Cellular responses to nanoparticles: Target structures and mechanisms

References

• Abdelmohsen K, Gerber PA, von Montfort C, Sies H, Klotz LO. Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: Role of glutathione and tyrosine phosphatases. J Biol Chem 2003; 278: 38360–38367
   PubMed Web of Science ®Google Scholar
• Aderem A, Underhill DM. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 1999; 17: 593–623
   PubMed Web of Science ®Google Scholar
• Albrecht C, Borm PJA, Unfried K. Signal transduction pathways relevant for neoplastic effects of fibrous and non-fibrous particles. Mut Res 2004; 553: 59–65
   PubMed Web of Science ®Google Scholar
• Ames BN. Identifying environmental chemicals causing mutations and cancer. Science 1979; 204: 587–593
   PubMed Web of Science ®Google Scholar
• Andreassen PR, Ho GP, D'Andrea AD. DNA damage responses and their many interactions with the replication fork. Carcinogenesis 2006; 27: 883–892
   PubMed Web of Science ®Google Scholar
• Barlow PG, Clouter-Baker A, Donaldson K, MacCallum J, Stone V. Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Part Fibre Toxicol 2005; 2: 11
   PubMed Web of Science ®Google Scholar
• Barthel A, Klotz LO. Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress. Biol Chem 2005; 386: 207–216
   PubMed Web of Science ®Google Scholar
• Beck-Speier, I, Daynal, N, Karg, E, Maier Kl, Schumann, G, Schulz, H, Semmler, M, Takenaka, S, Stettmaier, K, Bors, W, , et al. 2005. Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles. Free Radic Biol Med, 38:1080–1092.
   PubMed Web of Science ®Google Scholar
• Berken A, Abel J, Unfried K. Beta1-integrin mediates asbestos-induced phosphorylation of AKT and ERK1/2 in a rat pleural mesothelial cell line. Oncogene 2003; 22: 8524–8528
   PubMed Web of Science ®Google Scholar
• Berneburg M, Kamenisch Y, Krutmann J. Repair of mitochondrial DNA in aging and carcinogenesis. Photochem Photobiol Sci 2006; 5: 190–198
   PubMed Web of Science ®Google Scholar
• Blanchet S, Ramgolan K, Baulig A, Marano F, Baeza-Squiban A. Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 2003; 30: 421–427
   PubMed Web of Science ®Google Scholar
• Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J. The potential risk of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol 2006; 3: 11
   PubMed Web of Science ®Google Scholar
• Borm PJA., Cakmak G, Jermann E, Weishaupt C, Kempers P, van Schooten FJ, Oberdörster G, Schins RPF. Formation of PAH-DNA adducts after in vivo and in vitro exposure of rats and lung cells to different commercial CB types. Toxicol Appl Pharmacol 2005; 205: 157–167
   PubMed Web of Science ®Google Scholar
• Borm PJA, Schins RPF. Toxicological characterisation of engineered nanoparticles. Nanoparticle technology for drug delivery, RB Gupta, UB Kompella. Marcel Dekker Inc, New York 2006; 161–197
   Google Scholar
• Brown DM, Donaldson K, Borm PJ, Schins RP, Denhardt M, Gilmour P, Jimenez LA, Stone V. Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Biol 2004; 286: L344–353
   PubMed Web of Science ®Google Scholar
• Cadenas E. Mitochondrial free radical production and cell signaling. Mol Aspects Med 2004; 25: 17–26
   PubMedGoogle Scholar
• Campisi J. Senescent cells, tumour suppression, and organismal aging: good citizens, bad neighbours. Cell 2005; 120: 513–522
   PubMed Web of Science ®Google Scholar
• Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979; 59: 527–605
   PubMed Web of Science ®Google Scholar
• Chen M, von Mikecz A. Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res 2005; 305: 51–62
   PubMed Web of Science ®Google Scholar
• Chnari E, Nikitczuk JS, Uhrich KE, Moghe PV. Nanoscale anionic macromolecules can inhibit cellular uptake of differentially oxidized LDL. Biomacromolecules 2006a; 7: 597–603
   PubMed Web of Science ®Google Scholar
• Chnari E, Nikitczuk JS, Wang J, Uhrich KE, Moghe PV. Engineered polymeric nanoparticles for receptor-targeted blockage of oxidized low density lipoprotein uptake and atherogenesis in macrophages. Biomacromolecules 2006b; 7: 1796–1805
   PubMed Web of Science ®Google Scholar
• Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science 1995; 268: 233–239
   PubMed Web of Science ®Google Scholar
• Cremer T, Cremer C. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nature Rev Genet 2001; 2: 292–301
   PubMed Web of Science ®Google Scholar
• Dellinger B, Pryor WA, Cueto R, Squadrito GL, Hegde V, Deutsch WA. Role of free radicals in the toxicity of airborne fine particulate matter. Chem Res Toxicol 2001; 14: 1371–1377
   PubMed Web of Science ®Google Scholar
• Devereux TR, Risinger JI, Barrett JC. Mutations and altered expression of the human cancer genes: What they tell us about causes. IARC Sci Publ 1999; 146: 19–42
   Google Scholar
• Dobson J. Gene therapy progress and prospects: Magnetic nanoparticle-based gene delivery. Gene Ther 2006; 13: 283–287
   PubMed Web of Science ®Google Scholar
• Don Porto Carero A, Hoet PHM, Verschaeve L, Schoeters G, Nemery B. Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1). Environ Mol Mutagen 2001; 37: 155–163
   PubMed Web of Science ®Google Scholar
• Donaldson K, Beswick PH, Gilmour PS. Free radical activity associated with the surface of particles: A unifying factor in determining biological activity?. Toxicol Lett 1996; 88: 293–298
   PubMed Web of Science ®Google Scholar
• Donaldson K, Stone V, Clouter A, Renwick L, MacNee W. Ultrafine particles. Occup Environ Med 2001; 58: 211–216
   PubMed Web of Science ®Google Scholar
• Donaldson K, Stone V, Tran CL, Kreyling W, Borm PJ. Nanotoxicology. Occup Environ Med 2004; 61: 727–728
   PubMed Web of Science ®Google Scholar
• Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V. Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Part Fibre Toxicol 2005; 2: 10
   PubMed Web of Science ®Google Scholar
• Driscoll KE, Howard BW, Carter JM, Janssen YM, Mossman BT, Isfort RJ. Mitochondrial-derived oxidants and quartz activation of chemokine gene expression. Adv Exp Med Biol 2001; 500: 489–496
   PubMed Web of Science ®Google Scholar
• Duffin R, Tran CL, Clouter A, Brown DM, MacNee W, Stone V, Donaldson K. The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles. Ann Occup Hyg 2002; 46(S 1)242–245
   Google Scholar
• Dugan LL, Turetsky DM, Du C, Lobner D, Wheeler M, Almli CR, Shen C K-F, Luh T-Y, Choi DW, Lin T-S. Carboxyfullerenes as neuroprotective agents. Proc Natl Acad Sci USA 1997; 94: 9434–9439
   PubMed Web of Science ®Google Scholar
• Dybdahl M, Risom L, Bornholdt J, Autrup H, Loft S, Wallin H. Inflammatory and genotoxic effects of diesel particles in vitro and in vivo. Mutat Res 2004; 562: 119–131
   PubMed Web of Science ®Google Scholar
• Fang C, Shi B, Pei YY, Hong MH, Wu J, Chen HZ. In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size. Eur J Pharm Sci 2006; 27: 27–36
   PubMed Web of Science ®Google Scholar
• Foged C, Brodin B, Frokjaer S, Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm 2005; 298: 315–322
   PubMed Web of Science ®Google Scholar
• Foley S, Crowley C, Smaihi M, Bonfils C, Erlanger BF, Seta P, Larroque C. Cellular localisation of a water-soluble fullerene derivative. Biochem Biophys Res Commun 2002; 294: 116–119
   PubMed Web of Science ®Google Scholar
• Fubini B, Aust AE, Bolton RE, Borm PJA, Bruch J, Ciapetti G, Donaldson K, Elias Z, Gold J, Jaurand MC, et al. Non-animal tests for evaluating the toxicity of solid xenobiotics. ECVAM Workshop report 30. ATLA 1998; 26: 579–617
   Google Scholar
• Fujishima A, Rao TN, Tryk DA. Titanium dioxide photocatalysis. J Photochem Photobiol C: Photochem Rev 2000; 1: 1–21
   Web of Science ®Google Scholar
• Garcion E, Lamprecht A, Heurtault B, Paillard A, Aubert-Pouessel A, Denizot B, Menei P, Benoit JP. A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats. Mol Cancer Ther 2006; 5: 1710–1722
   PubMed Web of Science ®Google Scholar
• Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005; 113: 1555–1560
   PubMed Web of Science ®Google Scholar
• Gillet LC, Scharer OD. Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem Rev 2006; 106: 253–276
   PubMed Web of Science ®Google Scholar
• Godbey WT, Wu KK, Mikos AG. Tracking and intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc Natl Acad Sci USA 1999; 96: 5177–5181
   PubMed Web of Science ®Google Scholar
• Gorlich D. Transport into and out of the cell nucleus. EMBO J 1998; 17: 2721–2727
   PubMed Web of Science ®Google Scholar
• Gruenberg J. The endocytic pathway: A mosaic of domains. Nat Rev Mol Cell Biol 2001; 2: 721–730
   PubMed Web of Science ®Google Scholar
• Gupta AK, Curtis AS. Surface modified superparamagnetic nanoparticles for drug delivery: Interaction studies with human fibroblasts in culture. J Mater Sci Mater Med 2004a; 15: 493–496
   PubMed Web of Science ®Google Scholar
• Gupta AK, Curtis AS. Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors. Biomaterials 2004b; 25: 3029–3040
   PubMed Web of Science ®Google Scholar
• Gupta AK, Gupta M. Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 2005; 26: 1565–1573
   PubMed Web of Science ®Google Scholar
• Gurr JR, Wang AS, Chen CH, Jan KY. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 2005; 213: 66–73
   PubMed Web of Science ®Google Scholar
• Hall M, Grover PL. Polycyclic aromatic hydrocarbons: Metabolism, activation and tumor initiation. Chemical carcinogenesis and mutagenesis, CS Cooper, PL Grover. Springer Verlag, Berlin 1990; 227–272
   Google Scholar
• Handwerger K, Gall JG. Subnuclear organelles: New insights into form and function. Trends Cell Biol 2006; 16: 19–26
   PubMed Web of Science ®Google Scholar
• Hartwig A. Role of DNA repair in particle- and fiber-induced lung injury. Inhal Toxicol 2002; 14: 91–100
   PubMed Web of Science ®Google Scholar
• Heckel K, Kiefmann R, Dorger M, Stoeckelhuber M, Goetz AE. Colloidal gold particles as a new in vivo marker of early acute lung injury. Am J Physiol Lung Cell Mol Physiol 2004; 287: L867–878
   PubMed Web of Science ®Google Scholar
• Hoeijmakers JHJ. Genome maintenance mechanisms for preventing cancer. Nature 2001; 411: 366–374
   PubMed Web of Science ®Google Scholar
• Hoshino A, Fujioka K, Oku T, Nakamura S, Suga M. Quantum dots targeted to the assigned organelle in living cells. Microbiol Immunol 2004; 48: 985–994
   PubMed Web of Science ®Google Scholar
• Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 2005; 19: 975–983
   PubMed Web of Science ®Google Scholar
• Jia G, Wang H, Yan L, Wang X, Pei R, Yan T, Zhao Y, Guo X. Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 2005; 39: 1378–1383
   PubMed Web of Science ®Google Scholar
• Jiang H, Nucifora FC, Ross CA, DeFranco DB. Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. Hum Mol Genet 2003; 12: 1–12
   PubMed Web of Science ®Google Scholar
• Kawanishi S, Hiraku Y, Murata M, Oikawa S. The role of metals in site-specific DNA damage with reference to carcinogenesis. Free Radic Biol Med 2002; 32: 822–832
   PubMed Web of Science ®Google Scholar
• Kessel M, Liu SX, Xu A, Santella R, Hei TK. Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem 2002; 234–235: 301–308
   PubMed Web of Science ®Google Scholar
• Kim JS, Yoon TJ, Yu KN, Noh MS, Woo M, Kim BG, Lee KH, Sohn BH, Park SB, Lee JK, Cho MH. Cellular uptake of magnetic nanoparticle is mediated through energydependent endocytosis in A549 cells. J Vet Sci 2006; 7: 321–326
   PubMed Web of Science ®Google Scholar
• Kim Y-M, Reed W, Lenz AG, Jaspers I, Silbajoris R, Nick HS, Samet JM. Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells. Am J Physiol Lung Cell Lol Physiol 2005; 288: L432–441
   PubMed Web of Science ®Google Scholar
• Klotz LO. Oxidant-induced signaling: Effects of peroxynitrite and singlet oxygen. Biol Chem 2002; 383: 443–456
   PubMed Web of Science ®Google Scholar
• Klotz LO, Sies H. Defenses against peroxynitrite: selenocompounds and flavonoids. Toxicol Lett 2003; 140–141: 125–132
   PubMed Web of Science ®Google Scholar
• Knaapen AM, Borm PJA, Albrecht C, Schins RPF. Inhaled particles and lung cancer, part A. Mechanisms. Int J Cancer 2004; 109: 799–809
   PubMed Web of Science ®Google Scholar
• Konaka R, Kasahara E, Dunlap WC, Yamamoto Y, Chien KC, Inoue M. Irradiation of titanium dioxide generates both singlet oxygen and superoxide anion. Free Radic Biol Med 1999; 27: 294–300
   PubMed Web of Science ®Google Scholar
• Kopito R. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 2000; 10: 524–530
   PubMed Web of Science ®Google Scholar
• Kumagai Y, Arimoto T, Shinyashiki M, Shimojo N, Nakai Y, Yoshikawa T, Sagai M. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Free Radic Biol Med 1997; 22: 479–487
   PubMed Web of Science ®Google Scholar
• Kuwano K, Hagimoto N, Nakanishi Y. The role of apoptosis in pulmonary fibrosis. Histol Histopathol 2004; 19: 867–881
   PubMed Web of Science ®Google Scholar
• Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004; 200: 377–389
   PubMed Web of Science ®Google Scholar
• Lesniak W, Bielinska AU, Sun K, Janczak KW, Shi X, Baker JR, Jr, Balogh LP. Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection. Nano Lett 2005; 5: 2123–2130
   PubMed Web of Science ®Google Scholar
• Li, H, Haberzettl, P, Albrecht, C, Höhr, D, Knaapen, AM, Borm, PJA, Schins, RPF. Inhibition of the mitochondrial respiratory chain function abrogates quartz induced DNA damage in lung epithelial cells. Mutat Res, 617:46–57.
   PubMed Web of Science ®Google Scholar
• Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 2003; 111: 455–460
   PubMed Web of Science ®Google Scholar
• Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, Gunther D, Stark WJ. Oxide nanoparticle uptake in human lung fibroblasts: Effects of particle size, agglomeration, and diffusion at low concentrations. Environ Sci Technol 2005; 39: 9370–9376
   PubMed Web of Science ®Google Scholar
• Lindahl T. Instability and decay of the primary struture of DNA. Nature 1993; 362: 709–715
   PubMed Web of Science ®Google Scholar
• Lohbach C, Neumann D, Lehr CM, Lamprecht A. Human vascular endothelial cells in primary cell culture for the evaluation of nanoparticle bioadhesion. J Nanosci Nanotechnol 2006; 6: 3303–3309
   PubMed Web of Science ®Google Scholar
• Luch A. Nature and nurture – lessons from chemical carcinogenesis. Nat Rev Cancer 2005; 5: 113–125
   PubMed Web of Science ®Google Scholar
• Mandavilli BS, Santos JH, Van Houten B. Mitochondrial DNA repair and aging. Mutat Res 2002; 509: 127–151
   PubMed Web of Science ®Google Scholar
• Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis. 2000; 21: 316–370
   Web of Science ®Google Scholar
• Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdorster G, Philbert MA, Ryan J, Seaton A, Stone V, et al. Safe handling of nanotechnology. Nature 2006; 444: 267–269
   PubMed Web of Science ®Google Scholar
• Mehta D, Bhattacharya J, Matthay MA, Malik AB. Integrated control of lung fluid balance. Am J Physiol Lung Cell Mol Physiol 2004; 287: L1081–1090
   PubMed Web of Science ®Google Scholar
• Moghimi SM, Hunter AC, Murray JC. Nanomedicine: Current status and future prospects. FASEB J 2005; 19: 311–330
   PubMed Web of Science ®Google Scholar
• Moore A, Weissleder R, Bogdanov A, Jr. Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages. J Magn Reson Imaging 1997; 7: 1140–1145
   PubMed Web of Science ®Google Scholar
• Moro L, Venturio M, Bozzo C, Silengo L, Altruda F, Beguinot L, Tarone G, Defilippi P. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion dependent cell survival. EMBO J 1998; 17: 6622–6632
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Ghosh RN, Maxfield FR. Endocytosis. Physiol Rev 1997; 77: 759–803
   PubMed Web of Science ®Google Scholar
• Muro S, Mateescu M, Gajewski C, Robinson M, Muzykantov VR, Koval M. Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na + /H+ exchanger proteins. Am J Physiol Lung Cell Mol Physiol 2006; 290: L809–817
   PubMed Web of Science ®Google Scholar
• Nakagawa Y, Wakuri S, Sakamoto K, Tanaka N. The photogenotoxicity of titanium dioxide particles. Mutat Res 1997; 394: 125–132
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006; 311: 622–627
   PubMed Web of Science ®Google Scholar
• Nucifora FC, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, et al. Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science 2001; 291: 2423–2428
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Part Fibre Toxicol 2005a; 2: 8
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005b; 113: 823–839
   PubMed Web of Science ®Google Scholar
• Panduri V, Weitzman SA, Chandel N, Kamp DW. The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis. Am J Respir Cell Mol Biol 2003; 28: 241–248
   PubMed Web of Science ®Google Scholar
• Pante N, Kann M. Nuclear pore complex is able to transport macromolecules with diameters of ∼39 nm. Mol Biol Cell 2002; 13: 425–434
   PubMed Web of Science ®Google Scholar
• Park JB. Phagocytosis induces superoxide formation and apoptosis in macrophages. Exp Mol Med 2003; 35: 325–335
   PubMed Web of Science ®Google Scholar
• Park S, Nam H, Chung N, Park JD, Lim Y. The role of iron in reactive oxygen species generation from diesel exhaust particles. Toxicol In Vitro 2006; 20: 851–857
   PubMed Web of Science ®Google Scholar
• Peters A, Wichmann HE, Tuch T, Heinrich J, Heyder J. Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med 1997; 155: 1376–1383
   PubMed Web of Science ®Google Scholar
• Porter AE, Muller K, Skepper J, Midgley P, Welland M. Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: studied by high resolution electron microscopy and electron tomography. Acta Biomater 2006; 2: 409–419
   PubMed Web of Science ®Google Scholar
• Pourazar J, Mudway IS, Samet JM, Helleday R, Blomsberg A, Wilson SJ, Frew AJ, Kelly FJ, Sandström T. Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways. Am J Physiol Lung Cell Mol Physiol 2005; 289: L724–730
   PubMed Web of Science ®Google Scholar
• Qaddoumi MG, Gukasyan HJ, Davda J, Labhasetwar V, Kim KJ, Lee VH. Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: Role in PLGA nanoparticle endocytosis. Mol Vis 2003; 9: 559–568
   PubMed Web of Science ®Google Scholar
• Qi LF, Xu ZR, Li Y, Jiang X, Han XY. In vitro effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803 cells. World J Gastronenterol 2005; 11: 5136–5141
   PubMed Web of Science ®Google Scholar
• Rahman Q, Lohani M, Dopp E, Pemsel H, Jonas L, Weiss DG, Schiffmann D. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ Health Perspect 2002; 110: 797–800
   PubMed Web of Science ®Google Scholar
• Raynal I, Prigent P, Peyramaure S, Najid A, Rebuzzi C, Corot C. Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: Mechanisms and comparison of ferumoxides and ferumoxtran-10. Invest Radiol 2004; 39: 56–63
   PubMed Web of Science ®Google Scholar
• Rejman J, Oberle V, Zuhorn IS, Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 2004; 377: 159–169
   PubMed Web of Science ®Google Scholar
• Renwick LC, Brown D, Clouter A, Donaldson K. Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 2004; 61: 442–447
   PubMed Web of Science ®Google Scholar
• Rogers WJ, Basu P. Factors regulating macrophage endocytosis of nanoparticles: Implications for targeted magnetic resonance plaque imaging. Atherosclerosis 2005; 178: 67–73
   PubMed Web of Science ®Google Scholar
• Roser M, Fischer D, Kissel T. Surface-modified biodegradable albumin nano- and microspheres. II: Effect of surface charges on in vitro phagocytosis and biodistribution in rats. Eur J Pharm Biopharm 1998; 46: 255–263
   PubMed Web of Science ®Google Scholar
• Ross CA, Pickart C. The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases. Trends Cell Biol 2004; 14: 703–711
   PubMed Web of Science ®Google Scholar
• Roy I, Ohulchanskyy TY, Bharali DJ, Pudavar HE, Mistretta RA, Kaur N, Prasad PN. Optical tracking of organically modified nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery. Proc Natl Acad Sci USA 2004; 102: 279–284
   Web of Science ®Google Scholar
• Salnikov, VV, Lukyanenko, YO, Frederick, CA, Lederer, WJ, Lukyanenko, VI. 2006. Probing the Outer Mitochondrial Membrane in Cardiac Mitochondria with Nanoparticles. Biophys J, 92:1058–1071
   PubMed Web of Science ®Google Scholar
• Salvi SS, Nordenhall C, Blomberg A, Rudell B, Pourazar J, Kelly FJ, Wilson S, Sandström T, Holgate ST, Frew AJ. Acute Exposure to diesel exhaust increases IL-8 and GRO-α production in healthy human airways. Am J Respir Crit Care Med 2000; 161: 550–557
   PubMed Web of Science ®Google Scholar
• Satoh MS, Lindahl T. Enzymatic repair of oxidative DNA damage. Cancer Res 1994; 54: 1899s–1901
   PubMed Web of Science ®Google Scholar
• Savic R, Luo L, Eisenberg A, Maysinger D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 2003; 300: 615–618
   PubMed Web of Science ®Google Scholar
• Schins RPF. Mechanisms of genotoxicity of particles and fibres. Inhal Toxicol 2002; 14: 57–78
   PubMed Web of Science ®Google Scholar
• Schins RPF, Hei TK. Genotoxic effects of particles. Particle toxicology, K Donaldson, P Borm, R Boca. CRC Press/Taylor & Francis Group, New York 2006; 285–298
   Google Scholar
• Schins, RPF, Knaapen, AM: Genotoxicity of poorly soluble particles. Inhal Toxicol, in press.
   Google Scholar
• Scott CC, Botelho RJ, Grinstein S. Phagosome maturation: A few bugs in the system. J Membrane Biol 2003; 193: 137–152
   PubMed Web of Science ®Google Scholar
• Sera N, Tokiwa H, Miyata N. Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides. Carcinogenesis 1996; 17: 2163–2169
   PubMed Web of Science ®Google Scholar
• Shi X, Mao Y, Daniel LN, Saffiotti U, Dalal NS, Vallyathan V. Silica radical-induced DNA damage and lipid peroxidation. Environ Health Perspect 1994; 102(Suppl. 10)149–154
   PubMed Web of Science ®Google Scholar
• Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF. Apoptosis and lung cancer: A review. J Cell Biochem 2003; 88: 885–898
   PubMed Web of Science ®Google Scholar
• Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview. Langmuir 2005; 21: 10644–10654
   PubMed Web of Science ®Google Scholar
• Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui S. Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene 2005; 354: 140–146
   PubMed Web of Science ®Google Scholar
• Speiser PP. Nanoparticles and liposomes: A state of the art. Methods Find Exp Clin Pharmacol 1991; 13: 337–342
   PubMed Web of Science ®Google Scholar
• Steinhauser I, Spankuch B, Strebhardt K, Langer K. Trastuzumab-modified nanoparticles: optimisation of preparation and uptake in cancer cells. Biomaterials 2006; 27: 4975–4983
   PubMed Web of Science ®Google Scholar
• Stoeger T, Reinhard C, Takenaka S, Schroeppel A, Karg E, Ritter B, Heyder J, Schulz H. Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ Health Perspect 2006; 114: 328–333
   PubMed Web of Science ®Google Scholar
• Sydlik U, Bierhals K, Soufi M, Abel J, Schins RPF, Unfried K. Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R. Am J Physiol Lung Cell Mol Physiol 2006; 291: 725–733
   PubMed Web of Science ®Google Scholar
• Takenaka S, Karg E, Kreyling WG, Lentner B, Moller W, Behnke-Semmler M, Jennen L, Walch A, Michalke B, Schramel P, et al. Distribution pattern of inhaled ultrafine gold particles in the rat lung. Inhal Toxicol 2006; 18: 733–740
   PubMed Web of Science ®Google Scholar
• Takenaka, S, Karg, E, Roth, Ch, Schulz, H, Ziesenis, A, Heinzmann, U, Schramel, P, Heyder, J. 2001. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environm Health Persp, 109((Suppl. 4)):547–551.
   PubMed Web of Science ®Google Scholar
• Tamaoki J, Isono K, Takeyama K, Tagaya E, Nakata J, Nagai A. Ultrafine carbon black particles stimulate proliferation of human airway epithelium via EGF-R. Am J Physiol Lung Cell Mol Physiol 2004; 287: 1127–1133
   PubMed Web of Science ®Google Scholar
• Tiera MJ, Winnik FO, Fernandes JC. Synthetic and natural polycations for gene therapy: State of the art and new perspectives. Curr Gene Ther 2006; 6: 59–61
   PubMed Web of Science ®Google Scholar
• Timblin CR, Shukla A, Berlanger I, BeruBe KA, Churg A, Mossman BT. Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells. Toxicol Appl Pharmacol 2002; 179: 98–104
   PubMed Web of Science ®Google Scholar
• Tkachenko AG, Xie H, Liu Y, Coleman D, Ryan J, Glomm WR, Shipton MK, Franzen S, Feldheim DL. Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains. Bioconjug Chem 2004; 15: 482–490
   PubMed Web of Science ®Google Scholar
• Tornaletti S. Transcription arrest at DNA damage sites. Mutat Res 2005; 577: 131–145
   PubMed Web of Science ®Google Scholar
• Tran HP, Prakash AS, Barnard R, Chiswell B, Ng JC. Arsenic inhibits the repair of DNA damage induced by benzo(a)pyrene. Toxicol Lett 2002; 133: 59–67
   PubMed Web of Science ®Google Scholar
• Upadhyay D, Kamp DW. Asbestos-induced pulmonary toxicity: Role of DNA damage and apoptosis. Exp Biol Med (Maywood) 2003; 228: 650–659
   PubMed Web of Science ®Google Scholar
• Vijayanathan V, Thomas T, Thomas TJ. DNA nanoparticles and development of DNA delivery vehicles for gene therapy. Biochemistry 2002; 41: 14086–14094
   Web of Science ®Google Scholar
• Vinzents PS, Moller P, Sorensen M, Knudsen LE, Hertel O, Jensen FP, Schibye B, Loft S. Personal exposure to ultrafine particles and oxidative DNA damage. Environ Health Perspect 2005; 113: 1485–1490
   PubMed Web of Science ®Google Scholar
• von Mikecz A. The nuclear ubiquitin-proteasome system. J Cell Sci 2006; 119: 1977–1984
   PubMed Web of Science ®Google Scholar
• Wilson MR, Lightbody JH, Donaldson K, Sales J, Stone V. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol 2002; 184: 172–179
   PubMed Web of Science ®Google Scholar
• Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 1996; 313: 17–29
   PubMed Web of Science ®Google Scholar
• Wong HL, Bendayan R, Rauth AM, Xue HY, Babakhanian K, Wu XY. A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system. J Pharmacol Exp Ther 2006; 317: 1372–1381
   PubMed Web of Science ®Google Scholar
• Xia T, Korge P, Weiss JN, Li N, Venkatesen MI, Sioutas C, Nel A. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: Implications for ultrafine particle toxicity. Environ Health Perspect 2004; 112: 1347–1358
   PubMed Web of Science ®Google Scholar
• Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 2006; 6: 1794–1807
   PubMed Web of Science ®Google Scholar
• Xing X, He X, Peng J, Wang K, Tan W. Uptake of silica-coated nanoparticles by HeLa cells. J Nanosci Nanotechnol 2005; 5: 1688–1693
   PubMed Web of Science ®Google Scholar
• Xu A, Wu LJ, Santella RM, Hei TK. Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res 1999; 59: 5922–5926
   PubMed Web of Science ®Google Scholar
• Yamakoshi Y, Umezawa N, Ryu A, Arakane K, Miyata N, Goda Y, Masumizu T, Nagano T. Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2−* versus 1O2. J Am Chem Soc 2003; 125: 12803–12809
   PubMed Web of Science ®Google Scholar
• Zhang Q, Kleeberger SR, Reddy SP. DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung. Am J Physiol Lung Cell Lol Physiol 2003; 286: L427–436
   Web of Science ®Google Scholar
• Zhang Y, Kohler N, Zhang M. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials 2002; 23: 1553–1561
   PubMed Web of Science ®Google Scholar
• Zhou BB, Elledge SJ. The DNA damage response: Putting checkpoints in perspective. Nature 2000; 408: 433–439
   PubMed Web of Science ®Google Scholar
• Zhu Y, Zhao Q, Li Y, Cai X, Li W. The interaction and toxicity of multi-walled carbon nanotubes with Stylonychia mytilus. J Nanosci Nanotech 2006; 6: 1357–1364
   PubMed Web of Science ®Google Scholar