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Original Articles

SYNTHESIS OF THE SELECTIVE BLADDER CARCINOGEN, N-(n-BUTYL)-N-(3-CARBOXYPROPYL)NITROSAMINE (BCPN)

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Pages 49-52 | Received 03 Mar 1977, Published online: 10 Feb 2009

References

  • Okada , M. , Suzuki , E. , Aoki , J. , Iiyoshi , M. and Hashimoto , Y. 1975 . Gann Monogr. Cancer Res. , 17 : 161 C.A., 84, 84955k (1976)
  • Blattmann , L. and Preussmann , R. 1973 . Z. Krebsforsch. Klin. Onkol. , 79 : 3 W. Lijinsky and H. W. Taylor, Cancer Res., 35, 958 (1975); S. Fukushima, M. Hirose, H. Tsuda, T. Shirai, K. Hirao, M. Arai and N. Ito, Gann, 67, 81 (1976); M. Okada and M. Ishidate, Xenobiotica, 7, 11 (1977)
  • Corey , E. J. and Hertler , W. R. 1960 . J. Am. Chem. Soc. , 82 : 1657
  • Hashimoto , Y. , Suzuki , E. and Okada , M. 1972 . Gann , 63 : 637
  • Schmähl , D. and Krüger , F. W. 1972 . Arzneim.-Forsch. , 22 : 999
  • Hashimoto , Y. , Iiyoshi , M. and Okada , M. 1974 . Gann , 65 : 565
  • Adams , R. and Mahan , J. E. 1942 . J. Am. Chem. Soc. , 64 : 2588 Lactam II was formed by reaction of butyrolactone with n-butylamine
  • The multiplets at δ 4.16 and 3.71 are each the sum of two protons, i.e. I exists as 1:1 mixture of E Z isomers

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