial M1/M2 polarization through MAPK/ERK pathway. Neurochem Res. 2020;45(2):345–353.
   PubMed Web of Science ®Google Scholar
• Montilla A, Mata GP, Matute C, et al. Contribution of p2x4 receptors to CNS function and pathophysiology. Int J Mol Sci. 2020;21(15):1–16.
   Web of Science ®Google Scholar
• Bertin E, Deluc T, Pilch KS, et al. Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice. Mol Psychiatry. 2021;26(2):629–644.
   PubMed Web of Science ®Google Scholar
• Duveau A, Bertin E, Boué-Grabot E. Implication of neuronal versus microglial P2X4 receptors in Central nervous system disorders. Neurosci Bull. 2020;36(11):1327–1343.
   PubMed Web of Science ®Google Scholar
• Nguyen HM, di Lucente J, Chen YJ, et al. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. 2020;68(11):2377–2394.
   PubMed Web of Science ®Google Scholar
• Jin TW, Han R, Yao N, et al. Activation of P2X4 receptor exacerbates acute brain injury after intracerebral hemorrhage. 2022;28(7):1008–1018.
   Google Scholar
• Haneklaus M, O’Neill LAJ. NLRP3 at the interface of metabolism and inflammation. Immunol Rev. 2015;265(1):53–62.
   PubMed Web of Science ®Google Scholar
• Shao A, Fei J, Feng S, et al. Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway. Pharmacol Rep. 2020;72(4):833–845.
   PubMed Web of Science ®Google Scholar
• Tian D, Xing Y, Gao W. Sevoflurane aggravates the progress of Alzheimer’s disease through NLRP3/caspase-1/gasdermin D pathway. Front Cell Dev Biol. 2022;9:1–12.
   Web of Science ®Google Scholar
• Fang P, Chen C, Zheng F, et al. NLRP3 inflammasome inhibition by histone acetylation ameliorates sevoflurane-induced cognitive impairment in aged mice by activating the autophagy pathway. Brain Res Bull. 2021;172:79–88.
   PubMed Web of Science ®Google Scholar
• Fan Y, Du L, Fu Q, et al. Inhibiting the NLRP3 inflammasome with MCC950 ameliorates isoflurane-induced pyroptosis and cognitive impairment in aged mice. Front Cell Neurosci. 2018;12:1–9.
   PubMed Web of Science ®Google Scholar
• Ye JS, Chen L, Lu YY, et al. Honokiol-mediated mitophagy ameliorates postoperative cognitive impairment induced by surgery/sevoflurane via inhibiting the activation of NLRP3 inflammasome in the hippocampus. Oxid Med Cell Longev. 2019;2019:8639618.
   PubMed Web of Science ®Google Scholar
• Zhang L, Xiao F, Zhang J, et al. Dexmedetomidine mitigated NLRP3-mediated neuroinflammation via the ubiquitin-autophagy pathway to improve perioperative neurocognitive disorder in mice. Front Pharmacol. 2021;12:1–17.
   Web of Science ®Google Scholar
• Li H, Zhang X, Chen M, et al. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by C-FOS/NLRP3/CASPASE-1 Cascades. EXCLI J. 2018;17:302–311.
   PubMed Web of Science ®Google Scholar
• Chen K, Zhang J, Zhang W, et al. ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy. Int J Biochem Cell Biol. 2013;45(5):932–943.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang XN, Fang JN, et al. The mechanism behind activation of the nod-like receptor family protein 3 inflammasome in Parkinson’s disease. Neural Regen Res. 2022;17(4):898–904.
   PubMed Web of Science ®Google Scholar
• He W, Wang Q, Sha W, et al. P2X4 inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. J Clin Neurosci. 2022;99:224–232.
   PubMed Web of Science ®Google Scholar